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myocyte necrosis
相关语句
  心肌细胞坏死
     During early cellular rejection episodes, the myocyte necrosis and degeneration can be found by electron microscopy and the nature of the infiltrating cells confirmed.
     在早期细胞排斥反应阶段 ,电镜检查可发现显著的心肌细胞坏死和变性 ,并可确定浸润炎细胞的性质。
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  “myocyte necrosis”译为未确定词的双语例句
     On the contrary, AI in GH group was lighter and IGF-1 expression was higher than that of I/R group(P<0 05). Local myocyte necrosis and inflammatory cell infiltration were diminished in the GH group than that of I/R group.
     GH组心肌细胞凋亡率明显小于 I/ R组 (P<0 .0 5 ) ,IGF- 1染色强度明显高于另外两组 (P<0 .0 5 ) ,心肌细胞间炎症细胞、坏死灶少于I/ R组。
短句来源
     Results Compared with control group,median survival time of heart allografts in group A,group B,group C was prolonged(P<0.01),lymphocyte infiltration and myocyte necrosis were relieved,mRNA expression of IL-2 in allografts was lower,mRNA expression of IL-10 was higher(P<0.01).
     结果与对照组比较,A组、B组、C组移植心存活时间延长(P<0.01),淋巴细胞浸润和心肌坏死程度较对照组轻,心肌IL-2mRNA表达较对照组减弱(P<0.01),IL-10mRNA表达较对照组增强(P<0.01)。
短句来源
     Conclusion:①In acute rejection,there are large quantity of inflammatory cells infiltration and severe myocyte necrosis within cardiac allografts.
     结论 :①急性排斥反应时 ,移植心脏内大量炎性细胞浸润 ;
短句来源
     Results Result were showed that the levels of serum CPK and myocardial MDA increased after reperfusion, and reached the highest at 3hrs followed reperfusion, the content in the L-Arg groups were significantly lower(P <0.05 Vs CON) and that histopathologically the myocanlial neutrophil infiltration appeared at 1h followed reperfusion, and increased with the continue of the reperfusion , accompanied by the myocyte necrosis in the control group.
     结果 (1)CPK及心肌匀浆MDA测定结果:再灌注后各时相血清CPK及肌匀浆MDA含量较缺血前明显上升,再灌注3h后达到高峰。 L-Arg组中再灌注后各时相点血清CPK及肌匀浆MDA明显低于CON组(P<0.05)。
短句来源
     Local myocyte necrosis and inflammatory cell infiltration was diminished more obviously in the GH group than that of IR group. Conclusion The AI and PDI of NF-κB protein in myocardial cell nuclear lessened obviously due to usage of GH which indicated GH can protect myocardial after IR.
     结论 GH可以减少心肌缺血 /再灌注后心肌细胞凋亡及细胞核NF -κB染色阳性指数 ,说明GH对IR后的心肌具有保护作用
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  相似匹配句对
     And it was associated with necrosis and inflammation.
     同时与肿瘤组织内坏死及癌间质中炎症反应有关(P均<0.05)。
短句来源
     (3)The electron microscope showed the characteristics of myocyte apoptosis episodes,the others showed the characteristics of necrosis.
     电镜发现猝死者梗死区内的心肌细胞核膜完整、染色质浓集、电子密度增加的凋亡特征 ,有的则出现核膜破裂、染色质溶解成碎屑的坏死现象。
短句来源
     Bone Marrow Necrosis
     骨髓坏死
短句来源
     Cardiac myocyte cell death triggered by ischemia/ reperfusion can occur by both apoptosis and necrosis.
     随着冠脉溶栓术、经皮冠状动脉腔内成形术等技术的推广应用,心肌缺血再灌注损伤作为阻碍缺血心肌从再灌注疗法中获得最佳疗效的主要难题,一直备受医学界关注。
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     The effect of CsA on myocyte apoptosis
     环孢素A对心肌细胞凋亡的影响
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  myocyte necrosis
This irreversible myocyte necrosis travels transmurally towards epicardium in the form of a wavefront [1].
      
The circulating markers of myocyte necrosis are not increased by apoptosis.
      
The morphologic changes are dose-related and have lesions of different ages, which include myocyte necrosis with hemorrhage and vasculitis.
      
(c) Severe acute rejection, which is more difficult to reverse, includes a more prolific infiltrate with the addition of neutrophils, hemorrhage, and increased myocyte necrosis.
      
(b) Moderate acute rejection has an increased infiltrate extending into the interstitium and causing focal myocyte necrosis.
      
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Objective:To investigate the development of cardiac allograft arteriosclerosis (CGA) and other myopathy in cardiac allografts so as to provide a theoretical basis for the prevention and treatment of immunologic ejection. Methods:Heterotopic cervical heart transplantation model was established.The recipient was pretreated with infusion of donor splenocytes(SPC)followed by cyclophospharmide(CP).The paraffin sections of cardiac allograft were stained by H E、Massons trichrome and Van.Gieson,and Smooth muscle cell(SMC)were...

Objective:To investigate the development of cardiac allograft arteriosclerosis (CGA) and other myopathy in cardiac allografts so as to provide a theoretical basis for the prevention and treatment of immunologic ejection. Methods:Heterotopic cervical heart transplantation model was established.The recipient was pretreated with infusion of donor splenocytes(SPC)followed by cyclophospharmide(CP).The paraffin sections of cardiac allograft were stained by H E、Massons trichrome and Van.Gieson,and Smooth muscle cell(SMC)were stained by immunocytochemistry.Slides were studied about inflammatory cell infiltration,myocyte necrosis,myocardial fibrosis and graft arteriosclerosis. Results:Pretreatment with SPC and CP could prolong the cardiac allograft survival time while inflammatory cell infiltration,myocyte necrosis,myocardial fibrosis and CGA were significantly alleviated. Conclusion:①In acute rejection,there are large quantity of inflammatory cells infiltration and severe myocyte necrosis within cardiac allografts.②The inflammatory cells infiltration in cardiac allograft originated from epicardial area to intimal area.③The pretreatment of SPC followed by CP can prevent and relieve the development of myofibrosis and CGA.

目的 :探讨在心脏移植中心肌及血管病变的发生和发展情况 ,为预防和治疗移植排斥反应提供理论依据。方法 :采用颈部心脏移植模型 ,用供体脾细胞 (SPC)和环磷酰胺 (CP)预处理受体 ,H E、Masson三色、VanGieson和免疫组化平滑肌细胞染色 ,对移植心脏的浸润细胞 ,心肌纤维化和移植心脏动脉硬化进行分析研究。结果 :经SPC和CP预处理后 ,移植心脏的存活时间明显延长 ,炎性细胞浸润 ,心肌纤维化和心脏动脉硬化明显减轻。结论 :①急性排斥反应时 ,移植心脏内大量炎性细胞浸润 ;②炎性细胞浸润是由心外膜心肌开始逐渐向心内膜方向发展 ;③SPC和CP联合预处理 ,可以预防和减缓移植心脏心肌纤维化和心脏动脉硬化。

Objective To investigate the changes of apoptosis and the expression of Fas and FasL genes in rats myocardium with myocardial ischemia/reperfusion(MIR)and its relation with myocardium injury. Methods Rat models with MIR were established by occluding left coronary artery(LCA)and followed by release of it with ligation.Sixty four rats were divided randomly into sham group(sham operated for 24h),MIR group Ⅰ(30min of ischemia followed by 24h of reperfusion),MIR group Ⅱ(30min ischemia followed by 72h of reperfusion)and...

Objective To investigate the changes of apoptosis and the expression of Fas and FasL genes in rats myocardium with myocardial ischemia/reperfusion(MIR)and its relation with myocardium injury. Methods Rat models with MIR were established by occluding left coronary artery(LCA)and followed by release of it with ligation.Sixty four rats were divided randomly into sham group(sham operated for 24h),MIR group Ⅰ(30min of ischemia followed by 24h of reperfusion),MIR group Ⅱ(30min ischemia followed by 72h of reperfusion)and MIR group Ⅲ(3h of ischemia followed by 24h of reperfusion).Terminal deoxynucleotidyl transferase-mediated dUTP-fluorescein nick end labeling(TUNEL)and S-P immunohistochemical staining were used respectively to detect the changes of apoptosis and protein expression of Fas/FasL genes, and mRNA expression of Fas gene was evaluated by RT-PCR analysis. Histopathological changes in myocardium was also observed. Results Apoptotic index(AI) and possitive index(PI) of Fas protein in myocytes and PI of FasL protein in inflammatory cells were increased in myocardium with MIR,and gradually upregulated with duration of ischemia or reperfusion.mRNA induction of Fas gene was increased following MIR and peaked at 24h of reperfusion.Local myocyte necrosis and inflammatory cell infiltration around infarcted area were observed in myocardium with MIR. Conclusions The increase of mentioned parameters suggests that apoptosis and Fas/FasL system are involved in the process of MIR injury.

目的 探讨大鼠实验性心肌缺血再灌注时心肌细胞凋亡与Fas及Fas蛋白配体 (FasLigand ,FasL)基因表达的变化及与心肌组织损伤的关系。方法 以穿线结扎或松扎左冠状动脉制备大鼠心肌缺血再灌注模型。 6 4只大鼠随机分成假手术组 (假手术 2 4h)、缺血再灌注Ⅰ组 (缺血30min、再灌注 2 4h)、缺血再灌注Ⅱ组 (缺血 30min、再灌注 72h)及缺血再灌注Ⅲ组 (缺血 3h、再灌注2 4h)。以缺口末端标记法检测心肌细胞凋亡的变化 ,S P免疫组化法分别检测Fas与FasL蛋白水平变化 ,采用逆转录聚合酶链反应法检测Fas基因mRNA的表达改变 ,并分析心肌组织病理学损伤程度。结果 心肌缺血再灌注后心肌细胞凋亡指数及Fas蛋白阳性染色指数与炎性细胞FasL蛋白阳性染色指数均增加 ,且均随缺血或再灌注时间延长而进一步增高 ;Fas基因的mRNA表达也上调 ,但以再灌注2 4h时达高峰 ;心肌缺血再灌注后心肌组织呈大小不一的灶性坏死 ,坏死周围有炎性细胞浸润。结论心肌缺血再灌注时心肌细胞凋亡、Fas基因的蛋白与mRNA表达水平及炎性细胞的FasL蛋白表达量均增加 ,心肌细胞凋亡与Fas/Fas...

目的 探讨大鼠实验性心肌缺血再灌注时心肌细胞凋亡与Fas及Fas蛋白配体 (FasLigand ,FasL)基因表达的变化及与心肌组织损伤的关系。方法 以穿线结扎或松扎左冠状动脉制备大鼠心肌缺血再灌注模型。 6 4只大鼠随机分成假手术组 (假手术 2 4h)、缺血再灌注Ⅰ组 (缺血30min、再灌注 2 4h)、缺血再灌注Ⅱ组 (缺血 30min、再灌注 72h)及缺血再灌注Ⅲ组 (缺血 3h、再灌注2 4h)。以缺口末端标记法检测心肌细胞凋亡的变化 ,S P免疫组化法分别检测Fas与FasL蛋白水平变化 ,采用逆转录聚合酶链反应法检测Fas基因mRNA的表达改变 ,并分析心肌组织病理学损伤程度。结果 心肌缺血再灌注后心肌细胞凋亡指数及Fas蛋白阳性染色指数与炎性细胞FasL蛋白阳性染色指数均增加 ,且均随缺血或再灌注时间延长而进一步增高 ;Fas基因的mRNA表达也上调 ,但以再灌注2 4h时达高峰 ;心肌缺血再灌注后心肌组织呈大小不一的灶性坏死 ,坏死周围有炎性细胞浸润。结论心肌缺血再灌注时心肌细胞凋亡、Fas基因的蛋白与mRNA表达水平及炎性细胞的FasL蛋白表达量均增加 ,心肌细胞凋亡与Fas/FasL系统参与了心肌缺血再灌注损伤过程。

Objective: The ultrastructural changes of transplanted hearts were examined. Methods: The endomyocardial biopsy specimens of explanted hearts from cardiac transplant recipients were collected. The tissues were fixed and ultrathin sections prepared as routine. Sections were examined under a JEM 2000EX transmission electron microscope. Results: In the early posttransplant period,endomyocardial biopsy specimens from negative transplanted hearts often showed interstitial edema and occasional endothelial cell swelling...

Objective: The ultrastructural changes of transplanted hearts were examined. Methods: The endomyocardial biopsy specimens of explanted hearts from cardiac transplant recipients were collected. The tissues were fixed and ultrathin sections prepared as routine. Sections were examined under a JEM 2000EX transmission electron microscope. Results: In the early posttransplant period,endomyocardial biopsy specimens from negative transplanted hearts often showed interstitial edema and occasional endothelial cell swelling of capillaries. The lysosomes within myocytes were distinctly increased. During early cellular rejection episodes, the myocyte necrosis and degeneration can be found by electron microscopy and the nature of the infiltrating cells confirmed. In episodes of vascular rejection, endothelial activation,endothelial cell damage,and basement membrane changes can be identified without difficulty.The myofilament composition of ischemic hearts in patients with allograft coronary artery disease is distinctive: there is a disproportionate loss of actin over myosin,giving a coarse appearance to the myofilaments. Conclusion: These ultrastructural changes are useful in further defining the morphologic features associated with rejection and ischemia in cardiac transplant recipients.

目的 :观察心脏移植标本的超微结构变化。方法 :通过移植后心脏的心内膜活检 ,经固定、常规超薄切片制备 ,JEM 2 0 0 0EX透射电镜检查。结果 :移植后的早期阶段 ,未见明显移植排斥反应的心脏心内膜活检显示间质水肿 ,偶尔可见毛细血管内皮细胞的肿胀。心肌细胞和内皮细胞内溶酶体明显增多。在早期细胞排斥反应阶段 ,电镜检查可发现显著的心肌细胞坏死和变性 ,并可确定浸润炎细胞的性质。在血管排斥反应阶段 ,容易辨认内皮细胞增生、内皮细胞损伤和基底膜的改变。在患有移植性冠状动脉病的病人 ,其缺血性心脏具有显著特点 :肌动蛋白丝的缺失比肌球蛋白丝更明显 ,肌微丝相对较粗大。结论 :这些改变对于进一步确诊心脏移植受体的排斥和局部缺血是有用的形态学特征

 
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