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sinoatrial node san
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     INNERVATION OF THE SINOATRIAL NODE OF THE DOG
     心脏窦房结的神经支配
短句来源
     Surgical anatomy of the sinoatrial node
     窦房结的外科解剖
短句来源
     Objective:To research the morphological structure of rabbit sinoatrial node (SAN).
     目的 :了解窦房结的形态结构。
短句来源
     METHODS: Sinoatrial node cells were randomized to five groups: (① Control);
     方法:取培养2 d的乳鼠窦房结细胞,随机分为①对照组;
短句来源
     Objective To observe the morphological structures of sinoatrial node (SAN) in pig hearts.
     目的 观测猪心窦房结形态学结构特点。
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  sinoatrial node san
We focus on the regulatory properties of delayed rectifier K+ (IK) channels in guinea-pig sinoatrial node (SAN) and compare SAN IK to the better characterized ventricular IK.
      
The sinoatrial node (SAN) was discovered in 1906 by Keith and Flack.
      
We investigated whether in the sinoatrial node (SAN) there are two different pacemaker mechanisms and whether either one can maintain spontaneous discharge.
      
The aim of the present experiments was to study the characteristics and mechanisms of the rhythm induced by overdrive ('overdrive excitation', ODE) in the sinoatrial node (SAN) superfused in high [K+]o (8-14 mM).
      
The functional anatomy of the sinoatrial node (SAN) in man is first reviewed, together with its possible anatomical substructure.
      
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The location, shape and internal architecture of the sinoatrial node (SAN) were studied histologically in serial section in 15 hearts (7 adults, 8 foetuses). Based on our observation, the human SAN may be divided into four layers, namely, (1) thesinoatrial node artery layer: its outer longitudinal muscular layer of its media partly lacked in the SAN concentrically; (2) the periarterial layer: the cells of this layer surround the artery concentrically; (3) the central layer,...

The location, shape and internal architecture of the sinoatrial node (SAN) were studied histologically in serial section in 15 hearts (7 adults, 8 foetuses). Based on our observation, the human SAN may be divided into four layers, namely, (1) thesinoatrial node artery layer: its outer longitudinal muscular layer of its media partly lacked in the SAN concentrically; (2) the periarterial layer: the cells of this layer surround the artery concentrically; (3) the central layer, making up the main mass of the node: most P cells in which are arranged parallel to the node artery. In adult the diameter of P cells in this layer is 5.18 μm; (4) the peripheral layer: most transitional cells in this layer radiate from SAN into the atrial muscle. These "tongues of transitional cells" extend mostly into right atrial-muscle and a few into the musculature of superior vena cava. The diameter of transitional cells of this layer in the adult is 7.28 μm. In the adult the arrangement of dense collagen fibers appears circular in the periarterial layer, longitudinal in the central layer and radiative in the peripheral layer.

用组织学连续切片方法,在15例人心窦房结标本上(7例成人,8例胎儿)分别观察窦房结的位置,形态和内部纤维构筑。人窦房结可分为4层,从内到外分别为: 1.窦房结动脉层;该动脉的结内段有的部分缺乏纵行肌; 2.动脉周围层:此层细胞呈环形围绕结动脉; 3.中央层:该层P细胞束沿着窦房结动脉平行排列,并组成结的大部分,其细胞直径在成人为5.18μm;4.外周层:此层移行细胞的大部分呈现从窦房结放射排列进入心房肌的趋势,大部分“移行细胞舌”伸入到右侧心房肌,但很少伸入到上腔静脉侧。该层移行细胞在成人直径为7.28μm。在成人胶原纤维的排列方向有内环、中纵、外放射的排列现象。本文就窦房结的内部构筑讨论了其功能意义及窦房结折返的形态学基础。

Standard microelectrode and two-microelectrodes voltage clamp techniques were used to study the effects of linesinine(Lien), an alkaloid extracted from the green seed embryo of Nelumbo nucifera Gaertn, on slow action potentials (AP) and slow inward current (I_(si)). Lien 10~ 100 μmol/L was shown to concentration-dependently decrease the action potential amplitude (APA), the maximal velocity of phase O depolarization (V_(max)) and prolong the sinus cycle length (SCL) of slow AP in isolated sinoatrial node...

Standard microelectrode and two-microelectrodes voltage clamp techniques were used to study the effects of linesinine(Lien), an alkaloid extracted from the green seed embryo of Nelumbo nucifera Gaertn, on slow action potentials (AP) and slow inward current (I_(si)). Lien 10~ 100 μmol/L was shown to concentration-dependently decrease the action potential amplitude (APA), the maximal velocity of phase O depolarization (V_(max)) and prolong the sinus cycle length (SCL) of slow AP in isolated sinoatrial node (SAN) pacemaker cells of rabbits. On both slow APs of rabbit SAN cells and guinea pig papillary muscles partly depolarized by high K~+, Bay K 8644 0.03 μmol/L markedly increased the APA and V_(max), which were obviously antagonized by Lien 10 μmol/L. Moreover, Lien 1~100 μmol/L was found to inhibit the I_(si) of canine cardiac Purkinje fiber in concentration—dependent manner. Lien 3 and 100 μmol/L reduced the peak value of I_(si) by 14% and 88% respectively. The results suggest that Lien possesses calcium antagonistic effects.

莲心碱(Lien)10~100μmol/L可浓度依赖性地降低离体兔窦房结(SAN)起搏细胞慢反应动作电位幅度(APA)及零相最大上升速率((?)_(max)),延长窦性周长(SCL),并可明显拮抗Bay K 8644增大SAN起搏细胞及高K~-诱发的豚鼠乳头肌慢反应动作电位的APA和((?)_(max))作用。Lien 1~100 μmol/L还可浓度依赖性地抑制犬浦氏纤维慢内向电流(I_(si)),3和100μmol/L分别使I_(si)峰值下降14和88%。结果表明Lien具有抗钙作用。

Abstract The age-related changes in areas and amount of interstitial tissue of human sinoatrial node (SAN) were studied.106 autopsy hearts were taken from cases died at different ages (2 days-83 years) without clinical or pathologic evidence of cardiac diseases.Serial sections 2μm in thickness were prepared parallel to the long axis of SAN.The thin sections selected from the largest ar eas of SAN were stained with HE and Betty's method.The largest areas of sections of SAN...

Abstract The age-related changes in areas and amount of interstitial tissue of human sinoatrial node (SAN) were studied.106 autopsy hearts were taken from cases died at different ages (2 days-83 years) without clinical or pathologic evidence of cardiac diseases.Serial sections 2μm in thickness were prepared parallel to the long axis of SAN.The thin sections selected from the largest ar eas of SAN were stained with HE and Betty's method.The largest areas of sections of SAN in 7 age groups were calculated by computer image analysis system.The area of total SAN and SAN cells increased with age before 20 years of age.In adults,the area reached the maximal plateau.Over 40 years of age,the area of SAN decreased with aging.And the percentage of areas of SAN interstitial tissue were estimated by mesh micrometer.Before 10 years of age,the SAN contains very little interstitium.The percentage of area of SAN interstitium increased with aging (I to V degrees).Age-related changes of the human SAN were discussed.

对106例无明显心脏疾患的法医解剖人体的心脏传导系统窦房结(SAN)的主、间质形态学进行研究,应用计算机显微图像分析系统测量每例SAN纵切最大面积,用网格测微器半定量估算正常人SAN内间质所占百分比,发现SAN主、间质形态学改变与年龄之间呈现增龄性生理变化,应避免与SAN病理改变相混淆。

 
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