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immunological hepatic
相关语句
  免疫性肝
     Experimental study of Ganyingke Granule(肝硬克颗粒) on immunological hepatic injury induced by the serum of pig in rat
     肝硬克颗粒抗猪血清致大鼠免疫性肝纤维化的实验研究
短句来源
     Experimental Study of Dantian Ruangan Granule on Rat Immunological Hepatic Injury Induced by Pig Serum
     丹田软肝颗粒抗猪血清致大鼠免疫性肝纤维化的实验研究
短句来源
     On the base of models of BCG+LPS-induced immunological liver injury, cordyceps polysaccharides ( 150, 250, 500 ing ' kg'', ig ) had the same protective effect on immunological hepatic injury as those caused by the above two drugs.
     在尾静脉iv BCG+LPS成功诱导免疫性肝损伤模型的基础上,采用虫草多糖(150、250、500 nlg·kg一,)19给药能显著降低BeG+LPs诱导的免疫性肝损伤引起的血浆中升高的ALT、AST和肝匀浆中升高的MDA水平,并增加肝匀浆中SOD的活性。
短句来源
     Using an in situ collagenase-pronase E perfusion technique, Kupffer's cells were isolated from hepatocytes in rat immunological hepatic injury, and nitric oxide (NO) production in culture supernatant was measured by the method of the Griess's reaction.
     采用胶原酶-链霉蛋白酶灌流法对免疫性肝损伤大鼠肝实质细胞与枯否细胞进行分离与原代培养,Griess反应法检测细胞培养上清中一氧化氮(NO)生成量的变化。
短句来源
     These results implie that NO mainly originate from hepatocytes in rat immunological hepatic injury and LPS regulated NO production via promoting TNFα release in Kupffer's cells.
     提示免疫性肝损伤中NO生成主要源于肝实质细胞; LPS通过使枯否细胞释放TNFα对NO生成进行调节。
短句来源
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  “immunological hepatic”译为未确定词的双语例句
     OBJECTIVE:Adopt immunological hepatic fibrosis induced by porcins serum in rats.
     目的:采用猪血清免疫损伤性大鼠肝纤维化模型,观察大黄酸抗肝纤维化的效应并探讨其可能机制。
短句来源
     Effects of selective induceble nitric oxide synthase inhibitor on immunological hepatic injury in rat
     诱导型一氧化氮合酶选择性抑制剂对大鼠免疫性肝损伤的影响
短句来源
     Cellular Source of Inducible Nitric Oxide Synthase in Rat Immunological Hepatic Injury
     免疫性肝损伤中诱导型一氧化氮合酶的细胞来源
短句来源
     The efficacy and mechanisms of the chinese traditional patent drugs ganfule against the immunological hepatic fibrosis in rats
     中药肝复乐治疗大鼠肝纤维化模型的效应研究
短句来源
     Conclusion: Swertia Punicea has antioxidation and a protective action on the chemical and immunological hepatic injury, especially on the chemical hepatic injury.
     结论紫红獐牙菜总提物具有一定保肝降酶及抗氧化作用,对CCl4肝损伤的保护作用比对BCG/LPS性肝损伤的保护效果好。
短句来源
  相似匹配句对
     Clinical and immunological features of patients with autoimmune hepatic disease
     自身免疫性肝病临床及免疫学特征
短句来源
     Comparison between Immunological and Chemical Injury Hepatic Fibrosis
     免疫性和化学性损伤肝纤维化动物模型的比较
短句来源
     Hepatic amyloidosis
     肝脏淀粉样变性
短句来源
     Therapy for hepatic encephalopathy
     肝性脑病的治疗
短句来源
     Immunological adjuvant and chitosan
     免疫佐剂与壳聚糖
短句来源
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Objective To investigate the role and induced regulation of nitric oxide (NO) in rat immunological hepatic injury, and the effect of selective inhibitor on induceble nitric oxide synthase (iNOS). Methods The intracellular NOS gene expression in the immune damaged hepatocytes was determined by in situ PCR technique, and NO concentration and lactate dehydrogenase (LDH) activity in culture supernatant were measured. Results Administration of bacille calmette guerin (BCG, 15,30,50mg/rat, iv) alone or BCG...

Objective To investigate the role and induced regulation of nitric oxide (NO) in rat immunological hepatic injury, and the effect of selective inhibitor on induceble nitric oxide synthase (iNOS). Methods The intracellular NOS gene expression in the immune damaged hepatocytes was determined by in situ PCR technique, and NO concentration and lactate dehydrogenase (LDH) activity in culture supernatant were measured. Results Administration of bacille calmette guerin (BCG, 15,30,50mg/rat, iv) alone or BCG with the inflammatory cytokines mixture (CM), including IL 1β, IFN γ, TNF α and lipopolysacchride (LPS) significantly increased NO production and LDH release in culture medium( P <0 05). NO production was enhanced with hepatic injury degree in direct proportion, and with BCG dose in inverse proportion. Under immunological stimuli condition, hepatocytes NOS mRNA mainly expressed an induceble and soluble isoform (iNOS) in cytoplasm. Aminoguanidine (AG), a selective iNOS inhibitor,inhibited NO production and LDH release(83.4% and 36.0%, P <0 05), but the transcription inhibitor actinomycin D enhanced LDH level in the medium (25 5%, P <0 05). Conclusion NO produced by immunological stimuli participates in rat hepatic injury mechanism.

目的探讨大鼠免疫性肝损伤模型中一氧化氮(NO)的作用及诱生规律,诱导型一氧化氮合酶(iNOS)选择性抑制剂的作用机制。方法采用原位PCR法对免疫损伤性肝细胞NOS基因表达进行原位检测,并观察细胞培养上清中NO生成量及乳酸脱氢酶(LDH)活性的变化。结果用卡介苗(BCG,15、30、50mg/只静脉注射)单独投与或与炎性细胞因子配伍(CM,含白细胞介素1β,干扰素γ,肿瘤坏死因子α及细菌脂多糖)可引起培养上清NO浓度及LDH活性明显升高(均P<0.05),NO生成量与肝损伤程度成正比,而与BCG剂量成反比;大鼠免疫损伤性肝实质细胞NOS基因表达以可溶性胞浆型iNOS为主;iNOS选择性抑制剂氨基胍在明显抑制细胞培养上清中NO生成(83.4%,P<0.05)的同时,减轻肝细胞损伤的程度(36.0%,P<0.05);而转录抑制剂放线菌素D则加重肝损伤(增加25.5%,P<0.05)。结论在免疫刺激条件下诱导生成的NO主要参与肝损伤机制

Using an in situ collagenase-pronase E perfusion technique, Kupffer's cells were isolated from hepatocytes in rat immunological hepatic injury, and nitric oxide (NO) production in culture supernatant was measured by the method of the Griess's reaction. The results indicated that NO production in hepatocytes was significantly higher than in Kuffer's cells under the similar stimulating conditions;TNFα-monoclonal antibody inhibited NO production induced by bacterial lipopolysaccharide (LPS) in Kupffer's cells,...

Using an in situ collagenase-pronase E perfusion technique, Kupffer's cells were isolated from hepatocytes in rat immunological hepatic injury, and nitric oxide (NO) production in culture supernatant was measured by the method of the Griess's reaction. The results indicated that NO production in hepatocytes was significantly higher than in Kuffer's cells under the similar stimulating conditions;TNFα-monoclonal antibody inhibited NO production induced by bacterial lipopolysaccharide (LPS) in Kupffer's cells, but did not affect that by stimulated bacille calmette guerin (BCG). These results implie that NO mainly originate from hepatocytes in rat immunological hepatic injury and LPS regulated NO production via promoting TNFα release in Kupffer's cells.

采用胶原酶-链霉蛋白酶灌流法对免疫性肝损伤大鼠肝实质细胞与枯否细胞进行分离与原代培养,Griess反应法检测细胞培养上清中一氧化氮(NO)生成量的变化。结果显示在刺激条件及细胞数量同等情况下,肝实质细胞NO生成量显著高于枯否细胞;肿瘤坏死因子(TNFα)单克隆抗体可拮抗枯否细胞由细菌脂多糖(LPS)刺激所致NO生成的增加,而对卡介苗(BCG)所致NO生成无显著影响。提示免疫性肝损伤中NO生成主要源于肝实质细胞;LPS通过使枯否细胞释放TNFα对NO生成进行调节。

Objective: to observe the protective effect of Swertia Punicea on experimental hepatic injury induced by CCl4 and BCG/LPS respectively. Methods: Mouse models of hepatic injury were induced by CCl4 and BCG/LPS. Serum levels of ALT and AST, MDA content and the pathological changes of hepatic tissue were observed. Results: Swertia Punicea obviously inhibited the rising levels of serum ALT and AST, improved the histological features and relieved hepatic edema induced by CCl4 in mice. However, it has no obvious action...

Objective: to observe the protective effect of Swertia Punicea on experimental hepatic injury induced by CCl4 and BCG/LPS respectively. Methods: Mouse models of hepatic injury were induced by CCl4 and BCG/LPS. Serum levels of ALT and AST, MDA content and the pathological changes of hepatic tissue were observed. Results: Swertia Punicea obviously inhibited the rising levels of serum ALT and AST, improved the histological features and relieved hepatic edema induced by CCl4 in mice. However, it has no obvious action on the rising levels of ALT and AST induced by BCG/LPS. It also reduced MDA content and decreased the hepatic index and the splenic index. Conclusion: Swertia Punicea has antioxidation and a protective action on the chemical and immunological hepatic injury, especially on the chemical hepatic injury.

目的观察紫红獐牙菜总提物对几种物质诱导小鼠肝损伤的保护作用。方法采用CCl4及BCG/LPS造成小鼠肝损伤,并测定小鼠血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)和肝组织丙二醛(MDA)的含量,同时观察肝组织病理改变。结果紫红獐牙菜总提物能明显降低由CCl4引起的小鼠ALT、AST的升高,缓解肝组织病理变化,减轻肝脏水肿。而对BCG/LPS所致小鼠血清ALT、AST的升高无明显降低作用,但能降低MDA及肝脏和脾脏指数,也能缓解肝组织病理改变。结论紫红獐牙菜总提物具有一定保肝降酶及抗氧化作用,对CCl4肝损伤的保护作用比对BCG/LPS性肝损伤的保护效果好。

 
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