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resting tension
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  张力
     RESULTS ATP (0.1 μmol·L~ -1-1 mmol·L~ -1) produced a complicated response including an inhibition of rhythmic contraction and a weakly transient decrease in basic tone (0.05-0.08 g) followed by a concentration-dependent contraction (0.04-0.44 g) in longitudinal muscle strips of the rat proximal colon at resting tension.
     结果在静息张力下,1μmol·L-1~1mmol·L-1ATP对大鼠近端结肠纵行肌产生3种效应,即抑制自发性收缩反应,一过性轻度降低基础张力(0.05~0.08g),随后产生浓度依赖性收缩反应(0.04~0.44g)。
短句来源
     Results:Piclamilast and ciclamilast showed bronchorelaxant effect in ASM at resting tension. EC 50 values of piclamilast and cic-lamilast were 1.00×10 -5 mol/L and 0.84×10 -5 mol/L.
     结果 :piclami-last和 ciclamilast对静息张力气管平滑肌均有直接松弛作用 ,EC50 分别为 :piclamilast1.0 0× 10 -5mol/ L,ciclami-last 0 .84× 10 -5mol/ L ;
短句来源
     VP (1 nmol/L) significantly increased the resting tension of CD (P<0.05).
     浓度为1nmol/L的VP增加远端结肠环行肌静息张力(P<0.05)。
短句来源
     Adenosine (1-100 μmol·L~ -1) did not produce an obvious contractile response in the preparation at resting tension.
     在静息张力下,1~100μmol·L-1腺苷对近端结肠纵行肌未产生明显的收缩反应。
短句来源
     Arecoline (10~(-6)mol/L) increased the resting tension of antral circular muscle strips.
     10~(-6)mol/L浓度槟榔碱增高环行肌条的张力
短句来源
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  静息张力
     RESULTS ATP (0.1 μmol·L~ -1-1 mmol·L~ -1) produced a complicated response including an inhibition of rhythmic contraction and a weakly transient decrease in basic tone (0.05-0.08 g) followed by a concentration-dependent contraction (0.04-0.44 g) in longitudinal muscle strips of the rat proximal colon at resting tension.
     结果在静息张力下,1μmol·L-1~1mmol·L-1ATP对大鼠近端结肠纵行肌产生3种效应,即抑制自发性收缩反应,一过性轻度降低基础张力(0.05~0.08g),随后产生浓度依赖性收缩反应(0.04~0.44g)。
短句来源
     Results:Piclamilast and ciclamilast showed bronchorelaxant effect in ASM at resting tension. EC 50 values of piclamilast and cic-lamilast were 1.00×10 -5 mol/L and 0.84×10 -5 mol/L.
     结果 :piclami-last和 ciclamilast对静息张力气管平滑肌均有直接松弛作用 ,EC50 分别为 :piclamilast1.0 0× 10 -5mol/ L,ciclami-last 0 .84× 10 -5mol/ L ;
短句来源
     VP (1 nmol/L) significantly increased the resting tension of CD (P<0.05).
     浓度为1nmol/L的VP增加远端结肠环行肌静息张力(P<0.05)。
短句来源
     Adenosine (1-100 μmol·L~ -1) did not produce an obvious contractile response in the preparation at resting tension.
     在静息张力下,1~100μmol·L-1腺苷对近端结肠纵行肌未产生明显的收缩反应。
短句来源
     In the model of oxygen paradox in isolated perfused rat heart, Kappaselenocarrageenan(Se-Car)27mg/L(equals to selenium 0.3mg/L) significantly decreased the incidence of ventricular fibrillation(60%~10%, P<0.05)and the resting tension (P<0.01)during reoxygenation period.
     在离体大鼠心脏氧反常模型上,硒化角叉菜胶27mg/L(含硒0.3mg/L)可明显降低复氧时的室颤发生率(P<0.05)和静息张力(p<0.01)。
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  “resting tension”译为未确定词的双语例句
     BA 1 μmol/L apparently improved the recovery of coronary flow (P<0.05) and contraction am plitude (p<0.01), and inhibited the rise of resting tension (p<0.01) during reperfusion.
     BA 1μmol/L明显促进再灌注后冠脉流量(P<0.05)和心肌收缩幅度(P<0.01)的恢复,并抑制静息张力的升高(P<0.01).
短句来源
     Propranolol (10~(-6)mol/L), L-NNA (10~(-4)mol/L), indomethacin (10~(-5)mol/L) and phentolamine (10~(-6)mol/L) did not inhibit the decreasing action of the mean contractile amplitude and the resting tension of CM of gastric body.
     厚朴酚(10~(-4.5)mol/L)能明显抑制胃体环行肌条在无Ca~(2+)的Krebs液中CaCl_2诱发的第二时相收缩。
短句来源
     Adenosine (1μmol·L~(-1) -100 μmol·L~(-1)) did not produce an obviouslycontractile response in the preparation at resting tension.
     低浓度ATP(1 μmol·L~(-1)-10 μmol·L~(-1))先增大后减低胃窦环行肌的自发性收缩幅度,同时加快收缩频率;
短句来源
     Methods: The anococcygeal muscle from male Sprague-Dawley rats (300~350 g) was isolated, removed and suspended in a 20-ml organ chamber containing Krebs solution at 37 ℃, pH 7.4. The muscle preparations were set at a resting tension of 1.0 g and allowed to equilibrate for 1 h in the Krebs solution.
     方法 :分离雄性SD大鼠 (30 0~ 35 0g)肛尾肌 ,置于盛Krebs液 (37℃、pH 7.4 )的 2 0ml浴槽内 ,静息负荷 1g ,平衡 1h。
短句来源
     When nicardipine ( 0.1μmol/L ) was used in combination with ouabain ( 1 μmol/L ) in the perfusion medium, it could significantly delay or abolish the decline in contractile force induced by ouabain (P< 0.0l)and could attenuate the increase in resting tension (P<0.0l) induced by ouabain.
     尼卡的平(0.1μmol/L)与哇巴因(1μmol/L)合用灌流离体豚鼠心脏,明显推迟和减轻哇巴因中毒时表现的心肌收缩力降低,并明显减弱哇巴因所致心脏静息张力的升高。
短句来源
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  resting tension
The opposite behavior is observed after abrupt releases when-subsequent to an increase in resting tension-diastolic force attains its new equilibrium.
      
In 17 Wistar rats isovolumetric pressure-volume diagrams, the rate of pressure rise, and the resting tension curve were recorded prior to and during acute alcohol intoxication.
      
In isolated and electrically driven (1/s) papillary muscles peak tension and, to a slighter degree, resting tension increased through treatment with Na3VO4 in concentrations higher than 104 M.
      
From the same hearts, the distensibility of the left ventricular papillary muscle was analyzed by means of resting tension curves, and the collagen content of the whole left ventricular wall was determined by means of hydroxyproline concentration.
      
When there was a calcium-depleted period of longer than 8 min, a marked increase in resting tension was observed and reached maximum at 2 to 4 min.
      
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For years calcium entry blockers have been of increasing importance in the therapy of cardiovascular diseases. In this paper, a potent dihydropyridine derivative M-nifedipine (M-Nif) had been studied. The purpose of this series of experiments was to compare the effect of M-Nif on the contractile response of isolated myocardium and coronary vessels with that of nifedipine (Nif). The left atria of guinea pigs were dissected out and suspended in an organ bath (20 ml) containing Krebs′ solution. Th resting tension...

For years calcium entry blockers have been of increasing importance in the therapy of cardiovascular diseases. In this paper, a potent dihydropyridine derivative M-nifedipine (M-Nif) had been studied. The purpose of this series of experiments was to compare the effect of M-Nif on the contractile response of isolated myocardium and coronary vessels with that of nifedipine (Nif). The left atria of guinea pigs were dissected out and suspended in an organ bath (20 ml) containing Krebs′ solution. Th resting tension was kept at 0.5 g. After an equilibration period of 1h, the bathing solution was switched to a high potassium (8.5 mM) and low calcium (0.6 mM) media. After a further equilibration period of 10min, cumulative concentration-response curves for calcium in atrial preparation were obtained. Then curves were determind in the presence of M-Nif 2.67×10~(-7) and Nif 2.88×10~(-7)M. M-Nif and Nif reduced the maximum contractile response and shifted the concentration-response curves to the right in a non-parallel manner. The calcium antagonistic activity of Nif (PD_2′=7.19) was found to be stronger than that of M-Nif (PD′_2=7.05).M-Nif and Nif exhibited a concentration-dependent relaxant effect on the isolated atrial muscle preparations of the guinea pig. Nif (IC_(50)=2.9×10~(-6)M) was also 2.6 times more potent than M-Nif (IC_(50)=7.5×10~(-6)M).In contrast to the atrium, M-Nif and Nif showed nearly equipotent inhibitory effects on the isolated pig coronary vessel strips. However, M-Nif (PD′_2=7.06, IC_(50)=6.166×10~(-7)M) was slightly stronger (1.14 times) than Nif (PD′_2=6.88, IC_(50)=7.02×10~(-7)M). Therefore, it is concluded that M-Nif is a potent calcium antagonistic coronary vasodilator with less cardiodepresant effect as compared to Nif, which may be clinically useful as a vasodilator for treatment of congestive heart failure and possibly as a hypotensive agent.

M-Nif对离体豚鼠左心房的钙拮抗作用PD_2~′=7.05较Nif PD_2~′=7.19弱,抑制心肌的IC_(50)=7.5×10~(-8)M亦较Nif IC_(50)=2.9×10~(-6)M弱2.6倍。在离体猪冠脉条实验中M-Nif PD_2~′=7.06,Nif PD_2~′=6.88,前者稍强,前者抑制血管的作用IC_(50)=6.166×10~(-7)M亦强于后者IC_(50)=7.02×10~(-7)M 114倍,Nif扩张血管作用较抑制心肌作用强10倍,提示M-Nif扩张血管与抑制心肌的宽度更大,对治疗心力衰竭、降压将更有利。

Berberine could reverse the phenylephrine-induced contraction of aortic strips of rabbits, but not those induced by histamine, serotonin and high-K. It showed no effect on the resting tension of the strips.

用离体家兔主动脉条观察Ber和NP的作用;NP降低血管条的基本张力,明显逆转由PE,HT、5-HT和KCl所引起的收缩,Ber仅逆转PE引起的收缩,对HT,5-HT和KCl引起的收缩无影响,也不影响血管条的基本张力。 Ber和Pra均阻断PE对血管条的收缩作用,两药的IC_(50)分别为30μM和0.2μM。 实验结果表明;NP非特异性逆转几种激动剂所致血管条的收缩,Ber仅逆转PE引起的血管收缩,其作用性质和Pra相似,提示Ber对血管条的α_1-肾上腺素受体具有选择性阻断作用。

The purpose of our study is to determine whether the slow Ca2 + channel blocker, nicardipiae, could prevent or reduce the cardiac to-xicity induced by ouabain. The guinea pig heart in vivo and vitro perfusion of the isolated heart were used for the study . The results demonstrated that nicardipine ( i .v .50μg· kg-1') could significantly increase the doses of ouabain induced arrhythmias and death(P<0.01 ) . When nicardipine ( 0.1μmol/L ) was used in combination with ouabain ( 1 μmol/L ) in the perfusion medium,...

The purpose of our study is to determine whether the slow Ca2 + channel blocker, nicardipiae, could prevent or reduce the cardiac to-xicity induced by ouabain. The guinea pig heart in vivo and vitro perfusion of the isolated heart were used for the study . The results demonstrated that nicardipine ( i .v .50μg· kg-1') could significantly increase the doses of ouabain induced arrhythmias and death(P<0.01 ) . When nicardipine ( 0.1μmol/L ) was used in combination with ouabain ( 1 μmol/L ) in the perfusion medium, it could significantly delay or abolish the decline in contractile force induced by ouabain (P< 0.0l)and could attenuate the increase in resting tension (P<0.0l) induced by ouabain. The activity of membrane Na+, K+-ATPase, which was almost completely inhibited by 1 μmol/L ouabain, was unaffected by 10μmol/L nicardipine. The results metioned above suggest that simultaneous use of nicardipine and ouabain may protect against cardiac toxicity induced by ouabain.

豚鼠iv尼卡的平(50μg/kg),可显著增加哇巴因引起心律失常的剂量及致死量。尼卡的平(0.1μmol/L)与哇巴因(1μmol/L)合用灌流离体豚鼠心脏,明显推迟和减轻哇巴因中毒时表现的心肌收缩力降低,并明显减弱哇巴因所致心脏静息张力的升高。1μmo/L哇巴因几乎完全抑制心肌Na~+、K~+—ATP酶活性;尼卡的平对该酶活性则无影响。实验结果提示尼卡的平与哇巴因合用可减轻哇巴因引起的心脏毒性作用。

 
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