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valsartan an
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  缬沙坦
     Method: For determination of the plasma concentration of valsartan, an aliquot of 50-μL plasma was treated by liquid-liquid extraction, then the analytes of interest were analyzed on a Zorbax SB-C_(18) column with the mobile phase consisted of methanol-5 mmol/L ammonium acetate (80: 20, v/v).
     方法:50μL含缬沙坦的血浆样品加入内标坎地沙坦,经液—液萃取处理后,以甲醇-5mmol/L乙酸铵(80:20,v/v)为流动相,采用Zorbax SB-C_(18)柱分离;
短句来源
     Objective To investigate the therapeutic effects of perindopril, an angiotensin-converting enzyme inhibitor, and valsartan, an angiotensin Ⅱ receptor blocker on TGF β1 and TGF β receptor Ⅱ mRNA, Smad3 and Smad? on rat liver fibrosis.
     目的 观察培哚普利和缬沙坦抗大鼠肝纤维化的疗效和对转化生长因子β(TGF β1)及其Ⅱ型受体(TGF β1RⅡ)mRNA与Smad3、Smad7的影响。
短句来源
     Phosphorylated extracellular signal regulated kinase (P-ERK) 1/2 activity increased in cells treated with 0.1 μmol/L AngⅡ for 24 h (P<0.01 vs control), which was inhibited by the presence of 1 μmol/L valsartan, an AT_1-receptor blocker.
     用AngⅡ0.1μmol/L刺激心肌细胞24h,磷酸化ERK1/2(P-ERK1/2)活性高于对照组(P<0.01),AT1受体拮抗剂缬沙坦(1μmol/L)能完全阻断AngⅡ增加P-ERK1/2活性;
短句来源
     Mechanism of cardioprotection against ischemia/reperfusion injury by valsartan:an experiment with isolated rat hearts
     缬沙坦对离体大鼠缺血再灌注心肌保护作用的机制
短句来源
     Valsartan,an angiotensin Ⅱ receptor antagonist,can inhibite vassel constriction and the release of aldosterone with significant antihypertensive effect in mild and moderate hypertensive patients and mild adverse effects.
     缬沙坦(valsartan , V A L) 为血管紧张素Ⅱ( Ang Ⅱ) 受体 A T1 的阻断剂,它可阻止 Ang Ⅱ所引起的血管收紧及醛固酮释放,对轻中度高血压的降压效果显著,不逊于现有降压药物。 又可逆转高压所引起的心肌肥大,且不良反应少。
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  “valsartan an”译为未确定词的双语例句
     In cultured in vitro fibroblasts, AngⅡ may accelerate the collagen synthesis significantly (P<0.05), which was inhibited by valsartan, an AT1 receptor blocker, but augmented by PD123319, an AT2 receptor antagonist.
     在培养的人增生性瘢痕成纤维细胞中,AngⅡ可显著促进成纤维细胞胶原的合成,AT1受体阻断剂Valsartan明显抑制该作用,而AT2受体拮抗剂PD123319则明显增强该作用。
短句来源
     In cultured fibroblasts, Ang II stimulation significantly increased DNA synthesis (P<0.05 vs negative control), which was inhibited by valsartan, an AT1 receptor blocker, but augmented by PD123319, an AT2 receptor antagonist. Valsartan or PD123319 alone did not influence the proliferation of fibroblasts derived from hypertrophic scars.
     在培养的人增生性瘢痕成纤维细胞,AngⅡ明显促进成纤维细胞3H-TdR的掺入率,AT1受体阻断剂Valsartan明显抑制AngⅡ的这种促进作用,AT2受体拮抗剂PD123319明显增强AngⅡ的这种作用。
短句来源
  相似匹配句对
     C~(An)(?)
     C~(An)A~(B(?)
短句来源
     In an X.
     X.
     Conclusion: Valsartan is an effective drug to reverse left ventricular hypertrophy.
     结论:缬沙坦在降压的同时可逆转LVH,且安全、有效。
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Objective:To investigate the effects of Valsartan (a sort of nonheterocyclic angiotensin Ⅱ antagonist) and Enalapril on systolic blo od pressure(SBP), left ventricular hypertrophy(LVH) and blood platelet aggregati on in renovascular hypertension rats(RHR).Methods:Establish the mode l of RHR with LVH by clipping the left renal artery (two kidneys, one clip model ). Eight weeks later,Valsartan and Enalapril were given by perfusing stomach to rats daily for twelve weeks to examine the affects on SBP, LVH...

Objective:To investigate the effects of Valsartan (a sort of nonheterocyclic angiotensin Ⅱ antagonist) and Enalapril on systolic blo od pressure(SBP), left ventricular hypertrophy(LVH) and blood platelet aggregati on in renovascular hypertension rats(RHR).Methods:Establish the mode l of RHR with LVH by clipping the left renal artery (two kidneys, one clip model ). Eight weeks later,Valsartan and Enalapril were given by perfusing stomach to rats daily for twelve weeks to examine the affects on SBP, LVH and blood platele t aggregation. Results: After twenty weeks of clippling of the left renal artery,the SBP,the ratio of left ventricar wet weight/body weight(LVWW/BW) and blood platelet aggregation were more increased than those in the control gro up. Twelve weeks treatment of valsartan and Enalapril can decrease SBP, LVWW/BW and blood platelet aggregation on RHR with LVH.Conclusion:Both Valsartan and Enalapril have regressive effects and ca n decrease blood pressure and blood platelet aggregation.

目的 :观察血管紧张素 的 1型 (AT1 )受体拮抗剂缬沙坦与血管紧张素转换酶抑制剂依那普利对肾性高血压左室肥厚大鼠血压、心肌重量及对血小板聚集率的影响。方法 :建立两肾一夹 (Goldblott)肾性高血压大鼠致左室肥厚模型。大鼠左室肥厚形成后 ,缬沙坦与依那普利灌胃给药连续 12周 ,观察两药对大鼠血压、心肌重量和血小板聚集率的影响。结果 :大鼠左侧肾动脉部分钳夹后 ,其收缩压、左心室湿重与体重的比值及血小板聚集率均高于正常对照组。在大鼠左室肥厚形成后 ,缬沙坦与依那普利连续给药 12周 ,可显著降低收缩压、左心室湿重与体重的比值 ,抑制血小板聚集率。结论 :肾性高血压大鼠左室肥厚形成后 ,缬沙坦与依那普利长期给药 ,具有降压、逆转左心室肥厚及抑制血小板聚集率的作用

Objective:To investigate the protectine mechanism of valsartan in the kidney of streptozotocin-induced diabetic rats.Methods:Sprague-dawley rats were randomly divided into diabetic model group treated with valsartan(A),diabetic model group (B) and normal control group (C).The plasma glucose,kidney mass/body mass ratio,serum creatinine,and 24 urinary albumin excretion rate were measured in the 6th week respectively.TGF-β 1 mRNA expression in renal cortinal was analysed with RT-PCR in the 6th week.And...

Objective:To investigate the protectine mechanism of valsartan in the kidney of streptozotocin-induced diabetic rats.Methods:Sprague-dawley rats were randomly divided into diabetic model group treated with valsartan(A),diabetic model group (B) and normal control group (C).The plasma glucose,kidney mass/body mass ratio,serum creatinine,and 24 urinary albumin excretion rate were measured in the 6th week respectively.TGF-β 1 mRNA expression in renal cortinal was analysed with RT-PCR in the 6th week.And the kidney samples were observed with light microscope,mean glomerular transverse sectional area and mean glomerular volume were calculated by analysis system of the image.Results:After 6 weeks,kidney mass/body mass ratio,serum creatinine and 24 urinary albumin excretion rate in both diabetic group B were higher than that of normal group C( P <0.01),but they were decreased significantly in group A than that in group B.For the urinary albumin in two stages,there was no difference between A and C( P <0.05).Furthermore,the MGPA and MGV in group A were significantly smaller than that of group B ( P <0.01).The expression of TGF-β 1 mRNA in group B was significantly increased than that of group C ( P <0.01),at the same time the expression in group A was decreased than that of group B ( P <0.05). Conclusion: Valsartan could reduce the expression of TGF-β 1 mRNA, and the level of urinary albumin, and might prevent the glomerular sclerosis,and the pathological progress of kidney in diabetic rats.

目的 :探讨血管紧张素Ⅱ受体拮抗剂缬沙坦 (Valsartan)对实验性糖尿病大鼠肾皮质TGF - β1表达的影响 ,为糖尿病肾病的防治提供实验性理论基础。方法 :选择健康雄性SD大鼠 2 4只 ,任取其中 16只腹腔注射链脲佐菌素制成糖尿病大鼠模型。将糖尿病大鼠随机分为糖尿病缬沙坦治疗组 (A组 ,8只 ,缬沙坦 10mg·kg-1·d-1灌胃 ) ;糖尿病对照组 (B组 ,8只 ) ;其余 8只为正常对照组 (C组 )。分别于实验第 6周末测定各组大鼠血糖、血肌酐、尿白蛋白排泄率 ,对肾脏标本进行光镜观察 ,用图像分析仪测量各组大鼠平均肾小球面积、平均肾小球体积。并取各组大鼠肾皮质提取RNA ,用逆转录 -PCR(RT -PCR)方法对肾皮质TGF - β1mRNA表达进行半定量分析。结果 :在糖尿病第 6周末 ,B组上述指标较C组均有不同程度的升高 (P <0 .0 1) ,而A组则显著低于同时期的B组。其中 ,A组、C组尿白蛋白排泄率始终无统计学差异 ,肾小球平均面积、平均体积A组显著低于B组 (P <0 .0 1)。RT -PCR半定量结果分析显示 ,B组TGF - β1mRNA表达较A组、C组显著...

目的 :探讨血管紧张素Ⅱ受体拮抗剂缬沙坦 (Valsartan)对实验性糖尿病大鼠肾皮质TGF - β1表达的影响 ,为糖尿病肾病的防治提供实验性理论基础。方法 :选择健康雄性SD大鼠 2 4只 ,任取其中 16只腹腔注射链脲佐菌素制成糖尿病大鼠模型。将糖尿病大鼠随机分为糖尿病缬沙坦治疗组 (A组 ,8只 ,缬沙坦 10mg·kg-1·d-1灌胃 ) ;糖尿病对照组 (B组 ,8只 ) ;其余 8只为正常对照组 (C组 )。分别于实验第 6周末测定各组大鼠血糖、血肌酐、尿白蛋白排泄率 ,对肾脏标本进行光镜观察 ,用图像分析仪测量各组大鼠平均肾小球面积、平均肾小球体积。并取各组大鼠肾皮质提取RNA ,用逆转录 -PCR(RT -PCR)方法对肾皮质TGF - β1mRNA表达进行半定量分析。结果 :在糖尿病第 6周末 ,B组上述指标较C组均有不同程度的升高 (P <0 .0 1) ,而A组则显著低于同时期的B组。其中 ,A组、C组尿白蛋白排泄率始终无统计学差异 ,肾小球平均面积、平均体积A组显著低于B组 (P <0 .0 1)。RT -PCR半定量结果分析显示 ,B组TGF - β1mRNA表达较A组、C组显著增高 (P <0 .0 1) ,A组TGF - β1mRNA表达较C组为高 (P <0 .0 1) ,但仍较B组为低 (P <0 .0 5 )。结论 :缬沙坦能够抑制肾组织TGF - β1mRNA的表达 ,减少糖尿病大鼠的尿白蛋白 ,减轻及延缓肾小球?

Objective To explore the surpressing effect of valsartan an d spironolactone on expression of integrin β\-1 in cardiac myocytes in spontaneously hypertensive rats. Methods Eighteen 6-week-old SHRs were randomly to receive valsartan (20 mg·kg -1 ·d -1 ) or spironolactone (10 mg·kg -1 ·d -1 ).\ 6 SHR and 6 WKY rats served as control. After 14 weeks, expression of integrin β 1 in cardiac myocytes were studied by immunohistochemistry. Results The ex pression of integrin β 1 were higher...

Objective To explore the surpressing effect of valsartan an d spironolactone on expression of integrin β\-1 in cardiac myocytes in spontaneously hypertensive rats. Methods Eighteen 6-week-old SHRs were randomly to receive valsartan (20 mg·kg -1 ·d -1 ) or spironolactone (10 mg·kg -1 ·d -1 ).\ 6 SHR and 6 WKY rats served as control. After 14 weeks, expression of integrin β 1 in cardiac myocytes were studied by immunohistochemistry. Results The ex pression of integrin β 1 were higher in SHR than in WKY group(P<0 05).\ Losartan inhibit the expression of integrin β 1, while no change in integrin by spironolactone was found.\ Both valsartan and spironolactone decreased blood pressure, left vnticular mass to body weight ratio(LVM/BW) and the extent of cardiac fibrosis. Conclusion Although both valsartan and spironolactone decreased blood pressure, the inhibition effect on the integrin β\-1 in cardial myocytes was ma nifested only by valsartan treatment. Valsartan was more effective i n attenuating myocardial fibiosis than that by spironolactone. Integrin β 1 may play a role in hypertensive cardiac fibrosis.

目的 比较自发性高血压大鼠 (SHR)和WKY心肌整和素β1的表达以及缬沙坦和螺内酯对SHR整和素 β1的影响。方法 将 18只 6周龄SHR随机分成 3组 ,每组 6只。其中 2组分别灌喂缬沙坦 2 0mg·kg- 1·d- 1,和螺内酯 10mg·kg- 1·d- 1,另一对照组给正常饮水 ,并与雄性同周龄WKY6只比较。实验期 14周 ,免疫组化法检测四组大鼠心肌整和素 β1的表达。结果 SHR对照组心肌整和素 β1表达明显高于WKY组 ,和SHR对照组比较缬沙坦组整和素 β1的表达下降 (P <0 0 5) ,而螺内酯组整和素 β1的表达无显著改变 ;两治疗组血压、LVM/BW以及心肌纤维化程度均显著低于SHR组 (P <0 0 5) ,而且两治疗组间比较缬沙坦组血压和心肌纤维化程度降低更明显 (P <0 0 5)。结论 缬沙坦除降低血压外 ,还能抑制整和素 β1表达 ,而螺内酯对整和素β1的表达无明显抑制作用 ;而缬沙坦对心肌纤维化的抑制作用优于螺内酯。提示整和素 β1在高血压心肌纤维化进程中起了一定作用

 
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