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striatum tissues
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  纹状体
     ① Content of 5-HT: The contents of 5-HT in the cerebral cortex and striatum tissues were significantly lower in the ischemia reperfusion group than in the sham-operated group (P< 0.01), but significantly higher in the trihexyphenidyl 1.5, 1 and 0.5 mg / kg groups and nimodipine group than in the ischemia reperfusion group (P < 0.01 or 0.05).
     ①5-羟色胺含量:脑皮质和纹状体缺血再灌注组均显著低于假手术组(P<0.01),苯海索1.5,1,0.5mg/kg剂量组和尼莫地平3mg/kg组均显著高于缺血再灌注组(P<0.01或0.05)。
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     ② Level of norepinephrine: The levels of norepinephrine in the cerebral cortex and striatum tissues were significantly lower in the ischemia reperfusion group than in the sham-operated group (P < 0.01), but significantly higher in the trihexyphenidyl 1.5, 1 and 0.5 mg / kg groups and nimodipine group than in the ischemia reperfusion group (P < 0.01 or 0.05).
     ②去甲肾上腺素水平:脑皮质和纹状体缺血再灌注组均显著低于假手术组(P<0.01),苯海索1.5,1,0.5mg/kg剂量组和尼莫地平3mg/kg组均显著高于缺血再灌注组(P<0.01或0.05)。
短句来源
     ③ Content of dopamine: The contents of dopamine in the cerebral cortex and striatum tissues were significantly lower in the ischemia reperfusion group than in the sham-operated group (P < 0.01), but significantly higher in the trihexyphenidyl 1.5, 1 and 0.5 mg / kg groups and nimodipine group than in the ischemia reperfusion group (P < 0.01 or 0.05).
     ③多巴胺含量:脑皮质和纹状体缺血再灌注组均显著低于假手术组(P<0.01),苯海索1.5,1,0.5mg/kg剂量组和尼莫地平3mg/kg组均显著高于缺血再灌注组(P<0.01或0.05)。
短句来源
     RESULTS: Compared with blank control group, the contents of monoamines transmitter in cerebral contex, hippocampus and striatum tissues of doxepin 15, 10, 5 mg·kg -1 groups and nimodipine 3 mg·kg -1 group increased significantly ( P <0.05 or P <0.01). Activity of EEG was recovered significantly ( P <0.05 or P <0.01).
     结果 :与空白对照组比较 ,多塞平 15 ,10 ,5mg·kg- 1剂量组及尼莫地平 3mg·kg- 1组大脑皮层、海马、纹状体各单胺类递质含量显著升高 (P <0 .0 5或P <0 .0 1) ,脑电活动亦显著恢复 (P<0 .0 5或P <0 .0 1)。
短句来源
     AIM: To observe the effects of trihexyphenidyl (THP) on the content of monoamine neurotransmitters in the cerebral cortex and striatum tissues in rats with acute cerebral ischemia-reperfusion injury, and take nimodipine as positive control.
     目的:观察中枢性抗胆碱药苯海索对急性脑缺血再灌注大鼠大脑皮质、纹状体单胺类递质含量的影响,并与尼莫地平进行阳性对照。
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     tissues.
     然而正常组织对放射线也有一定的耐受量。
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     striatum sp.n.
     striatum sp.n.
短句来源
     tissues and cells.
     从而致使细胞和组织器官受损。 基于上述情况.
短句来源
     Conclusion Edaravone may enhance antioxidation of brain tissues, especially in striatum.
     结论大剂量依达拉奉可增强脑组织的抗氧化能力,以纹状体最为显著。
短句来源
     MethodsBrain water content of parietal cortex and striatum tissues are measured with specific gravity (SG).
     使用比重法(SG)检测顶叶皮层和纹状体的组织含水量。
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  striatum tissues
The striatum tissues were isolated, and proteins were extracted at different time points after injection.
      


The content of somatostatin (SS) in hippocampus,striatum and frontal cortex tissues of rats exposed to 600 kpa hyperbaric oxygen was determined by means of radioimmunoassay.Initial time of convulsion, severity of convulsion and survival time of rats with convulsion exposed to 700 kpa hyperbaric oxygen after intraperitoneal injection of cysteamine or intracerebroventricular injection of anti-somatostatin serum were also observed.The results showed that the content of SS in hippocampus and striatum tissues...

The content of somatostatin (SS) in hippocampus,striatum and frontal cortex tissues of rats exposed to 600 kpa hyperbaric oxygen was determined by means of radioimmunoassay.Initial time of convulsion, severity of convulsion and survival time of rats with convulsion exposed to 700 kpa hyperbaric oxygen after intraperitoneal injection of cysteamine or intracerebroventricular injection of anti-somatostatin serum were also observed.The results showed that the content of SS in hippocampus and striatum tissues increased markedly before rats were at unconvulsion, by the time rats developed convulsion,it had a significant increase in all of the brain areas observed. Intraperitoneal injection of cysteamine or intracerebroventricular injection of anti-somatostatin serum could delay initial time of convulsion,prolong survival time and decrease severity of convulsion.These results suggest that SS might play a role in oxygen-induced convulsion and be one of the endogenous agents which caused oxygen-induced convulsion.

用放射免疫分析技术测定大鼠在600kPa高压氧暴露下海马、纹状体和额叶皮质中生长抑素(SS)含量的变化,并在700kPa高压氧暴露下,观察腹腔内注射半胱胺(CSH)及侧脑室内注射SS抗血清对大鼠氧惊厥始发时间(Initialtimeofconvulsion;ITC)、惊厥严重程度(Severityofconvulsion;SOC)和氧惊厥大鼠存活时间(Survivaltime;ST)的影响。结果显示大鼠濒临氧惊厥时海马、纹状体中SS含量显著升高,氧惊厥时所观察脑区SS含量均显著升高;CSH和SS抗血清预处理显著延迟大鼠ITC,减轻SOC和延长其ST。提示SS可能参与氧惊厥发作过程,并可能是导致氧惊厥的内源性物质之一。

The content of somatostatin(SS) in hippocampus,striatum and frontal cortex tissues of rats exposed to 600 kpa hyperbaric oxygen was determined by means of radioimmunoassay. Initial time of convulsion, severity of convulsion and survival time of rats with convulsion exposed to 700 kPa hyperbaric oxygen after intraperitoneal injection of cysteamine (CSH) or intracerebroventricular injection of anti-somatostatin serum(ASS) were also observed. The results showed that the content of SS in hippocampus and striatum...

The content of somatostatin(SS) in hippocampus,striatum and frontal cortex tissues of rats exposed to 600 kpa hyperbaric oxygen was determined by means of radioimmunoassay. Initial time of convulsion, severity of convulsion and survival time of rats with convulsion exposed to 700 kPa hyperbaric oxygen after intraperitoneal injection of cysteamine (CSH) or intracerebroventricular injection of anti-somatostatin serum(ASS) were also observed. The results showed that the content of SS in hippocampus and striatum tissues increased remarkably when rats were at near-convulsion ; by the time the rats developed convulsion,it had a significant increase in all brain areas observed. Intraperitoneal injection of CSH or intracerebroventricular injection of ASS could delay initial time of convulsion (ITC),prolong survival time (ST) and reduce severity of convulsion (SOC). These results suggest that SS might play a role in oxygen-induced convulsion and be one of the endogenous agents which caused oxygeninduced convulsion.

Changesofsomatostatincontentinsomebrainareasofratsduringoxygen-inducedconvulsionHuChanghong(胡长虹);NiGuotan(倪国坛);HangRongchun(杭...

AIM: To observe the effects of doxepin on monoamines transmitter in the rat brain after acute cerebral ischemia reperfusion. METHODS: Acute cerebral ischemia reperfusion injury was produced by 4 vessels occlusion. Rats were divided into six groups: sham operation group, blank contral group, nimodipine 3 mg·kg -1 group and doxepin 15, 10, 5 mg·kg -1 groups. Drugs were administered ip to the rats before ischemia and before reperfusion. The contents of monoamines (5 HT, DA, NE) in cerebral cortex,...

AIM: To observe the effects of doxepin on monoamines transmitter in the rat brain after acute cerebral ischemia reperfusion. METHODS: Acute cerebral ischemia reperfusion injury was produced by 4 vessels occlusion. Rats were divided into six groups: sham operation group, blank contral group, nimodipine 3 mg·kg -1 group and doxepin 15, 10, 5 mg·kg -1 groups. Drugs were administered ip to the rats before ischemia and before reperfusion. The contents of monoamines (5 HT, DA, NE) in cerebral cortex, hippocampus, striatum and brain stem were determined by fluorospectrophotometry. RESULTS: Compared with blank control group, the contents of monoamines transmitter in cerebral contex, hippocampus and striatum tissues of doxepin 15, 10, 5 mg·kg -1 groups and nimodipine 3 mg·kg -1 group increased significantly ( P <0.05 or P <0.01). Activity of EEG was recovered significantly ( P <0.05 or P <0.01). CONCLUSION: The protective effects of doxepin on acute brain ischemia reperfusion injury are related to its effects on monoamines transmitter.

目的 :观察多塞平对急性脑缺血再灌注大鼠各脑区单胺类递质含量的影响。方法 :以阻断四血管方法造成急性脑缺血再灌注模型。动物随机分成假手术组 ,空白对照组 ,尼莫地平 3mg·kg- 1组和多塞平 15 ,10 ,5mg·kg- 1组共 6组。在缺血前及再灌注前分别腹腔给药 ,用荧光分光光度计测定大脑皮层、海马、纹状体、脑干中 5 羟色胺、去甲肾上腺素及多巴胺的含量。结果 :与空白对照组比较 ,多塞平 15 ,10 ,5mg·kg- 1剂量组及尼莫地平 3mg·kg- 1组大脑皮层、海马、纹状体各单胺类递质含量显著升高 (P <0 .0 5或P <0 .0 1) ,脑电活动亦显著恢复 (P<0 .0 5或P <0 .0 1)。结论 :多塞平对缺血再灌注脑损伤的保护作用与其改善单胺类递质的代谢紊乱有关

 
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