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striatum tissues
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  纹状体
    RESULTS: Compared with blank control group, the contents of monoamines transmitter in cerebral contex, hippocampus and striatum tissues of doxepin 15, 10, 5 mg·kg -1 groups and nimodipine 3 mg·kg -1 group increased significantly ( P <0.05 or P <0.01). Activity of EEG was recovered significantly ( P <0.05 or P <0.01).
    结果 :与空白对照组比较 ,多塞平 15 ,10 ,5mg·kg- 1剂量组及尼莫地平 3mg·kg- 1组大脑皮层、海马、纹状体各单胺类递质含量显著升高 (P <0 .0 5或P <0 .0 1) ,脑电活动亦显著恢复 (P<0 .0 5或P <0 .0 1)。
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    AIM: To observe the effects of trihexyphenidyl (THP) on the content of monoamine neurotransmitters in the cerebral cortex and striatum tissues in rats with acute cerebral ischemia-reperfusion injury, and take nimodipine as positive control.
    目的:观察中枢性抗胆碱药苯海索对急性脑缺血再灌注大鼠大脑皮质、纹状体单胺类递质含量的影响,并与尼莫地平进行阳性对照。
短句来源
    ① Content of 5-HT: The contents of 5-HT in the cerebral cortex and striatum tissues were significantly lower in the ischemia reperfusion group than in the sham-operated group (P< 0.01), but significantly higher in the trihexyphenidyl 1.5, 1 and 0.5 mg / kg groups and nimodipine group than in the ischemia reperfusion group (P < 0.01 or 0.05).
    ①5-羟色胺含量:脑皮质和纹状体缺血再灌注组均显著低于假手术组(P<0.01),苯海索1.5,1,0.5mg/kg剂量组和尼莫地平3mg/kg组均显著高于缺血再灌注组(P<0.01或0.05)。
短句来源
    ② Level of norepinephrine: The levels of norepinephrine in the cerebral cortex and striatum tissues were significantly lower in the ischemia reperfusion group than in the sham-operated group (P < 0.01), but significantly higher in the trihexyphenidyl 1.5, 1 and 0.5 mg / kg groups and nimodipine group than in the ischemia reperfusion group (P < 0.01 or 0.05).
    ②去甲肾上腺素水平:脑皮质和纹状体缺血再灌注组均显著低于假手术组(P<0.01),苯海索1.5,1,0.5mg/kg剂量组和尼莫地平3mg/kg组均显著高于缺血再灌注组(P<0.01或0.05)。
短句来源
    ③ Content of dopamine: The contents of dopamine in the cerebral cortex and striatum tissues were significantly lower in the ischemia reperfusion group than in the sham-operated group (P < 0.01), but significantly higher in the trihexyphenidyl 1.5, 1 and 0.5 mg / kg groups and nimodipine group than in the ischemia reperfusion group (P < 0.01 or 0.05).
    ③多巴胺含量:脑皮质和纹状体缺血再灌注组均显著低于假手术组(P<0.01),苯海索1.5,1,0.5mg/kg剂量组和尼莫地平3mg/kg组均显著高于缺血再灌注组(P<0.01或0.05)。
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  striatum tissues
The striatum tissues were isolated, and proteins were extracted at different time points after injection.
      


AIM: To observe the effects of doxepin on monoamines transmitter in the rat brain after acute cerebral ischemia reperfusion. METHODS: Acute cerebral ischemia reperfusion injury was produced by 4 vessels occlusion. Rats were divided into six groups: sham operation group, blank contral group, nimodipine 3 mg·kg -1 group and doxepin 15, 10, 5 mg·kg -1 groups. Drugs were administered ip to the rats before ischemia and before reperfusion. The contents of monoamines (5 HT, DA, NE) in cerebral cortex,...

AIM: To observe the effects of doxepin on monoamines transmitter in the rat brain after acute cerebral ischemia reperfusion. METHODS: Acute cerebral ischemia reperfusion injury was produced by 4 vessels occlusion. Rats were divided into six groups: sham operation group, blank contral group, nimodipine 3 mg·kg -1 group and doxepin 15, 10, 5 mg·kg -1 groups. Drugs were administered ip to the rats before ischemia and before reperfusion. The contents of monoamines (5 HT, DA, NE) in cerebral cortex, hippocampus, striatum and brain stem were determined by fluorospectrophotometry. RESULTS: Compared with blank control group, the contents of monoamines transmitter in cerebral contex, hippocampus and striatum tissues of doxepin 15, 10, 5 mg·kg -1 groups and nimodipine 3 mg·kg -1 group increased significantly ( P <0.05 or P <0.01). Activity of EEG was recovered significantly ( P <0.05 or P <0.01). CONCLUSION: The protective effects of doxepin on acute brain ischemia reperfusion injury are related to its effects on monoamines transmitter.

目的 :观察多塞平对急性脑缺血再灌注大鼠各脑区单胺类递质含量的影响。方法 :以阻断四血管方法造成急性脑缺血再灌注模型。动物随机分成假手术组 ,空白对照组 ,尼莫地平 3mg·kg- 1组和多塞平 15 ,10 ,5mg·kg- 1组共 6组。在缺血前及再灌注前分别腹腔给药 ,用荧光分光光度计测定大脑皮层、海马、纹状体、脑干中 5 羟色胺、去甲肾上腺素及多巴胺的含量。结果 :与空白对照组比较 ,多塞平 15 ,10 ,5mg·kg- 1剂量组及尼莫地平 3mg·kg- 1组大脑皮层、海马、纹状体各单胺类递质含量显著升高 (P <0 .0 5或P <0 .0 1) ,脑电活动亦显著恢复 (P<0 .0 5或P <0 .0 1)。结论 :多塞平对缺血再灌注脑损伤的保护作用与其改善单胺类递质的代谢紊乱有关

AIM: To observe the effects of trihexyphenidyl (THP) on the content of monoamine neurotransmitters in the cerebral cortex and striatum tissues in rats with acute cerebral ischemia-reperfusion injury, and take nimodipine as positive control. METHODS: The experiment was carried out in the laboratory of Department of Pharmacology, Medical College of Zhengzhou University in 1998. Sixty male Wistar rats were randomly divided into 6 groups with 10 rats in each group: sham-operated group, ischemia-reperfusion...

AIM: To observe the effects of trihexyphenidyl (THP) on the content of monoamine neurotransmitters in the cerebral cortex and striatum tissues in rats with acute cerebral ischemia-reperfusion injury, and take nimodipine as positive control. METHODS: The experiment was carried out in the laboratory of Department of Pharmacology, Medical College of Zhengzhou University in 1998. Sixty male Wistar rats were randomly divided into 6 groups with 10 rats in each group: sham-operated group, ischemia-reperfusion group, trihexyphenidyl 1.5, 1 and 0.5 mg / kg groups and nimodipine group respectively. ① Administration: Rats in the trihexyphenidyl 1.5, 1 and 0.5 mg / kg groups and nimodipine group were treated with intraperitoneal injections of trihexyphenidyl (1.5, 1 and 0.5 mg / kg) and nimodipine (3 mg / kg) respectively, and no administration was given in the other two groups. ② Model establishment: At 30 minutes after administration, except the sham-operated group, the rats in the other groups were made into models of acute cerebral ischemia-reperfusion injury by means of middle cerebral artery occlusion (MCAO) with thread embolism. ③ Observed indexes: The contents of serotonin (5-HT), norepinephrine and dopamine in the cerebral cortex and striatum tissues were determined with fluorospectrophotometry. The neurologic impairment score was observed. RESULTS: All the 60 rats were involved in the analysis of results. ① Content of 5-HT: The contents of 5-HT in the cerebral cortex and striatum tissues were significantly lower in the ischemia reperfusion group than in the sham-operated group (P< 0.01), but significantly higher in the trihexyphenidyl 1.5, 1 and 0.5 mg / kg groups and nimodipine group than in the ischemia reperfusion group (P < 0.01 or 0.05). ② Level of norepinephrine: The levels of norepinephrine in the cerebral cortex and striatum tissues were significantly lower in the ischemia reperfusion group than in the sham-operated group (P < 0.01), but significantly higher in the trihexyphenidyl 1.5, 1 and 0.5 mg / kg groups and nimodipine group than in the ischemia reperfusion group (P < 0.01 or 0.05). ③ Content of dopamine: The contents of dopamine in the cerebral cortex and striatum tissues were significantly lower in the ischemia reperfusion group than in the sham-operated group (P < 0.01), but significantly higher in the trihexyphenidyl 1.5, 1 and 0.5 mg / kg groups and nimodipine group than in the ischemia reperfusion group (P < 0.01 or 0.05). ④ Neurologic impairment score: The neurologic impairment score in the trihexyphenidyl 1.5, 1 and 0.5 mg / kg groups and nimodipine group were all lower than that in the ischemia reperfusion group 2.5±0.2, 2.6±0.5, 3.0±0.2, 2.4±0.4, 3.8±0.4, P < 0.05, 0.01, but there was no difference among the trihexyphenidyl groups (P > 0.05). CONCLUSION: Trihexyphenidyl can obviously ameliorate the neuromotor dysfunction, and stop the decrease of monoamine neurotransmitter after cerebral ischemia reperfusion, indicating that trihexyphenidyl can play a role against cerebral ischemia by ameliorating the disturbance of monoamine neurotransmitter, and its role is similar to that of nimodipine.

目的:观察中枢性抗胆碱药苯海索对急性脑缺血再灌注大鼠大脑皮质、纹状体单胺类递质含量的影响,并与尼莫地平进行阳性对照。方法:实验于1998年在郑州大学医学院药理教研室实验室进行。取雄性Wistar大鼠60只,随机分为假手术组、缺血再灌注组,苯海索1.5,1,0.5mg/kg剂量组和尼莫地平3mg/kg组6组,每组10只。①给药:苯海索1.5,1,0.5mg/kg剂量组及尼莫地平3mg/kg组分别腹腔注射苯海索1.5,1,0.5mg/kg及尼莫地平3mg/kg,其他两组不给药。②造模:给药30min后,除假手术外所有大鼠线栓法阻断大脑中动脉制作大鼠急性脑缺血再灌注模型,假手术组不栓塞。③观察指标:用荧光分光光度计测定大脑皮质、纹状体、5-羟色胺、去甲肾上腺素及多巴胺的含量,观察大鼠神经功能缺损评分。结果:60只大鼠进入结果分析。①5-羟色胺含量:脑皮质和纹状体缺血再灌注组均显著低于假手术组(P<0.01),苯海索1.5,1,0.5mg/kg剂量组和尼莫地平3mg/kg组均显著高于缺血再灌注组(P<0.01或0.05)。②去甲肾上腺素水平:脑皮质和纹状体缺血再灌注组均显著低于假手术组(P<0.01),苯海索1.5,...

目的:观察中枢性抗胆碱药苯海索对急性脑缺血再灌注大鼠大脑皮质、纹状体单胺类递质含量的影响,并与尼莫地平进行阳性对照。方法:实验于1998年在郑州大学医学院药理教研室实验室进行。取雄性Wistar大鼠60只,随机分为假手术组、缺血再灌注组,苯海索1.5,1,0.5mg/kg剂量组和尼莫地平3mg/kg组6组,每组10只。①给药:苯海索1.5,1,0.5mg/kg剂量组及尼莫地平3mg/kg组分别腹腔注射苯海索1.5,1,0.5mg/kg及尼莫地平3mg/kg,其他两组不给药。②造模:给药30min后,除假手术外所有大鼠线栓法阻断大脑中动脉制作大鼠急性脑缺血再灌注模型,假手术组不栓塞。③观察指标:用荧光分光光度计测定大脑皮质、纹状体、5-羟色胺、去甲肾上腺素及多巴胺的含量,观察大鼠神经功能缺损评分。结果:60只大鼠进入结果分析。①5-羟色胺含量:脑皮质和纹状体缺血再灌注组均显著低于假手术组(P<0.01),苯海索1.5,1,0.5mg/kg剂量组和尼莫地平3mg/kg组均显著高于缺血再灌注组(P<0.01或0.05)。②去甲肾上腺素水平:脑皮质和纹状体缺血再灌注组均显著低于假手术组(P<0.01),苯海索1.5,1,0.5mg/kg剂量组和尼莫地平3mg/kg组均显著高于缺血再灌注组(P<0.01或0.05)。③多巴胺含量:脑皮质和纹状体缺血再灌注组均显著低于假手术组(P<0.01),苯海索1.5,1,0.5mg/kg剂量组和尼莫地平3mg/kg组均显著高于缺血再灌注组(P<0.01或0.05)。④神经功能缺损评分:苯海索1.5,1,0.5mg/kg组和尼莫地平3mg/kg组分别为2.5±0.2,2.6±0.5,3.0±0.2,2.4±0.4,均低于缺血再灌注组(3.8±0.4,P<0.05,0.01),但苯海索各剂量组间无差异(P>0.05)。结论:苯海索可明显改善动物神经运动功能障碍、阻止脑缺血再灌注后单胺类递质含量的降低,表明苯海索可通过改善脑组织单胺类递质的紊乱发挥其抗脑缺血作用。其作用与尼莫地平相似。

AIM: To analyze the conditions in vitro of culture and differentiation of neural stem cells of corpus striatum obtained from embryonic, fetal and adult mice and compare the proliferation and differentiation of them.METHODS: The experiment was conducted at lab of Department of Neurology, Xijing Hospital, Fourth Military Medical University of Chinese PLA from February to May 2005. One pregnant for 14 days mice, one 24-hours neonatal mice and one 4-month adult mice were selected. ①Primary culture of neural stem...

AIM: To analyze the conditions in vitro of culture and differentiation of neural stem cells of corpus striatum obtained from embryonic, fetal and adult mice and compare the proliferation and differentiation of them.METHODS: The experiment was conducted at lab of Department of Neurology, Xijing Hospital, Fourth Military Medical University of Chinese PLA from February to May 2005. One pregnant for 14 days mice, one 24-hours neonatal mice and one 4-month adult mice were selected. ①Primary culture of neural stem cells: Corpus striatum tissues of embryonic, fetal and adult mice were isolated and blew into single cell. Cells were cultured in D/F12 medium and passaged once every 6 to 7 days. ②Identification of neural stem cells: Single clone of neural stem cells was obtained with limiting dilution. Sub-clone of single cell was gained after continuously culture. Immunofluorescence staining was performed to identify the neural stem cells. ③Proliferation ability and differentiation condition among three kinds of neural stem cells was reflected by MTT test and immunofluorescence staining.RESULTS: ①The neural stem cells obtained from corpus striatum of different mice were cultured successfully. ②Neurons and astrocytes were differentiated from three kinds of neural stem cells. The proportions of neurons and astrocytes were 7%-11% and 76%-88%, and there was insignificant difference between three kinds of neural stem cells (P > 0.01). ③Neural stem cells from embryonic and fetal mice proliferated faster than those that from adult mice significantly (P < 0.01), but there were no significant difference between the cells from embryonic and fetal mice. CONCLUSION: The ability of proliferation of neural stem cells from the corpus striatum decreases gradually with the increase of age of mice, but still keeps the abilities of differentiating into neurons and colloid daughter cell. Embryonic and fetal mice have stronger ability of proliferation, which provides thought for seeking ideal graft cells.

目的:分析胚胎、新生以及成年小鼠纹状体神经干细胞的体外培养和分化条件,并比较其体外增殖和分化情况。方法:实验于2005-02/05在解放军第四军医大学西京医院神经内科实验室完成。选取孕14d小鼠、出生24h内的新生小鼠和4月龄的成年小鼠各1只用于实验。①神经干细胞的原代培养:分别将孕14d小鼠、新生小鼠和成年小鼠处死后取出纹状体组织,轻轻吹打制成单个细胞悬液,接种于无血清的D/F12培养基中,每六七天机械分离克隆传代1次。②神经干细胞的鉴定:采用有限稀释法获得神经干细胞单克隆,继续培养得到大量来自单个细胞的亚克隆。对神经球行免疫荧光染色鉴定。③通过四甲基偶氮唑盐比色法及免疫荧光染色比较胚胎鼠、新生鼠及成年小鼠的神经干细胞的增殖和分化情况。结果:①成功地从胚胎鼠、新生鼠以及成年小鼠的纹状体中分离培养出神经干细胞。②胚胎鼠、新生鼠及成年小鼠的神经干细胞分化为神经元的比例均为7%~11%,分化为星形胶质细胞的比例均为76%~88%,差异无显著性意义(P>0.01)。③与成年小鼠比较,胚胎鼠和新生鼠的神经干细胞增殖旺盛(P<0.01),而胚胎鼠和新生鼠之间差异无显著性意义。结论:随着小鼠年龄的增加纹状体神经干细胞的增...

目的:分析胚胎、新生以及成年小鼠纹状体神经干细胞的体外培养和分化条件,并比较其体外增殖和分化情况。方法:实验于2005-02/05在解放军第四军医大学西京医院神经内科实验室完成。选取孕14d小鼠、出生24h内的新生小鼠和4月龄的成年小鼠各1只用于实验。①神经干细胞的原代培养:分别将孕14d小鼠、新生小鼠和成年小鼠处死后取出纹状体组织,轻轻吹打制成单个细胞悬液,接种于无血清的D/F12培养基中,每六七天机械分离克隆传代1次。②神经干细胞的鉴定:采用有限稀释法获得神经干细胞单克隆,继续培养得到大量来自单个细胞的亚克隆。对神经球行免疫荧光染色鉴定。③通过四甲基偶氮唑盐比色法及免疫荧光染色比较胚胎鼠、新生鼠及成年小鼠的神经干细胞的增殖和分化情况。结果:①成功地从胚胎鼠、新生鼠以及成年小鼠的纹状体中分离培养出神经干细胞。②胚胎鼠、新生鼠及成年小鼠的神经干细胞分化为神经元的比例均为7%~11%,分化为星形胶质细胞的比例均为76%~88%,差异无显著性意义(P>0.01)。③与成年小鼠比较,胚胎鼠和新生鼠的神经干细胞增殖旺盛(P<0.01),而胚胎鼠和新生鼠之间差异无显著性意义。结论:随着小鼠年龄的增加纹状体神经干细胞的增殖能力逐渐减弱,但仍保持着分化为神经元和胶质子细胞的能力。胚胎和新生鼠源性的神经干细胞均具有较强的增殖能力,为寻找理想的移植细胞提供了思路。

 
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