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   binding lectin 在 内分泌腺及全身性疾病 分类中 的翻译结果: 查询用时:0.451秒
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binding lectin
相关语句
  凝集素
    The Role of Mannose Binding Lectin in the Pathogenesis of Systemic Lupus Erythematosus
    甘露糖结合凝集素在系统性红斑狼疮发病机制中的作用
短句来源
    Objectives1. To detect serum level of mannose binding lectin (MBL) in systemic lupus erythematosus (SLE) patients and healthy blood donors.
    1.检测系统性红斑狼疮(SLE)患者和健康献血员甘露糖结合凝集素(MBL)的血清水平。
短句来源
    Objective To detect the serum level of mannose binding lectin(MBL) and its genovariation in systemic lupus erythematosus(SLE) patients and to investigate the role of MBL in the pathogenesis of SLE.
    目的通过检测系统性红斑狼疮(SLE)患者甘露糖结合凝集素(MBL)的血清水平及其基因变异情况,探讨MBL在SLE发病机制中的作用。
短句来源
    The role of mannose binding lectin in the pathogenesis of systemic lupus erythematosus
    甘露糖结合凝集素在系统性红斑狼疮发病机制中的初步研究
短句来源
    Objective To investigate the relationship between mannose binding lectin(MBL) gene exon 1 site mutations and chronic rheumatic heart disease(CRHD).
    目的 探讨风湿性心脏病易感性与甘露糖结合凝集素基因第一外显子点突变的关系。
短句来源
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  “binding lectin”译为未确定词的双语例句
    Study on Polymorphism in Promoter Region of Mannose Binding Lectin Gene in Patients with Systemic Lupus Erythematosus
    系统性红斑狼疮患者MBL基因启动子区多态性的研究
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  binding lectin
Features of the structure of the hydrocarbon-binding lectin domains were elucidated in some species of legume genera from the temperate climatic zone.
      
In experiment 1, in vitro matured pig oocytes were freed from cumulus cells and treated with fluorescein isothiocyanate-labelled Lens culinaris (FITC-LCA), a D-mannose specific binding lectin.
      
Molecular characterization and expression analysis of a gene encoding mannose-binding lectin from bulb of Zephyranthes grandiflo
      
Bioinformatics analysis results clearly indicate that ZGBL belongs to the monocot mannose-binding lectin family, which contains 3 putative mannose-binding sites per subunit.
      
Mannan-binding lectin (MBL) is a vital and versatile component of innate immunity.
      
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Objective To investigate the relationship between mannose binding lectin(MBL) gene exon 1 site mutations and chronic rheumatic heart disease(CRHD). Methods Polymerase chain reaction (PCR) and restrictive fragment length Polymorphism (RFLP) were used to investigate the MBL exon 1 alleles in 36 patients with CRHD and 39 normal people. Results No C and D alleles of MBL gene were found in both groups. Eleven patients had A/B alleles, 1 patient had B/B alleles, 15 normal people had A/B alleles but none...

Objective To investigate the relationship between mannose binding lectin(MBL) gene exon 1 site mutations and chronic rheumatic heart disease(CRHD). Methods Polymerase chain reaction (PCR) and restrictive fragment length Polymorphism (RFLP) were used to investigate the MBL exon 1 alleles in 36 patients with CRHD and 39 normal people. Results No C and D alleles of MBL gene were found in both groups. Eleven patients had A/B alleles, 1 patient had B/B alleles, 15 normal people had A/B alleles but none of the 39 normal people had B/B alleles. Statistic analyses showed no significant difference between CRHD group and normal group. But when the age of heart disease symptom onset (HDSO) of the CRHD group were considered, we found that the mean HDSO age of patients with B allele was 30±14 years and the mean HDSO age of patients with AA homozygous was 37±11 years. P <0.05. Conclusion MBL gene mutations may not be a main factor of the pathogenesis of CRHD, but MBL deficiency may facilitate the development of CRHD in younger people and accelerate the progress of CRHD. This is consistent with the phenomenon that the most susceptible people of rheumatic heart disease are teenagers.

目的 探讨风湿性心脏病易感性与甘露糖结合凝集素基因第一外显子点突变的关系。方法 采用PCR和限制性片段长度多态性分析对 36例慢性风湿性心脏病病人和 39名正常人的甘露糖结合凝集素 (MBL)等位基因分布情况进行分析。结果 风湿性心脏病病人及正常人均未发现有MBLC和D等位基因的出现 ;11例病人为MBLA/B等位基因杂合子 ,1例病人为MBLB/B等位基因纯合子 ;15名正常人为MBLA/B等位基因杂合子 ,未发现有MBLB/B等位基因纯合子。携带B等位基因的风湿性心脏病病人平均症状出现年龄为 30岁± 14岁 ,AA纯合子病人的平均症状出现年龄为37岁± 11岁 ,差异有显著意义 (P <0 0 5 )。结论 甘露糖结合凝集素基因的点突变所造成的甘露糖结合凝集素功能低下或血清浓度偏低 ,可能不是风湿性心脏病发病的主要原因 ,但会加速风湿性心脏病的进展 ,这与风湿性心脏病易感人群在青少年中最高是一致的

Objective To establish a method for detecting the content of mannose-binding lectin (MBL) in human serum and investigate the relationship between chronic rheumatic heart disease and the serum content of MBL.Methods Affinity chromatography,SDS-PAGE and SDS-PAGE gel scanning were used to purify and identify human MBL (hMBL) protein.New Zealand rabbits were immunized with the purified hMBL to obtain rabbit anti-hMBL antiserum.ELISA and Western blot were used to identify its titer and recognition specificity...

Objective To establish a method for detecting the content of mannose-binding lectin (MBL) in human serum and investigate the relationship between chronic rheumatic heart disease and the serum content of MBL.Methods Affinity chromatography,SDS-PAGE and SDS-PAGE gel scanning were used to purify and identify human MBL (hMBL) protein.New Zealand rabbits were immunized with the purified hMBL to obtain rabbit anti-hMBL antiserum.ELISA and Western blot were used to identify its titer and recognition specificity to hMBL.ELISA was used to determine the MBL concentration in serums from 65 cases of chronic rheumatic heart disease (CRHD) and 51 normal people.Results hMBL protein was obtained with purity as 72%.The 32 000 protein band after SDS-PAGE was cut down and used to immunize New Zealand rabbit.The titer of antiserum was 1∶3 200 measured by ELISA.A single band protein with its Mr as 32 000 from human serum could be recognized specifically by the antiserum using Western blot.The serum MBL concentrations of CRHD patients and normal people were (1.2±0.7) mg/L and (1.5±0.9) mg/L,respectively (P<0.05).The patients could be divided into two groups according to their syndrome-appearing ages.The MBL concentrations in the serum of the younger group and older group were (0.8±0.5) mg/L and (1.5±0.8) mg/L,respectively (P<0.01).Conclusion Low serum MBL concentration may be a predisposition to rheumatic heart disease,and also it may accelerate the progress of the disease.

目的 建立人甘露糖结合凝集素血清浓度的检测方法 ,探讨慢性风湿性心脏病与甘露糖结合凝集素 (mannose bindinglectin ,MBL)血清浓度之间的关系。 方法 采用亲和色谱法提取纯化人MBL蛋白 ,免疫新西兰兔获取兔抗人MBL抗血清 ,ELISA方法和Westernblot方法鉴定其效价和特异性。ELISA方法检测 6 5例慢性风湿性心脏病病人和 5 1名正常人的血清MBL浓度 ,进行统计学分析。结果 抗血清效价为 1∶32 0 0 ,Westernblot方法鉴定该抗血清能特异性识别人血浆中MBL蛋白 ,在相对分子质量为 32 0 0 0处显示单一条带。慢性风湿性心脏病病人和正常人血清MBL浓度分别为 (1 2± 0 7)mg/L和 (1 5± 0 9)mg/L ,(P <0 0 5 )。以平均症状出现年龄为界 (34 0岁 )分为大小两个症状出现年龄组 ,其血清MBL浓度分别为 (1 5± 0 8)mg/L和(0 8± 0 5 )mg/L ,(P <0 0 1)。结论 血清MBL水平低下可能是风湿性心脏病的一个易感因素 ,同时也可能是病情发展的促进因素。

Objective:To investigate the relationship between Mannose binding lectin structural gene polymorphisms and susceptibility to SLE in Han Nationality population from Hubei province of China.Methods:The genotypes of MBL structural gene of SLE patients and control population were detected using a combined technique of heteroduplex generator and polymerase chain reaction.Results:Two alleles,a wild type allele A and a variant allele B(a previously reported mutation of GGC to GAC at the codon 54) were identified...

Objective:To investigate the relationship between Mannose binding lectin structural gene polymorphisms and susceptibility to SLE in Han Nationality population from Hubei province of China.Methods:The genotypes of MBL structural gene of SLE patients and control population were detected using a combined technique of heteroduplex generator and polymerase chain reaction.Results:Two alleles,a wild type allele A and a variant allele B(a previously reported mutation of GGC to GAC at the codon 54) were identified in the MBL exon one.The frequencies of B allele(0.146) among SLE patients were higher than that among healthy control samples(0.090),but the difference was not statistically significant (P>0.05).Conclusion:MBL B allele is not a risk component in the developing process of SLE Chinese patients.

目的 :分析湖北汉族人群甘露糖结合凝集素 (Mannose BindingLectin或Mannose BindingProtein ,MBL或MBP)基因外显子 1多态性 ,探讨其与系统性红斑狼疮 (SystemicLupusErythematosus ,SLE)的易感性关系。方法 :采用异源双链杂交技术对 111例健康正常人和 4 1例SLE患者的MBL基因外显子 1多态性进行分析。结果 :①共检测出两种等位基因 :野生型A和变异型B(在 5 4位密码子由GGC→GAC) ,未检出变异型C、D等位基因。②正常对照中A等位基因及B等位基因的基因频率分别为 0 910和 0 0 90 ,符合Hardy Wernberg定律 ;与此前在日本人中报道的A及B等位基因频率 0 76 7和 0 2 33相比 ,变异型B的等位基因频率明显低于后者 (P <0 0 5 )。③SLE病人组中B等位基因频率为 0 14 6 ,高于正常对照组 ,但差异无显著性意义。结论 :在湖北汉族人群中MBL基因外显子 1具有遗传多态性 ,而且与已知其他人群的分布频率有一定差异。MBL基因外显子 1的遗传多态性并不与系统性红斑狼...

目的 :分析湖北汉族人群甘露糖结合凝集素 (Mannose BindingLectin或Mannose BindingProtein ,MBL或MBP)基因外显子 1多态性 ,探讨其与系统性红斑狼疮 (SystemicLupusErythematosus ,SLE)的易感性关系。方法 :采用异源双链杂交技术对 111例健康正常人和 4 1例SLE患者的MBL基因外显子 1多态性进行分析。结果 :①共检测出两种等位基因 :野生型A和变异型B(在 5 4位密码子由GGC→GAC) ,未检出变异型C、D等位基因。②正常对照中A等位基因及B等位基因的基因频率分别为 0 910和 0 0 90 ,符合Hardy Wernberg定律 ;与此前在日本人中报道的A及B等位基因频率 0 76 7和 0 2 33相比 ,变异型B的等位基因频率明显低于后者 (P <0 0 5 )。③SLE病人组中B等位基因频率为 0 14 6 ,高于正常对照组 ,但差异无显著性意义。结论 :在湖北汉族人群中MBL基因外显子 1具有遗传多态性 ,而且与已知其他人群的分布频率有一定差异。MBL基因外显子 1的遗传多态性并不与系统性红斑狼疮相关联。

 
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