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binding lectin
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  凝集素
    The mannose binding lectin serum levels and mutation on the 54 code of MBL in the children with recurrent respiratory tract infections.
    反复呼吸道感染儿童血清甘露聚糖结合凝集素水平及54密码子基因突变筛查
短句来源
    Relationship between mannose binding lectin in serum and recurrent respiratory tract infections
    血清甘露聚糖凝集素水平及与反复呼吸道感染关系的初步研究
短句来源
    Objective To establish the children′s reference range of serum level of mannose binding lectin (MBL) serum levels, and to find the relationship between MBL and recurrent respiratory tract infections(RRTI).
    目的 建立儿童血清甘露聚糖凝集素 (MBL)水平正常值参考范围 ,了解血清MBL低水平与反复呼吸道感染的关系。
短句来源
  “binding lectin”译为未确定词的双语例句
    Modulating effects of mannose binding lectin genotype on arterial stiffness in children after Kawasaki disease
    甘露糖结合植物凝血素基因型对川崎病后儿童动脉硬度的调节效果
短句来源
    Recently, some research has shown that the polymorphisms of Mannose binding lectin (MBL) gene can decrease the serum MBL level, and MBL deficiency may be associated with increased susceptibility to infection and autoimmune diseases.
    MBL基因多态性影响MBL水平。 过敏性紫癜 (Henoch Sch nleinpurpura ,HSP)是一种全身性血管炎综合征 ,其病因被认为可能与免疫损伤有关。
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  binding lectin
Features of the structure of the hydrocarbon-binding lectin domains were elucidated in some species of legume genera from the temperate climatic zone.
      
In experiment 1, in vitro matured pig oocytes were freed from cumulus cells and treated with fluorescein isothiocyanate-labelled Lens culinaris (FITC-LCA), a D-mannose specific binding lectin.
      
Molecular characterization and expression analysis of a gene encoding mannose-binding lectin from bulb of Zephyranthes grandiflo
      
Bioinformatics analysis results clearly indicate that ZGBL belongs to the monocot mannose-binding lectin family, which contains 3 putative mannose-binding sites per subunit.
      
Mannan-binding lectin (MBL) is a vital and versatile component of innate immunity.
      
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Objective Henoch Schnlein purpura (HSP) is an autoimmune vasculitis syndrome of unknown etiology. Recently, some research has shown that the polymorphisms of Mannose binding lectin (MBL) gene can decrease the serum MBL level, and MBL deficiency may be associated with increased susceptibility to infection and autoimmune diseases. This study aims at exploring the correlation between MBL codon 54 polymorphism and HSP in Han nationality children. Methods One hundred and four children with HSP and 160...

Objective Henoch Schnlein purpura (HSP) is an autoimmune vasculitis syndrome of unknown etiology. Recently, some research has shown that the polymorphisms of Mannose binding lectin (MBL) gene can decrease the serum MBL level, and MBL deficiency may be associated with increased susceptibility to infection and autoimmune diseases. This study aims at exploring the correlation between MBL codon 54 polymorphism and HSP in Han nationality children. Methods One hundred and four children with HSP and 160 healthy controls were enrolled in this study. The genotypes of MBL gene 54 codon were detected by Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR RFLP). Results The genotype frequency of heterozygote (GGC/GAC) in the HSP group was significantly higher than that in the healthy controls ( 51.9% vs 25.0% ) (P< 0.05 ), whereas that of homozygote (GGC/GGC) in the former was significantly lower than that of the latter (46.2% vs 73.8%) (P< 0.05 ). The allele frequency of GAC was higher in HSP patients than that in controls ( 0.279 vs 0.138 ) (P< 0.05 ), whereas that of GGC in HSP patients was lower than that in controls ( 0.721 vs 0.862 ) (P< 0.05 ). The variant allele (GAC) was markedly associated with onset of HSP (OR= 2.46 , 95% CI= 1.32 - 4.48 ; P< 0.05 ). In addition, in the HSP group more patients carrying the variant allele (GAC) had episodes of upper respiratory or gastrointestinal infections before onset of HSP compared with those with GGC homozygote (P< 0.05 ). Conclusions MBL gene condon 54 mutation might be related to the pathogenesis of HSP.

目的 近来有研究认为某些自身免疫性疾病可能与甘露糖结合凝集素 (MBL)缺陷有关。MBL基因多态性影响MBL水平。过敏性紫癜 (Henoch Sch nleinpurpura ,HSP)是一种全身性血管炎综合征 ,其病因被认为可能与免疫损伤有关。该研究探讨MBL基因第 5 4号密码子多态性与中国汉族儿童过敏性紫癜 (HSP)的关系。方法 应用聚合酶链反应 -限制性内切酶片段长度多态性分析 ,对 1 6 0例健康中国汉族儿童及 1 0 4例过敏性紫癜(HSP)患儿的MBL基因多态性进行检测。结果 ①HSP患儿MBL基因GGC/GAC基因型频率明显高于健康对照组 (5 1 .9%vs 2 5 .0 % ) (P <0 .0 5 ) ,而GGC/GGC基因型频率显著低于健康对照组 (4 6 .2 %vs 73.8% ) (P <0 .0 5 )。HSP患儿GAC等位基因频率明显高于健康对照组 (0 .2 79vs 0 .1 38) (P <0 .0 5 ) ,而GGC等位基因频率明显低于健康对照组 (0 .72 1vs 0 .86 2 ) (P <0 .0 5 ) ;GAC等位基因与HSP的发病明显相关 (OR =...

目的 近来有研究认为某些自身免疫性疾病可能与甘露糖结合凝集素 (MBL)缺陷有关。MBL基因多态性影响MBL水平。过敏性紫癜 (Henoch Sch nleinpurpura ,HSP)是一种全身性血管炎综合征 ,其病因被认为可能与免疫损伤有关。该研究探讨MBL基因第 5 4号密码子多态性与中国汉族儿童过敏性紫癜 (HSP)的关系。方法 应用聚合酶链反应 -限制性内切酶片段长度多态性分析 ,对 1 6 0例健康中国汉族儿童及 1 0 4例过敏性紫癜(HSP)患儿的MBL基因多态性进行检测。结果 ①HSP患儿MBL基因GGC/GAC基因型频率明显高于健康对照组 (5 1 .9%vs 2 5 .0 % ) (P <0 .0 5 ) ,而GGC/GGC基因型频率显著低于健康对照组 (4 6 .2 %vs 73.8% ) (P <0 .0 5 )。HSP患儿GAC等位基因频率明显高于健康对照组 (0 .2 79vs 0 .1 38) (P <0 .0 5 ) ,而GGC等位基因频率明显低于健康对照组 (0 .72 1vs 0 .86 2 ) (P <0 .0 5 ) ;GAC等位基因与HSP的发病明显相关 (OR =2 .4 6 ,95 %CI =1 .32 - 4 .4 8,P <0 .0 5 )。②在HSP患儿中 ,GAC型等位基因携带者中有前驱感染史者明显多于GGC纯合子 (P<0 .0 5 )。结论 HSP发病受遗传背景影响 ,MBL第 5 4号密码子基因多态性可能是HSP易感性标志

Objective Human mannose binding lectin (MBL) is a C type serum lectin synthesized by the liver as an acute phase protein MBL can bind to glycoproteins terminated with mannose and N acetylglucosamine present in the cell walls on a variety of microorganisms Therefore, MBL appears to play an important role in the immune system Low levels of MBL in human have been associated with a susceptibility to recurrent infections MBL deficiency and low serum MBL levels are strongly associated...

Objective Human mannose binding lectin (MBL) is a C type serum lectin synthesized by the liver as an acute phase protein MBL can bind to glycoproteins terminated with mannose and N acetylglucosamine present in the cell walls on a variety of microorganisms Therefore, MBL appears to play an important role in the immune system Low levels of MBL in human have been associated with a susceptibility to recurrent infections MBL deficiency and low serum MBL levels are strongly associated with the presence of three point mutations at codon 52, 54 and 57 of exon 1 in the human MBL gene, and in Chinese population, the codon 54 mutation occurs at a frequency of 0 11~0 17 The data suggested that MBL insufficiency might also predispose to the development of autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) The possibility that Kawasaki disease (KD) is an infectous disease has been discussed and investigated for decades,in light of the implication that infections are involved in the pathogenesis of KD It has been suggested that MBL insufficiency might predispose to the occurrence of KD This study was aimed to investigate the genetic association of MBL codon 54 polymorphism in patients with KD,and to investigate possible associations with clinical manifestations of the disease Methods There were 95 patients with KD and 160 healthy subjects in the study The genotype of MBL gene 54 codon was detected by polymerase chain reaction restriction fragment length polymorphism(PCR RFLP) Clinical characteristics and biochemical examination were also performed Results The genotype frequency of heterozygote (GGC/GAC) was significantly higher in KD group than that in healthy subjects(45 2% vs 25 0%, P <0 01), and the allele frequency of GAC mutation was also higher in KD patients than that in control group(0 258 vs 0 138, P <0 01) The variant allele (GAC) was markedly associated with KD ( OR =2 18, 95%CI=1 38~3 44, P <0 05) But there was no significant difference in the allele frequency of GAC between patients with and without coronary artery lesion (CAL) in KD cases (0 281 vs 0 246, P >0 05) In addition, in cases of KD, more patients carrying the variant allele (GAC) had episodes of upper respiratory or gastrointestinal infections prior to the onset of KD than wild homozygotes ( P <0 01) Conclusion The codon 54 polymorphism of MBL gene was associated with KD It is possible that MBL gene codon 54 mutation might be related to the pathogenesis of KD

目的 探讨甘露糖结合凝集素 (MBL)基因第 5 4号密码子多态性与中国汉族儿童川崎病的易感性和临床表型的关系。方法 应用聚合酶链反应 限制性内切酶片段长度多态性分析 ,对16 0例中国汉族健康儿童及 95例川崎病患儿的MBL基因多态性进行检测。结果  ( 1)中国汉族健康儿童MBL基因多态性分布与文献报道的香港华人及高加索人种接近 ,无统计学差异。( 2 )川崎病患儿GAC等位基因频率高于健康对照组 ( 0 2 5 8vs 0 138,P <0 0 1) ,而GGC等位基因频率低于健康对照组 ( 0 74 2vs 0 86 2 ,P <0 0 1)。GAC型等位基因与中国汉族儿童川崎病密切相关 [OR =2 18,95 %CI(OR值的 95 %置信区间 )为 1 38~ 3 4 4 ,P <0 0 5 ]。 ( 3)在川崎病患儿中 ,GAC型等位基因携带者其病史有前驱感染史者多于GGC纯合子 (P <0 0 1)。结论 川崎病发病受遗传背景的影响 ,与MBL第 5 4号密码子基因多态性密切相关

Objective To establish the children′s reference range of serum level of mannose binding lectin (MBL) serum levels, and to find the relationship between MBL and recurrent respiratory tract infections(RRTI). Methods Serum levels of MBL were determinded in ninety one newborns, two hundred seventy four children and sixteen adults, then the case history of IRRTI was reviewed in the children with low serum levels. Results The evaluation in newborns and adults were (1.71±1.60) μg/ml and (2.26±1.56) μg/ml,...

Objective To establish the children′s reference range of serum level of mannose binding lectin (MBL) serum levels, and to find the relationship between MBL and recurrent respiratory tract infections(RRTI). Methods Serum levels of MBL were determinded in ninety one newborns, two hundred seventy four children and sixteen adults, then the case history of IRRTI was reviewed in the children with low serum levels. Results The evaluation in newborns and adults were (1.71±1.60) μg/ml and (2.26±1.56) μg/ml, and no significant difference was found ( P >0.05); the corresponding values for five groups of children were (3.16±2.00) μg/ml, (3.19±1.88) μg/ml, (3.30±2.05) μg/ml, (3.69±2.22) μg/ml and (2.80±1.38) μg/ml, respectively. There was a significant difference between newborns and these five groups( P <0.05), but not among these five groups( P >0.05). Of 16 children with low serum MBL levels, 7 children had RRTI(43.7%), and the children with lower levels of MBL(<200 ng/ml) showed the tendence of more respiratory tract infections as compared with the children with levels ranged from 100 ng/ml to 200 ng/ml. Conclusion There is maturation in MBL levels in newborns, and the values for newborns are obviously lower than those in children, while there is not significant difference among children. The risk of RRTI was found in MBL insufficient children, and the lower level means higher risk.

目的 建立儿童血清甘露聚糖凝集素 (MBL)水平正常值参考范围 ,了解血清MBL低水平与反复呼吸道感染的关系。方法 用ELISA方法检测重庆地区 91例新生婴儿脐血MBL水平 ,2 6 3例学龄前儿童、1 6例成人血清MBL水平 ,并对学龄前各年龄组血清低MBL水平的儿童进行反复呼吸道感染的病史回顾。结果 新生儿脐血MBL水平为 ( 1 .71± 1 .6 0 ) μg/ml,成人外周血 ( 2 .2 6± 1 .56 ) μg/ml,两组比较差异无统计学意义 (P >0 .0 5) ,学龄前各年龄组MBL水平分别为 ( 3.1 6±2 .0 0 ) μg/ml、( 3.1 9± 1 .88) μg/ml、( 3.30± 2 .0 5) μg/ml、( 3.6 9± 2 .2 2 ) μg/ml、( 2 .80± 1 .38) μg/ml,与新生儿比较明显增高 (P <0 .0 0 5) ,但学龄前期各组间比较差异无统计学意义 (P >0 .0 5) ;1 6例血清低MBL水平儿童中 7例在 3岁前出现反复呼吸道感染 ( 4 3.7% ) ,主要感染方式为上呼吸道感染 ,血清MBL水平低于 1 0 0ng/m...

目的 建立儿童血清甘露聚糖凝集素 (MBL)水平正常值参考范围 ,了解血清MBL低水平与反复呼吸道感染的关系。方法 用ELISA方法检测重庆地区 91例新生婴儿脐血MBL水平 ,2 6 3例学龄前儿童、1 6例成人血清MBL水平 ,并对学龄前各年龄组血清低MBL水平的儿童进行反复呼吸道感染的病史回顾。结果 新生儿脐血MBL水平为 ( 1 .71± 1 .6 0 ) μg/ml,成人外周血 ( 2 .2 6± 1 .56 ) μg/ml,两组比较差异无统计学意义 (P >0 .0 5) ,学龄前各年龄组MBL水平分别为 ( 3.1 6±2 .0 0 ) μg/ml、( 3.1 9± 1 .88) μg/ml、( 3.30± 2 .0 5) μg/ml、( 3.6 9± 2 .2 2 ) μg/ml、( 2 .80± 1 .38) μg/ml,与新生儿比较明显增高 (P <0 .0 0 5) ,但学龄前期各组间比较差异无统计学意义 (P >0 .0 5) ;1 6例血清低MBL水平儿童中 7例在 3岁前出现反复呼吸道感染 ( 4 3.7% ) ,主要感染方式为上呼吸道感染 ,血清MBL水平低于 1 0 0ng/ml组与血清MBL水平在 1 0 0~ 2 0 0ng/ml的儿童比较反复呼吸道感染频率有增多趋势。结论 新生儿期MBL水平可达成人水平 ,但明显低于学龄前各年龄组儿童 ,学龄前儿童组间比较没有显著差异 ;低血清MBL水平儿童在免疫脆弱阶段存在反复呼吸道感染的易患倾向 ,血清MBL水平下降时 ,呼吸道感染频率有增?

 
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