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related markers
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  相关指标
     Comparison of the related markers on plaque stability among different types of coronary heart disease
     冠心病不同类型间斑块稳定性相关指标的比较研究
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     Effect of calcitonin on bone metabolism and related markers in postmenopausal osteoporosis
     鲑鱼降钙素对绝经后骨质疏松骨代谢及相关指标的影响
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     MethodsThe rat aging models were established by injection of D galactose and the related markers of the free radical metabolism (SOD?CAT?XOD?MDA?ONOO) from mitochondria and cell plasma were detected in brain, stomach, liver, large intestine and small intestine with fuzzy statistical method.
     方法 引用模糊综合分析的数理统计方法 ,与对照组比较 ,对以上脏器细胞浆及线粒体自由基代谢相关指标进行模糊综合分析。 结果 发现线粒体 SOD、CAT、XOD、MDA、ONOO-的综合作用对衰老有影响 ,影响程度为 45% ;
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     Objective To study the effect of Acrylonitrile(ACN)on age related markers in rat brain.
     目的 探讨丙烯腈 (ACN)染毒大鼠脑组织中与衰老相关指标水平变化。
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     Conclusions The results indicated that comparatively high dosage of ACN might induce the change of the age related markers in brain of experimental rats showing consistent trend with elderly ones.
     结论 ACN染毒在较高剂量下引起的大鼠脑组织中与衰老相关指标 (GSH ,SOD ,MDA ,ChE)的变化已达到老年对照组大鼠的水平。
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  “related markers”译为未确定词的双语例句
     Among five kinds of MDR related markers,there were positive correlations between P-gP and GST-π expressions and between LRP and MRP expressions(r=0.66,P=0.000,r=0.434,P=0.004,respectively).
     乳腺癌组织中各耐药基因之间存在共表达现象,P-gp和GST-π的表达及LRP与MRP的表达均存在正相关性(r=0.66,P=0.000;r=0.434,P=0.004)。
短句来源
     Objective To investigate the expression of cell-cycle related markers PCNA、 cyclin D1、 and P27 in condyloma acuminatum (CA) and their significance.
     目的:探讨细胞周期相关因子增殖细胞核抗原(PCNA)、细胞周期素D1(cyclin D1)及P27在尖锐湿疣(CA)中的表达及其意义。
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     Characteristics of morphology, differentiation related markers, and proliferation dynamics of differentiated brain tumor stem cells in vitro
     脑肿瘤干细胞体外分化的形态、标志物及细胞增殖动力学特征
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     Since the expression of CD44 and CD29 was more than 99% by flow cytometric analysis, and the expression of AFP, ALB, CK8, CK18, GGT, DPPIV, c-Met and c-kit were detected by immunocytochemistry in almost all of the cells, we supposed that there was coexpression of mesenchymal markers and hepatic stem cell related markers in hFLSC.
     其中流式分析显示CO44、CO29的表达率高达99%以上,而免疫细胞化学分析显示AFP、ALB、CKS、CK18、GGT、DPPfV、c一Met和c一kit等标志也几乎在全部细胞都有所表达,由此推测hFLSC可以共表达间质细胞和肝干细胞的相关分子标志。
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     Conclusion:C-met,S-100 protein expression and DNA ploid type are closely related to the biological behavior of gastric carcinoma. Detecting the related markers above could objectively judge the metastasis and prognosis of gastric carcinoma.
     结论:c-met、S-100蛋白表达和DNA倍体类型与胃癌的生物学行为密切相关,对胃癌中上述指标联合检测能更客观、更全面地判断病人的转移及预后。
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     Markers Related with Vascular Cognitive Impairment
     血管性认知障碍的相关指标
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     4. Study on the related immunohestochemical markers of esophageal carcinoma.
     4.食管癌相关免疫组化标记物的研究。
     It is related to A.
     该种与秦岭无心菜A.
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     related to prepositions.
     3 与介词结构有关的后置形式。
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     were its chromosome markers.
     等为其标志染色体,未显示有完整Y染色体存在。
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  related markers
Effect of Ginkgo biloba extract (EGb761) on glucose metabolism-related markers in streptozotocin-damaged rat brain
      
Alloantigens are usually codominantly expressed in somatic cell hybrids, whereas differentiation-related markers are usually suppressed.
      
This novel finding may provide clues to clarify the basic molecular mechanisms of pituitary adenoma formation, and to identify new tumor-related markers.
      
Thymic Function-Related Markers Within the Thymus and Peripheral Blood: Are They Comparable
      
Often initially reported studies of a marker show great promise, but subsequent studies on the same or related markers yield inconsistent conclusions or stand in direct contradiction to the promising results.
      
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A group of estrogen-related markers were employed to study breast carcInoma retrospectively in 54 women with the average age of 47. 9. The 5-year-survial rate were 81. 5%. The mean length of the breast tumors was 3. 4cm. There were invasive ductal carcinoma in 49 cases and high grade rnalignancies in 36 cases. No significcnt relationship between the prognosis and the tumor size, his tological typing or grading was found. The positive rate of estrogen receptor(ER) was 55. 6% and progesterone receptDr(PR),...

A group of estrogen-related markers were employed to study breast carcInoma retrospectively in 54 women with the average age of 47. 9. The 5-year-survial rate were 81. 5%. The mean length of the breast tumors was 3. 4cm. There were invasive ductal carcinoma in 49 cases and high grade rnalignancies in 36 cases. No significcnt relationship between the prognosis and the tumor size, his tological typing or grading was found. The positive rate of estrogen receptor(ER) was 55. 6% and progesterone receptDr(PR), 38. 9%,which were related to cathepsin D. Cathepsin D expressed in tumor cells were found in 15 cases (27. 8 % ) and intetstitial macrophages,in all cases, which were close associated with ER, PR and also related to the prognosis.

用一组雌激素相关标志对54例女性乳腺癌进行回顾性研究。患者平均47.9岁,5年生存率为81.5%。癌肿长径平均3.4cm,浸润性导管癌49例,Ⅲ级36例。肿瘤大小、组织学类型、分级与预后关系不明显。ER阳性率55.6%,PR阳性率389%,与组织蛋白酶D有较好相关性。组织蛋白酶D在癌细胞的阳性年为278%,间质巨噬细胞阳性率为100%,与ER、PR关系较密切,并与预后相关。

The relationship between the infiltrating density of S-100+DC in resected specimen and the expressions of tumor-related markers in various gall bladder lesions including cancer 30. gallstone 20,and chronic inflammation 20 were studied by immunohistochemistry with monoclonal anti-p53 protein,anti-PCNA,anti-CEA,and polyclonal anti S-100 protein antibodies. The results showed : in cancer patients,p53 protein immunostaining 46. 7% (14/30), PCNA 86. 7%(26/30),CEA 30. 0%(9/30) were found; but the s-100+ DC was...

The relationship between the infiltrating density of S-100+DC in resected specimen and the expressions of tumor-related markers in various gall bladder lesions including cancer 30. gallstone 20,and chronic inflammation 20 were studied by immunohistochemistry with monoclonal anti-p53 protein,anti-PCNA,anti-CEA,and polyclonal anti S-100 protein antibodies. The results showed : in cancer patients,p53 protein immunostaining 46. 7% (14/30), PCNA 86. 7%(26/30),CEA 30. 0%(9/30) were found; but the s-100+ DC was only 40. 0% (12/ 30);ingallstone patients,p53 protein negtive,PCNA 35. 0% (7/20),CEA 15. 0% (3/20), and S-100+DC 50. 0%(10/20) were detected;in flammatory patiens,p53 protein negative, PCNA 25. 0%(5/20),CEA negative,and S-100+DC 85. 0%(17/20) were detected. Present data suggested that: (1 )inflammatory lesions, there was a simple epithelial proliferation, no tumor-related markers expression, but with more higher celluar immunologic competence than other lesions can be found; (2)in gallstone lesions,the epithelum had some atypic-al changes that revealed not only expression of tumor markers but also accompanied with a decline immunoreactivity to tumor that may facilitate the carcinogenesis; (3)in cancer patients, mutant p53 gene over-expression and a clearly cut increasing celluar proliferation may reflect an impairing of immunological competence concerning immunologic surveillance of neoanti-gen-bearing tumor cells that tumor cells could be escaped from immunological attack.

应用免疫组化对胆囊不同病变内S-100~+树突状细胞浸润与肿瘤相关分子的表达相互关系进行对比研究.包括胆囊癌症病人切除标本30例,结石20例,慢性炎症20例.用单克隆抗p53蛋白、抗增殖细胞核抗原(PCNA)、抗癌胚抗原(CEA)及多克隆抗S-100蛋白抗体,LSAB法检查上述病变标本.结果发现癌症病人p53蛋白阳性为46.7%(14/30),PCNA为86.7%(26/30),CEA为30.0%(9/30),S-100~+DC浸润仅为40.0%(12/30);结石标本p~(53)蛋白阴性,PCNA为35.0%(7/20),CEA为15%(3/20),S-100~+DC浸润为50%(10/20);慢性炎病例p53蛋白、CEA均为阴性,PCNA为25%(5/20),而S-100~+DC浸润为 85%(17/20).S-100~+DC浸润病例数与细胞密度,在恶性肿瘤中明显低于非肿瘤良性病变(P<0.05).本研究说明:①炎性病变的上皮组织多属单纯性增生而无肿瘤相关标记分子表达,同时伴有较高的细胞免疫活性;②胆囊结石上皮存在某些不典型变化有少许肿瘤标记分子表达,并伴有机体抗肿瘤免疫反应的下降,易于癌变;③癌症病人标...

应用免疫组化对胆囊不同病变内S-100~+树突状细胞浸润与肿瘤相关分子的表达相互关系进行对比研究.包括胆囊癌症病人切除标本30例,结石20例,慢性炎症20例.用单克隆抗p53蛋白、抗增殖细胞核抗原(PCNA)、抗癌胚抗原(CEA)及多克隆抗S-100蛋白抗体,LSAB法检查上述病变标本.结果发现癌症病人p53蛋白阳性为46.7%(14/30),PCNA为86.7%(26/30),CEA为30.0%(9/30),S-100~+DC浸润仅为40.0%(12/30);结石标本p~(53)蛋白阴性,PCNA为35.0%(7/20),CEA为15%(3/20),S-100~+DC浸润为50%(10/20);慢性炎病例p53蛋白、CEA均为阴性,PCNA为25%(5/20),而S-100~+DC浸润为 85%(17/20).S-100~+DC浸润病例数与细胞密度,在恶性肿瘤中明显低于非肿瘤良性病变(P<0.05).本研究说明:①炎性病变的上皮组织多属单纯性增生而无肿瘤相关标记分子表达,同时伴有较高的细胞免疫活性;②胆囊结石上皮存在某些不典型变化有少许肿瘤标记分子表达,并伴有机体抗肿瘤免疫反应的下降,易于癌变;③癌症病人标本突变型p53基因过度表达、PCNA明显多曾多及 S-100~+DC明显减少,可能反映了免疫监视系统受损,使肿瘤细胞逃避机体的免疫攻击以促进肿瘤发生与发展.

Objective To investigate the role of IL 1βin the initiation of psoriatic phenotype in the transwell skin organ culture model using biopsies from healthy human skin and non lesional skin from patients with psoriasis. Methods The skin biopsies were cultured for 24 hours and stimulated with IL 1βor IL 1 receptor antagonist (IL 1ra), and the induction of epidermal psoriatic phenotype was analysed using immunostaining (APAAP). Results In the presence of IL 1β, the psoriasiform epidermal phenotype was...

Objective To investigate the role of IL 1βin the initiation of psoriatic phenotype in the transwell skin organ culture model using biopsies from healthy human skin and non lesional skin from patients with psoriasis. Methods The skin biopsies were cultured for 24 hours and stimulated with IL 1βor IL 1 receptor antagonist (IL 1ra), and the induction of epidermal psoriatic phenotype was analysed using immunostaining (APAAP). Results In the presence of IL 1β, the psoriasiform epidermal phenotype was clearly induced, i.e. a strong upregulation of keratin 16, keratin 17 and transglutaminase type Ⅰwas found in the suprabasal layers of cultured normal skin; the expression of ICAM 1 and HLA DR was induced on basal keratinocytes, epidermal dendritic cells as well as endothelial cells in the dermis. Integrin β1 was also upregulated by IL 1βfrom the basal to suprabasal keratinocytes. The effects of IL 1βon the skin organ cultures could be completely neutralized by anti IL 1 polyclonal antibodies. Conclusion IL 1βis able to induce a series of psoriasis related markers in cultured normal human skin, which suggests that IL 1 be involved in the initiation of psoriasis.

目的对白介素 -1β(IL 1β)在启动银屑病免疫病理表型中的作用进行研究。方法取健康人正常皮肤在跨膜(transwell)皮肤器官培养模型中进行培养 ,观察在IL 1β或白介素 -1受体拮抗剂(IL 1ra)等细胞因子刺激下 ,培养皮肤表达银屑病免疫病理特征标记物的情况。结果在IL 1β 刺激下 ,正常人皮肤表达了一系列银屑病相关的蛋白分子 ,即角蛋白16、17在表皮棘细胞层强阳性 ;Ⅰ型转谷酰胺酶从表皮颗粒层到棘细胞层过度表达 ;ICAM 1、HLA DR以及β1整合素在表皮基底细胞层和棘细胞层诱导表达或增强表达。培养基中加入IL 1ra可使上述标记物的表达受到显著抑制。培养基中加入抗IL 1β抗体可完全阻断IL 1β的上述诱导作用。结论在培养条件下IL 1β可诱导正常人皮肤表达银屑病的免疫病理表型 ,提示IL 1系统参与了银屑病的皮损形成。

 
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