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nimodipine
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     Compatibility of nimodipine
     尼莫地平输液的配伍实验
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     Determination of nimodipine by HPLC
     高效液相色谱法测定尼莫地平含量
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  nimodipine
The PA1b effect on [Ca2+]i elevation was abolished in the absence of extracellular Ca2+ or in the presence of L-type Ca2+ channel blocker, nimodipine.
      
Influence of nimodipine on cerebral blood flow in human cerebral ischaemia
      
Cerebral blood flow (CBF) was measured by xenon-133 inhalation and single photon emission computerized tomography (SPECT) in 7 patients with acute cerebral ischaemia prior to and 30 min after intravenous infusion of nimodipine (1 mg).
      
Nimodipine infusion significantly decreased the mean arterial blood pressure (P>amp;lt;0.01), while PaCO2 and clinical symptoms remained unchanged.
      
A significant CBF improvement (P>amp;lt;0.05) after nimodipine was seen in the border zone of the ischaemic infarct but not in the core of the lesion or in the unaffected contralateral hemisphere.
      
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Nimodipine, nifedipine and vincamine were shown to improve anisod-ine-induced impairment of acquisition of memory and sodium nitrite elicited deficit of consolidation of memory in one trial passive avoidance response in mice. Of the three drugs, nimodipine was the most potent agent and its action was 100 and 1,000 times as potent as nifedipire and vincamine respectively. Nimodipine was also shown to improve anisodine induced disruption of active and passive avoidance response in rats. By using doses...

Nimodipine, nifedipine and vincamine were shown to improve anisod-ine-induced impairment of acquisition of memory and sodium nitrite elicited deficit of consolidation of memory in one trial passive avoidance response in mice. Of the three drugs, nimodipine was the most potent agent and its action was 100 and 1,000 times as potent as nifedipire and vincamine respectively. Nimodipine was also shown to improve anisodine induced disruption of active and passive avoidance response in rats. By using doses for accelerating memory, antihypoxic effect was obtained with nifedipine and vincamine, but not with nimodipine. This result indicates that facilitation of memory induced by nimodipine may involve an extra mechanism other than increase of cerebral blood flow.

采用小鼠一次性试验的被动回避性反应方法观察到尼莫地平,硝苯吡啶和长春胺具有改善樟柳碱和亚硝酸钠所致记忆获得和记忆巩固不良的作用。尼莫地平作用分别比硝苯吡啶和长春胺强100和1000倍。尼莫地平对樟柳碱造成的大鼠主动和被动回避性反应的缺失也有明显改善作用。在影响记忆的有效剂量下,硝苯吡啶和长春胺有抗急性脑缺氧的作用,而尼莫地平则否。推测尼莫地平促进记忆的作用机制与脑血液循环改善的关系不大。

Nimodipine was shown to improve anisodine-induced impairments of active and passive avoidance responses, while nifedipine and vincamine increased passive avoidance response only in rats. The potency of nimodipine on amnesia was 100~200 and 1,000~2,000 times as large as nifedipine and vineamine respectively. Nimodipine was capable of antagonizing pentobarbital-induced impairment of learning in water maze and cycloheximide-elicited deficit of consolidation of memory in step down and step through tests...

Nimodipine was shown to improve anisodine-induced impairments of active and passive avoidance responses, while nifedipine and vincamine increased passive avoidance response only in rats. The potency of nimodipine on amnesia was 100~200 and 1,000~2,000 times as large as nifedipine and vineamine respectively. Nimodipine was capable of antagonizing pentobarbital-induced impairment of learning in water maze and cycloheximide-elicited deficit of consolidation of memory in step down and step through tests in mice. However, nifedipine and vincamine did not show significant effect on the parameters mentioned above. Effects of the three cerebral vasodilators on alcohol-induced deficit of retrieval of mice were also studied in step down test. Good result was obtained with vincamine, but not with nimodipine and nifedipine.

采用多次性训练的主动和被动迴避反应和水迷宫法,观察了尼莫地平、硝苯吡啶和长春胺对樟柳碱和戊巴比妥钠引起的大鼠和小鼠记忆障碍的改善作用。三种药物皆有不同程度的改善作用,其中尼莫地平的作用强度比硝苯吡啶和长春胺各大200和2,000倍。尼莫地平还可拮抗环己酰亚胺引起的记忆巩固不良,而其它两种药物则无此作用。长春胺对40%乙醇引起的小鼠记忆再现缺失有明显改善作用,其它两药则否。

Iv nimodipine (Nm) decreased the size of myocardial infarction induced by coronary ligation in the rabbits. In the anesthetized dogs.iv Nm 1,3, 10μg/kg slowed the heart rate and decreased the resistance of coronary, vertebral and femoral arteries; left ventricular pressure end cardiac oxygen comsumption were also declined by iv Nm 3 ;ug/kg; In the isolated guinea pig heart, Nm 1-10μg inhibited cardiac contraction, increased the coronary flow, the heart rate was slowed by 10μg of Nm. In the isolated acrtic...

Iv nimodipine (Nm) decreased the size of myocardial infarction induced by coronary ligation in the rabbits. In the anesthetized dogs.iv Nm 1,3, 10μg/kg slowed the heart rate and decreased the resistance of coronary, vertebral and femoral arteries; left ventricular pressure end cardiac oxygen comsumption were also declined by iv Nm 3 ;ug/kg; In the isolated guinea pig heart, Nm 1-10μg inhibited cardiac contraction, increased the coronary flow, the heart rate was slowed by 10μg of Nm. In the isolated acrtic strips of rabbit, Nm exerted no influence to the cumulative dose-response curves (CDRC) of norepinephrine ( NE ) ; but the CDRC of KC1 were shifed to right noncompetitively, the IC_(50) was 1.2 nM. Nm also antagonized the effects of NE and CaCl2 to contract the central arteries of rabbit ear, the IC_(50) was 10 nM. The LD_(50) of Nm by oral administration in the mice was 1.66± 0.2g/kg.

iNm 10μg/kg可显著缩小家兔心肌梗塞范围;1、3、10μg/kg降低麻醉犬HR、BP、CAR、VAR及FAR;3μg/kg降低LVP及MVO_2;1~10μg明显抑制离体豚鼠心脏收缩,增加CBF;10μg可减慢HR。Nm9.6~960nM非竞争性对抗KCl收缩兔主动脉条,但不影响NE引起的收缩;Nm也可非竞争性对抗CaCl_2及NE所致兔耳中央动脉收缩,IC_(50)分别为10nM及60μM。小鼠口服Nm LD50(95%可信限)为1.66±0.2g/kg;大鼠亚急性毒性在大剂量组(125mg/kg)心肌有小灶性胞浆浅染.有2鼠有心肌壁小瘢痕灶,其他未见异常。

 
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