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its clinicopathological
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  临床病理学
    Epigenetics of Colorectal Cancer: Multiple Gene Promoter Methylation Profile and Its Clinicopathological Significance
    结直肠癌表现遗传学研究——多基因启动子甲基化及其临床病理学意义
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    Immunohistochemical Detection of ras P_(21) Expression in Pancreatic Adenocarcinoma and Its Clinicopathological Significance
    Ras P_(21)在胰腺癌组织中的表达及其临床病理学意义
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    Immunohistochemical Detection of p53 Protein Alterated Expression in 1364 Patients with Maligant Tumors and Its Clinicopathological Significance
    1364例恶性肿瘤p53蛋白表达的检测及其临床病理学意义
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    Relationship between abnormal expression of E-cadherin-catenin complex in gastric carcinoma and its clinicopathological features as well as patient survival
    E-钙粘蛋白-连接素复合体表达与胃癌临床病理学及生存期的关系
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    Cloning and identification of a novel gene HCCA3 highly expressed in human hepatocellular carcinoma and its clinicopathological significance
    人类新的肝癌高表达基因HCCA3的克隆、鉴定及其临床病理学意义
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    nm23/NDPK expression in colorectal neoplasia and its clinicopathological significance
    肿瘤转移抑制基因nm23在良、恶性大肠组织中的表达及临床病理意义
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    THE ANTI KI 67 ANTIBODY MIB 1 EXPRESSION IN COLORECTAL EPITHELIAL TUMOURS AND ITS CLINICOPATHOLOGICAL SIGNIFICANCE
    抗Ki-67抗体MIB-1在大肠上皮性肿瘤中的表达及临床意义
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    p53 Gene in Colorectal Cancer and Its Clinicopathological Significance
    大肠癌组织p53基因突变及其与临床病理关系的探讨
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    Expression of P53 protein in nonsmall cell lung carinoma and its clinicopathological significance
    非小细胞肺癌P53蛋白表达的临床病理意义
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    ObjectiveTo investigate the expression level of HIF-1α during breast carcinogenesis and tumor progression and its clinicopathological significance.
    目的探讨乳腺导管增生癌变过程中缺氧诱导因子-1α(hypoxia inducible factor-1α,HIF-1α)的表达变化及其意义。
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  its clinicopathological
Malignant melanoma in the oral region is reviewed in its clinicopathological aspects.
      
Hepatoid adenocarcinoma is reviewed in its clinicopathological and oncogenetic aspects.
      
Immunohistochemical expression of cyclin E in endometrial adenocarcinoma (endometrioid type) and its clinicopathological signifi
      
Overexpression of cyclin B1 in gastric cancer and its clinicopathological significance: an immunohistological study
      
The prevalence of BCL-2 immunoreactivity in breast carcinomas and its clinicopathological correlates, with particular reference
      
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Objective Detection of tumor micrometastases in resected lymph nodes of cancer patients to obtain more reliable information concerning nodal status and its clinicopathological importance. Methods Paraffin blocks of 3 715 resected lymph nodes from 350 Stage Ⅰ cancer patients, suffering from NSCLC ( n =94),breast cancer ( n =112), esophageal cancer ( n =115), and vulvar cancer ( n =29), were re examined by immunohisto chemical staining, using monoclonal anti cyokeratins (AE1/AE3), anti EMA,...

Objective Detection of tumor micrometastases in resected lymph nodes of cancer patients to obtain more reliable information concerning nodal status and its clinicopathological importance. Methods Paraffin blocks of 3 715 resected lymph nodes from 350 Stage Ⅰ cancer patients, suffering from NSCLC ( n =94),breast cancer ( n =112), esophageal cancer ( n =115), and vulvar cancer ( n =29), were re examined by immunohisto chemical staining, using monoclonal anti cyokeratins (AE1/AE3), anti EMA, and polyclonal anti keratins antibodies. Results Occult nodal metastases was obsesved in 113 of 350 cancer patients (32.5%), and in 203 of 3 715 lymph nodes examined. The positive rates both in patients and in lymph nodes were higher in NSCLC than in others. Occult nodal metastasis was seen in 58% of pulmonary squamous cell carcinomas and 53.8% of adenocarcinomas, while it was seen in 22.5% of esophageal and 10.3% of vulval squamous cell carcinomas, and in 27.7% of breast adenocarcinomas ( P <0 05). Follow up of a fraction of breast cancer patients showed that the prognosis of patients with positive nodes was worse than that in patients with negative nodes ( P <0 05). Conclusion The data suggested that the immunohistochemical technique can significantly facilitate the detection of micrometastatic tumor cells in lymph nodes. The frequency of occult lymph node metastasis may have significant impact on the prognosis of cancer patients.

目的 检查癌症患者切除淋巴结内有无微小癌转移 ,具有临床、病理重要性。方法  350例 期癌症患者包括非小细胞肺癌 94例 ,乳腺癌 112例 ,食管癌 115例及外阴癌 2 9例病理报告无癌转移的淋巴结 3715枚。应用单克隆抗细胞角蛋白 ( AE1/ AE3)、抗上皮细胞膜 ( EMA) ,及多克隆抗角蛋白抗体进行免疫组化染色重新检查。结果 所有病例的 32 .3% ( 113/ 350 )、被检淋巴结的 5.5%( 2 0 3/ 3715)有淋巴结内隐匿性肿瘤转移。肺癌患者及被检淋巴结的阳性率均比其他肿瘤高。肺鳞癌58%、腺癌 53.8%的淋巴结为阳性 ,分别比食管鳞癌 2 2 .5%、外阴鳞癌 10 .3%及乳腺癌 2 7.7%高 ( P<0 .0 5)。部分乳腺癌患者术后随访显示 :淋巴结阳性患者比阴性者预后更差 ( P<0 .0 5)。结论 说明免疫组化技术可大大提高淋巴结微小癌转移的检出率 ,其阳性率的不同可能与患者的临床经过甚至癌患者的死亡率相关联。

The clinico-pathological characters of 3 cases with neuroendocrine carcinoma of liver and gallbladder were studied by using histological, immunohistochemical methods and electron microscopy. The primary antibodies including anti-chromogranin A, serotonin, insulin, somatostatin, gastrin, pancreatic polypeptide, adreno-corticotropic hormone (ACTH), calcitonin, bombesin, β-human chorionic gonadotropin (β-HCG) were employed to identify the property of tumors. The tumors in two cases were neuroendocrine carcinoma...

The clinico-pathological characters of 3 cases with neuroendocrine carcinoma of liver and gallbladder were studied by using histological, immunohistochemical methods and electron microscopy. The primary antibodies including anti-chromogranin A, serotonin, insulin, somatostatin, gastrin, pancreatic polypeptide, adreno-corticotropic hormone (ACTH), calcitonin, bombesin, β-human chorionic gonadotropin (β-HCG) were employed to identify the property of tumors. The tumors in two cases were neuroendocrine carcinoma including one in the gallbladder and another one in the liver. The tumor in the third case occurring in the gallbladder is a typical carcinoid.In the immunohistochemistry study, the tumor cells showed positive reaction to chromogranin A and contained positive cells of gastrin, serotonin, insulin and pancreatic polypeptide. Electron microscopic examinations showed that the cytoplasm contained dense round granules. The neuroendocrine carcinoma of liver and gallbladder is a special type neoplasm. With references in the literature, its clinicopathological characteristics, classification, nomenclature and histogenesis were discussed.

收集了1例经尸体解剖证实的肝及2例外科手术切除胆囊的神经内分泌肿瘤。应用组织学、免疫组织化学和电子显微镜对其肿瘤病理特点进行了观察。免疫组化第一抗体包括抗-嗜铬蛋白A、胃泌素、五羟色氨、胰岛素、生长抑素、胰多肽、肾上腺皮质激素(ACTH)、降钙素、蛙皮素、β绒毛膜促性腺激素(β-HCG)。结果发现1例发生在胆囊的为典型类癌;另两侧诊断为神经内分泌癌分别发生在肝和胆囊。在免疫组织化学中,3例肿瘤大部分细胞(50%以上)对嗜铬蛋白A呈阳性反应。并在肿瘤细胞中分别发现胃泌素、五羟色氨、胰岛素和胰多肽阳性细胞。电子显微镜显示胞浆内含有电子致密圆颗粒。结合文献对肝及胆囊的神经内分泌癌的临床病理特点、神经内分泌癌的分类命名及组织来源进行了探讨。

Objective: To probe into the diagnosis in midline malignant reticulosis (MMR) and its clinicopathological significance. Methods: MMR was studied clinicopathologically and immunophenotypically. Results: The study showed that of the 50 cases of MMR there were 43 cases of T cell lymphoma, 2 cases of B cell lymphoma, and 5 cases being of uncertain lineage in the study. This study also covered the differential diagnosis of MMR from some other diseases. Conclusion: 1) the results suggest that most of MMR are...

Objective: To probe into the diagnosis in midline malignant reticulosis (MMR) and its clinicopathological significance. Methods: MMR was studied clinicopathologically and immunophenotypically. Results: The study showed that of the 50 cases of MMR there were 43 cases of T cell lymphoma, 2 cases of B cell lymphoma, and 5 cases being of uncertain lineage in the study. This study also covered the differential diagnosis of MMR from some other diseases. Conclusion: 1) the results suggest that most of MMR are T cell lymphoma (socalled midline T cell lymphoma (MTL); 2) it is believed that the clinical manifestations and pathologic features combined with immunophenotyping technique could help make a definite diagnosis of MMR.

目的:探讨中线恶网的诊断及其临床病理意义,与其他一些疾病的鉴别诊断。方法:对中线恶网进行临床病理分析和免疫表型标记。结果:50例中线恶网中,T细胞淋巴瘤43例,B细胞淋巴瘤2例,余5例尚不能分类。结论:结果表明本病多数是T细胞淋巴瘤(即所谓的中线T淋巴瘤)。认为本病的临床、病理特点结合免疫标记技术有助于中线T淋巴瘤的确诊。

 
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