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target receptors
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  靶受体
     It indicates that there are special target receptors for BmK AS type scorpion neurotoxins on both mammal and insect excitable cell membranes.
     结果提示, Bm K A S类蝎神经毒素在哺乳动物和昆虫兴奋性细胞膜上存在着特异的靶受体
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  “target receptors”译为未确定词的双语例句
     The notion of the reader's equal response, actually, is not only a kind of deception to the target receptors but also a kind of disrespect to "the Other", which will hinder cultural exchange and cultural development.
     这种理论追求“同一”,对译文读者实质上是一种蒙蔽,对“他者”也是一种不尊重,其结果只能是阻碍文化交流,进而阻碍文化发展与繁荣。
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  相似匹配句对
     The target is opioid receptors
     病原是外源性阿片类化合物,靶部位是阿片受体。
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     N TARGET
     命中目标
短句来源
     ROLE OF NON-TARGET RECEPTORS IN PSYCHOACTIVE SUBSTANCE DEPENDENCE
     非靶受体在精神活性物质依赖中的作用
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     Target Compounds.
     目标化合物:
短句来源
     GF receptors
     说明SS对EGF受体有下调节作用。
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  target receptors
The performance of such strategies depends in part on the instantaneous response of target receptors; therefore, the sequence of events is of considerable consequence and individual exemplar plume realizations are required.
      
Thus, if the kinetics of a radioligand for target receptors does not permit an appropriate reference region, BP imaging is unattainable.
      
Agmatine binds to several target receptors in the brain and has been proposed as a novel neuromodulator.
      
A new classification is also proposed for peptides targeting tumour cells based on the biological function of target receptors.
      
We show herein that the rGR DBD, while necessary, is not sufficient to target receptors to the nuclear matrix.
      
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BmK AS, one novel neurotoxic polypeptide from Chinese scorpion Buthus martensi Karsch was labeled by 125 I with INDOGEN method. Iododerivative was used in binding experiments on mammal and insect synaptosomes. BmK AS binds specifically to a single class of non interacting binding sites with high affinity ( K d=1.49 nmol/L) and low capacity ( B max =1.39 nmol/g) on rat brain synaptosomes. Likewise, BmK AS also binds specifically to a single class of non interacting binding sites with...

BmK AS, one novel neurotoxic polypeptide from Chinese scorpion Buthus martensi Karsch was labeled by 125 I with INDOGEN method. Iododerivative was used in binding experiments on mammal and insect synaptosomes. BmK AS binds specifically to a single class of non interacting binding sites with high affinity ( K d=1.49 nmol/L) and low capacity ( B max =1.39 nmol/g) on rat brain synaptosomes. Likewise, BmK AS also binds specifically to a single class of non interacting binding sites with high affinity ( K d=0.79 nmol/L) and low capacity ( B max =6.60 nmol/g) on cockroach nerve cord synaptosomes. It indicates that there are special target receptors for BmK AS type scorpion neurotoxins on both mammal and insect excitable cell membranes.

用 I N D O G E N 法对一个新型东亚钳蝎活性多肽 Bm K A S 进行了125 I标记。分别在哺乳动物和昆虫标本上观察了标记物的药理结合特性。结果表明 Bm K A S 在大鼠脑突触体标本上有单一非协同结合位点, 其平衡解离常数 Kd 与最大结合容量 Bmax 分别为1 .49 nmol/ L 和1 .39 nmol/g 。此外, Bm K A S 在蟑螂神经索突触体标本同样也只有单一非协同结合位点, 其平衡解离常数 Kd 与最大结合容量 Bmax 分别为0 .79 nmol/ L 和6 .60 nmol/g 。结果提示, Bm K A S类蝎神经毒素在哺乳动物和昆虫兴奋性细胞膜上存在着特异的靶受体。

Effects of anti peptide antibodies against the second extracellular loop of human M 2 muscarinic receptors on the cAMP production and calcium currents(I Ca ) in guinea pig ventricular myocytes were studied by using radioimmunoassay and whole cell patch clamp technique and a comparison was also made with those of the muscarinic receptor agonist. Both muscarinic receptor agonist carbachol (Carb 10 μmol/L) and anti peptide antibodies (Abs 100 nmol/L) could decrease the isoprenaline...

Effects of anti peptide antibodies against the second extracellular loop of human M 2 muscarinic receptors on the cAMP production and calcium currents(I Ca ) in guinea pig ventricular myocytes were studied by using radioimmunoassay and whole cell patch clamp technique and a comparison was also made with those of the muscarinic receptor agonist. Both muscarinic receptor agonist carbachol (Carb 10 μmol/L) and anti peptide antibodies (Abs 100 nmol/L) could decrease the isoprenaline (Iso 0.8 μmol/L) induced increases of cAMP〔from (108.2±7.0) to (88.4±7.2) pmol/(mg·min)for Carb and (88.6±5.1) pmol/(mg·min) for Abs respectively〕 production and increases of I Ca 〔from (53.5± 7.0)% to (13.0±2.0)% for Carb and (66.9± 10.5)% to (34.5±8.0)% for Abs respectively〕. The muscarinic receptor antagonist atropine (Atr) was able to prevent these effects of Carb and Abs.These results indicated that the anti peptide antibodies against an epitope located in the second extracellular loop of human M 2 muscarinic receptors, similar to muscarinic receptor agonist, could decrease the β receptor agonist stimulated increase of I Ca by decreasing the β receptor agonist stimulated increase of cAMP productions and therefore could have an effect on their target receptor. These results further suggest that autoimmunity may participate in the pathogenesis of human idiopathic dilated cardiomyopathy(DCM) and the second extracellular loop of human M 2 musarinic receptor could be the main immunodominant region.

应用放射免疫分析方法及全细胞膜片钳技术研究了抗M2 受体细胞外第二环上的抗肽段抗体 (Abs )对豚鼠心室肌细胞cAMP产生量和内向钙电流 (ICa)的影响并同M受体激动剂的效应进行了比较。结果如下 :M受体激动剂carbachol(Carb10 μmol/L)和抗肽段抗体 (Abs 10 0nmol/L)两者均可抑制异丙肾上腺素 (Iso 0 .8μmol/L)所引起的cAMP量的增加〔Carb可使组织中cAMP从 (10 8.2± 7.0 )降为 (88.4± 7.2 )pmol/ (mg·min) ,Abs可使组织中cAMP从 (10 8.2± 7.0 )降为 (88.6± 5 .1)pmol/ (mg·min)〕及ICa的增加〔Carb可使ICa从 (5 3.5± 7 0 ) %降为 (13.0± 2 0 ) % ,而Abs可使ICa从 (6 6 .9± 10 .5 ) %降为(34 .5± 8 0 ) %〕。M受体阻断剂阿托品 (Atr)可以阻断Carb和Abs的以上效应。以上结果提示 :此抗肽段抗体同M受体激动剂一样可以通过减少 β受体激动剂所引起的cAMP的增加从而达到降低 β受体激动剂所引起...

应用放射免疫分析方法及全细胞膜片钳技术研究了抗M2 受体细胞外第二环上的抗肽段抗体 (Abs )对豚鼠心室肌细胞cAMP产生量和内向钙电流 (ICa)的影响并同M受体激动剂的效应进行了比较。结果如下 :M受体激动剂carbachol(Carb10 μmol/L)和抗肽段抗体 (Abs 10 0nmol/L)两者均可抑制异丙肾上腺素 (Iso 0 .8μmol/L)所引起的cAMP量的增加〔Carb可使组织中cAMP从 (10 8.2± 7.0 )降为 (88.4± 7.2 )pmol/ (mg·min) ,Abs可使组织中cAMP从 (10 8.2± 7.0 )降为 (88.6± 5 .1)pmol/ (mg·min)〕及ICa的增加〔Carb可使ICa从 (5 3.5± 7 0 ) %降为 (13.0± 2 0 ) % ,而Abs可使ICa从 (6 6 .9± 10 .5 ) %降为(34 .5± 8 0 ) %〕。M受体阻断剂阿托品 (Atr)可以阻断Carb和Abs的以上效应。以上结果提示 :此抗肽段抗体同M受体激动剂一样可以通过减少 β受体激动剂所引起的cAMP的增加从而达到降低 β受体激动剂所引起的ICa的增加 ,由此可以对心室肌M2 受体产生作用。以上结果进一步提示自身免疫有可能参与了特发性扩张性心肌病的发病过程 ,而M2 受体细胞外第二环上的氨基酸肽段可能为免疫反应的靶作用区。

The voltage gated sodium channel is the major target receptor for DDT and pyrethroids, and is the basis of their cross resistance (knockdown resistance). The characters of pyrethroid being high toxic to insects and other invertebrate but low toxic to mammals, make the mechanisms of toxicity and resistance very important for our safety and pest control in agriculture.

电压门控的钠通道是拟除虫菊酯 (Pyrethroid)和滴滴涕 (dichloro diphenyl trichloroethane)的共同靶变点 ,是它们产生交互抗性 (击倒抗性 ,Knockdownresistance)的基础。由于拟除虫菊酯具有对昆虫和其他无脊椎动物呈高毒性 ,而对哺乳动物呈低毒性等特点 ,研究拟除虫菊酯的杀虫和抗药性机理 ,无论对人畜中毒的防治 ,还是对农业害虫的治理都有极为重大的意义

 
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