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tumor necrosis factor
相关语句
  肿瘤坏死因子-
     Calcium Activated Non-selective Cation Channel in Endothelial Cell Line ECV304 and Inhibition of Tumor Necrosis Factor-α
     ECV304内皮细胞株的钙激活非选择性阳离子通道及肿瘤坏死因子-α的抑制作用
短句来源
     Dynamic observation of splasma tumor necrosis factor-αand Interleukin-1βin patients with cerebral infarction
     脑梗死患者恢复期脑组织血浆肿瘤坏死因子-α、白介素-1β含量变化
短句来源
     Objective To study the character of non-selective cation channel in human umblical cord vein endothelial cell line ECV304 and the effect of tumor necrosis factor-α (TNF-α ) on channel activity.
     目的 研究人脐静脉内皮细胞株 ECV304的钙激活非选择性阳离子通道的特征和肿瘤坏死因子-α (TNF-α )对该通道的调控作用。
短句来源
  “tumor necrosis factor -”译为未确定词的双语例句
     Objective To observe the change of plasma levels of tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) in patients with acute cerebral infarction(ACI) and its clinical significance.
     目的观察急性脑梗死患者血浆肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)含量变化。
短句来源
     THE CHANGE OF FAT METABOLIZATION AND TUMOR NECROSIS FACTOR-α IN ACUT E GLUCOSE METABOLISM
     急性糖代谢过程中血脂和肿瘤坏死因子-α动态变化观察
短句来源
     Changes of the content of water in the rat's guts and Tumor Necrosis Factor-α、Interleukin 6 in the blood plasma and its implications after imitated thermal radiation
     大鼠光辐射烧伤后早期组织器官功能指标变化
短句来源
  相似匹配句对
     ③Tumor incompletely necrosis.
     ③肿瘤不完全坏死。
短句来源
     ④Tumor necrosis and ulceration;
     ④肿瘤坏死和溃疡;
短句来源
     RESEARCH ADVANCES OF TUMOR NECROSIS FACTOR
     肿瘤坏死因子研究进展
短句来源
     Tumor Necrosis Factor-alpha and Psoriasis
     肿瘤坏死因子α与银屑病
短句来源
     Tumor necrosis factor and diabetic retinopathy
     TNF与糖尿病视网膜病变
短句来源
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TNF (tumor necrosis factors) was obtained from the serum of Japanese Polish Rabbit which was sensitized with Propionibacterium acnes and injected with LPS(lipopolysaccharide). The morphological changes of the cultured rat glioma cells (GAI, C-6) and human glioma cells (marcus) were observed after using TNF. It showed granules appeared in cytoplasma and became most evident on the 3rd day. This study represented the possibility of treatment of human brain glioma with TNF, although it is necessary to further...

TNF (tumor necrosis factors) was obtained from the serum of Japanese Polish Rabbit which was sensitized with Propionibacterium acnes and injected with LPS(lipopolysaccharide). The morphological changes of the cultured rat glioma cells (GAI, C-6) and human glioma cells (marcus) were observed after using TNF. It showed granules appeared in cytoplasma and became most evident on the 3rd day. This study represented the possibility of treatment of human brain glioma with TNF, although it is necessary to further study the effect of TNF on the glioma.

作者研究了由兔产生的肿瘤坏死因子(TNF)对鼠源性脑胶质瘤细胞GAI、C-6和人脑胶质瘤细胞marcus的作用,发现TNF对上述三种细胞都显示了明显的细胞毒作用,肿瘤细胞崩解死亡。本实验提示了将来TNF作为治疗恶性脑胶质瘤的一种新方法的可能性。

Using light microscope and electron microscope,we observed the morphological changes in the SMMC-7721 human hepatocellular carcinoma cell line after it was exposed to the rabbit tumor necrosis factor (TNF)and the cytocidal effect of TNF on the heterotransplanted human hepatocellular carcinoma (SMMC-7721 cell line).It was found that the changes occurred earlier in the cell membranes than in the nuclei during the course of TNF killing SMMC-7721 cell line and there was no special varieties around the necrotic...

Using light microscope and electron microscope,we observed the morphological changes in the SMMC-7721 human hepatocellular carcinoma cell line after it was exposed to the rabbit tumor necrosis factor (TNF)and the cytocidal effect of TNF on the heterotransplanted human hepatocellular carcinoma (SMMC-7721 cell line).It was found that the changes occurred earlier in the cell membranes than in the nuclei during the course of TNF killing SMMC-7721 cell line and there was no special varieties around the necrotic area in the heterotransplanted human hepatocellular carcinoma in the nude mice as compared with that appearing in SMMC-7721 cell line,In addition, we detected the DNA contents of TNF treated SMMC-7721 cells and control ones, but there was no significant difference of the DNA contents between them.Ace of ding to the results of this study, we think that the mechanism by wluch TNF exerts its tumour-selective killing effect is probably as follows.TNF binds to a specific plasma membrane receptor and then disturbs synthesis or assembly of cell membrane components, leading the changes of cell structure(for example, swollen microvilli, a number of vesicles and small holes on the surface of tumor cells), and the lysis of tumor cells.

应用光镜和电镜观察了肿瘤坏死因子(TNF)杀伤人肝癌细胞系(SMMC-7721)的过程,同时测定了其DNA含量的变化,并观察了TNF对裸鼠人肝癌移植瘤的作用。结果表明,TNF与SMMC-7721细胞接触后,癌细胞膜系统先有变化,而胞核的变化出现在后。作者认为TNF选择性杀伤肿瘤细胞的机理可能是TNF与癌细胞膜上某种正常细胞不具有的物质发生作用,引起癌细胞的膜系统损伤,终致细胞死亡。

A high level expression vector has been constructed,which contains PR PL promoter, cIts857 gene, multiple cloning sites ( MCS ) and two strong transcription terminators. Foreign gene with ATG signal can be inserted into the MCS, expressing non-fusion protein. Using this vector, we have expressed successfully the human interferon r,human interleukin-2 and human tumor necrosis factor. The foreign gene product accounts for more than 20% of the total cell protein.

我们组建了一个含P_RP_L自动子的原核高效表达载体,它同时含有cI调控基因、多酶切点和两个强的转录终止序列。带起始密码子ATG的外源基因可以插入启动子下游的多酶切点,表达非融合蛋白,产品可供临床使用。我们实验室已用它成功地表达了人γ干扰素、人白细胞介素-2和人肿瘤坏死因子等,表达量均占菌体总蛋白的20%以上。

 
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