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眼科与耳鼻咽喉科
肿瘤学
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or hypopharyngeal
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  喉咽
     STUDY OF SOLUBLE Cyfra21_1 IN PATIENTS WITH LARYNGEAL OR HYPOPHARYNGEAL CARCINOMA
     喉癌喉咽癌患者血清Cyfra21-1水平的研究
短句来源
     Methods:Standardized sandwich enzyme linked immunosorbent assay was used to determine soluble Cyfra21 1 in 30 normal individuals,8 patients with benign tumor, and 32 patients with laryngeal or hypopharyngeal carcinoma.
     方法 :应用酶联免疫夹心抗体对 30例正常人、8例咽喉部良性肿瘤、32例喉癌、喉咽癌患者手术前后进行血清Cyfra2 1 1测定。
短句来源
     Conclusion:Cyfra21 1 may be a new marker of laryngeal or hypopharyngeal carcinoma and may have important clinical value.
     结论 :Cyfra2 1 1作为一种新的肿瘤标志物 ,对喉癌和喉咽癌的病程进展、治疗监测和预后判断有重要临床价值。
短句来源
     Methods:From January 1998 to June 2001,thirty six patients with advanced laryngeal or hypopharyngeal carcinoma (laryngeal cancer 14,hypopharyngeal cancer 22)were treated by neoadjuvant chemotherapy. Thirty one patients received Cisplatin(DDP)+5 Fluorouracil (5 FU)+ Bleomycin (BLM)regimen,the other five patients received DDP+Taxol regimen.
     方法 :采用DFB(DDP +5 -FU +BLM)或TP(Taxol+DDP)方案对 36例晚期喉癌、喉咽癌患者进行两个周期以上的化疗 ,观察近期客观疗效及毒副反应 ,然后进行放疗或手术治疗。
短句来源
     Methods In 29 patients who suffered from laryngeal or hypopharyngeal carcinoma with N0 neck, the patent blue was injected into the surrounding tissue of the tumor during the operation to identify the sentinel lymph nodes.
     方法 用手术中注射蓝染料的方法 ,对 2 9例颈淋巴结N0的喉癌喉咽癌患者进行了哨位淋巴结的临床研究。
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  “or hypopharyngeal”译为未确定词的双语例句
     Methods The expression of CD44 and nm23-H1 in specimens from the primary and metastatic lymph node lesions of the 41 cases with supraglottic or hypopharyngeal cancer were studied with immunohistochemistry method and flow cytometry.
     方法应用免疫组织化学方法和流式细胞检测方法观察了22例无淋巴转移的非转移组和41例病理证实有淋巴转移的声门上型喉癌、下咽癌患者的原发灶与淋巴转移灶中的CD44和nm23-H1表达情况。
短句来源
     Results No correlation was found between the expression of CD44,nm23-H1 and the tumor differentiation of the supraglottic or hypopharyngeal cancer,but their expression related with the chinical staging.
     结果喉癌淋巴转移组CD44蛋白表达高于非转移组,nm23-H1,蛋白表达低于非转移组(P值均<0.05)。 CD44、nm23-H1蛋白表达与声门上型喉癌、下咽癌的临床分期有关,和病理分级无关。
短句来源
     Methods:The precontrast and three-phase postcontrast helical CT scans were performed in 64 patients with laryngeal or hypopharyngeal carcinoma(primary tumor 49 cases and postoperative evaluation 15 cases).
     方法:64例喉及下咽癌患者(原发肿瘤49例、术后评价15例)进行螺旋CT平扫及三期增强扫描。
短句来源
     Conclusions The expressions of CD44 and nm23-H1 in the metastatic lymph node tumor had no difference compared with that in primary tumor of the supraglottic or hypopharyngeal cancer. The difference of metastasis potentials between the primary and metastatic lymph node lesions in the same patient was not proved in this study and should be further investigated from multiple oncogens markers.
     结论声门上型喉癌及下咽癌原发灶与其转移淋巴结CD44、nm23-H1蛋白表达无明显差异,未能证明原发灶与其淋巴结转移灶肿瘤细胞转移潜能的差异,原发灶及其转移淋巴结的转移潜能比较还应从多靶点深入探讨。
短句来源
     Methods:The MRI data of 36 cases of primary laryngeal or hypopharyngeal cancers were retrospectively staged,and compared with the clinical and postsurgical pathologic staging.
     方法 :对 36例喉、下咽癌患者的MRI资料进行回顾性分期 ,并与临床分期及手术病理分期相对照。
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     , or G.
     、或小秦艽G.
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     or (?)
     或(?)
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     The Surgical Treatment of the Severe Hypopharyngeal Steonsis or Atresia
     喉咽部严重狭窄的手术治疗
短句来源
     The article reports 17 cases of severe hypopharyngeal or/and
     17例严重喉咽或(及)颈段食管狭窄缺损患者,15例经手术治疗恢复了正常吞咽功能,12例有喉者10例恢复了喉全功能。
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  or hypopharyngeal
Dysphagia in the elderly is most often oropharyngeal or hypopharyngeal in location and neuropathologic in etiology.
      
Surgical procedures and in particular laryngectomy can become a life-saving treatment for patients with laryngeal or hypopharyngeal cancer, but can result in permanent damage.
      
Dynamic TYR PET was performed on 31 patients with T1-T4 laryngeal or hypopharyngeal carcinoma before therapy.
      
In patients suspected of having recurrent laryngeal or hypopharyngeal cancer in whom FDG-PET is negative, endoscopy may be omitted for at least 6 months and possibly for up to 1 year.
      
Forty-eight patients (43 male, 5 female; mean age ±SD, 61±9.5 years) with suspected recurrent laryngeal or hypopharyngeal cancer were prospectively studied.
      
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Several investigations revealed that lymphocytes from patients with head and neck cancers showed a high sensitivity to mutagens. However, whether lymphocytes from healthy blood relatives of the patients were sensitive to mutagen or not had not been reported. This study was aimed to investigate the unknown problem. Mutagen sensitivity was investigated in 116 laryngeal and 38 hypopharyngeal cancer patients, 107 healthy controls, and 30 blood relatives of laryngeal or hypopharyngeal...

Several investigations revealed that lymphocytes from patients with head and neck cancers showed a high sensitivity to mutagens. However, whether lymphocytes from healthy blood relatives of the patients were sensitive to mutagen or not had not been reported. This study was aimed to investigate the unknown problem. Mutagen sensitivity was investigated in 116 laryngeal and 38 hypopharyngeal cancer patients, 107 healthy controls, and 30 blood relatives of laryngeal or hypopharyngeal cancer patients. Chromosome damage was measured by enumerating mutagen induced chromatid breaks. the average number of chromatid breaks per cell (b/c value) was used as marker which reflects variable host susceptibility to the action of environmental carcinogens. The b/c values were 0.61± 0.27, 0.66±0.31, 0.28±0.12, and 0.45 ± 0. 26 for patients with laryngeal cancer, hypopharyngeal cancer, healthy controls, and blood relatives respectively. A significant difference of b/c value was found between patients and controls ( P <0.01), but not between patients and their blood relatives (P>0.05). Our findings suggest that genetic predisposition plays an important role in the eitiology of laryngeal and hypopharyngeal cancers. Both patients with laryngeal or hypopharyngeal cancers and their blood relatives should be considered as in high cancer risk.

为探讨遗传因素与喉癌下咽癌的关系,检测了几组不同人群淋巴细胞染色体对致突变物诱发畸变的敏感性,结果:喉癌组、下咽癌组及对照组每细胞染色单体断裂率(b/c值)分别为0.61±0.27,0.66±0.31和0.28±0.12。喉癌和下咽癌的一级亲属组(亲属组)的b/c值为0.45±0.26。把健康一级亲属的喉癌、下咽癌患者从喉癌组和下咽癌组中抽出另列为患者组,其b/c值为0.59±0.29。亲属组与患者组比较b/c值差别无显著性(P>0.05),但明显高于健康对照组(P<0.001),明显低于喉癌组和下咽癌组(P<0.01)。结果显示喉癌和下咽癌患者及其健康一级亲属对致突变物敏感性均高于健康人,因此喉癌下咽癌患者的一级亲属应列为患癌高风险人群,注意预防癌肿的发生。

Objective:To evaluate the value of the preoperative T staging of laryngeal and hypopharyngeal cancers by MRI at high field strength(1.5T).Methods:The MRI data of 36 cases of primary laryngeal or hypopharyngeal cancers were retrospectively staged,and compared with the clinical and postsurgical pathologic staging.Results:The accuracy of staging in each T stage of laryngeal and hypopharyngeal cancers was:T 1:92%;T 2:86%;T 386%;T 4:100% by MRI vs.T 1:100%;T 286%;T 3:57%;T 4:22% by clinic/laryngoscope.The...

Objective:To evaluate the value of the preoperative T staging of laryngeal and hypopharyngeal cancers by MRI at high field strength(1.5T).Methods:The MRI data of 36 cases of primary laryngeal or hypopharyngeal cancers were retrospectively staged,and compared with the clinical and postsurgical pathologic staging.Results:The accuracy of staging in each T stage of laryngeal and hypopharyngeal cancers was:T 1:92%;T 2:86%;T 386%;T 4:100% by MRI vs.T 1:100%;T 286%;T 3:57%;T 4:22% by clinic/laryngoscope.The total accuracy of MRI and clinic/laryngoscope respectively was 92% vs 69%.P<0.05.Conclusion:MRI can correctly depict the original tumors site and invasion extension of laryngeal and hypopharyngeal cancers by comparing T 1WI and T 2WI with multiplanar,consequently improve the accuracy for staging significantly.

目的 :评价高场MRI(1.5T)在喉、下咽癌术前分期中的价值。方法 :对 36例喉、下咽癌患者的MRI资料进行回顾性分期 ,并与临床分期及手术病理分期相对照。结果 :MRI对各期喉、下咽癌的准确率分别是T1:92 % ,T2 :86 % ,T3:86 % ,T4 :10 0 %。临床分期准确率分别是T1:10 0 % ,T2 :86 % ,T3:5 7% ,T4 :2 2 %。MRI和临床分期总准确率分别是 92 % ,6 9%。二者之间有显著性差异。结论 :高场MRI通过不同加权像的对比和从多角度准确显示肿瘤的部位形态及浸润范围 ,因而显著性提高喉、下咽癌术前分期的准确性

Objective:To measure tumor marker Cyfra21 1 in patients with laryngeal,hypopharyngeal carcinoma and evaluate its value in early diagnosis,progress and treatment surveillance.Methods:Standardized sandwich enzyme linked immunosorbent assay was used to determine soluble Cyfra21 1 in 30 normal individuals,8 patients with benign tumor, and 32 patients with laryngeal or hypopharyngeal carcinoma.Results:Cyfra21 1 in patients with malignant tumor was significantly higher than that of patients with benign...

Objective:To measure tumor marker Cyfra21 1 in patients with laryngeal,hypopharyngeal carcinoma and evaluate its value in early diagnosis,progress and treatment surveillance.Methods:Standardized sandwich enzyme linked immunosorbent assay was used to determine soluble Cyfra21 1 in 30 normal individuals,8 patients with benign tumor, and 32 patients with laryngeal or hypopharyngeal carcinoma.Results:Cyfra21 1 in patients with malignant tumor was significantly higher than that of patients with benign tumor(P<0.01) or normal individuals (P<0.01).Half a month after operation,the Cyfra21 1 contents were obviously decreased,the difference was not statistically significant compared with those of normal individuals.Cyfra21 1 levels were positively correlated with the tumor stages.Conclusion:Cyfra21 1 may be a new marker of laryngeal or hypopharyngeal carcinoma and may have important clinical value.

目的 :探讨肿瘤标志物Cyfra2 1 1在喉癌、喉咽癌早期诊断、病程进展、治疗监测中的作用。方法 :应用酶联免疫夹心抗体对 30例正常人、8例咽喉部良性肿瘤、32例喉癌、喉咽癌患者手术前后进行血清Cyfra2 1 1测定。结果 :喉癌、喉咽癌患者Cyfra2 1 1明显高于正常人及良性肿瘤患者 (P <0 0 1)。喉癌、喉咽癌术后半月Cyfra2 1 1明显下降 ,与正常人比较差异无显著性 ,Cyfra2 1 1与肿瘤TNM分期呈正相关。 结论 :Cyfra2 1 1作为一种新的肿瘤标志物 ,对喉癌和喉咽癌的病程进展、治疗监测和预后判断有重要临床价值。

 
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