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retinoic acid-induced
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  视黄酸诱导
     The changes of protein kinase C and its substrates in the cytosol and nuclei upon retinoic acid-induced differentiation of HL-60 cells were studies by incubation of [γ-32P]ATP with proteins in vitro.
     本文观察视黄酸诱导HL-60细胞分化后胞浆及核中蛋白激酶C活性和底物的变化。 视黄酸诱导分化后,胞浆中蛋白激酶C活性升高,而核中则降低;
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  “retinoic acid-induced”译为未确定词的双语例句
     All-trans retinoic acid-induced differentiation was enhanced by bufalin in NB4 cells in vitro
     蟾蜍灵增强全反式维甲酸对NB4细胞的诱导分化作用
     Expression of retinoic acid receptor β mediates retinoic acid-induced growth arrest and apoptosis in lung cancer cell line A549
     维甲酸β受体的表达介导肺腺癌细胞系A549凋亡的研究
短句来源
     Effect of Bugu Mixture on all-trans retinoic acid-induced apoptosis of bone marrow stromal cells
     补骨合剂对全反式维甲酸诱导的骨髓基质细胞凋亡的保护作用
短句来源
     Objective To investigate the effect of bufalin combined with all-trans retinoic acid-induced (ATRA) proliferation inhibition and differentiation and of acute promyelocytic leukemia (APL) cells NB4 in culture.
     目的:研究蟾蜍灵与全反式维甲酸(ATRA)联合对急性早幼粒细胞白血病(APL)细胞株NB4 细胞的增殖抑制及诱导分化作用。 方法:细胞增殖及凋亡检测:将NB4细胞浓度调整至5×105个/ml, 接种于24孔培养皿中,每孔1ml。
     Study of all-trans retinoic acid-induced apoptosis of Hep-2 laryngeal carcinoma cells
     全反式维甲酸诱导喉癌细胞凋亡的实验研究
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  相似匹配句对
     The Preparation of Cis-retinoic Acid
     异维A酸的制备方法
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     Retinoic acid in experimental myopia
     视黄醛在实验性近视中的作用
短句来源
     Effect of retinoic acid on fracture healing
     维甲酸在骨折愈合中的作用
短句来源
     The preparation of inclusion of retinoic acid in β-cyclodextrin
     维甲酸环糊精包合物的制备
短句来源
     THE DIFFERENTIATION -INDUCING EFFECT OF TANSHINONE AND RETINOIC ACID
     丹参酮和维甲酸对人宫颈癌细胞株的体外诱导分化作用
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  retinoic acid-induced
In this report, we present an in vitro study on the ATRA effects on lysosomal glycohydrolases expression and the eventual relationship with the retinoic acid-induced differentiation of HL-60 cells.
      
Our findings provide the first evidence that the modulation of Rpn10 is linked to the control of retinoic acid-induced differentiation of neuroblastoma cells.
      
We have found that retinoic acid-induced neural differentiation of Neuro2a cells significantly stimulates the incorporation of Rpn10 into HMW fractions, although the amounts of 26S proteasome subunits were not changed.
      
Association of Rpn10 with high molecular weight complex is enhanced during retinoic acid-induced differentiation of neuroblastom
      
Expression of NMDA receptors in multipotent stromal cells of human adipose tissue under conditions of retinoic acid-induced diff
      
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The changes of protein kinase C and its substrates in the cytosol and nuclei upon retinoic acid-induced differentiation of HL-60 cells were studies by incubation of [γ-32P]ATP with proteins in vitro. The activity of protein kinase C in the cytosol rose,and that in the nuclei declined after differentiation. The substrates of protein kinase C in the cytosol of HL-60 cells were 75 kD,67kD,47kD,40kD and 21kD proteins,and 35kD protein was the substrate of protein

本文观察视黄酸诱导HL-60细胞分化后胞浆及核中蛋白激酶C活性和底物的变化。视黄酸诱导分化后,胞浆中蛋白激酶C活性升高,而核中则降低;胞浆中蛋白激酶C的底物减少,而核中蛋白激酶C底物的种类没有改变,但21kD的蛋白激酶C底物的磷酸化明显减弱。进一步分析表明,21kD蛋白是0.75mol/L高氯酸可溶蛋白。结果提示胞浆和核中蛋白激酶C及其底物的变化,可能与视黄酸对HL-60细胞的诱导分化作用有关。

Our recent studies showed that glucocorticoids play an important role in the processes responsible for proliferation and differentiation of a human megakaryoblastic leukemia cell line (HIMeg) and that the effects of glucocorticoids are mediated by glucocorticoid receptor(GR) in these cells.The regulation of GR expression in HIMeg cells by retinoic acid was further studied utilizing radioligand binding assay and molecular hybridization analysis.It was shown that retinoic acid could significantly increase the...

Our recent studies showed that glucocorticoids play an important role in the processes responsible for proliferation and differentiation of a human megakaryoblastic leukemia cell line (HIMeg) and that the effects of glucocorticoids are mediated by glucocorticoid receptor(GR) in these cells.The regulation of GR expression in HIMeg cells by retinoic acid was further studied utilizing radioligand binding assay and molecular hybridization analysis.It was shown that retinoic acid could significantly increase the GR binding activities in a time-dependent manner,reaching a maximum of about 2-fold 24h following treatment.Dot blot hybridization analysis utilizing 32P-labeled GR cDNA fragment as a probe showed that GR mRNA was also up-regulated by retinoic acid,suggesting that the regulating effects of retinoic acid on GR occurred at least partially at GR mRNA levels. To explore further the possible consequence of retinoic acid-induced regulation of GR exp ression in HIMeg cells,the combined effects of glucocorticoids and retinoic acid on HIMeg cell proliferation were evaluated.It was found that the inhibitory effects of combinations of glucocorticoids and retinoic acid on HIMeg cell proliferation showed an additive property,suggesting that the regulation of GR expression by retinoic acid was of biological significance.

糖皮质激素对人原始巨核白血病细胞系(HIMeg)的增殖分化过程有调节作用,且由糖皮质激素受体(GR)介导。用放射配体结合分析法及分子杂交进一步研究了视黄酸对HIMeg细胞GR的表达调节作用。结果表明,视黄酸可使GR结合活性明显提高,且具有时间依赖性,24h后约提高2倍:以[32P]标记的GRcDNA片段为探针,用dotblot杂交分析表明,视黄酸亦可使GRmRNA水平升高,表明视黄酸对GR结合活性的影响至少部分地发生于mRNA水平。为进一步阐明视黄酸对GR调节的可能意义,还观察了糖皮质激素与视黄酸联合应用对HIMeg细胞增殖过程的影响,发现二者具有相加作用,提示视黄酸对GR的调节作用具有生物学意义。

Retinoic acid is a chemical teratogen which causes varieties of congenital cardiac malformations, such as overriding aorta, ventricular septal defect. In this study the changes of laminin (LN) and fibronectin (FN) in the development of cogenital heart malformations induced by excessive retinoic acid were observed by the immunohistochemical method. The results were as follows: 1. When endocardial cells transformed into endocardiac cushion cells, they lost laminin and fibronectin in their basal surfaces;...

Retinoic acid is a chemical teratogen which causes varieties of congenital cardiac malformations, such as overriding aorta, ventricular septal defect. In this study the changes of laminin (LN) and fibronectin (FN) in the development of cogenital heart malformations induced by excessive retinoic acid were observed by the immunohistochemical method. The results were as follows: 1. When endocardial cells transformed into endocardiac cushion cells, they lost laminin and fibronectin in their basal surfaces; The staining for LN and FN became positively strong in the endocardiac jelly and myocardium. 2. The quantity of LN and FN within endocardiac jelly decreased after th formation and fusion of endocardiac cushion. 3. At 18 hours after the treatment the staining intensity for LN and FN in the endocardium, endocardiac jelly (EJ) and myocardium was weaker in the experimental group than in the control group, suggesting that LN and FN may be the medium to which the endocardiac cushion cells adhered and migrated. Excessive retinoic acid could reduce the quantity of laminin and fibronectin whithin endocardiac jelly during embryonic development, and thereby disturbed the normal adhesion and the migration of endocardiac cushion cells. It might be an important route by which excessive retinoic acid induced congenital cardiac malformation.

维生素A酸是常见的一类化学致畸因子,可引起各种心脏畸形,如主动脉骑跨、室间隔缺损等.实验采用免疫组织化学方法观察层粘连蛋白和纤维粘连蛋白在心脏正常和异常发育过程中的分布和变化规律,以探讨过量维生素A酸致心脏畸形发生的机理.结果显示:心内膜垫形成之前,心内膜细胞基底面呈层粘连蛋白和纤维粘连蛋白阳性;当内膜细胞转化为内膜垫细胞时,其基底面的层粘连蛋白和纤维粘连蛋白消失,心胶质和心肌膜中层粘连蛋白、纤维粘连蛋白免疫组化染色明显增强;心内膜垫形成并融合后,其染色又明显减弱.给孕鼠灌服过量的维生素A酸18小时后,各时间组胚胎心脏的心内膜、心胶质、心肌膜的层粘连蛋白和纤维粘连蛋白均出现了不同程度的减弱.这说明层粘连蛋白和纤维粘连蛋白是内膜垫细胞粘着和迁移的主要介导物质,维生素A酸抑制其两者的合成是引起心脏畸形的一个重要途径.

 
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