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irbesartan treatment
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  伊贝沙坦
     Methods 85 patients with AMI were selected into the study. 42 patients were randomized to conventional treatment group,43 patients to irbesartan treatment group.
     方法将85例AMI随机分为常规治疗组(对照组)42例、伊贝沙坦治疗组(治疗组)43例。
短句来源
     HbA_(1c), urinary albumin excretion rate and urinary β_(2)-microglobulin excretion, serum nitric oxide and plasma endothelin-1 levels in irbesartan treatment group were significantly decreased after 12 weeks treatment.
     治疗12周,伊贝沙坦组HbA1c、尿白蛋白排泄率、尿β2微球蛋白、血清一氧化氮和血浆内皮素1水平均有明显下降,提示伊贝沙坦可延缓糖尿病患者肾功能损害。
短句来源
     Objective 1. To explore the relationship between serum electrolyte and the antihypertensive efficacy response to Irbesartan treatment in essential hypertension patients.
     目的 1.探讨原发性高血压患者血清电解质与伊贝沙坦降压疗效的关系;
短句来源
     Irbesartan treatment markedly increases ACE2 mRNA expression in SHR kidney and may take part in down-regulating the activated renin-angiotensin system in a new way.
     AngⅡ-1型受体阻滞剂伊贝沙坦上调SHR肾组织ACE2 mRNA表达,提示这可能是该药物反向调节过度激活的肾素-血管紧张素系统又一新途径。
短句来源
     Clinical-Epidemiology Study on the Relationship Among Serium Electrolyte and Antihypertensive Efficacy Response to Irbesartan Treatment and Baseline Blood Pressure
     血清电解质与伊贝沙坦降压疗效和基线血压关系的临床流行病学研究
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  “irbesartan treatment”译为未确定词的双语例句
     ③The thickening rate of glomerular base membrane of the Irbesartan treatment group was lower than the model group (38%, 81%, P < 0.01).
     ③肾小球基底膜增厚率厄贝沙坦组低于模型组(38%,81%,P<0.01)。
短句来源
     Mice were randomly divided into three groups, sham operation (C, N=20), UUO (N=40) and UUO with irbesartan treatment (UUO+Irb, N=40).
     方法:将清洁级、健康雄性CD-1小鼠(10周龄、18-22克)随机分为三大组,假手术组(C,N=20)、单侧输尿管结扎组(UUO,N=40)和Irbesartan干预组(UUO+Irb,N=40)。
短句来源
     ④ At 4 and 8 weeks after modeling, the urinary protein excretion, serum creatinine and triglyceride concentrations of the Irbesartan treatment group and model group were all higher than the control group (P < 0.01), but the Irbesartan treatment group was lower than the model group (P < 0.01).
     ④造模后4,8周模型组和厄贝沙坦尿蛋白排泄率和血肌酐、三酰甘油浓度均高于正常对照组(P<0.01),但厄贝沙坦组低于模型组(P<0.01)。
短句来源
     ②Since the second day after modeling, the Irbesartan treatment group were treated by Irbesartan (50 mg/kg daily), and the other groups were given matching normal saline.
     ②模型建立后第2天起,厄贝沙坦组给予厄贝沙坦50mg/(kg·d)灌胃,其他两组给予等量生理盐水灌胃。
短句来源
     METHODS: The experiment was conducted in the Department of Pathology and central laboratory of Qingdao University Medical School from December 2003 to February 2005. ①Thirty healthy Wistar rats were randomly divided into control group, model group and Irbesartan treatment group with 12 rats in each group.
     方法:实验于2003-12/2005-02在青岛大学医学院病理学教研室及中心实验室进行。 ①将正常Wistar大鼠36只随机分为正常对照组、模型组和厄贝沙坦组,每组12只。
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  相似匹配句对
     L. P. treatment.
     L. P.
短句来源
     Clinical Study of Irbesartan in the Treatment of Hypertension
     国产伊贝沙坦治疗高血压病的临床研究
短句来源
     Efficacy and the Safety of Irbesartan in Treatment of Hypertension
     伊贝沙坦治疗轻中度高血压疗效和安全性的临床研究
短句来源
     the treatment and prevention;
     卒中的治疗和预防知识;
短句来源
     Synthesis of Irbesartan
     厄贝沙坦的合成
短句来源
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  irbesartan treatment
Health economic implications of irbesartan treatment versus standard blood pressure control in patients with type 2 diabetes, hy
      
Irbesartan treatment prevented the development of albuminuria and completely abrogated the down regulation of nephrin in diabetic rats.
      
Kidney function during and after withdrawal of long-term irbesartan treatment in patients with type 2 diabetes and microalbuminuria.
      
Irbesartan treatment also produced a relative-risk reduction of 23% compared to patients treated with amlodipine.
      


Aim To evaluate the effect of angiotensin Ⅱ type 1 receptor antagonist Irbesartan on the expression of vascular cell adhesion molecule-1 (VCAM-1)in a rabbit model of high cholesterol diet induced atherosclerosis. Methods Twenty-five rabbits were divided into three groups: control group, high cholesterol group, Irbesartan group [50 mg/(kg·d)]. The later two groups received 1% cholesterol diet for 12 weeks to establish the early atherosclerosis model. Blood samples were collected for cholesterol...

Aim To evaluate the effect of angiotensin Ⅱ type 1 receptor antagonist Irbesartan on the expression of vascular cell adhesion molecule-1 (VCAM-1)in a rabbit model of high cholesterol diet induced atherosclerosis. Methods Twenty-five rabbits were divided into three groups: control group, high cholesterol group, Irbesartan group [50 mg/(kg·d)]. The later two groups received 1% cholesterol diet for 12 weeks to establish the early atherosclerosis model. Blood samples were collected for cholesterol assessment and angiotensin Ⅱ concentrations. The levels of expression of VCAM-1 mRNA were evaluated by RT-PCR and Northern Blot. Results There is no difference between the two high-cholesterol groups, although the cholesterol level of these groups are much higher than control group. Rabbits received Irbesartan showed reduced intimal thickness and the ratio of aortic intimal thickness to medial thickness compared with high cholesterol group (P<0.05). Irbesartan administration for 12 weeks caused a down-regulation in arterial expression of VCAM-1 normalized to GAPDH (P<0.05). Conclusion Chronic Irbesartan treatment ameliorated the severity of the early atherosclerosis lesions, possibly because of the suppression of VCAM-1 mRNA expression.

利用高脂饮食诱发兔动脉粥样硬化模型 ,观察血管紧张素Ⅱ 1型受体拮抗剂Irbesartan对早期动脉粥样硬化的影响。将纯种雄性日本大耳白兔 2 5只随机分为三组 :对照组 8只 ,高胆固醇组 8只和Irbesartan组 9只。给予 1%胆固醇饮食建立动脉粥样硬化模型并检测如下指标 :①测定血脂、血浆脂蛋白及血管紧张素Ⅱ水平 ;②测量动脉内膜最大厚度及内膜 中膜厚度比 ;③RT PCR、NorthernBlot检测组织中血管细胞粘附分子 1表达水平。结果发现 ,与对照组相比 ,Irbesartan组和高胆固醇组总胆固醇和甘油三酯水平明显升高 ;Irbesartan组主动脉内膜最大厚度及内膜 中膜厚度比较高胆固醇组明显降低 (P <0 .0 5 ) ;Irbesartan明显降低主动脉组织中血管细胞粘附分子 1在转录水平的表达 (P <0 .0 5 )。结果提示 ,血管紧张素Ⅱ 1型受体拮抗剂Irbesartan通过抑制血管细胞粘附分子 1的表达而延缓早期动脉粥样硬化病变进展。

Objective:To investigate the effect of irbesartan on circadian rhythm(CR)of blood pressure and left ventricular hypertrophy(LVH)*"in gerontal hypertensive patients and to observe the relation between CR and LVH. Methods:Essential hypertensive patients,aged 60 years or older(n=93),underwent ambulatory blood pressure monitoring(ABPM)and ultrasonic cardiography(UCG).The CR changes of blood pressure and the left ventricular construction including the thickness of interventricular septum and posterior...

Objective:To investigate the effect of irbesartan on circadian rhythm(CR)of blood pressure and left ventricular hypertrophy(LVH)*"in gerontal hypertensive patients and to observe the relation between CR and LVH. Methods:Essential hypertensive patients,aged 60 years or older(n=93),underwent ambulatory blood pressure monitoring(ABPM)and ultrasonic cardiography(UCG).The CR changes of blood pressure and the left ventricular construction including the thickness of interventricular septum and posterior wall were assessed.The patients with missed CR(n=54)were randomly given irbesartan(n=30)75 to 150 mg or indapamide(n=24)*"2 5 mg to 5 mg once a day.After 12 weeks of treatment the patients underwent ABPM and UCG again.CR and the parameters of the left ventricle after treatment were compared with those before treatment. Results:CR was missing in about 79 2%(42/53)of the patients with LVH.However,almost 70 per cent of patients presented with CR in those without LVH.Twenty two patients(73 3%)in irbesartan group(p<0 01)and 9(9/24) in indapamide group recovered CR after 12 weeks of treatment.The patients with LVH in irbesartan group had no significant change in the measurement of left ventricle compared with those before treatment (p<0.05)and the controls(p<0.01). Conclusion:The missed CR of blood pressure may be associated with the occurrence of LVH in gerontal hypertensive patients.Irbesartan treatment can effectively recover CR and delay or even depress the development of LVH.

目的 :探讨伊贝沙坦对老年原发性高血压患者的血压昼夜节律及左心室肥厚 (LVH)的影响。  方法 :选择 93例年龄≥ 60岁的老年原发性高血压患者 ,通过 2 4小时动态血压监测了解其血压昼夜节律变化 ,通过超声心动图观察左心室内径、室间隔和左心室后壁厚度 ,并测算左心室重量指数。选择血压昼夜节律消失的 5 4例患者随机分为伊贝沙坦治疗组 (伊贝沙坦组 ) 3 0例 ,吲达帕胺对照组 (吲达帕胺组 ) 2 4例。治疗 12周后两组患者再次接受动态血压监测和超声心动图检查 ,对比治疗前后血压昼夜节律及左心室参数的变化。  结果 :93例老年原发性高血压患者中合并左心室肥厚者 5 3例 ,其中血压昼夜节律消失者为 42例 (79 2 % ) ;40例无LVH患者中昼夜节律消失者为 12例 (3 0 0 % ) ,合并LVH者中血压昼夜节律消失者显著多于无LVH者 (P <0 0 0 5 ) ,有极显著性差异 ;5 4例血压昼夜节律消失者治疗 12周后昼夜节律恢复者伊贝沙坦组 2 2例 (2 2 /3 0 ) ,吲达帕胺组 9例 (9/2 4) ,两组比较有极显著性差异 (P <0 0 1) ;伊贝沙坦组高...

目的 :探讨伊贝沙坦对老年原发性高血压患者的血压昼夜节律及左心室肥厚 (LVH)的影响。  方法 :选择 93例年龄≥ 60岁的老年原发性高血压患者 ,通过 2 4小时动态血压监测了解其血压昼夜节律变化 ,通过超声心动图观察左心室内径、室间隔和左心室后壁厚度 ,并测算左心室重量指数。选择血压昼夜节律消失的 5 4例患者随机分为伊贝沙坦治疗组 (伊贝沙坦组 ) 3 0例 ,吲达帕胺对照组 (吲达帕胺组 ) 2 4例。治疗 12周后两组患者再次接受动态血压监测和超声心动图检查 ,对比治疗前后血压昼夜节律及左心室参数的变化。  结果 :93例老年原发性高血压患者中合并左心室肥厚者 5 3例 ,其中血压昼夜节律消失者为 42例 (79 2 % ) ;40例无LVH患者中昼夜节律消失者为 12例 (3 0 0 % ) ,合并LVH者中血压昼夜节律消失者显著多于无LVH者 (P <0 0 0 5 ) ,有极显著性差异 ;5 4例血压昼夜节律消失者治疗 12周后昼夜节律恢复者伊贝沙坦组 2 2例 (2 2 /3 0 ) ,吲达帕胺组 9例 (9/2 4) ,两组比较有极显著性差异 (P <0 0 1) ;伊贝沙坦组高血压合并LVH者治疗后室间隔、左心室后壁厚度无显著性改变 ,但左心室重量指数与治疗前及吲达帕胺组比较均有下降 (P均 <0 0 5 ) ,均有显著性差异。  结论 :在血压昼夜节律消失的老年原发

Objective: To investigate the efficacy of irbesartan in the treatment of essential hypertension. Methods: 96 patients with essential hypertension were randomized to two group, 56 cases to irbesartan treatment group ( irbesartan 150- 300md/d) and 40 cases to amlodipine treatment group (amlodipine 5 -10mg/d) . At 4th week and 8th week after therapy, the blood pressure were measured by dynamic blood pressure monitor. Results: At 8th week, The total efficacy rate in irbesartan group was 71,6%...

Objective: To investigate the efficacy of irbesartan in the treatment of essential hypertension. Methods: 96 patients with essential hypertension were randomized to two group, 56 cases to irbesartan treatment group ( irbesartan 150- 300md/d) and 40 cases to amlodipine treatment group (amlodipine 5 -10mg/d) . At 4th week and 8th week after therapy, the blood pressure were measured by dynamic blood pressure monitor. Results: At 8th week, The total efficacy rate in irbesartan group was 71,6% and in amlodipine geoup was 68.2% , respectively (P > 0.05). Conclusion: Irbesartan is effective in patients with mild to moderate essential hypertension.

目的:探讨厄贝沙坦治疗轻、中度原发性高血压的疗效。方法:96例轻、中度原发性高血压患者随机分为两组;厄贝沙坦组(56例)150~300mg/d口服,氨氯地平组(40例)5~10mg/d口服,疗程均为8周,治疗前、治疗后4周和8周行动态血压监测。结果:在疗程第4周和第8周厄贝沙坦和氨氯地平均有较好的降压效果,两组间血压下降差别无统计学意义,第8周厄贝沙坦组总有效率为71.6%,氨氯地平组为68.2%,两组用药耐受性良好,氨氯地平组与用药相关的水肿发生率略高。结论:厄贝沙坦对高血压有确切疗效,且耐受性良好,无特征性毒副作用。

 
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