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gentamicin gm
相关语句
  相似匹配句对
     salicylate gentamicin(SAGM);
     水杨酸庆大霉素(SAGM)组;
短句来源
     P. aeruginosa was sensitive to Gentamicin;
     绿脓杆菌对庆大霉素高度敏感;
短句来源
     SPECTROPHOTOMETRIC DETERMINATION OF GENTAMICIN
     庆大霉素的紫外分光光度测定法
短句来源
     ④gentamicin (GM) alone.
     ④庆大霉素组 (GM)。
短句来源
     Gentamicin and Anisodamine (p<0.01).
     两组相比,腹泻灵组对各项观察指标的改善情况均明显优于西药组(p<0.01)。
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  gentamicin gm
This study was designed to investigate the renoprotective potential of Erdosteine against gentamicin (GM)-induced renal dysfunction by using Technetium-99 m dimercaptosuccinic acid (Tc-99 m DMSA) uptake and scintigraphy in rats.
      
Gentamicin (GM) is an antibiotic whose clinical use is limited by its nephrotoxicity.
      
However, some Staphylococcus haemolyticus strains showed high MIC values for cefazolin (CEZ), arbekacin (ABK), gentamicin (GM), ofloxacin (OFLX), or imipenem (IPM).
      
To induce nephrotoxicity in a short time, gentamicin (GM) was also coadministered.
      
The effects of kanamycin (KM) and gentamicin (GM) on the in-vitro electroretinogram of the albino rabbit were studied.
      
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Micronomicin (MCR) is one of new aminoglycoside antibi-otics. A controlled clinical trial of MCR was carried out in comparisonwith gentamicin (GM), 117 patients with various acute bacterial infectiousdiseases were allocated sequentially at random into two groups. 78 ca-ses were treated by MCR in group A and 39 cases by GM in group B ascontrol. Among them 53 in group A and 27 in group B were patientswith Gram negative infection. An equal dose of MCR or GM, 120mgbid was given intramuscularly...

Micronomicin (MCR) is one of new aminoglycoside antibi-otics. A controlled clinical trial of MCR was carried out in comparisonwith gentamicin (GM), 117 patients with various acute bacterial infectiousdiseases were allocated sequentially at random into two groups. 78 ca-ses were treated by MCR in group A and 39 cases by GM in group B ascontrol. Among them 53 in group A and 27 in group B were patientswith Gram negative infection. An equal dose of MCR or GM, 120mgbid was given intramuscularly in adults and 3 to 4mg/kg daily in chil-dren for 4 to 10 days generally. We found that the marked effectiverate was 74.4% in group A and 53.8% in group B. The result showed that the therapeutic effectiveness of MCR was better, especially for Gramnegative bacterial infections. Antibiotic susceptibility tests were donein bacteria isolated from clinical specimens, which showed that mostof the Gram negative bacteria were more susceptible to MCR (Suscep-tibility Rate 79.2%) than to GM (Susceptibility Rate 55.6%) (P<0.01).No impairment of auditory, cardiac, kidney and liver function and dis-turbance in blood electrolytes were observed.

小诺霉素(小单孢菌素Micronomicin,MCR)是一种新的氨基糖甙类抗生素,作者将它与庆大霉素(Gentamicin GM)比较。进行临床对照试验。117例各种急性细菌感染性疾病随机分为两组,A组78例用MCR治疗;B组39例用GM治疗作为对照。A、B两组分别包括53例及27例革兰氏阴性菌感染患者。MCR与GM剂量成人均为120mg肌注,一日二次,儿童日剂量为3—4mg/kg,疗程4—10天。结果MCR的显效率为74.4%,GM为53.8%,显示MCR的疗效较好,特别是对革兰氏阴性菌感染的疗效更明显。临床分离各种细菌的药物敏感试验证明大多数(79.2%)革兰氏阴性菌对MCR的敏感性在中度以上,显著地高于GM(55.6%)。本研究未发现MCR对听力、心、肝、肾功能及血液电解质的影响。

This study was done to identify the ototoxic liability of gentamicin (GM) to the inner ear and kidney of 99 guinea pigs by electro-physiological and histo pathological methods.Additionally,the pharmacokinetics of GM in the plasma and perilymph were determined.It revealed that the large dosage (80mg/kg/day),admin- istered continually (13-26 days),produced obviously lesions within the inner ear and kidney,and with more than moderate hearing threshold shift.Some correlations existed in the damage...

This study was done to identify the ototoxic liability of gentamicin (GM) to the inner ear and kidney of 99 guinea pigs by electro-physiological and histo pathological methods.Additionally,the pharmacokinetics of GM in the plasma and perilymph were determined.It revealed that the large dosage (80mg/kg/day),admin- istered continually (13-26 days),produced obviously lesions within the inner ear and kidney,and with more than moderate hearing threshold shift.Some correlations existed in the damage between the inner ear and kidney of same individual,but were not parallel absolutely.By the GM pharmacokinetic analysis,it suggested that the accumulation of drugs in perilymph be a key point of GM ototoxicity by the distur- bance of the blood-labyrinth barrier. We suggested that the valley level of drug concentration of GM in plasma could be a monitoring criterion as important as the peak level and might be a more effective one.

采用电生理学及组织病理学方法对99只豚鼠进行实验研究,以证实庆大霉素对内耳及肾的中毒易损性。同时测定了庆大霉素在血清及外淋巴中的药物代谢动力学诸参数。当大剂量(80mg/kg/day)连续给药(13-26天)时,内耳及肾产生明显病损,并中等度以上听力阈移。同一机体中内耳与肾的损害存在一定的相关性,但非绝对平行。由药代动力学分析,内耳外淋巴中药物蓄积是庆大霉素耳中毒的重要环节,在于破坏了血-迷路屏障。作者建议庆大霉素在血清中的药物谷值浓度和峰值一样,同为临床监测指标,且可能是更为有效的一个监测拒标。

Comparative clinical trial of homemade Sagamicin(Micronomycin, MCN) was carried out with Gentamicin(GM).

小诺霉素(MCR,曾译相模湾霉素,Sagamicin,)是一种新的氨基糖苷类抗生素,我们将它与庆大霉素(GM)比较,进行临床对照试验。242例各种细菌感染性疾病被随机顺序分配在两组中,A组162例用MCR治疗;B组80例用GM治疗作为对照。在这些病例中A组和B组各含有革蓝氏阴性菌感染126例和63例。无论是MCR,还是GM,剂量皆相同,成人都是肌注120mg,一日2次,而儿童日剂量为3~4mg/kg,疗程4~10天(少数超过10天),结果MCR的显效率为75.3%,而GM为66.3%,显示MCR的疗效较好.特别是对革蓝氏阴性菌感染疗效更好。试管内临床分离的各种细菌对MCR的抑菌试验也证明大多数革蓝氏阴性菌是敏感的(82.9%),显著地高于GM(74.4%)。本研究未发现MCR对听觉、心、肝、肾功能及血液电解质的影响。

 
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