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   invasive capability 的翻译结果: 查询用时:0.196秒
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invasive capability
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  侵袭能力
     Conclusion: TGF-β_1 could promote the invasive capability of SW480 independed on Smad4 signaling pathway. The effects of growth inhibition and pro-invasion of TGF-β_1 might be carried out via different signaling pathways.
     结论:TGF β1 能促进SW480细胞的侵袭能力,这种作用不依赖于Smad 4信号途径,TGF β1 发挥生长抑制和促进侵袭能力的作用可能是通过不同的信号路径实现的。
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     Conclusion Zilongjin has the effect in inhibi- ting proliferation,decreasing colony cell growth and depressing the invasive capability of prostate cancer cells in vitro,which may realized through increase the expressions of ICAM-1 and E-Cadherin.
     结论紫龙金具有抑制前列腺癌细胞增殖、降低集落生长和体外侵袭能力,其作用可能是通过增加ICAM-1和E-Cadherin表达而实现的。
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     Conclusion NCTD not only inhibited the GBC-SD cell growth of human gallblader carcinoma,but also could inhibit its invasive capability under lower concentration.
     结论 NCTD 不仅能抑制人胆囊癌 GBC-SD 细胞生长,亦可在低浓度下抑制其体外侵袭能力;
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     Conclusion TGF-pl have no effect on proliferation of SW480 and LS174T,but TGF-pi can promoted the invasive capability of SW480 and this effect was independent with Smad4 signaling pathway. The effects of growth inhibition and pro-invasion of TGF-pi might be carried out via different signaling pathway.
     结论 TGF-β1不能抑制人结肠癌SW480和LS174T细胞的增殖,却能显著促进SW480细胞的运动和侵袭能力,这种作用不依赖于Smad4信号途径并且与细胞增殖无关,TGF-β1发挥生长抑制和促进侵袭能力的作用可能是通过不同的信号路径实现的。
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     Inhibitory Effect of Silencing Heparanase Expression with Antisense Oligodeoxynucleotide on Invasive Capability of Human Esophageal Squamous Cancer Cell Line TE-13
     反义寡核苷酸沉默乙酰肝素酶对食管鳞癌细胞株TE-13侵袭能力的影响
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  “invasive capability”译为未确定词的双语例句
     The expression level of RhoC,but not R hoA and ROCK-1,was significantly correlated with the invasive capability of th e se cells in vitro ( r =0.95, P <0.01).
     结果 RhoA、RhoC和ROCK 1在 4种卵巢癌细胞中呈不同程度表达 ,其中仅RhoC的表达水平与癌细胞侵袭力和迁移能力呈正相关 (r=0 .95 ,P <0 .0 1)。
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     In the meantime the invasive capability changes were observed after cell suspensions were preincubated with anti-α 5, anti-α 3 and anti-β 1 integrin antibodies, respectively.
     分别给予细胞抗α3 整合素、抗α5整合素、抗 β1整合素单抗预处理后 ,观察侵袭性的变化。
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     Their invasive capability was decreased by 46.7%.
     侵袭并穿透人工基膜的细胞数降低 46 .7% ;
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     CONCLUSION: Norcantharidin can inhibit the invasive capability of GBC-SD cells in human gallbladder carcinomas. The mechanism may correlate with inhibition of GBC-SD cell movement and influence of the expression of MMP_2 and TIMP_2 of GBC-SD cells.
     结论 :NCTD在低浓度下即可抑制人胆囊癌细胞的体外侵袭、运动能力 ,其机制可能与抑制GBC SD细胞迁移运动和干扰GBC SD细胞MMP2 ,TIMP2 表达有关。
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     AIM: To study the expression of thrombospondin-1 (TSP-1) and receptor-CD36, and investigate the relationship between tumor invasive capability and microvessel density and thrombospondin-1. METHODS: 43 hepatocellular carcinoma (HCC) cases were under investigation.
     目的:研究肝细胞性肝癌(HCC)中血小板反应蛋白-1及受体CD36的表达及其与侵袭转移和血管生成的关系。
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  相似匹配句对
     Their invasive capability was decreased by 46.7%.
     侵袭并穿透人工基膜的细胞数降低 46 .7% ;
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     On the Capability in Innovation
     论创新能力
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     NAT has the capability.
     本文重点研究利用NAT和IPsec技术进行防火墙设计。
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     Invasive manipulation.
     接受侵入性操作。
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     UPA has turned out to be essential for the invasive and metastatic capability of tumor cells.
     为uPA、VEGF用于MOGCT的监测治疗及评估预后提供理论依据和实验基础。
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  invasive capability
Cell invasive capability was evaluated by Transwell method.
      
At first glance, loss of ADAM-10 expression would be expected to result in decreased invasive capability, due to loss of matrix metalloprotease activity.
      
An ovarian cancer cell line (CABA?I) established from ascitic fluid cells of this patient, grew in Matrigel and formed tubular structures suggesting invasive capability.
      
Examination of 10 tissue blocks represents the minimum effort to estimate the invasive capability of a follicular tumor, whereas sequential sections through less than 10 blocks are of little help in most cases.
      
As this species has a substantial invasive capability and is a potential vector of the crayfish plague pathogen, it represents a threat to the native crayfish species and its spread should be monitored.
      
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Abstract Using limiting dilution assay,variants were cloned from the CNE-2Z cell line.The variants CNE2L2,CNE2H2,CNE2L4 and CNE2M2,with cell electrophoresis rates which differed greatly,were assayed for their invasive capahilities by observing their ability to invade preculture embryonic chicken heart fragment(PHF)in organ culture using a gyrotory shaker system.The results indicated that CNE2L2 variant cells invaded 9-day-old chicken embryonic heart fragments at a rate significantly higher than those seen...

Abstract Using limiting dilution assay,variants were cloned from the CNE-2Z cell line.The variants CNE2L2,CNE2H2,CNE2L4 and CNE2M2,with cell electrophoresis rates which differed greatly,were assayed for their invasive capahilities by observing their ability to invade preculture embryonic chicken heart fragment(PHF)in organ culture using a gyrotory shaker system.The results indicated that CNE2L2 variant cells invaded 9-day-old chicken embryonic heart fragments at a rate significantly higher than those seen using CNE2L4 and CNE2M2 in 7-day assay. Computer image analysis showed that the CNE2L2 cells occupied 80.2%of the PHF area much greater than that occupied by CNE2L4(46.5%)or CNE2M2(36.5%).This experiment also showed that the electrophoresis rate of the CNE2Z variants was positively related to their invasive capabilities in vitro.

应用体外器官培养研究人鼻咽癌不同克隆细胞株的侵袭特性郁多男,高进(中国医学科学院中国协和医科大学北京基础医学研究所,北京100005)研究肿瘤细胞体外侵袭能力的方法很多,如利用单层内皮细胞[1]、人类羊膜[2,3]、小鼠膀胱[4]、眼晶状体囊[5]以...

Objective To study the mechanism of enhanced invasiveness of human hepatocellular carcinoma (HCC) by laminin (LN) receptor integrin α6β1.Methods A stable transfectant of HCC Bel 7402 cell line, the α6β1 receptors of which were replaced by non functional LN receptor α6β4 TR using dominant negative strategy, was used. Motility of the non transfected, mock transfected and transfected tumor cells was assessed by the number of cells migrated to an area scratched out of cells on tumor cell monolayer. Tumor cell...

Objective To study the mechanism of enhanced invasiveness of human hepatocellular carcinoma (HCC) by laminin (LN) receptor integrin α6β1.Methods A stable transfectant of HCC Bel 7402 cell line, the α6β1 receptors of which were replaced by non functional LN receptor α6β4 TR using dominant negative strategy, was used. Motility of the non transfected, mock transfected and transfected tumor cells was assessed by the number of cells migrated to an area scratched out of cells on tumor cell monolayer. Tumor cell invasion was examined by cell penetration through a Matrigel layer in Boyden chamber. Matrix metalloproteinases (MMPs) secretion was detected by gelatin zymography.Results The migration of HCC Bel 7402 cells expressing dominant negative α6β1 was significantly decreased. Their invasive capability was decreased by 46.7%. The secretion of MMP 9 was almost totally inhibited and the activated MMP 2 was decreased by 43.9%.Conclusion The decrease in cell motility, invasiveness and MMPs secretion of HCC cells expressing dominant negative α6β4 TR implies that LN integrin interaction plays important role in HCC progression.

目的 研究层粘连蛋白受体α6 β1整合素在人肝癌细胞侵袭行为中的作用。 方法 采用dominantnegative策略 ,以无功能的α6 β4 TR代替细胞表面α6 β1受体 ,从而消除了人肝癌细胞Bel740 2α6 β1受体的功能。用划痕法和Boyden小室法分别检测细胞的迁移和侵袭 ,明胶酶谱分析法检测细胞基质金属蛋白酶 (matrixmetalloproteinases,MMPs)的分泌。结果 消除α6 β1功能的人肝癌细胞迁移能力明显降低 ;侵袭并穿透人工基膜的细胞数降低 46 .7% ;MMP 9的分泌几乎被完全抑制 ,活化型的MMP 2降低 43.9%。结论 人肝癌细胞在层粘连蛋白基质上的迁移、侵袭及MMPs的分泌和活化主要由α6 β1受体介导。肝癌组织中层粘连蛋白和整合素α6 β1的高表达 ,对肝癌的发展可能起重要作用

Objective To investigate the invasion ability in vitro of two human salivary adenoid cystic carcinoma cell lines with different metastatic potentials.Methods The Acc-2 cell line with low lung metastatic potential and the Acc-M cell line (selected from the Acc-2 cell line) with high lung metastatic potential were used. The adhesive ability to various basement membrance components of the two cell lines was measured by MTT assay, the cell locomotive ability by wound assay, the type Ⅳ collagenase was assessed...

Objective To investigate the invasion ability in vitro of two human salivary adenoid cystic carcinoma cell lines with different metastatic potentials.Methods The Acc-2 cell line with low lung metastatic potential and the Acc-M cell line (selected from the Acc-2 cell line) with high lung metastatic potential were used. The adhesive ability to various basement membrance components of the two cell lines was measured by MTT assay, the cell locomotive ability by wound assay, the type Ⅳ collagenase was assessed by PAGE substrate zymography, and the invasion ability by modified Boyden chamber.Results ①The adhesive rates of Acc-2 cell line after 1 h were FN 61.8%、LN 42.9%、MG 60 4 %,and that of Acc-M cell line were FN 79.4%、LN 71.1%、MG 69.8% respectively.②In the wound assay, after 12 hr the locomotive rates of Acc-2 and Acc-M were 1.15 μm/h and 2.26 μm/h.③The type Ⅳ collagenase activity was detected in serum-free supernatant of Acc-M cell line, whereas the Acc-2 cell line was lack of type Ⅳ collagenase activity.④Eight hours after the invasion of the basement membrance matrix, the number of invading cells in high power field of Acc-2 and Acc-M were 68.0±4.35 and 103.2±5.63. Conclusion The results showed that the invasion of Acc-2 and Acc-M was progressive in nature and the heterogeneous adhesive ability,motility,type Ⅳ collagenase activity and invasive capability of these two variants were significantly different and correlative with their metastatic potential.

目的 研究转移潜能不同的两个腺样囊性癌细胞系体外侵袭能力的差异。方法 选用肺低转移细胞系 Acc- 2和从中筛选出的肺高转移细胞系 Acc- M,利用 MTT法检测与几种基底膜成分的粘附能力 ;划痕法检测运动能力 ;PAGE底物酶谱法检测分泌 型胶原酶的能力 ;改良勃顿小室法观察对重组基底膜的侵袭能力。结果  11小时后Acc- 2细胞系对 3种细胞外基质的粘附率分别是纤维粘连蛋白 (FN) 6 1.8%、层粘连蛋白 (L N) 4 2 .9%和基底膜胶(Matrigel) 6 0 .4% ,Acc- M细胞系的粘附率分别是 FN79.4%、L N71.1%、Matrigel6 9.8%。 2 12小时终止实验时 ,测定 Acc- 2细胞系和 Acc- M细胞系的运动速度分别是1.15μm/h和 2 .2 6μm/h。 3Acc- M细胞系的培养上清中可以检测到 型胶原酶活性 ,而 Acc- 2细胞系的培养上清中检测不到 型胶原酶活性。 48小时终止实验时 Acc- 2细胞系和 Acc- M细胞系对重组基底膜的侵袭率分别是 6 8.0± 4.35和 10 3.2± 5 .6 3。结论 两个腺样囊性癌细胞...

目的 研究转移潜能不同的两个腺样囊性癌细胞系体外侵袭能力的差异。方法 选用肺低转移细胞系 Acc- 2和从中筛选出的肺高转移细胞系 Acc- M,利用 MTT法检测与几种基底膜成分的粘附能力 ;划痕法检测运动能力 ;PAGE底物酶谱法检测分泌 型胶原酶的能力 ;改良勃顿小室法观察对重组基底膜的侵袭能力。结果  11小时后Acc- 2细胞系对 3种细胞外基质的粘附率分别是纤维粘连蛋白 (FN) 6 1.8%、层粘连蛋白 (L N) 4 2 .9%和基底膜胶(Matrigel) 6 0 .4% ,Acc- M细胞系的粘附率分别是 FN79.4%、L N71.1%、Matrigel6 9.8%。 2 12小时终止实验时 ,测定 Acc- 2细胞系和 Acc- M细胞系的运动速度分别是1.15μm/h和 2 .2 6μm/h。 3Acc- M细胞系的培养上清中可以检测到 型胶原酶活性 ,而 Acc- 2细胞系的培养上清中检测不到 型胶原酶活性。 48小时终止实验时 Acc- 2细胞系和 Acc- M细胞系对重组基底膜的侵袭率分别是 6 8.0± 4.35和 10 3.2± 5 .6 3。结论 两个腺样囊性癌细胞系的异质型粘附能力、运动能力、分泌 型胶原酶的能力及侵袭重组基底膜能力明显不同 ,并与其转移潜能的强弱相一致

 
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