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   autologous bone marrow mononuclear cells transplantation 的翻译结果: 查询用时:0.315秒
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autologous
bone
marrow
mononuclear
cells
transplantation
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    Conclusion Autologous bone marrow mononuclear cells transplantation is safe and feasible.
    结论自体骨髓单个核细胞移植是安全有效的。
短句来源
    Autologous Bone Marrow Stromal Cells for Neovascularization
    自体骨髓基质细胞移植后成血管作用的实验研究
    Cryopreservated Human Bone Marrow Cells
    人骨髓细胞低温冷冻保存
短句来源
    BONE MARROW STROMA CELLS AND OSTEOGENESIS
    骨髓基质细胞与成骨
短句来源
    Multipotent differentiation of bone marrow cells
    骨髓细胞多向分化潜能的初步研究
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Objective: To evaluate the feasibility and efficacy of via coronary transplantation of bone marrow mononuclear cells in treating ischemic heart failure. Methods: 27 adults suffered from ischemic heart failure were enrolled in this study. Bone marrow mononuclear cells were isolated by Ficoll density gradient centrifugation from the marrow blood obtained from the patients. Results: These cells were injected into coronary artery through a peripheral...

Objective: To evaluate the feasibility and efficacy of via coronary transplantation of bone marrow mononuclear cells in treating ischemic heart failure. Methods: 27 adults suffered from ischemic heart failure were enrolled in this study. Bone marrow mononuclear cells were isolated by Ficoll density gradient centrifugation from the marrow blood obtained from the patients. Results: These cells were injected into coronary artery through a peripheral artery puncture. A 3-month follow-up was performed to evaluate the clinical symptom, NYHA classification, and re-hospitalization because of cardiovascular events after the treatment. Conclusion:Cellular cardiomyoplasty through autologous bone marrow mononuclear cell transplantation is safe and feasible. The results show that the treatment improved the clinical status of the patients and ischemic stress of the local cardiomyocyte.

目的 :为研究自体骨髓单个核细胞经冠脉内移植治疗缺血性心力衰竭的可行性和疗效。方法 :成人缺血性心力衰竭病人 2 7例 ,抽取骨髓后密度梯度离心法分离出骨髓单个核细胞 ,经外周动脉穿刺插管 ,直接将自体骨髓单个核细胞注入冠脉。结果 :术后随访显示病人的活动能力明显改善 ,NYHA提高 >2级 12例 ,>1级 4例 ,EF明显提高 (36 .4± 12 .5 % ,vs 4 6 .3±10 .6 % ,P <0 .0 0 1) ,99Tc心脏ECT检查心肌缺血区可见岛状放射性同位素充盈 ,提示有部分新生心肌存在。因心肌再梗死住院 1例 ,其他 15例均无明显症状并院外存活。结论 :自体骨髓细胞移植心肌细胞成形术 ,对缺血心肌的恢复和改善病人临床心功能有肯定疗效 ,该方法在临床上安全、简单、可行 ,对病人没有明显的负影响。

Objective To investigate the efficacy of the integrated therapy of autologous bone marrow mononuclear cell transplantation and TCM drugs in the treatment of lower limb ischemia. Method 6 Cases of lower limb ischemia were involved in the clinical study. Before the operation, granulocyte colony stimulating factor (G-CSF) was used in the patients for making their bone marrow be in an active proliferation state. And then, the bone marrow fluid was aspirated...

Objective To investigate the efficacy of the integrated therapy of autologous bone marrow mononuclear cell transplantation and TCM drugs in the treatment of lower limb ischemia. Method 6 Cases of lower limb ischemia were involved in the clinical study. Before the operation, granulocyte colony stimulating factor (G-CSF) was used in the patients for making their bone marrow be in an active proliferation state. And then, the bone marrow fluid was aspirated for the separation of mononuclear Cells. The amount of the mononuclear cells in the separated fluid was over 1×10 9. The transplantation of the mononuclear cells was performed by the method of multipoint injection in the ischemic lower limb, and the TCM drugs were given to the patients from the first day after the operation. The efficacy of the integrated therapy was assessed by scoring lower limb pain intensity, poikilothermia, ankle-brachial index (ABI), and the area of the ulcerative surface in the patients before and after the operation. Results The scores of the lower limb pain intensity and poikilothermia markedly decreased in the patients one week after the treatment, then rebounded to some degree two weeks after the treatment, and went down again one month after the treatment. ABI increased gradually after the treatment, and the average value of the increased ABI was 0.23 one month after the treatment. After the treatment, the ulcerative area markedly shrank in the 3 cases with ulcerative surface; and toe amputation was performed in the 2 cases with severe putrescence one month after the treatment, and the incision got healed by first intention. Conclusion The integrated therapy of autologous bone marrow mononuclear cell transplantation and TCM drugs can relieve the clinical symptoms and signs in the patients of lower limb ischemia.

目的 研究自体骨髓单个核细胞移植与中药合用对下肢缺血的治疗作用。方法 治疗对象为 6例严重下肢缺血患者。术前用集落细胞刺激因子使患者骨髓处于增生活跃状态 ,抽取骨髓液后在血管外科专属干细胞工作室分离单个核细胞 ,细胞总量达到 1× 10 9L-1以上。移植采用缺血肢体多点注射。移植后 1d起服中药。观察患者手术前后肢体疼痛、冷感评分、踝肱指数 (ABI)以及溃疡创面情况 ,评价治疗效果。结果 治疗后 1周患者肢体疼痛评分及冷感评分明显下降 ,2周时又有回升 ,术后 1月再下降。ABI在术后逐渐升高 ,术后 1月平均升高 0 2 3。 3例有溃疡的患者创面明显缩小 ,2例有严重坏死者术后 1月行截趾 ,创面 1期愈合。结论 自体骨髓单个核细胞移植合用中药可以改善下肢缺血患者的临床症状及体征。

Objective To assess the efficacy and safety of autologous bone marrow mononuclear cells transplantation by intracoronary infusion in patients with AMI. Methods We studied 32 patients who underwent percutaneous coronary intervention (PCI) after AMI with NYHAⅡ- Ⅲ class. Thirty- two patients (21males and 11females) , who had AMI within previous four weeks, were divided into trial group and control group randomly. Normal saline or autologous bone marrow mononuclear cells (BM-...

Objective To assess the efficacy and safety of autologous bone marrow mononuclear cells transplantation by intracoronary infusion in patients with AMI. Methods We studied 32 patients who underwent percutaneous coronary intervention (PCI) after AMI with NYHAⅡ- Ⅲ class. Thirty- two patients (21males and 11females) , who had AMI within previous four weeks, were divided into trial group and control group randomly. Normal saline or autologous bone marrow mononuclear cells (BM- MNCs) was infused into the infarct related artery (IRA) through the guiding catheter after PCI in control group and trial group respectively. ECG, Holter, SPECT were assessed before PCI , 45d, 90d after that. Results (1) BM- MNCs was cultured and harvested by the method of Ficoll. 1.6×108- 5.8×108 (3.5±1.8×108) BM- MNCs were obtained and more than 92% cells were alive.(2)SPECT scan.Results showed that perfusion defect decreased 34.32% and 23.05% than base- line at 45d in trial and control group respectively (P<0.05).The perfusion defect decreased 14.77% and 3.82% at 90d than 45d in trial and control group respectively (P <0.05). (3)24 h electrocardiographic monitoring demonstrated that there was no difference in the occurrence of ventriarrhythmia or bradycardia before PCI, 45 and 90 d after that (P>0.05).Conclusions BM- MNCs transplantation by intracoronary infusion have some efficacy in patients with AMI and malignant arrhythmias is not increased.

目的研究自体骨髓单个核细胞梗死相关冠脉内移植治疗急性心肌梗死的临床疗效与安全性。方法入选32例NYHA心功能分级Ⅱ~Ⅲ级行择期PCI术的AMI患者,年龄32~77(48.8±15.2)岁,心肌梗死病史时间小于4周,女性11例,男性21例。随机分为对照组(PCI+NS)与试验组(PCI+BM-MNCs)。对照组与试验组在PCI术结束后分别通过大腔导管于梗塞相关血管注入NS与BM-MNCs。对所有患者于PCI术前,术后45d、90d行ECG、24h动态心电图、静息Te99mSPECT检查。结果①试验组用Ficoll密度梯度离心法获得单个核细胞1.6×108~5.8×108[(3.5±1.8)×108]个,细胞活性均大于92%。②试验组与对照组术后45d静息Te99mSPECT灌注缺损区面积较术前分别缩小34.32%和23.05%(P<0.05),且两组组内比较差异有统计学意义(P<0.05);试验组与对照组术后90d静息Te99mSPECT灌注缺损区面积较术后45d分别缩小14.77%和3.82%(P<0.05),但两组组内比较仅试验组差异有统计学意义(P<0.05)。③24hHolter监测,室性心律失常及心动...

目的研究自体骨髓单个核细胞梗死相关冠脉内移植治疗急性心肌梗死的临床疗效与安全性。方法入选32例NYHA心功能分级Ⅱ~Ⅲ级行择期PCI术的AMI患者,年龄32~77(48.8±15.2)岁,心肌梗死病史时间小于4周,女性11例,男性21例。随机分为对照组(PCI+NS)与试验组(PCI+BM-MNCs)。对照组与试验组在PCI术结束后分别通过大腔导管于梗塞相关血管注入NS与BM-MNCs。对所有患者于PCI术前,术后45d、90d行ECG、24h动态心电图、静息Te99mSPECT检查。结果①试验组用Ficoll密度梯度离心法获得单个核细胞1.6×108~5.8×108[(3.5±1.8)×108]个,细胞活性均大于92%。②试验组与对照组术后45d静息Te99mSPECT灌注缺损区面积较术前分别缩小34.32%和23.05%(P<0.05),且两组组内比较差异有统计学意义(P<0.05);试验组与对照组术后90d静息Te99mSPECT灌注缺损区面积较术后45d分别缩小14.77%和3.82%(P<0.05),但两组组内比较仅试验组差异有统计学意义(P<0.05)。③24hHolter监测,室性心律失常及心动过缓在术前,术后45d、90d同期两组间比较差异无统计学意义(P>0.05)。结论自体骨髓单个核细胞梗死相关冠脉内移植治疗急性心肌梗死有一定的疗效,并且不增加心律失常的发生率。

 
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