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retinoic acid resistance
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  抗视黄酸
     Orphan receptor Nur77,which is rapidly induced by serum growth factors and is involved in retinoic acid resistance,was expressed in mRNA and protein levels at high serum concentration,detected by Northern blot and Western blot,but not expressed in protein level and expressed at low level of mRNA at low serum concentration in lung cancer cells.
     孤生受体Nur77受到血清生长因子刺激后会大量表达 ,具有抗视黄酸活性的作用 . 肺癌细胞培养在低浓度血清中 ,Nur77mRNA低水平表达和Nur77蛋白不表达 .
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  “retinoic acid resistance”译为未确定词的双语例句
     Objective To evaluate the applicability of proteomic methods for shedding light on the mechanisms of All-trans retinoic acid resistance.
     目的探讨采用蛋白质组学技术研究维甲酸的耐药机制。
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  相似匹配句对
     The Preparation of Cis-retinoic Acid
     异维A酸的制备方法
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     Retinoic acid in experimental myopia
     视黄醛在实验性近视中的作用
短句来源
     Mechanism of multidrug resistance caused by retinoic acid
     维甲酸导致多药耐药的机制初探
短句来源
     Effects of retinoic acid on chemotherapy resistance in neuroblastoma
     小剂量维甲酸诱导对神经母细胞瘤耐药的影响
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     Peracetic acid
     过氧乙酸
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  retinoic acid resistance
Retinoic acid resistance is a common phenomenon and appears to arise spontaneously in numerous types of cancer and tumor-derived cell lines.
      
Retinoic acid resistance occurs when tumors or tumor-derived cell lines cease to growth inhibit or differentiate in response to treatment with ATRA.
      
However, such remission is transient, and relapsed APL often has all-trans-retinoic acid resistance.
      
However, retinoic acid resistance limits the chemotherapeutic potential of ATRA.
      


The effects of serum concentration on growth inhibition of lung cancer cells by all trans retinoic acid(ATRA)were investigated.It was found that lung cancer cells,H292 and H460,were resistant to ATRA effect on their growth inhibitions when cells were cultured in 10% serum medium.However,the growth of cells was inhibited by ATRA while the cells were cultured in 1% serum medium.Northern blot showed that RARβ(retinoic acid receptor β),which is associated with anti cancer of ATRA,was induced by ATRA at low...

The effects of serum concentration on growth inhibition of lung cancer cells by all trans retinoic acid(ATRA)were investigated.It was found that lung cancer cells,H292 and H460,were resistant to ATRA effect on their growth inhibitions when cells were cultured in 10% serum medium.However,the growth of cells was inhibited by ATRA while the cells were cultured in 1% serum medium.Northern blot showed that RARβ(retinoic acid receptor β),which is associated with anti cancer of ATRA,was induced by ATRA at low serum concentration through activation of transcriptional activities of RARβ promoter and βRARE(β retinoic acid response element),revealed by transient transfection and CAT assay,but was not induced at high serum concentration.Orphan receptor Nur77,which is rapidly induced by serum growth factors and is involved in retinoic acid resistance,was expressed in mRNA and protein levels at high serum concentration,detected by Northern blot and Western blot,but not expressed in protein level and expressed at low level of mRNA at low serum concentration in lung cancer cells.In addition,EGF also induced Nur77 expression in lung cancer cells under the condition of serum free.Taken together,the data indicated that some of growth factors presented in serum might antagonize the effect of ATRA on growth inhibition of lung cancer cells.The pathway for serum action is likely to stimulate expression of Nur77 by some growth factors in serum,or suppress expression of RARβ through down regulation of transcriptional activity of RARβ promoter.

研究不同浓度的血清对全反式视黄酸 (ATRA)抑制肺癌细胞生长的影响 .当细胞培养在 10 %血清中 ,ATRA不能抑制肺癌细胞生长 ,但是当细胞培养在 1%血清中 ,ATRA能够有效地抑制肺癌细胞生长 .视黄酸受体RARβ介导视黄酸的抗癌作用 .Northern印迹分析表明 ,在高浓度血清中AT RA不能诱导RARβ表达 ,但在低浓度血清中ATRA可以诱导RARβ表达 ,并且瞬时转染和CAT测定证实是通过激活RABβ启动子转录活性而诱导RARβ表达的 .孤生受体Nur77受到血清生长因子刺激后会大量表达 ,具有抗视黄酸活性的作用 .肺癌细胞培养在低浓度血清中 ,Nur77mRNA低水平表达和Nur77蛋白不表达 .然而在高浓度血清中 ,Nur77mRNA和蛋白高水平表达 .另外 ,在无血清条件下 ,EGF也可以诱导Nur77表达 .结果提示 ,血清中的生长因子可能拮抗ATRA抑制肺癌细胞生长的作用 ,其作用途径可能是通过刺激细胞中Nur77表达 ,或者通过下调RARβ启动子的转录活性而抑制RARβ的表达

Objective To evaluate the applicability of proteomic methods for shedding light on the mechanisms of All-trans retinoic acid resistance. Methods The expression of cellular proteins in the retinoid acid sensitive cell line NB4 and retinoid acid resistant cell line MR2 was analyzed using the two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). Differentially expressed proteins were analyzed by mass spectrometry for peptide mass finger and identified by SWISS-PROT protein database. Results...

Objective To evaluate the applicability of proteomic methods for shedding light on the mechanisms of All-trans retinoic acid resistance. Methods The expression of cellular proteins in the retinoid acid sensitive cell line NB4 and retinoid acid resistant cell line MR2 was analyzed using the two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). Differentially expressed proteins were analyzed by mass spectrometry for peptide mass finger and identified by SWISS-PROT protein database. Results Approximately 600 spots appeared in an sodium dod(SDS-GEL). The match of the expression of cellular proteins between NB4 and MR2 was better. Three significantly differentially expressed proteins were screened and identified to DJ-1 and HSP70, as well as KIAA1289 of which the function is not yet known. Conclusion The utilization of 2D-PAGE, coupled with mass spectrometry is effective in screening the drug resistance-associated proteins and could provide molecular targets for the elucidation of resistance mechanisms.

目的探讨采用蛋白质组学技术研究维甲酸的耐药机制。方法提取维甲酸敏感细胞株NB4及维甲酸耐药细胞株MR2的总蛋白,进行双向凝胶电泳识别差异表达蛋白,经质谱分析、数据库搜索进行蛋白鉴定。结果单张凝胶电泳图上呈现约600多个蛋白点,组间的匹配性较好,初步筛选出三个表达差异蛋白,经鉴定分别为DJ-1蛋白、热休克蛋白70及KIAA1289未知功能蛋白。结论应用双向电泳连接质谱的蛋白质组学方法有助于筛选到耐药相关的表达蛋白,为进一步研究维甲酸耐药机制提供分子基础。

 
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