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drug delivery vehicle
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  给药系统
     Objective To investigate HER-2 targeting boron liposomes as a potential drug delivery vehicle for boron neutron capture therapy, in respect to cellular uptake, retention and the subcellular location.
     目的分析新制备的HER2靶向硼脂质体在细胞靶向、滞留及细胞内分布等方面的特性,探讨该脂质体作为靶向给药系统用于硼中子俘获治疗研究的可能性。
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     Intragastric floating system, an optimal controlled drug delivery vehicle, is currently utilized in the prolongation of the gastric residence time to extend significantly the period of time over which drug is released and increase the drug absorption and bioavailability.
     胃内漂浮给药系统是通过制剂手段来延长胃内滞留时间,达到增加药物吸收,提高生物利用度的目的。
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  “drug delivery vehicle”译为未确定词的双语例句
     Histological Effects of Sodium Alginate Gel-the Drug Delivery Vehicle on the Bullea of Guinea Pigs
     载药体-藻酸钠凝胶对豚鼠听泡的组织学影响
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     The product produced in this research should provide material for drug delivery vehicle with controlling to release made from the fluff and producing of antibacterial textile by wholesale manufacture.
     该研究为生物医学以壳聚糖作载体的丝网型药物控制释放系统和抗菌功能性纺织品的制备,提供了可批量生产的理想素材。
短句来源
     Conclusion Pullulan microparticles as a drug delivery vehicle were prepared by a W/O emulsion crosslink technique. The preparation method is simple and there are many factors influencing the morphosis of particles.
     结论采用W/O乳化交联法能够制备普鲁兰多糖微球,这种制备方法简单,多种因素控制微球形态与大小。
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     As a new drug delivery vehicle,liposomes can improve in vivo the stability of ATP and accumulate in infracted cardiac muscle and ischemic cerebrum. Supply of liposomally-entrapped ATP during preservation of transplant organs will improve its energy state and metabolism. So to prepare stable ATP-loaded liposome is of great significance.
     脂质体作为新载体可以提高ATP在体内的稳定性,并且能靶向于缺血的心肌和缺血的大脑,用于器官移植中能提高冷冻贮存器官的能级状态,提高移植的成活率,故制备稳定的ATP脂质体具有重要的意义。
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  相似匹配句对
     Drug delivery systems
     药物释放系统
短句来源
     Advance in Microemulsions as a Vehicle of Drug Delivery System
     微乳给药系统研究概况
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     A New Type of Nanostructural Vehicle for Drug Delivery—Dendrimers
     一种新型的药物纳米载体——树枝形聚合物
短句来源
     Nanoparticulate systems for drug delivery
     纳米药物和纳米载体系统
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     vehicle;
     整车建模;
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  drug delivery vehicle
The objective of this study was to develop a nontoxic and noncontraceptive vaginal drug delivery vehicle for lipophilic anti-human immunodeficiency virus (HIV) microbicides.
      
This liposome system demonstrates utility as a biocompatible, nontoxic drug delivery vehicle.
      
We conclude that the higher tumor inhibition effects of PPT-LDH hybrids result from the inorganic drug delivery vehicle, LDHs.
      
The suitability of the coated stent as a drug delivery vehicle was assessed in vivo using a radiolabeled analog of one of the more rapidly eluting drugs, angiopeptin.
      
In this study, one particular polymer is assessed for its suitability as a drug delivery vehicle.
      
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Objective To study the effects of chemoembolization with adriamycin alginate-chitosan microcapsules in the treatment of VX2 carcinoma in the extremity of the rabbit. Methods Twenty-four New Zealand white rabbits transplanted with VX2 carcinoma cells into the muscle tissue of the lower right thigh were devided into four groups namely groups A, B,C and D, and received regional infusion from femoral artery. Each group consisted of six rabbits: a group given natural saline(Group A), a group given adriamycin(Group...

Objective To study the effects of chemoembolization with adriamycin alginate-chitosan microcapsules in the treatment of VX2 carcinoma in the extremity of the rabbit. Methods Twenty-four New Zealand white rabbits transplanted with VX2 carcinoma cells into the muscle tissue of the lower right thigh were devided into four groups namely groups A, B,C and D, and received regional infusion from femoral artery. Each group consisted of six rabbits: a group given natural saline(Group A), a group given adriamycin(Group B), a group given blank alginate-chitosan microcapsules(Group C)and a group given adriamycin alginate-chitosan microcapsules(Group D). Three days after treatment, all groups were examined by histology and immunohistochemical detection(TdT-mediated dUTP nick end labeling technique, TUNEL; proliferating cell nuclear antigen, PCNA). Results The blood vessels of the tumor were almost embolized by the microcapsules. Extensive necrosis, high level of positive cells in TUNEL(60.85%±5.21%) and low level in PCNA detection with in the tumors were observed in Group D. Conclusion Adriamycin alginate-chitosan microcapsules can potentially play roles in two respects, 1 to serve as embolizing agents, and 2 to serve as drug delivery vehicles for local release. Chemoembolization with microparticals is an effective treatment of malignant osseous and soft tissue sarcomas in an experimental model.

目的 研究阿霉素海藻酸钠 壳聚糖微囊对兔VX2肢体肉瘤模型的化疗栓塞作用。方法  2 4只新西兰大白兔 ,于右大腿肌肉内注射 1× 10 8/mlVX2肿瘤细胞悬液 2ml,建立肢体肉瘤模型。随机分为 4组 ,每组 6只。分别经股动脉给予生理盐水 (A组 )、阿霉素药液 (B组 )、空白海藻酸钠 壳聚糖微囊 (C组 )、阿霉素海藻酸钠 壳聚糖微囊 (D组 )。 3d后对肿瘤标本进行病理组织学检查 ,测定肿瘤坏死面积 ,检测原位末端标记 (TdT mediateddUTPnickendlabelingtechnique ,TUNEL)及增殖细胞核抗原 (proliferatingcellnuclearantigen ,PCNA)。 结果 经股动脉给药微囊栓塞后 ,肿瘤血供明显减少。D组肿瘤广泛坏死 ,PCNA标记率明显降低 ,TUNEL阳性率 6 0 85 %± 5 2 1% ,高于其他 3组 (P <0 0 5 )。 结论 阿霉素海藻酸钠 壳聚糖微囊通过栓塞肿瘤供血动脉 ,局部释放化疗药物 ,可以提高兔VX2肢体肉瘤模型的化疗效果。

The technology of preparation for hollow hydroxyapatite (HAP) microspheres used as drug delivery vehicles was investigated in this paper.The lithium-calcium borate (LCB) glasses with good formability were prepared in the Li 2O-CaO-B 2O 3 ternary system,and the LCB glass microspheres were made through flame spray process.The Ca-P-OH compound precipitated on the LCB glass microspheres and formed porous microshells by soaking the microspheres into phosphate buffer (K 2HPO 4) solution.Then the microspheres...

The technology of preparation for hollow hydroxyapatite (HAP) microspheres used as drug delivery vehicles was investigated in this paper.The lithium-calcium borate (LCB) glasses with good formability were prepared in the Li 2O-CaO-B 2O 3 ternary system,and the LCB glass microspheres were made through flame spray process.The Ca-P-OH compound precipitated on the LCB glass microspheres and formed porous microshells by soaking the microspheres into phosphate buffer (K 2HPO 4) solution.Then the microspheres turned to be hollow ones with the same diameter as the glass microspheres after LCB glass worn out in the chemical reaction for 5 h at 37 ℃.The Ca-P-OH compound became HAP after heat treatment of 600 ℃ for 4 h,thus the hollow microspheres were produced.The hollow microspheres were observed by scanning electron microscope (SEM).And then the microstructure characteristics of them were revealed.The mechanism for forming hollow HAP microspheres from the chemical reaction between phosphate buffer and LCB glass,which was put forward in this paper,was confirmed by the X-ray diffraction (XRD) results for the Ca-P-OH precipitate.

研究了一种作为药物载体的中空羟基磷灰石 (HAP)微球的制备工艺 .在Li2 O -CaO -B2 O3 三元系统中 ,制得成形性能良好的锂钙硼酸盐 (LCB)玻璃 ,采用火焰漂浮法获得LCB玻璃微球 .该玻璃微球与磷酸盐缓冲溶液(K2 HPO4)溶液反应 ,在球表面沉积出Ca- P -OH产物 ,形成多孔的壳层 ,包覆在球外 ,37℃下反应 1 2 0h ,LCB玻璃微球全部被溶蚀 ,壳层形成了直径与原来微球几乎相等的中空微球 ,6 0 0℃下热处理 4h ,Ca- P- OH沉积物转化成HAP ,形成了中空的HAP微球 .采用扫描电子显微镜 (SEM )观察制备的中空HAP微球 ,揭示了微球的显微结构 ;反应产物的X射线衍射 (XRD)分析 ,结果验证了所提出的通过LCB玻璃与磷酸盐缓冲溶液的反应形成中空HAP微球的机理 .

Objective Dendrimer, a new class polymeric materials of highly branched, symmetric and nanoscale, are considered as potential drug delivery vehicle for their particular structure and character. The capability of G4.0 Polyamidoamie (PAMAM) dendrimer as anticancer drug methotrexate (MTX) carrier were studied. Methods UV has been employed to monitor the in vitro release of MTX from G4.0 PAMAM in different buffers. We discuss mechanism of complex by 1H and 13 C NMR. Results Each G4.0 PAMAM could conjugated...

Objective Dendrimer, a new class polymeric materials of highly branched, symmetric and nanoscale, are considered as potential drug delivery vehicle for their particular structure and character. The capability of G4.0 Polyamidoamie (PAMAM) dendrimer as anticancer drug methotrexate (MTX) carrier were studied. Methods UV has been employed to monitor the in vitro release of MTX from G4.0 PAMAM in different buffers. We discuss mechanism of complex by 1H and 13 C NMR. Results Each G4.0 PAMAM could conjugated 14 MTX molecules; An electronic interaction between G4.0 PAMAM primary amine groups and MTX carboxylic groups was demonstrated by 1H and 13 C NMR. It took 200 h to release 80% MTX from the G4.0 PAMAM-MTX complex in 10 mmol/L, pH 7.4 Tris-HCl buffer solution, while 20 h for pure MTX under same condition; With the increasing of ionic strength in Tris-HCl buffer solution, the G4.0 PAMAM-MTX complex released MTX fast and the stability of the G4.0 PAMAM-MTX system decreased. Conclusion 1H and 13 C NMR data demonstrated the interaction between G4.0 PAMAM dendrimer primary amine groups and MTX carboxylic groups is due to the electrostatic force; G4.0 PAMAM dendrimer could load 14 MTX molecules; the controlled release ability of G4.0 PAMAM-MTX complex was 10 times better than the control (pure MTX) in 10 mmol/L(pH 7.4) Tris-HCl buffer solution.

目的探讨了聚酰胺-胺(PAMAM)树状大分对抗癌药物甲氨蝶呤体外释放作用及其释放机制。方法采用紫外分光光度法测定G(代)4.0PAMAM树状大分子对抗癌药物甲氨蝶呤(MTX)的复合和缓释作用。用磁共振谱和氢谱探讨其复合的机制。结果G4.0PAMAM树状大分子能复合14个MTX分子;G4.0PAMAM树状大分子-MTX复合物在10mmol/LTris-HCl溶液中释放80%MTX需要200h,缓释效果是对照(游离MTX)的10倍;随着介质浓度的增加,G4.0PAMAM树状大分子-MTX复合物缓释效果降低,其稳定性也降低。结论1HNMR和13CNMR数据表明G4.0PAMAM树状大分子与MTX通过PAMAM树状大分子氨基阳离子与MTX羧基阴离子之间的静电作用而形成复合物。

 
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