til cells til细胞(9)   til细胞      Administration of LAK cells and TIL cells combined with _rIL_2 in the treatment of lung cancer with malignant pleural effusion      重组IL_2联合LAK和TIL细胞治疗癌性胸腔积液 短句来源      Methods: 30 patients of advanced cancer were studied in this trial Of them, 5 patients treated by IL-2/LAK cells alone (2 of 5 patients received TIL cells), 18 patients received IL-2/LAK cells combination radiotherapy (1 of them received artery infusion), 4 patients recei-ved IL-2/ LAK cells combination chemotherapy (1 of them received artery infusion), and 3 patients received IL-2/LAK cells combination radiotherapy and chemotherapy.      方法：本组共30例，其中单纯IL－2／LAK细胞治疗 5例（包括 2例TIL细胞胸腹腔灌注），IL－2／LAK细胞联合放疗18例（包括 1例动脉灌注），IL－2／LAK细胞联合化疗4例（包括1例动脉灌注），IL－2／LAK细胞联合放疗和化疗3例。 短句来源      Phenotype characterization of the preparations showed that the CD3,CD4 and CD8 phenotype expressions of non-induced TIL cells did not change in the process of cultivation. Whereas,the CD3 expression and the CD/CD8ratio increased significantly to 95% and 1.65 respectively in the culture of activated TIL at 32th day.      免疫组化分析结果：未经激活的TIL细胞其膜抗原（CD3，CD4，CD8）的表达动态变化不大，但经IL－2激活的TIL细胞随着培养无数的增加，其CD3细胞数比例及CD4／CD8比值上升明显，在培养至32天时分别达95％和1．65。 短句来源      The results showed that high activity of IL-2 in culture supernatants of LAK and TIL cells was found as well as it could be used for culture of IL-2 edpendent cell lines and clinic experiment.      结果表明LAK细胞和TIL细胞培养上清有较高的IL－2活性，可用于支持培养IL－2依赖株的生长； 短句来源      Methods TIL cells isolated from Lewis lung cancer tissues and LAK cells from spleen of tumor bearing mouse were irradiated with different low doses of X rays and were cultured after irradiation.      方法　从荷瘤小鼠的脾脏制得LAK细胞 ,从荷Lewis肺癌小鼠瘤组织中分离得TIL细胞 ,给予不同剂量的X射线照射后培养。 短句来源 更多          “til cells”译为未确定词的双语例句      Determination of Epitope of LAK and TIL cells      LAK和TIL细胞的表型测定 短句来源      These results show that liposome can mediated IL-2 gene transfer into tumor cells and TIL cells in situ,then increase the immunogenicity of the tumor cells and induce local tumor specific immune responses.      结果表明瘤体内注射脂质体包裹的IL－2基因后，可在肿瘤原位将基因转移至肿瘤细胞及TIL中，提高肿瘤细胞的MHCⅠ类抗原的表达，增强肿瘤细胞的免疫原性，并通过提高TIL粘附分子的表达，共同促进TIL的肿瘤特异性杀伤功能。 短句来源      Results Low dose ionizing radiation improved the amplification volume of LAK/TIL cells,decreased the cell death ratio in amplification process,and increased the toxicity of LAK/TIL cells.      结果　低剂量电离辐射可增加LAK/TIL细胞的扩增量 ,降低细胞扩增过程死亡率 ,并增加细胞毒性。 短句来源      Phenotypic characterization of the preparations showed the pnenotypic expression (CD3,CD4,CD8) of non-induced TIL cells did not change in the process of cultivation, The expration of CD3 and the CD4/CD8 ratio significantly increased in the culture of activated TIL respectively up to 93. 5% and 1. 75      免疫组比分析结果表明，未经激活的TIL膜抗原（CD3，CD4，CD8）的表达动态变化不大，但若经IL－2激活的TIL，随着培养天数的增加，其CD3细胞数及CD4／CD8细胞比值由0．69上升至1．75。 提示膀胱癌TIL可能在临床治疗上有一定的前景。 短句来源      Higher expression of MHC class Ⅰ(H-2b) molecules on tumor cells and much more LAF-1 molecules on TIL cells could be observed.      肿瘤细胞表面表达了较高水平的MHCⅠ类抗原（H－2K￣bD￣b）； 短句来源 更多          相似匹配句对      U cells.      Li/TK细胞3d,即可将其杀死. 短句来源      Determination of Epitope of LAK and TIL cells      LAK和TIL细胞的表型测定 短句来源      The whole cells of R.      直接将霉菌R. 短句来源      Experimental Proliferation of Mice TIL in Vitro and the Antioncotic Effect of Proliferated Cells      小鼠TIL细胞体外实验性扩增及其抗肿瘤作用的研究 短句来源 查询“til cells”译词为用户自定义的双语例句     我想查看译文中含有：的双语例句 为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法，我们为您准备了出自英文原文的大量英语例句，供您参考。   til cells Our results demonstrate defects in response to stimulation via TCR/CD3 and the IL-2R in T-TIL cells from patients with NHL that were not observed with T cells from the peripheral blood.        If this is a common feature, then the therapeutic approach of in vitro expanded TIL cells should take into consideration the requirement of two T cell subsets.        The results showed that higher activity of IL-2 in culture supernatant of LAK and TIL cells was found it could be used to support the culture of IL-2 dependent cell lines.        The relative position of the Til cells to the other neurons of the limb does not change.        The 660 TIL cells were depleted of IL2 for 4 days prior to their use in assays except where noted.        The activity of interleukine 2(IL-2) in culture supernatants of lymphokine-activated killer(LAK)cellsand tumor infiltrating lymphocytes (TIL)as well as cytotoxicity of LAK cells on cultured leukemic cells were detected by MTT colorimetry. The results showed that high activity of IL-2 in culture supernatants of LAK and TIL cells was found as well as it could be used for culture of IL-2 edpendent cell lines and clinic experiment. The significant cytotoxicity of LAK cells on... The activity of interleukine 2(IL-2) in culture supernatants of lymphokine-activated killer(LAK)cellsand tumor infiltrating lymphocytes (TIL)as well as cytotoxicity of LAK cells on cultured leukemic cells were detected by MTT colorimetry. The results showed that high activity of IL-2 in culture supernatants of LAK and TIL cells was found as well as it could be used for culture of IL-2 edpendent cell lines and clinic experiment. The significant cytotoxicity of LAK cells on leukemic cell lines could be found in vitro ,which was consistent with the ratio of effector cells to target cells. The number of living leukemic cells is consistently related with the concentration of formazan metabolite of MTT. It suggested that the numbers of living cells and cytotoxicity of LAK cells could be correctly estimated by the determina-tion of OD value. 本文采用ＭＴＴ比色法测定了ＬＡＫ和ＴＩＬ细胞培养上清ＩＬ－２活性及ＬＡＫ细胞介导对体外培养的白血病细胞株的杀伤活性。结果表明ＬＡＫ细胞和ＴＩＬ细胞培养上清有较高的ＩＬ－２活性，可用于支持培养ＩＬ－２依赖株的生长；ＬＡＫ细胞对体外培养的白血病细胞株有明显的杀伤作用。其杀伤效应随效靶比例增加而增高；同时亦证明：活的白血病细胞数与ＭＴＴ甲赞形成产物呈直线相关性，提示通过ＭＴＴ法测定ＯＤ值能较好地反映活细胞数目及细胞毒效应。 Tumor-infiltrating lymphocytes (TIL) isolated from two renal cell carcinoma were cultured in vitro in the presence of rh IL-2.The results showed that TIL was expanded 32-203 times and exhibited specific strong cytotoxic activity against autologous fresh renal tumor target cells (up to 53% and 640%).Phenotype characterization of the preparations showed that the CD3,CD4 and CD8 phenotype expressions of non-induced TIL cells did not change in the process of cultivation. Whereas,the... Tumor-infiltrating lymphocytes (TIL) isolated from two renal cell carcinoma were cultured in vitro in the presence of rh IL-2.The results showed that TIL was expanded 32-203 times and exhibited specific strong cytotoxic activity against autologous fresh renal tumor target cells (up to 53% and 640%).Phenotype characterization of the preparations showed that the CD3,CD4 and CD8 phenotype expressions of non-induced TIL cells did not change in the process of cultivation. Whereas,the CD3 expression and the CD/CD8ratio increased significantly to 95% and 1.65 respectively in the culture of activated TIL at 32th day. 对两例原发性肾癌患者手术切除肿瘤组织中肿瘤浸润性淋巴细胞（ＴＩＬ）进行了体外分离与培养。结果表明：ＴＩＬ体外扩增倍数分别达３２～２０３倍，对自体肿瘤靶细胞的最高杀伤活性达５３％和６４％，且呈现一定的靶细胞特异性。免疫组化分析结果：未经激活的ＴＩＬ细胞其膜抗原（ＣＤ３，ＣＤ４，ＣＤ８）的表达动态变化不大，但经ＩＬ－２激活的ＴＩＬ细胞随着培养无数的增加，其ＣＤ３细胞数比例及ＣＤ４／ＣＤ８比值上升明显，在培养至３２天时分别达９５％和１．６５。 In order to investigate the functions of tumor cells and tumorinfiltrating lymphocytes,IL-2 DNA liposome were directly injected into B16F10 melanoma mass; 10 days later,Northern blots analysis confirmed IL-2 mRNA expression both in tumor cells and TIL. IL2 could be detected in the supernatants of freshly isolated tumor cells after G418 resistant selection. Higher expression of MHC class Ⅰ(H-2b) molecules on tumor cells and much more LAF-1 molecules on TIL cells could be observed.... In order to investigate the functions of tumor cells and tumorinfiltrating lymphocytes,IL-2 DNA liposome were directly injected into B16F10 melanoma mass; 10 days later,Northern blots analysis confirmed IL-2 mRNA expression both in tumor cells and TIL. IL2 could be detected in the supernatants of freshly isolated tumor cells after G418 resistant selection. Higher expression of MHC class Ⅰ(H-2b) molecules on tumor cells and much more LAF-1 molecules on TIL cells could be observed. The cytotoxicity of TIL to B16F10 cells was augmented significantly after intratumoral injection of IL-2 DNA liposome.These results show that liposome can mediated IL-2 gene transfer into tumor cells and TIL cells in situ,then increase the immunogenicity of the tumor cells and induce local tumor specific immune responses. 将脂质体包裹的ＩＬ－２基因直接注射至Ｂ１６Ｆ１０黑色素瘤瘤体内，研究肿瘤细胞和肿瘤浸润性淋巴细胞（ＴＩＬ）的功能变化。１０ｄ后，Ｎｏｒｔｈｅｒｎｂｌｏｔ鉴定显示瘤体内注射ＩＬ－２基因后肿瘤细胞及ＴＩＬ中ＩＬ－２ｍＲＮＡ表达阳性；经Ｇ４１８筛选后的肿瘤细胞培养上清中可检测出ＩＬ－２；肿瘤细胞表面表达了较高水平的ＭＨＣⅠ类抗原（Ｈ－２Ｋ￣ｂＤ￣ｂ）；ＴＩＬ表面粘附分子ＬＡＦ－１表达也明显高于对照组，其杀伤Ｂ１６细胞的活性明显增强。结果表明瘤体内注射脂质体包裹的ＩＬ－２基因后，可在肿瘤原位将基因转移至肿瘤细胞及ＴＩＬ中，提高肿瘤细胞的ＭＨＣⅠ类抗原的表达，增强肿瘤细胞的免疫原性，并通过提高ＴＩＬ粘附分子的表达，共同促进ＴＩＬ的肿瘤特异性杀伤功能。   << 更多相关文摘      相关查询 cells til cells impedance myeloma cells polymorphonuclear cells amnion cells cells invasion dopaminergic cells mutant cells hlf cells cultural cells bm cells

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