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chronic lymphocytic thyroiditis clt
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     Seventy-seven children with chronic lymphocytic thyroiditis (CLT) were studied.
     为探讨儿童慢性淋巴细胞性甲状腺炎(CLT)的临床特点及预后,对1988年以来收治的77例患儿的临床资料进行了回顾性分析。
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     Diagnosis and treatment of chronic lymphocytic thyroiditis
     慢性淋巴细胞性甲状腺炎的诊断与治疗
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     A Case Chronic Lymphocytic Thyroiditis
     慢性淋巴细胞性甲状腺炎1例报告
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     Fifty - four children with chronic lymphocytic thyroiditis (CLT) were reviewed retrospectivety.
     对54例儿童慢性淋巴细胞性甲状腺炎(CLT)进行了回顾性分析。
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     Neuropathy and M yopathy in Patients with Chronic Lymphocytic Thyroiditis
     慢性淋巴性甲状腺炎的神经、肌病表现
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  chronic lymphocytic thyroiditis clt
The effect of chronic lymphocytic thyroiditis (CLT) on the behavior of papillary thyroid cancer (PTC) remains unclear.
      
Chronic lymphocytic thyroiditis (CLT) has an epidemiological relationship to papillary thyroid carcinoma (PTC).
      
The relationship between chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC) is a subject of controversy.
      


Eighty-one cases of primary hypothyroidism related with thyroid autoimmunity were analyzed. The data showed that the TGA or MCA>l:80 accounted for 64.9% and 84.8% of the cases respectively. Either one of the two kinds of antibodies was positive in 87% of the cases. 75% of the patients showed >10% of ~(131)I were washed out in pot. 63.8% of the cases showed >50% of ~(131)I were washed out in iodine perchlorate washout test. It is very similar to the result in a group of surgical and histopathological proved cases...

Eighty-one cases of primary hypothyroidism related with thyroid autoimmunity were analyzed. The data showed that the TGA or MCA>l:80 accounted for 64.9% and 84.8% of the cases respectively. Either one of the two kinds of antibodies was positive in 87% of the cases. 75% of the patients showed >10% of ~(131)I were washed out in pot. 63.8% of the cases showed >50% of ~(131)I were washed out in iodine perchlorate washout test. It is very similar to the result in a group of surgical and histopathological proved cases of chronic lymphocytic thyroiditis (CLT), and the distribution of sex and age was also similar to CLT group. Our findings support the view point that the disease is one stage or type of CLT, which may be the result of thyroid autoimmunity. The thyroid ~(131)I up-take, serum T_3, T_4, TSH and thyroid scintigraphy are briefly discussed.

本文分析81例与甲状腺自身免疫有关的原发性甲状腺功能低下(原发性甲低)病人的甲状腺免疫功能、碘代谢、甲状腺素有机合成障碍等临床资料,并与一组经病理证实的慢性淋巴性甲状腺炎病人比较后认为,我们的资料支持本病是慢性淋巴性甲状腺炎的不同阶段或不同类型,可能是甲状腺自身免疫的最终结果这一观点。

A morphological study on 34 chronic lymphocytic thyroiditis(CLT)wasmade in detail.Among these,15 cases associated with struma or struma nodu-lus and 5 cases with thyroid carcinoma,the incidence was 44.12% and14.7% respectively,much higher than that of previous datum It is thought thatthe geographic factor must be correlated.The intimate relationship of the stru-ma and carcinoma to CLT was emphasized.The authors classified the stru-ma into A and B type.Type A is similar to general...

A morphological study on 34 chronic lymphocytic thyroiditis(CLT)wasmade in detail.Among these,15 cases associated with struma or struma nodu-lus and 5 cases with thyroid carcinoma,the incidence was 44.12% and14.7% respectively,much higher than that of previous datum It is thought thatthe geographic factor must be correlated.The intimate relationship of the stru-ma and carcinoma to CLT was emphasized.The authors classified the stru-ma into A and B type.Type A is similar to general struma,and type B hasthe character of numerous lymphocytes and plasmocytes infiltration or theformation of lymphoid follicles and other inflammatory reactions.The histo-logic structure was similar to the group of surrounding thyroiditis.The strumanodulus is the strurna of type A and type B which are in formation.Thereare similar inflammatory changes to the type 3 struma in the stroma of 3eases of carcinoma as well.Based on the comparative study of morphogenesis,theauthors considered CLT may be a pretumorous or precancerous lesion,and thedevelopment of the 5 cases of thyroid carcinoma may be due to the hyperp-lasia and to be malignant of remnant follicular epithelium itn the scar tissuesof the CLT under the changes of the inner environment

34例慢性淋巴性甲状腺炎(慢甲炎)中15例伴发腺瘤或腺瘤样结节,5例伴发甲状腺癌,其伴发率分别为44%及15%,说明了两者的密切关系。作者将腺瘤分为 A 型和 B 型。A 型与一般甲状腺瘤相似。B 型特点为腺瘤间质内有多量淋巴、浆细胞浸润或淋巴滤泡形成及其他炎症反应,与周围甲状腺炎组织结构相似,腺瘤样结节为正在形成的 A 型或 B 型腺瘤。3例癌间质内亦有 B 型腺瘤类似的炎性改变。经形态发生的比较研究,认为慢甲炎可能是一种瘤前或癌前病变。这5例甲状腺癌的发生是慢甲炎疤痕组织内残留的滤泡上皮在内环境改变的情况下增生恶变所致。

Peripheral blood T lymphocyte subset in 20 cases of patients with advanced cervical cancer and 15 cases of patients with chronic lymphocytic thyroiditis(CLT) were studied by the use of the indireet fluorescent technic with OKT monoclonal antibodies. The results showed that comparing with normal controls, the total T cells and helper T cell (T_H cell)in patients with cervical cancer were much lower (P<0.001).So the T_H/T_3 cell ratio decreased significantly (P<0.001). In patients with...

Peripheral blood T lymphocyte subset in 20 cases of patients with advanced cervical cancer and 15 cases of patients with chronic lymphocytic thyroiditis(CLT) were studied by the use of the indireet fluorescent technic with OKT monoclonal antibodies. The results showed that comparing with normal controls, the total T cells and helper T cell (T_H cell)in patients with cervical cancer were much lower (P<0.001).So the T_H/T_3 cell ratio decreased significantly (P<0.001). In patients with CLT however, the total T cell was lower(P<0.001).And the T_H/T_3 cell ratio increased significantly (P<0.001). Our findings indicated that three was disorder of T lymphocyte subsets in both of cervical cancer and CLT,and these disorders represented completely opposite immunologic abnormalities. The immune system in pateints with cancer was sup pressed and in patients with CLT it was relatively active. Our studies suggested that maintenance of a state of relative equilibrium of Tr_H/T_3cell ratio is essential to body immune meechanism, and body immune rcsponsc.

应用OKT单抗对20例初诊晚期宫颈癌和15例慢性淋巴性甲状腺炎(CLT)患者的外周血T淋巴细胞亚群检测结果表明,与正常人相比,宫颈癌患者OKT_3和OKT_4细胞均明显减少,OKT_8细胞明显增多,OKT_4/OKT_8比值显著降低,CLT患者OKT_3和OKT_8细胞减少,OKT_4/OKT_8比值显著升高。本研究表明宫颈癌和CLT均有T细胞亚群的紊乱,提示OKT_4/OKT_8比值的相对平衡是决定机体免疫状态和免疫反应水平的中心环节。

 
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