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nimodipine tablet
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  尼莫地平片
     The relative bioavailability of domestic nimodipine tablet was ( 108.0± 7.2)%.
     国产尼莫地平片对进口尼莫地平片的相对生物利用度为 (10 8.0± 7.2 ) %。
短句来源
     Methods 120 patients with SAH were randomly divided into case group(70 patients) and control group(50 patients). The patients of case group were accepted both routine therapy just as control group and nimodipine injection 10mg/50 ml,ivbydrip,then,nimodipine tablet 30mg,po.
     方法 12 0例SAH病人随机分为治疗组 70例和对照组 5 0例 ,治疗组在与对照组相同的常规治疗基础上加用尼莫地平注射液 10mg/ 5 0ml,静脉滴注 ,然后改为尼莫地平片 3 0mg ,口服。
短句来源
     Study on pharmacokinetics and bioequivalent evaluation of Nimodipine tablet
     尼莫地平片相对生物利用度及药物动力学研究
短句来源
     Relative bioavailability of domestic nimodipine tablet was 97%±7% compared with nimodipine (Germany) tablet.
     国产尼莫地平片相对生物利用度为97%,经统计学处理证实二种片剂生物等效。
短句来源
     The interrelation of the dissolution and bioavailability of nimodipine tablet
     尼莫地平片的溶出度和生物利用度的相关性研究
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  尼莫通片
     Conclusion: The bioavailability of nimodipine molecular microcapsule is higher than that of nimodipine tablet.
     结论 :尼莫地平分子微囊剂的生物利用度高于尼莫通片
短句来源
  “nimodipine tablet”译为未确定词的双语例句
     Objective:The pharmacokinetics and relative bioavailability of oral nimodipine tablet were studied in healthy volunteers.
     目的 :研究尼莫地平片剂在健康人体内的药代动力学及相对生物利用度。
短句来源
     Conclusion: The relative bioavailability of nimodipine tablet was (93.77%±11.62%)compared with nimotop tablet, the results of statistical analysis showed that these two drugs were biologically equivalent.
     结论 :尼莫地平对尼莫通的相对生物利用度为(93.77 %±11.62) %,经统计学分析后认为两药体内生物等效性相同。
短句来源
     cmax, AUC0.8 and AUC0-∞ of Nim gelatin pill were significantly different compared with those of Nim tablet(P<0. 05). It is indicated that nimodipine gelatin pill is better than nimodipine tablet.
     Nim胶丸的t_(1/2)、t_(max)与Nim片无显著性差异,而c_(max)、AUC_(0~8)、AUC_(0~∞)明显高于Nim片(P<0.05),说明Nim胶丸相对于Nim片为一高效口服制剂。
短句来源
     STUDIES ON THE BIOAVAILABILITY AND PHARMACOKINETICS OF NIMODIPINE TABLET IN HUMAN BODY
     尼莫地平片剂生物利用度和健康人药代动力学研究
短句来源
     Bioavailability of nimodipine tablet In healthy volunteers
     尼莫地平片剂的人体生物利用度研究
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We assessed the effects of Nimodipine on LV diastolic functions in 26 patients with CHD (unstable angina pectoris) treated with nimodipine tablet therapy for two weeks. The diastolic filling velocity, filling time and filling fraction across the mitral valve were measured by pulsed Doppler e-chocardiography. The results showed that nimodipine significantly improved the PFVE, PFVA/PFVE, AEF, DEF, DT, RFF, 1/3FF, 1/2FF. especially the diastolic functional parameters of the active filling of LV.

本文利用脉冲式多普勒超声心动图技术(PDE)通过测定二尖瓣血流评价钙拮抗剂尼莫地平对26例冠心病(不稳定型心绞痛)患者左室舒张功能的影响。初步结果显示尼莫地平对舒张期二尖瓣血流充盈速度(PFVE、PFVA/PFVE、AEP、DEP),充盈时间DT及充盈分数RFF、1/3FF、1/2FF等左室主动充盈过程的舒张功能参数有良好的改善作用。

The article determined the bioavailability and pharmacokinetic parameters of two kinds of nimodipine tablets produced by Tianjin Center Pharmaceutical Factory in 6 healthy volunteers using HPLC method. The commercially available conventional tablet A and the tablet formulation B were compared with the reference solution C in vivo. The pharmacokinetic parameters of nimodipine in vivo were estimated by using PKBP--N1 program on the basis of one compartment open model. After administration...

The article determined the bioavailability and pharmacokinetic parameters of two kinds of nimodipine tablets produced by Tianjin Center Pharmaceutical Factory in 6 healthy volunteers using HPLC method. The commercially available conventional tablet A and the tablet formulation B were compared with the reference solution C in vivo. The pharmacokinetic parameters of nimodipine in vivo were estimated by using PKBP--N1 program on the basis of one compartment open model. After administration of 120 mg dose of B, the pharmacokinetic parameters were as follows: Tp=0.977 h, C_(max)=44.28ng/ml, ka=2.02 h~(-1), t 1/2=1.63 h, Vd=26. 25 L/ kg, AUC=130.56 ng·h~(-1)·ml~(-1). The result imply that nimodipine is absorbed rapidly, distributed widely in the body, and also eliminated at a fairly rapid rate.

用高效液相色谱法测定了6名健康志愿者口服二种尼莫地平片剂的相对生物利用度和药代动力学参数。结果表明:尼莫地平在人体内的浓度—时间数据可用一室开放模型拟合,主要动力学参数与国外文献报道一致。新片剂和普通片的人体相对生物利用度分别为82.39%和16.01%。

A HPLC method for the determination of nimodipine in human plasma was described.Under alkaline condition,nimodipine and internal standards nitrendipine and methyltestosterone are extracted with mixed solvent of ether and n-hexane(1:1).Then the separation is performed in an ODS column with a mobile phase of methanol-water-n-butylamine(65: 35 :0.001)and detected at 238nm.The linear concentration range of this method is 5~100 ng/ml and the detectable lowest concentration is 2ng/ml (S/N=3).This method...

A HPLC method for the determination of nimodipine in human plasma was described.Under alkaline condition,nimodipine and internal standards nitrendipine and methyltestosterone are extracted with mixed solvent of ether and n-hexane(1:1).Then the separation is performed in an ODS column with a mobile phase of methanol-water-n-butylamine(65: 35 :0.001)and detected at 238nm.The linear concentration range of this method is 5~100 ng/ml and the detectable lowest concentration is 2ng/ml (S/N=3).This method has been applied to the determination of pharmacokinetic parameters of six normal volunteers after single dose administration of nimodipine tablets. Results show that the pharmacokinetic parameters fit with one compartment model.

本文以反相高效液相色谱法测定人血浆中尼莫地平的浓度。以尼群地平和甲基睾丸素为内标物,碱性条件下用乙醚-正已烷(1:1)萃取,流动相为甲醇-水-正丁胺(65:35:0,001),流速1.2ml/min,紫外检测波长238nm,线性范围5~100ng/ml,最低检测浓度2ng/ml,日内差异小于5%,日间差异约为5%。6名健康受试者口服-种国产尼莫地平片剂后,以本方法测定其体内药代动力学符合一室模型。

 
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