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crossover
相关语句
  交叉
    A OUASILINEAR MODEL FOR ANALYSING DATA OF CROSSOVER TRIALS
    交叉试验设计分析的拟线性模型
短句来源
    Methods:Twenty male healthy volunteers received 2mg finasteride tablet orally in a random crossover design.
    方法采用随机双交叉实验设计,20名健康受试者口服受试制剂和参比制剂2mg,用LC-MS法测定国人血浆中的非那雄胺浓度。
短句来源
    METHODS: The study was conducted as a 3- way crossover design in 18 healthy volunteers whose plasma concentrations of cefixime were determined by HPLC after receiving a single oral dose of 200 mg trial preparations or reference preparation.
    方法:采用高效液相色谱法测定18名健康受试者三交叉单剂量口服受试制剂或参比制剂200mg后血浆中头孢克肟的浓度。
短句来源
    Methods Twenty healthy male volunteers received 200 mg nevirapine tablets orally in a random crossover design. Drug concentrations in the plasma were determined by HPLC.
    方法采用随机双交叉实验设计,20名健康受试者口服受试制剂和参比制剂200 mg,用HPLC法测定血浆中的奈韦拉平浓度。
短句来源
    Methods A single oral dose (100 mg of tested and reference formulation) were given to 20 healthy volunteers in a randomised crossover study.
    方法健康志愿者20名,随机双交叉单剂量口服盐酸舍曲林分散片和片剂100mg,分别于服药后120h内多点抽取静脉血;
短句来源
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  交叉
    A OUASILINEAR MODEL FOR ANALYSING DATA OF CROSSOVER TRIALS
    交叉试验设计分析的拟线性模型
短句来源
    Methods:Twenty male healthy volunteers received 2mg finasteride tablet orally in a random crossover design.
    方法采用随机双交叉实验设计,20名健康受试者口服受试制剂和参比制剂2mg,用LC-MS法测定国人血浆中的非那雄胺浓度。
短句来源
    METHODS: The study was conducted as a 3- way crossover design in 18 healthy volunteers whose plasma concentrations of cefixime were determined by HPLC after receiving a single oral dose of 200 mg trial preparations or reference preparation.
    方法:采用高效液相色谱法测定18名健康受试者三交叉单剂量口服受试制剂或参比制剂200mg后血浆中头孢克肟的浓度。
短句来源
    Methods Twenty healthy male volunteers received 200 mg nevirapine tablets orally in a random crossover design. Drug concentrations in the plasma were determined by HPLC.
    方法采用随机双交叉实验设计,20名健康受试者口服受试制剂和参比制剂200 mg,用HPLC法测定血浆中的奈韦拉平浓度。
短句来源
    Methods A single oral dose (100 mg of tested and reference formulation) were given to 20 healthy volunteers in a randomised crossover study.
    方法健康志愿者20名,随机双交叉单剂量口服盐酸舍曲林分散片和片剂100mg,分别于服药后120h内多点抽取静脉血;
短句来源
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  “crossover”译为未确定词的双语例句
    METHODS Sixteen healthy volunteers were given medicine 60mg in oral by an open randomized crossover design.
    方法:健康志愿者16名随机交叉口服给药60mg。
    marketedcapsule and marketed injection in a randomized crossover way. A two-compartment open model was adopted. Calculated areas under curve(AUC) were 2105 ug/ml-min 1344.31 ug/ml*min and 1456.7ug/ml*min with respective of sustained-release tablet (300mg).
    动力学特征符合二室模型,普通胶囊(300mg)和缓释片(300mg)的曲线下面积(AUC)分别为1344.31ug/ml~*min和2105ug/ml~*min;
短句来源
    The pharmacokinetics of Germanium was determined following a single oral dose of 200 mg given to each 10 volunteers in an open randomized crossover study The peak levels in serum averaged 8544±3019 ng/ml at 244 ±037 h;
    10名健康志愿者口服单剂量(200mg)有机锗胶囊,测得血清中药物浓度在2.44±0.37h达到峰值854.4±301.9ng/ml。
短句来源
    Following oral administrations of a single dose of 150 mg roxithromycin dispersible tablet (formulation A, a new formulation for clinical trial) and conventional tablet (formulation B, purchased from the market) to each of 10 healthy male volunteers in a randomized crossover design, the plasma levels of active drug at different times were determined by a microbial assay with Micrococcus luteus CMCC (B) 28001 and the plasma concentration—time profiles were obtained.
    为比较不同剂型罗红霉素的生物利用度,用微生物管碟检定法(藤黄微球菌CMCC(B)28001)测定了10名男性健康受试者口服罗红霉素分散片(制剂A)和罗红霉素片(制剂B)后不同时间血浆中活性药物的浓度,绘制了血药浓度—时间曲线。
短句来源
    A single oral dose containing 480 mg of rifampicin (RFP), 1000 mg of pyrazinamid (PZA) and 320 mg of isoniazid (INH) was given to 12 volunteers in an randomized crossover study .
    单剂量口服(内含利福平(RFP)480mg,吡嗪酰胺(PZA)1000mg,异烟肼(INH)320mg)参比药进口异福酰胺和国产试验药各4片 ,对国产复方利福平片与进口异福酰胺作人体生物利用度比较。
短句来源
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  crossover
At each iterate, by reduplication, crossover and mutation, a finite set of points can be used.
      
For the genetics algorithm, chromosome coding, fitness function, parameters selection, and the basic genetics operation including selection, crossover and aberrance, are described.
      
Eight young, healthy male volunteers were exposed to two 24 h periods of continuous wakefulness during the crossover experiment.
      
Numerical investigation of aerodynamic performance influenced by circumferentially pre-swirling coming flow on the crossover and
      
Numerical investigation is implemented on aerodynamic performance inside the crossover and de-swirling cascade of a multistage centrifugal compressor.
      
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The in vitro dissolution rates from 5mg prednisolone tablets anddropped pills were determined using de-ionized water as the dissolutionmedium. A three crossover bioavailability study was performed in 8 humanadult volunteers comparing the fastest-and slowest-dissolving brand anddropped pills. The plasma samples were assayed for prednisolone by acompetitive protein binding method. The mathematical two-compartmentmodel(oral) by digital computer program and statistical analysis of thedata for two brand tablets...

The in vitro dissolution rates from 5mg prednisolone tablets anddropped pills were determined using de-ionized water as the dissolutionmedium. A three crossover bioavailability study was performed in 8 humanadult volunteers comparing the fastest-and slowest-dissolving brand anddropped pills. The plasma samples were assayed for prednisolone by acompetitive protein binding method. The mathematical two-compartmentmodel(oral) by digital computer program and statistical analysis of thedata for two brand tablets showed significant differences between Cm.Tm.and Auc. of prednisolone samples. The dropped pills were essentiallyequivalent to the fastest tablet, but its potency was two times as highas the slowest one. The in vitro dissolution was correlated with thesein vivo results. The results of calculation on the two-compartment model show thatthe values of α and β are different from each other. A value becomes large,and the rate constant K_1, K_2, KE all positive It may be presumed thatprednisolone belongs to a two-compartment drug.

本研究系从体外试验中选择了溶解速度最快和最慢的二个不同厂的片剂与滴丸进行体内有效性试验。采用竞争性蛋白结合法测定血中强的松龙浓度。经两室模型(口服)的数学处理和电子计算机运算结果表明在两种片剂之间有显著差异。滴丸与片剂(A)是等效的,但倍效于片剂(C)。体外一体内存在相关关系。α与β值相差较大,A值也大,速度常数K_1、K_2、K_E均为正值,可以认为强的松龙属两室模型药物。

The study was carried out in a test group of six partially gastrotomized human volunteers by the urinary excretion method and results obtained were compared with a control group of nine healthy human volunteers. Both groups received three riboflavin solid dosage forms with two different dosage regimens in a crossover design. The observed data were fitted to a two compartment model by using the PKP Ⅱ (2) digital computer program on a microcomputer for both dosage regimens for each subject.A significant...

The study was carried out in a test group of six partially gastrotomized human volunteers by the urinary excretion method and results obtained were compared with a control group of nine healthy human volunteers. Both groups received three riboflavin solid dosage forms with two different dosage regimens in a crossover design. The observed data were fitted to a two compartment model by using the PKP Ⅱ (2) digital computer program on a microcomputer for both dosage regimens for each subject.A significant difference in the amount of excretion of riboflavin was found between the two groups, urinary recovery of riboflavin was lower in the test group than in the control group (P<0.01). In comparing the pharmacokinetic parameters, Ka was significantly greater and Tmax was significantly less in the test group than in the control group, but no statistically significant difference in the values of β was observed.These differences are attributed to gastric emptying rates as well as the dissolution rates of the dosage forms.These results suggest that it is practically possible to increase the bioavailability of persons after partial gastroctomy by administering rapid release preparations or by multiple dosage regimen,

以胃大部切除术(Billroth Ⅰ式)后已恢复健康的人为对象,研究核黄素的不同剂型、不同给药方法的生物利用度及动力学参数,将结果与正常人对比(对照组),探讨提高生物利用度的方法。数据处理按PKPⅡ(2)程序在微型计算机上进行。结果表明,胃大部切除者的核黄素口服吸收率低于正常人,而吸收速度大于正常人,动力学参数Ka、Tmax在胃切除组与对照组间可有非常显著或显著的差异,而β无显著差异。作者认为提高胃大部切除者的核黄素生物利用度,可通过制成释放速度较快的制剂或采用小剂量多次给药的方案来实现。

In order to avoid high initial peak of the commercially available indomethacin formulation and increase the interval between dosages, comparison of three sustained release indomethacin capsules on pellet coated with Eudragit-E_((?)0)D and a commercially available tablet was carried out by testing in vitro the dissolution behaviour and in vivo bioavailability. Dissolution studies on three batches of pellet capsules with varying drug to coat material ratios (mg/cm~2) exhibited a sustained release pattern. In vivo...

In order to avoid high initial peak of the commercially available indomethacin formulation and increase the interval between dosages, comparison of three sustained release indomethacin capsules on pellet coated with Eudragit-E_((?)0)D and a commercially available tablet was carried out by testing in vitro the dissolution behaviour and in vivo bioavailability. Dissolution studies on three batches of pellet capsules with varying drug to coat material ratios (mg/cm~2) exhibited a sustained release pattern. In vivo serum level for 8 adult male subjects of randomized crossover design showed no statistical difference in bioavailability between different capsule formulations and a tablet formulation available on the market. However, these three capsule formulations demonstrated a higher and smoother serum concentrationtime curves than that of the tablet formulation from 4 to 12 h following a single dose(50mg). The serum level of three capsule formulations was significantly higher than that of the tablet formulation (P<0.1) at the 12th h respectively. In vitro dissolution behaviour and in vivo bioavailability, the linear relationships were found between T_(50) or T_(m(?)x) and drug to coat material ratios.

消炎痛普通制剂口服吸收迅速,可出现不必要的高血药浓度,导致不良反应。为此我们对三种消炎痛缓释胶囊(A,B,C)和一种常用片剂(D)作了体外溶出试验和体内生物利用度比较。胶囊制剂由丙烯酸类树脂材料E_(30)D包衣的药物小丸制成,其体外溶出行为显示缓慢释放图象。在8名成年男性交叉实验中,不同胶囊制剂和普通片剂之间的Tmax,Cmax和AUC_(0~124)经方差分析无统计学差异,但是在给药后4至12小时的血清浓度—时间曲线,均比普通片剂高而平滑。在第12小时,三种胶囊产生的血清浓度显著高于普通片剂(P<0.1)。根据体外溶出行为和体内生物利用度发现T_(50)或Tmax和包衣厚度呈良好线性关系。

 
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