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系膜细胞增殖     
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  mesangial cell proliferation
     Results 1.Ox-LDL(80μg/ml) stimulated mesangial cell proliferation;
     结果1.Ox-LDL(80μg/ml)刺激系膜细胞增殖;
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     2.Ox-LDL(10μg/ml-80μg/ml)increased the expression of HGMCs TGF-β1 mRNA in a concentration-dependent manner; 3.Atorvastatin (6μg/ml-12μg/ml)inhibited mesangial cell proliferation and attenuated TGF β1 mRNA and p38MAPK expression upregulation induced by Ox-LDL.
     2.Ox-LDL(10μg/ml-80μg/ml)以浓度依赖的方式增加HGMCs TGF-β1 mRNA和p38MAPK蛋白表达,3.Atovastatin(6μg-12μg/ml)抑制系膜细胞增殖,降低ox-LDL引起的TGF-β1 mRNA表达上调,抑制p38MAPK信号途径激活。
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     Role of Akt/NF-κB signal transduction pathway in murine glomerular mesangial cell proliferation induced by immune complex
     Akt/NF-κB信号途径在免疫复合物诱导肾系膜细胞增殖中的作用
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     Lovastatin in regulation of mesangial cell proliferation and activity of TGF-β1 promoter in rats
     洛伐他汀对大鼠系膜细胞增殖及TGF-β1基因启动子活性的调控
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     Prostaglandin (PG) E_2 inhibited serum-stimulated mesangial cell proliferation.
     前列腺素E2(prostaglandin,PG)抑制血清所致的系膜细胞增殖
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  proliferation of mesangial cells
     Results 1. 10ng/ml HB-EGF could not stimulate the proliferation of mesangial cells﹙P>0.05﹚, but it in the concentration of 100ng/ml and 1000ng/ml could obviouslystimulate the proliferation of cells﹙P<0.01﹚. The most remarkable proliferation effectwas observed by 100ng/ml﹙P<0.01﹚.
     结果1. 10ng/ml HB-EGF 无刺激系膜细胞增殖作用﹙与对照组比较P>0.05﹚,但100ng/ml、1000ng/ml HB-EGF 均能明显刺激系膜细胞增殖﹙与对照组比较P<0.01﹚,且100ng/ml 时作用最明显﹙100 ng/ml 组与各组比较P<0.01﹚。
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     Effect of Heparin on the Proliferation of Mesangial Cells and the Expression of PAI-1
     肝素对大鼠系膜细胞增殖和PAI-1表达的影响
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     Thrombin promoted proliferation of mesangial cells, and enhanced the expression of ICAM1, MMP2, and MMP9 in mesangial cells.
     凝血酶还可以促进系膜细胞增殖、表达ICAM-1、纤溶酶原激活物抑制物-1(PAI-1)、基质金属蛋白酶-2(MMP-2)及基质金属蛋白酶-9(MMP-9)。
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     [Conclusions] The proliferation of mesangial cells and the expression of COX-2 are induced by LDL,when the LDL concentration is from 0.000 to 50.000 μg/mL,the proliferation of mesangial cell is correlated with LDL concentration,and the expression of COX-2 is correlated with LDL concentration and the proliferation of mesangial cell.
     结论LDL可以诱导系膜细胞增殖,上调COX-2表达,在LDL0.000~50.000μg/mL的范围内,系膜细胞增殖与LDL浓度具有相关性,COX-2的表达与LDL浓度、系膜细胞增殖具有相关性。
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     Conclusion Low level of TGF-β1 can trigger the proliferation of rat mesangial cells,induce the expression of PAI-1,and high level of TGFβ1 can inhibit the proliferation of mesangial cells.
     结论:低剂量TGF-β1促进大鼠系膜细胞增殖、诱导PAI-1表达; 高剂量TGF-β1则抑制系膜细胞增殖
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  proliferation of mesangial cell
     The expression of COX-2 mRNA and protein were upregulated by LDL of the concentration from 3.125 to 100.000 μg/mL,when the LDL concentration was from 0.000 to 50.000 μg/mL,the expression of COX-2 mRNA and protein was correlated with LDL concentration and the proliferation of mesangial cell.
     以浓度为3.125~100.000μg/mL的LDL刺激系膜细胞,可上调COX-2mRNA和蛋白的表达,在LDL0.000~50.000μg/mL的范围内,COX-2mRNA和蛋白的表达与LDL浓度、系膜细胞增殖呈正相关。
短句来源
     30 mmol/L glucose could significantly accelerate the proliferation of mesangial cell than that of 10 mmol/L glucose from 24 hours to 96 hours P < 0.05 or P < 0.01 and this effect was increasing with time in 72 hours and reduced after 72 hours.
     30mmol/L葡萄糖在实验的24h至96h里均能显著促进系膜细胞增殖(P<0.05或P<0.01),72h内随着作用时间的延长,促进增殖作用越明显,72h后作用减弱,但仍有统计学意义;
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     RUSULTS ① Effect of different concentrations glucose on the proliferation of mesangial cell Compared with low concentrations glucose 10 mmol/L 20 mmol/L glucose could accelerate the proliferation of mesangial cell during 96 hours experiment period but only had a statistically significant difference at 72 and 96 hours P < 0.05.
     结果:①不同浓度的葡萄糖对系膜细胞增殖的影响:与低糖组(10mmol/L)比较,20mmol/L葡萄糖在实验的96h里能促进系膜细胞增殖,但仅在72h和96h具有统计学意义(P<0.05)。
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     40 mmol/L glucose could significantly increase the proliferation of mesangial cell than of low concentrations glucose in 48 hours P < 0.05 and this effect was reduced after 48 hours and even conversed to restrain effect.
     40mmol/L浓度的葡萄糖在48h内对系膜细胞增殖有促进作用(P<0.05),48h后作用减弱,甚至转为抑制。
短句来源
     [Conclusions] The proliferation of mesangial cells and the expression of COX-2 are induced by LDL,when the LDL concentration is from 0.000 to 50.000 μg/mL,the proliferation of mesangial cell is correlated with LDL concentration,and the expression of COX-2 is correlated with LDL concentration and the proliferation of mesangial cell.
     结论LDL可以诱导系膜细胞增殖,上调COX-2表达,在LDL0.000~50.000μg/mL的范围内,系膜细胞增殖与LDL浓度具有相关性,COX-2的表达与LDL浓度、系膜细胞增殖具有相关性。
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  mesangial cells proliferation
     Conversely,lower expression of TGF β1 stimulated mesangial cells proliferation,decreased the lerel of PAI-1 mRNA and protein,and increased the activity of tPA.
     而低表达TGF β1的系膜细胞增殖加速 ,其PAI 1mRNA和蛋白表达降低 ,tPA酶活性增强。
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     RESULTS: AGEs (0-200 mg/L) did not influence mesangial cells proliferation, but stimulated FN , collagen IV and PAI-1 contents in mesangial cell cultured medium in different degrees.
     结果:与相应浓度的BSA比较,AGEs(0-200mg/L)对系膜细胞增殖无明显影响,但可不同程度地刺激系膜细胞FN、Ⅳ型胶原、PAI-1蛋白的产生。
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     Conclusion quercetin could significantly inhibit mesangial cells proliferation and make it arrest in GO/G1 phase and induce the cell apoptsis.
     结论槲皮素可显著抑制系膜细胞增殖,使系膜细胞阻滞于GO-G1期;
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     Effect of EGCG on Mesangial Cells Proliferation Cultured Condition and Expression of Cyclin Kinase Inhibitor p27 in High Glucose
     EGCG对高糖培养的系膜细胞增殖及周期素激酶抑制剂P27的作用
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     fiberonectin and typeⅣcollagen contents were detected by ELISA. Results Administration of 5~20μmol/L quercetin into culture medium could significantly inhibit mesangial cells proliferation in dose and time-dependent manner,subsequently increased the cells in GO/G1 phase and decreased the cells in S phase.
     结果在5~20μmol/L浓度范围内槲皮素能时间、剂量依赖性地抑制系膜细胞增殖,可使GO-G1期细胞增多,S期细胞减少,而较高浓度的槲皮素能剂量依赖性诱导系膜细胞的凋亡。
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  mesangial cell proliferation
Histological examination showed cell swelling, break-down and massive lipid deposition in renal tubules; perivascular and interstitial cell infiltration and mesangial cell proliferation.
      
A metabolic (WST-1) assay was used to measure mesangial cell proliferation and Western blot analysis was used to measure MMPs expression of mesangial cells.
      
Conclusions This study suggests that glucose can accelerate mesangial cell proliferation while heparin can reduce proliferation, being more obvious at high glucose concentrations.
      
Increasing evidence supports a role for glomerular mesangial cell proliferation and overproduction of extracellular matrix by mesangial cells in the development of focal or diffuse glomerulosclerosis.
      
While a multitude of mitogens for mesangial cells has been proposed on the basis of in vitro experiments, the factors involved in the regulation of mesangial cell proliferation in vivo remain largely undefined.
      
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  proliferation of mesangial cells
The main aim of this study is to explore whether heparin inhibits proliferation of mesangial cells grown in high glucose concentration and to measure the effect of heparin on matrix metalloproteinases (MMPs) expression in mesangial cells.
      
The proliferation of mesangial cells on cyclosporin (CsA) test medium was studied by MTT assay and TNF-α in cultured supernatant was examined by using ELISA.
      
The results showed that cyclosporin A significantly inhibited the proliferation of mesangial cells at the concentration between 0.
      
Both forms are characterized by a differently severe proliferation of mesangial cells and by a mostly extensiv thickening of the glomerular basement membrane.
      
The proliferation of mesangial cells and thickening of the glomerular basement membrane is more severe in the lobular form of MPGN.
      
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  mesangial cells proliferation
It was reported heparin could inhibit mesangial cells proliferation in vitro.
      
In the presence of heparin, mesangial cells proliferation was inhibited, which was more obvious at high glucose concentrations than at low glucose concentrations.
      
  其他


In this study, renal biopsy specimens from 150 cases of IgA nephropathy were studied with light-and electron microscopically. Histological lesions from minimal change to diffuse mesangial proliferation were observed. According to the degree of the renal lesions, the 150 cases were divided into 6 subtypes. Proliferation of mesangial matrix was found to be the striking ultrastructural alteration, which often appeared as focal segmental or global proliferation of mesangial cells, as well as marked increase in mesangial...

In this study, renal biopsy specimens from 150 cases of IgA nephropathy were studied with light-and electron microscopically. Histological lesions from minimal change to diffuse mesangial proliferation were observed. According to the degree of the renal lesions, the 150 cases were divided into 6 subtypes. Proliferation of mesangial matrix was found to be the striking ultrastructural alteration, which often appeared as focal segmental or global proliferation of mesangial cells, as well as marked increase in mesangial matrix. Electron-dense deposits were largely localized in mesangial matrix and in suben dothelial regions. However, no positive correlation could be seen between the number of the deposits and the degree of the lesions.

对150例IgA肾病的肾活检标本进行了光镜及透射电镜的形态学观察,[其组织学改变由轻微病变至弥漫性系膜增殖,根据病变的严重程度作者将其分为6个亚型。系膜基质的增生为其突出的超微结构改变,常显示为局灶节段性、球性系膜细胞增殖和显著的系膜基质的增加。电子致密沉着多见于系膜基质及内皮细胞下,这些沉着物的多少与病变的严重程度未见有肯定的联系。

In this paper. the effects of serum from 38 patients with IgA nephropathy on cultured gloumerular mesangial cells in vitro were studied. the IgA-CIC, IgG-CIC and IgM-CIC in the serum were measured by using ELISA. The results were summarized as follows: 1. the ~3H-TdR uptake into mesangial cells was markedly enhanced (P<0.01) by the serum of IgA nephropathy on culture medium, and the increment was closely related to the severity of glomerular pathological changes (r=0.429; 2. the levels of IgA-CIC and IgG-CIC...

In this paper. the effects of serum from 38 patients with IgA nephropathy on cultured gloumerular mesangial cells in vitro were studied. the IgA-CIC, IgG-CIC and IgM-CIC in the serum were measured by using ELISA. The results were summarized as follows: 1. the ~3H-TdR uptake into mesangial cells was markedly enhanced (P<0.01) by the serum of IgA nephropathy on culture medium, and the increment was closely related to the severity of glomerular pathological changes (r=0.429; 2. the levels of IgA-CIC and IgG-CIC increased in the serum of patients with IgA nephropathy than those in normal controls (P<0.05); and 3. there was a close relationship between the amount of urinary protein and the degree of renal pathological changes (r=0.616).

本研究采用系膜细胞培养技术观察了38例IgA肾病患者血清对系膜细胞增殖的影响,并采用ELlSA方法检测了血清中循环免疫复合物(CIC)的浓度,结果发现,IgA肾病血清对系膜细胞的增殖有明显刺激作用,而且这种刺激作用与肾组织病理改变程度成正相关,IgA肾病血清中IgA-CIC和IgG-CIC均较正常人明显增高,但血中IgA水平与系膜增殖及病理改变程度无相关性。

Our previous investigation proved that Emodin can inhibit the proliferation of mesangial cells. To explore its possible molecular mechanism, the effect of Emodin on the expression of c-myc mRNA in cultured rat mesangial cells were observed by dot hybridization. Mesangial cells (2×10~6) made quiescent by exposure to a defined serum-free medium were used in the experiment. Addition of LPS(10μg/ml) resulted in a high level expression of the proto-oncogene c-myc mRNA within 30 min which persisted for 6h. Interestingly,...

Our previous investigation proved that Emodin can inhibit the proliferation of mesangial cells. To explore its possible molecular mechanism, the effect of Emodin on the expression of c-myc mRNA in cultured rat mesangial cells were observed by dot hybridization. Mesangial cells (2×10~6) made quiescent by exposure to a defined serum-free medium were used in the experiment. Addition of LPS(10μg/ml) resulted in a high level expression of the proto-oncogene c-myc mRNA within 30 min which persisted for 6h. Interestingly, this effect can ben inhibited promptly by Emodin (25μg/ml) in 30 min and peaked in 2.5h. It was suggested that Emodin may participate in the regulation of cell-cycle, and the down-regulation effect of Emodin on c-mye mRNA over-expression might contribute to the inhibitory action of Emodin on mesangial cell proliferation.

为了进一步阐明大黄抑制系膜细胞增殖作用的分子机理。本研究应用斑点杂交技术观察了大黄素对大鼠系膜细胞c-myc原癌基因mRNA表达的影响,发现大黄素能有效地抑制由LPS诱导的系膜细胞c-myc癌基因的过度表达,加大黄素0.5h后c-myc mRNA的表达比原有水平降低50%,2.5h后降低75%,一直持续到6h后。该结果表明,大黄素可能通过影响c-myc癌基因表达而参与细胞周期的调控,其对LPS诱导c-myc癌基因mRNA过度表达的负性调节体用,可能是它抑制系膜细胞增殖的机理之一。

 
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