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rb gene     
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  rb基因
     Results:The positive expression rates of PCN A,p53,and Rb gene proteins were 84.7%(72/85),54.1%(46/85),58.8%(50/85)in the malignant group,but were 40%(17/42),16.7%(7/42),21.4%(9/42)in the benign group,respectively.
     结果:PCNA、p53、Rb基因产物在恶性组中的阳性表达率分别为84.7%72/85,54.1%46/85,58.8%50/85; 良性组中分别为40%17/4216.7%7/42,21.4%9/42。
短句来源
     The expression of c-myc、Rb gene mRNA were detected by RT-PCR.
     半定量RT-PCR分析c-myc、Rb基因mRNA的表达。
短句来源
     The study on mechanism of enhancing bystander effect of HSV-TK/GCV system by Rb gene
     Rb基因增强HSV-TK/GCV系统“旁观者效应”的机制研究
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     Effect of blocking BRCAA1 gene with siRNA on proliferation of MCF-7 cells and expression of Rb gene
     siRNA封闭BRCAA1基因对乳腺癌细胞MCF-7增殖和Rb基因表达的影响
短句来源
     RESULTS Positive rates of p15, Rb gene are 63%, 43% respectively.
     结果  p15基因阳性表达率为 6 3% ,Rb基因阳性表达率为 43% .
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  rb基因的
     Conclusions:(1) The results suggested P16 P53 Rb gene play important roles in occurance and development of BTCC,P16 gene major in deletion and P53 major in mutation.
     结论:①P16、P53、Rb基因的变化在膀胱癌发生发展中有重要作用,P16基因第2外显子以缺失为主,P53基因第5-8外显子以突变为主;
短句来源
     Expression and significance of p15 and Rb gene in human hepatocellular carcinoma tissue
     人肝细胞癌组织p15及Rb基因的表达意义
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     THE DETECTION OF RB GENE IN ORAL SQUAMOUS CELL CARCINOMA
     口腔鳞状细胞癌Rb基因的检测
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     Conclusion: the over-expression of E2F-1 gene and the low expression of Rb gene may contribute synergistically to the development and progression of lung cancer.
     结论:E2F-1基因的过度表达以及Rb基因的表达缺失或减低对肺癌的发生发展起协同促进作用。
短句来源
     mRNA expression of HSV-TK gene was demonstrated in OS732TK and OS732RbTK cells. Both exogenous and endogenous Rb gene expression could be detected in OS732Rb and OS732RbTK cells si-multa neously.
     并在mRNA水平检测到OS732TK和OS732RbTK细胞内HSV-TK基因的表达,在OS732Rb和OS732RbTK细胞内存在内源性和外源性Rb基因的表达;
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  rb表达
     Significance of p53, p16 and Rb gene expressions in tissues of human osteosarcoma and bone fibrous dysplasia
     人成骨肉瘤及骨纤维结构不良组织P53,P16及Rb表达的意义
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     THE EFFECT OF 9-cis-RA ON c-erB-2 AND Rb GENE EXPRESSION IN HUMAN LUNG CANCER CELL LINES
     9顺维甲酸对肺鳞、腺癌细胞株c-erbB-2和Rb表达的影响
短句来源
     The positivity rate of Rb expression in breast carcinomas was 36 2%(21/58) while there was a significant difference compared with that of benign breast tissues 75%(18/24) P<0 05 . The relevant analysis between the expression of cyclinD 1 gene and that of Rb gene suggested that overexpression of cyclinD 1 was positive relevant with Rb expression.
     乳腺癌中Rb蛋白表达阳性率为36.2%(21/58),显著低于良性乳腺组织的75%(18/24),P<0.05; 未见Rb失表达与临床病理参数间存在相关性,Rb表达与cyclinD1过表达呈正相关。
短句来源
     ②In A2 and A549,there was no Rb gene expression in experimence and control groups. In L78,a significant differential showed between experimental and control group.
     ②A2、A549实验组、对照组Rb未见表达 ,L78实验组Rb表达率 9 8% ,对照组Rb无表达 ,差异显著(P <0 0 1)。
短句来源
     ④The increase of Rb gene expression by 9 cis RA in L78 may have relationship with inducing apoptosis.
     ④ 9 cis RA处理后L78细胞株中Rb表达增加可能与诱导细胞凋亡有关。
短句来源
  “rb gene”译为未确定词的双语例句
     The negative or absent rate of Rb gene in lung cancer and normal lung tissues were 23. 3% (14/60) and 6. 3% (2/32) respectively ( P < 0. 05 ).
     抑癌基因Rb在正常组织与肺癌组织中的表达缺失率分别为6.3%(2/32)和23.3%,(14/60),P<0.05。
短句来源
     The overall incidences of Ha-ras, p53 and RB gene mutation and HPV infection in tumor were 61.5% ,36% ,30.8% and 15.4% , respectively.
     结果表明,膀胱癌组织中HPV16、18感染率及Ha-ras、p53、RB基因变异率分别为61.5%、36%、30.8%及15.4%;
短句来源
     P16 Rb gene expressions were related to the tumor grade(p<0.05);
     P16、Rb与病理分级密切相关(p<0.05)。
短句来源
     PCR-SSCP-HA analysis of ex-on24 showed that MC4-11 and MC3-138 had abnormal bands, but MC2-11 and MC3-ll weren't found mutation of Rb gene.
     SO-Rb50细胞系第775代的3个克隆株MC2、MC3及MC4的第11代细胞,只有MC4第24外显子突变;
短句来源
     Rb gene protein positive expression rate in tumor tissues was 51.4%,which was also lower than that in normal mucosal tissues of colon and rectum (χ2=4.234,P< 0.05); Rb protein positive expression correlated significantly with lymph node metastasis(χ2=14.596, P< 0.05), but did not correlated with tumor cell differentiation( P >0.05).
     Rb蛋白阳性表达率在大肠腺癌组织中为51.4%,显著低于正常大肠黏膜组织(χ2=4.234,P<0.05),并与大肠腺癌淋巴结转移有关(χ2=14.596,P<0.05),但与组织分化程度无关(P>0.05);
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  rb gene
We detected allelic losses in the Rb gene and in exon 4 of the TP53 gene in a tumor region corresponding to a glioblastoma multiforme.
      
In addition, Rb gene repression is dependent on the nature of Rb-E2F interaction and the activity of the Rb-bound proteins recruited to the promoter.
      
Gossypol plasma levels were measured (n=8) and the modulation of the retinoblastoma (Rb) gene protein and Cyclin D1 was assessed by serial biopsies (n=4).
      
Those cases showing LOH in the region of the RB gene, 13q14, were excluded from the study.
      
The retinoblastoma (RB) gene is the first such gene to be identified, and was isolated based on its chromosome localization and on the recessive nature of the tumor phenotype.
      
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Retinoblastoma(Rb)is a malignant eye tumor of childhood and a desirable model for the genetic study of oncogenesis in human being. The results of genetic investigation of RB since 1982 in WCUMS were summerized in this paper. 1.Clinical genetic studies of RB The records of 327 patients with RB between 1958 and 1986 were reviewed.The clinical investiga- tion included the laterality of the involved eyes,the mean age at diagnosis,the secondary malignant neoplasm in survivors,the spontaneous...

Retinoblastoma(Rb)is a malignant eye tumor of childhood and a desirable model for the genetic study of oncogenesis in human being. The results of genetic investigation of RB since 1982 in WCUMS were summerized in this paper. 1.Clinical genetic studies of RB The records of 327 patients with RB between 1958 and 1986 were reviewed.The clinical investiga- tion included the laterality of the involved eyes,the mean age at diagnosis,the secondary malignant neoplasm in survivors,the spontaneous regression of the tumor and RB in twins. 2.Cytogenetic studies of RB (1)Among 56 patients examined for chromosome constitution,4 cases showed abnormal or variant karyotypes:46,XY/46,XY,del(13)(q14.1 q14.3).46, XY,var(15)(p13,F55)mat.46,X,del(Y)(q12)pat. 46,XY,inv(9)(P13q13). (2)Chromosome fragility study in 14 RB patients and their parents showed an increased frequency of chromosome aberration in contrast with control group.Several chromosome fragile sites in RB patients were found. (3)The results of chromosomal study of solid tumor cells from 50 samples of RB showed that in all cases there were aberration of chromosome both in number and in structure.The commonest aber- ration was an i(6p)chromosome,and double minutes (DM),homogeneously staining regions(HSR)were found. 3.The esterase D(EsD)activity and phenotype of the red blood cells in 34 patients with RB were examined,but the EsD activity showed no differ- ence between the patients and the control groups. The same examinations performed in the RB tumor cells form 11 patients revealed that either one or both EsD alleles in tumor cells were inactivated,or that the tumor cells exhibited only one of the two isozvmic types of the EsD,but the red blood cells showed heterozygous at the EsD locus.These observations indicated that in RB tumor cells there were loss,inactivation or reduction to homozygosity at RB and EsD locus on 13q,this may be important for oncogenesis. 4.With the review of literature,it was thought that the Rb gene located at 13q14 may be a pair of allelic inhibitive genes which controls some potential cancer genes(proto-oncogene).If the allelic in hibi tive genes are inactivated or lost with some reasons, the cancer genes will be freed from the inhibitive gene,and cause the induction of RB.

视网膜母细胞瘤(简称 RB)是研究肿瘤遗传学的理想的天然模式。本文总结了自1982年以来对 RB 遗传学的研究。内容包括患病年龄、患病眼别、存活者的第二恶性肿瘤、肿瘤的自发消退、双生子患者等临床遗传学问题;RB 患者外周血淋巴细胞和肿瘤细胞染色体改变、染色体脆性部位等细胞遗传学问题;以及患者红细胞和瘤细胞酯酶 D 活性和表型改变等生化遗传学问题。对 RB 的发病机理进行了初步探讨,认为癌基因和抗癌基因平衡失调是 RB 为代表的一大类恶性肿瘤发病的关键。

We found the change of proliferation with 6.2kb Hind ⅠⅡ fragment of Rb gene inretinoblastoma while the Rb gene was detected.The existence of proliferation of Rb genein retinoblastoma is first reported by us.It is contrary to the current theory that Rb geneis an antioncogene and the deletions of Rb gene is responsible for the tumorigenesis ofretinoblastoma.It is possible that the proliferation of Rb gene plays an important rolefor the tumorigenesis,so we discuss the finding preliminarily...

We found the change of proliferation with 6.2kb Hind ⅠⅡ fragment of Rb gene inretinoblastoma while the Rb gene was detected.The existence of proliferation of Rb genein retinoblastoma is first reported by us.It is contrary to the current theory that Rb geneis an antioncogene and the deletions of Rb gene is responsible for the tumorigenesis ofretinoblastoma.It is possible that the proliferation of Rb gene plays an important rolefor the tumorigenesis,so we discuss the finding preliminarily

在对视网膜母细胞瘤病人的Rb 基因存在状态进行检测时,发现一例患者体细胞Rb 基因有明显扩增改变。Rb 基因在视网膜母细胞瘤患者中的扩增改变,为首次报导,是否意味着Rb 基因扩增与肿瘤发生有着某种关联。

The deletion and rearrangement of p53 and Rb genes were studied in gastric cancer with Southern blot hybridization and the point mutation in 248 and 249 codons of p53 was studied with PCR-RFLP.It was found that deletion or rearrangement of p53 was seen in 9 cases out of 30 cases of gastric cancer and point mutation at 248 codon of p53 in 2 cases out of 42 cases,and deletion and rearrangement of Rb gene were seen in 2 cases out of 15 cases.

本文使用Southern杂交方法分析了胃癌组织中p53基因和Rb基因的缺失和重排;使用PCR-RFLP技术分析了p53基因第248位、249位密码子的点突变。研究结果显示:30例胃癌组织中9例有p53基因的缺失或重排;42例胃癌组织中两例有p53基因第248位密码子的点突变;15例胃癌组织中两例有Rb基因的缺失和重排。

 
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