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rb gene
相关语句
  rb基因
    Effect of blocking BRCAA1 gene with siRNA on proliferation of MCF-7 cells and expression of Rb gene
    siRNA封闭BRCAA1基因对乳腺癌细胞MCF-7增殖和Rb基因表达的影响
短句来源
    In order to study the relationships between p53,Rb gene and Chinese os-teosarcoma,authers used labelled streptavidin-biotin method(LSAB)to detect the expressionof p. 53 and Rb protein in 30 human osteosarcomas,15 human normal bone and 15 human fetalbone tissues,respectively.
    为了研究p53、Rb基因和国人骨肉瘤的关系,作者应用LSAB免疫组织化学方法检测了30例人骨肉瘤、15例胎儿骨和15例正常骨组织中p53蛋白和Rb蛋白的表达情况。
短句来源
    Objective: To investigate the role of Rb gene in inhibiting breast cancer MCF-7 cells induced by genistein.
    目的:研究Rb基因在染料木黄酮(genistein,Gen)抑制人乳腺癌细胞MCF-7细胞增殖中的作用。
短句来源
    [Objective] To study the effects of Rb gene on the growth of osteosarcoma cells.
    目的从分子水平研究Rb基因对骨肉瘤生长的影响,为骨肉瘤的基因治疗提供依据。
短句来源
    Objective:To investigate the effect of blocking BRCAA1 gene expression with siRNA on the proliferation of tumor cell line MCF-7 and Rb gene expression.
    目的:研究siRNA封闭乳腺癌抗原相关基因1(BRCAA1)对乳腺癌细胞MCF-7增殖和Rb基因表达的影响。
短句来源
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  “rb gene”译为未确定词的双语例句
    Methods:Cyclin D1,Rb gene product and ER were immunostained by S P immunohistochemical method from 86 cases of breast carcinoma.
    方法 :应用甲醛固定石蜡包埋切片行免疫组化染色 ( S- P法 ) ,检测 cyclin D1、Rb、ER在 86例乳腺癌、1 2例乳腺纤维腺瘤和 1 2例乳腺增生病中的表达。
短句来源
    Objective To study the association between RB gene and the oncogenesis of bone tumors.
    目的探讨抑癌基因RB的改变与骨肿瘤的关系。
短句来源
    Methods Southern blot and immunohistochemical techniques were used to detect the structural anomalies of RB gene in 34 cases of bone tumors and the expression of RB protein in 99 paraffinembedded bone neoplasma.
    方法采用地高辛标记的RBcDNA探针对34例侵袭性骨肿瘤组织及同体正常软组织进行SouthernBlot检测,同时应用LSAB免疫组化法对99例侵袭性骨肿瘤及14例瘤旁软组织进行RB蛋白表达的检测。
短句来源
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  rb gene
We detected allelic losses in the Rb gene and in exon 4 of the TP53 gene in a tumor region corresponding to a glioblastoma multiforme.
      
In addition, Rb gene repression is dependent on the nature of Rb-E2F interaction and the activity of the Rb-bound proteins recruited to the promoter.
      
Gossypol plasma levels were measured (n=8) and the modulation of the retinoblastoma (Rb) gene protein and Cyclin D1 was assessed by serial biopsies (n=4).
      
Those cases showing LOH in the region of the RB gene, 13q14, were excluded from the study.
      
The retinoblastoma (RB) gene is the first such gene to be identified, and was isolated based on its chromosome localization and on the recessive nature of the tumor phenotype.
      
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In order to study the relationships between p53,Rb gene and Chinese os-teosarcoma,authers used labelled streptavidin-biotin method(LSAB)to detect the expressionof p.53 and Rb protein in 30 human osteosarcomas,15 human normal bone and 15 human fetalbone tissues,respectively.The results showed that there were high levels of expression of p53 protein and low levels of Rb protein in osteosarcomas,which owned dramaticly statisticaldifference contrast to those in normal bone and fetal bones respectively(P<0.05).Besides,the...

In order to study the relationships between p53,Rb gene and Chinese os-teosarcoma,authers used labelled streptavidin-biotin method(LSAB)to detect the expressionof p.53 and Rb protein in 30 human osteosarcomas,15 human normal bone and 15 human fetalbone tissues,respectively.The results showed that there were high levels of expression of p53 protein and low levels of Rb protein in osteosarcomas,which owned dramaticly statisticaldifference contrast to those in normal bone and fetal bones respectively(P<0.05).Besides,the relationships between the expression of p53 and Rb protein was negative correlation(rs=-0.414,P<0.05).The results suggest that the mutation of p53 gene and abnormalities ofRb gene may plaY some roles in genisis of human osteosarcoma.

为了研究p53、Rb基因和国人骨肉瘤的关系,作者应用LSAB免疫组织化学方法检测了30例人骨肉瘤、15例胎儿骨和15例正常骨组织中p53蛋白和Rb蛋白的表达情况。结果发现,与正常骨和胎儿骨相比,骨肉瘤中有高水平的p53蛋白和低水平Rb蛋白表达,差异均有显著意义(P<0.05)。此外还发现,骨肉瘤中p53蛋白和Rb蛋白的表达结果呈负相关(r=-0.414,P<0.05)。本研究结果提示,p53基因突变和Rb基因异常在骨肉瘤的发生中可能起着一定的作用。

Objective To study the association between RB gene and the oncogenesis of bone tumors. Methods Southern blot and immunohistochemical techniques were used to detect the structural anomalies of RB gene in 34 cases of bone tumors and the expression of RB protein in 99 paraffinembedded bone neoplasma. Results The deletion and/or rearrangement of RB gene were detected only in 42.9%(9/21) of osteosarcoma; lack of RB protein expression was noticed in 12 cases including 7 cases of...

Objective To study the association between RB gene and the oncogenesis of bone tumors. Methods Southern blot and immunohistochemical techniques were used to detect the structural anomalies of RB gene in 34 cases of bone tumors and the expression of RB protein in 99 paraffinembedded bone neoplasma. Results The deletion and/or rearrangement of RB gene were detected only in 42.9%(9/21) of osteosarcoma; lack of RB protein expression was noticed in 12 cases including 7 cases of osteosarcoma (7/26, 26.9%) and 5 cases of chondrosarcoma (5/23, 21.7%). Beniga giant cell tumor of bone and chondroblastoma showed positive RB protein expression; osteosarcoma cells presenting poor differentiation and apparent atypia all showed no expression of RB protein. Most of the highgrade chondrosarcoma also had no RB protein expression. Conclusion The alterations of RB gene and loss of RB protein may play a role in the pathogenesis and progression of malignant bone neoplasms.

目的探讨抑癌基因RB的改变与骨肿瘤的关系。方法采用地高辛标记的RBcDNA探针对34例侵袭性骨肿瘤组织及同体正常软组织进行SouthernBlot检测,同时应用LSAB免疫组化法对99例侵袭性骨肿瘤及14例瘤旁软组织进行RB蛋白表达的检测。结果21例骨肉瘤中有9例可检出RB基因的结构异常(42.9%),RB蛋白的缺失仅在26.9%(7/26)的骨肉瘤和21.7%(5/23)的软骨肉瘤中检测到,良性的骨巨细胞瘤和软骨母细胞瘤中未检出RB蛋白的缺失,其二者差异有意义(P<0.05);分化差、异型性明显的骨肉瘤细胞其RB蛋白表达为阴性,低分化的软骨肉瘤及间叶性软骨肉瘤其RB蛋白亦多为阴性。结论RB基因结构的异常、RB蛋白的缺失,可能与骨的恶性肿瘤的发生及其演进有关。

Purpose To study the relationship between the expressions of cyclinD 1 gene as well as Rb gene in breast carcinoma and the pathogenesis of the carcinoma. Methods The expressions of cyclinD 1 protein and Rb protein were studied by ABC immunohistochemical labelling in both 24 cases of benign breast tissues and 58 cases of breast carcinoma. Results The positivity rate of cyclinD 1 overexpression in the breast carcinoma was 58 62%(34/58), while there was a significant difference compared...

Purpose To study the relationship between the expressions of cyclinD 1 gene as well as Rb gene in breast carcinoma and the pathogenesis of the carcinoma. Methods The expressions of cyclinD 1 protein and Rb protein were studied by ABC immunohistochemical labelling in both 24 cases of benign breast tissues and 58 cases of breast carcinoma. Results The positivity rate of cyclinD 1 overexpression in the breast carcinoma was 58 62%(34/58), while there was a significant difference compared with that of benign breast tissues 16 67%(4/24), P<0 05 . The overexpression of cyclinD 1 had been all observed in the ductal invasive carcinoma as well as metastasis foci in lymphode, which originally detected from the ductal carcinomas in situ. There was no significant difference between cyclinD 1 overexpression and histologic type, tumor size, age of patient as well as lymphiod status, while there was a inverse significant difference between the histologic grades. The positivity rate of Rb expression in breast carcinomas was 36 2%(21/58) while there was a significant difference compared with that of benign breast tissues 75%(18/24) P<0 05 . The relevant analysis between the expression of cyclinD 1 gene and that of Rb gene suggested that overexpression of cyclinD 1 was positive relevant with Rb expression. Conclusion Both of cyclinD 1 overexpression and loss expression of Rb are the important events in the pathogenesis of breast carcinoma, of them, the former might be the earlier moleculer event, it is suggested that abnormalities of proteins expression of cell cycle regulatory genes are involved in breast carcinomagenesis.

目的:探讨cyclinD1基因及Rb基因的表达与乳腺癌发生发展的关系。方法:应用ABC免疫组化法检测24例良性乳腺组织及58例乳腺癌中cyclinD1及Rb蛋白表达。结果:乳腺癌中cyclinD1过表达阳性率58.62%(34/58)显著高于良性乳腺组织中的16.67%(4/24),P<0.05。cyclinD1过表达出现于导管原位癌并持续于浸润、转移等进展过程中,与年龄、肿瘤大小、组织学类型及淋巴结状态无相关性,但与组织学分级负相关。乳腺癌中Rb蛋白表达阳性率为36.2%(21/58),显著低于良性乳腺组织的75%(18/24),P<0.05;未见Rb失表达与临床病理参数间存在相关性,Rb表达与cyclinD1过表达呈正相关。结论:cyclinD1过表达及Rb失表达是乳腺癌发生中的重要事件且前者是一早期分子事件;cyclinD1过表达发挥作用可能部分依赖于Rb蛋白的存在;提示细胞周期调控异常参与乳腺癌的发生。

 
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