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rb gene
相关语句
  rb基因
    Loss of Rb gene protein expression and P_(53) gene mutation in human testicular seminoma
    人类睾丸精原细胞瘤组织中P_(53)基因突变和Rb基因蛋白产物表达的缺失
短句来源
    P16 and Rb gene expressions in bladder transitional cell carcinoma
    膀胱移行细胞癌中P16及Rb基因表达的关系
短句来源
    Expression and correlation analysis of Rb gene and PCNA in prostatic cancer
    Rb基因和PCNA在前列腺癌中表达的意义及相关性分析
短句来源
    Conclusions:(1) The results suggested P16 P53 Rb gene play important roles in occurance and development of BTCC,P16 gene major in deletion and P53 major in mutation.
    结论:①P16、P53、Rb基因的变化在膀胱癌发生发展中有重要作用,P16基因第2外显子以缺失为主,P53基因第5-8外显子以突变为主;
短句来源
    The positive rate of P16 and Rb gene was 47.46%(28/59)and 71.19%(42/59) respectively. In only 18.64% (11/59),both P16 and Rb could be simultaneously detected. Lack of both the expressions in the same tumor tissue has not been observed.
    结果显示:59例中P16及Rb基因阳性表达率分别为4746%、7119%,其中11例肿瘤组织(1864%)P16及Rb基因均阳性表达,未发现同一肿瘤组织中同时存在P16及Rb基因的表达缺失。
短句来源
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  rb基因的
    Conclusions:(1) The results suggested P16 P53 Rb gene play important roles in occurance and development of BTCC,P16 gene major in deletion and P53 major in mutation.
    结论:①P16、P53、Rb基因的变化在膀胱癌发生发展中有重要作用,P16基因第2外显子以缺失为主,P53基因第5-8外显子以突变为主;
短句来源
    Immunohistochemical method was used to detect the P16 and Rb gene expressions in 59 cases of transitional cell carcinoma (TCC) of bladder.
    应用免疫组织化学方法对59例膀胱移行细胞癌中P16及Rb基因的表达进行研究。
短句来源
    The positive rate of P16 and Rb gene was 47.46%(28/59)and 71.19%(42/59) respectively. In only 18.64% (11/59),both P16 and Rb could be simultaneously detected. Lack of both the expressions in the same tumor tissue has not been observed.
    结果显示:59例中P16及Rb基因阳性表达率分别为4746%、7119%,其中11例肿瘤组织(1864%)P16及Rb基因均阳性表达,未发现同一肿瘤组织中同时存在P16及Rb基因的表达缺失。
短句来源
    Rb deletion or aberration was found in many kinds of tumors, but no report has been appeared in the literature concerning the relationship between Rb gene and Wilms tumor(WT). By the use of a 3.8 kb cDNA Rb probe,a case of WT with deletion of the Rb gene was demonstrated after screening of 14 WT cases. Further indirect evidence was obtained by using PCR-amplification of exon 8,12,and 27 of the Rb gene.
    用视网膜母细胞瘤(Rb)基因3.8kb的cDNA探针,以Southern印迹杂交法,在14例肾母细胞瘤中,发现1例有Rb基因的缺失,在文献中尚未见报道。
短句来源
    The data showed that abnormal expression of P16 and Rb gene play an important role in the genesis and malignant progression of TCC. However,absence of both the tumor suppressor genes appears to be a distinctly uncommon phenomenon.
    结果提示:P16及Rb基因的异常表达在膀胱肿瘤的发生、发展过程中起重要作用,膀胱肿瘤中P16及Rb基因同时表达缺失是少见现象
短句来源
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  “rb gene”译为未确定词的双语例句
    Mutation of RB Gene in Wilms- Tumor
    肾母细胞瘤中RB基因突变的研究
短句来源
    Analysis and Clinical Implication of Ha-ras, p53 and RB Gene Mutations and Infection of Bladder Cancer with Papillomavirus
    膀胱癌人乳头瘤病毒感染与Ha-ras、p53、RB基因变异及其临床意义的研究
短句来源
    Expression and clinical significance of Rb gene and MCM2 in prostate cancer
    Rb和MCM2蛋白在前列腺癌中的表达及临床意义
短句来源
    Objective:To explore the relationship and significanceamong the alteration of P16 P53 Rb gene and biological behavior of bladder transitional cell carcinoma(BTCC).
    目的:研究抑癌基因P16、P53、Rb在膀胱移行细胞癌发生发展中的作用及相关性。
短句来源
    P16 Rb gene expressions were related to the tumor grade(p<0.05);
    P16、Rb与病理分级密切相关(p<0.05)。
短句来源
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  rb gene
We detected allelic losses in the Rb gene and in exon 4 of the TP53 gene in a tumor region corresponding to a glioblastoma multiforme.
      
In addition, Rb gene repression is dependent on the nature of Rb-E2F interaction and the activity of the Rb-bound proteins recruited to the promoter.
      
Gossypol plasma levels were measured (n=8) and the modulation of the retinoblastoma (Rb) gene protein and Cyclin D1 was assessed by serial biopsies (n=4).
      
Those cases showing LOH in the region of the RB gene, 13q14, were excluded from the study.
      
The retinoblastoma (RB) gene is the first such gene to be identified, and was isolated based on its chromosome localization and on the recessive nature of the tumor phenotype.
      
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With western blot analysis and DNA polymerase chain reaction-single strand conformation polymorphism assay,protein product of Rb gene and mutation in exon 5~8 of P_(53) gene were examined in 17 cases of human testicular seminoma. Loss of expression of Rb gene was found in 3 and mutations in P_(53) gene were identified in 4 cases of seminoma. Rb protein was detected in normal testicular and retina tissues in normal controls and no mutation in P_(53) gene was found in normal...

With western blot analysis and DNA polymerase chain reaction-single strand conformation polymorphism assay,protein product of Rb gene and mutation in exon 5~8 of P_(53) gene were examined in 17 cases of human testicular seminoma. Loss of expression of Rb gene was found in 3 and mutations in P_(53) gene were identified in 4 cases of seminoma. Rb protein was detected in normal testicular and retina tissues in normal controls and no mutation in P_(53) gene was found in normal testicular tissue. The results are suggest that inactivation of Rb gene and mutation in P_(53) gene associated with the development of human testicular seminoma.

采用Western印迹和DNA聚合酶链反应-单股构造多态性分析法对17例人睾丸精原细胞瘤组织标本的抗癌基因Rb表达的蛋白产物和P_(53)基因外显子5~8的突变进行检测,发现有3例标本的Rb基因表达的蛋白产物缺失,有4例标本的P_(53)基因有点突变,对照的正常人睾丸组织和视网膜组织均呈Rb基因蛋白产物表达阳性,对照的正常人睾丸组织中未发现P_(53)基因突变。本结果提示人睾丸精原细胞瘤的发生与抗癌基因Rb蛋白产物表达的缺失和P_(53)基因的突变有关。

To investigate the correlation between Rb tumor suppressor gene and bladder and renal cell carcinoma,the gene in primary RCC, baldder carcinoma and cell lines Were analyzed by northern blot,One RCC and two bladder carcinoma cell lines showed noramal Rb expression.One of 13 RCC,and two hing-grade bladder carcinomas lacked Rb mRNA expression. None of the low-grade carcimomas showed an altration in Rb gene,The result suggests that the loss of Rb gene corrclates with bladder...

To investigate the correlation between Rb tumor suppressor gene and bladder and renal cell carcinoma,the gene in primary RCC, baldder carcinoma and cell lines Were analyzed by northern blot,One RCC and two bladder carcinoma cell lines showed noramal Rb expression.One of 13 RCC,and two hing-grade bladder carcinomas lacked Rb mRNA expression. None of the low-grade carcimomas showed an altration in Rb gene,The result suggests that the loss of Rb gene corrclates with bladder carcinoma and is more frequent in high-grade ones Rb loss might have a role in certain renal cell carcinoma.

对正常肾和肾细胞癌组织,正常膀胱粘膜和膀胱移行细胞癌组织以及肾癌细胞和膀胱癌细胞株BIU-87和E-J中的抗癌基因Rb进行Northernblot分析。肾和膀胱癌细胞都表达正常的RbmRNA。1/13例肾癌组织和2/8例膀胱癌组织中发现Rb基因缺失。此2例Rb缺失的膀胱癌均为低分化肿瘤,在分化较高的膀胱癌中未发现Rb基因缺失。结果表明,Rb基因缺失与膀胱癌的关系密切,同时与肿瘤的分化程度有关。结合文献对Rb抗癌基因与泌尿系肿瘤的关系及其在肿瘤发生中的作用进行讨论。

Retinoblastoma gene (Rb) is a well-known tumorsuppressor gene.Rb deletion or aberration was found in many kinds of tumors, but no report has been appeared in the literature concerning the relationship between Rb gene and Wilms tumor(WT).By the use of a 3.8 kb cDNA Rb probe,a case of WT with deletion of the Rb gene was demonstrated after screening of 14 WT cases.Further indirect evidence was obtained by using PCR-amplification of exon 8,12,and 27 of the Rb gene.The...

Retinoblastoma gene (Rb) is a well-known tumorsuppressor gene.Rb deletion or aberration was found in many kinds of tumors, but no report has been appeared in the literature concerning the relationship between Rb gene and Wilms tumor(WT).By the use of a 3.8 kb cDNA Rb probe,a case of WT with deletion of the Rb gene was demonstrated after screening of 14 WT cases.Further indirect evidence was obtained by using PCR-amplification of exon 8,12,and 27 of the Rb gene.The results were briefly discussed.

用视网膜母细胞瘤(Rb)基因3.8kb的cDNA探针,以Southern印迹杂交法,在14例肾母细胞瘤中,发现1例有Rb基因的缺失,在文献中尚未见报道。

 
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