助手标题  
全文文献 工具书 数字 学术定义 翻译助手 学术趋势 更多
查询帮助
意见反馈
   rb gene 在 妇产科学 分类中 的翻译结果: 查询用时:0.008秒
图标索引 在分类学科中查询
所有学科
妇产科学
肿瘤学
眼科与耳鼻咽喉科
基础医学
泌尿科学
生物学
外科学
中药学
口腔科学
更多类别查询

图标索引 历史查询
 

rb gene
相关语句
  rb基因
    Rb GENE AND HPV16 E7 ONCOGENE IN CERVICAL SQUAMOUS CELL CARCINOMA
    子宫颈鳞癌 Rb 基因与 HPV16 E7 基因的相关性研究
短句来源
    Relationship between Human Papillomavirus E7 Protein and Rb Gene Product in Fresh Tissues of Squamous Cervical Carcinoma
    子宫颈鳞癌组织中人乳头状瘤病毒E_7蛋白与Rb基因产物的关系
短句来源
    Inhibition of Recombinant Rb Gene Adenovirus Vector on the Growth of Ovarian Cancer Cell Line
    外源性Rb基因对卵巢癌细胞株生长的抑制作用
短句来源
    The clinical significance of expression of Rb gene and cyclinD_1 in epithelial ovarian neoplasms
    Rb基因及细胞周期素D_1在原发性卵巢上皮性肿瘤中的表达及临床意义
短句来源
    The affection of HR-HPV to Rb gene is occurred in posttranscriptional level. And affect the expression of p16 indirectly.
    HR一HPv对Rb基因的影响发生在转录后水平,并间接影响pl6的表达。
短句来源
更多       
  “rb gene”译为未确定词的双语例句
    In the 1970s, oncologist bought up "two hit hypothesis" when they studied the genetic tumors , and found RB gene lost in all Retinoblastoma patients. From then on , the study on TSG is in the ascendant.
    70年代,肿瘤学家对遗传性肿瘤进行谱系分析以研究肿瘤基因时,提出了“二步论假说”,并且发现了视网膜母细胞瘤(Retinoblastoma,RB)中均有RB这种抑癌基因的缺失,由此,肿瘤抑制基因的研究方兴未艾。
短句来源
    To clarify the association between Rb gene alteration and the presence of HPV E7 oncogene in the oncogenesis of cervical squmous cell carcinoma,30 primary cervical squmous cell carcinomas for the structure of Rb gene(exon 20)by PCRSSCP silver staining method were examined. The presence of HPV16E7 DNA sequences was also analyzed by dotblot hybridization using digoxigenin labelled HPV16 E7 probe.
    用多聚酶链反应—单链构象多态性分析(Single-strandconformationpolymorphismanalysisofpolymerasechainreaction,PCR-SSCP)以及地高辛标记探针斑点杂交技术对30例子宫颈鳞癌组织中Rb抑癌基因及HPV16E7癌基因进行分析。
短句来源
查询“rb gene”译词为用户自定义的双语例句

    我想查看译文中含有:的双语例句
例句
为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。
  rb gene
We detected allelic losses in the Rb gene and in exon 4 of the TP53 gene in a tumor region corresponding to a glioblastoma multiforme.
      
In addition, Rb gene repression is dependent on the nature of Rb-E2F interaction and the activity of the Rb-bound proteins recruited to the promoter.
      
Gossypol plasma levels were measured (n=8) and the modulation of the retinoblastoma (Rb) gene protein and Cyclin D1 was assessed by serial biopsies (n=4).
      
Those cases showing LOH in the region of the RB gene, 13q14, were excluded from the study.
      
The retinoblastoma (RB) gene is the first such gene to be identified, and was isolated based on its chromosome localization and on the recessive nature of the tumor phenotype.
      
更多          


objective: To detect the effects of p53 and Rb genes in uterine leiomyoma. Methods: Total RNA was extracted from samples of 14 leiomyomas and adjacent normal myometrium and 3 leiomyosarcomas. p53 and Rb mRNA levels were evaluated by Northern blot. Results: Northern blot analysis indicated that p53 and Rb mRNA levels in the secretory phase of the menstrual cycle were significantly higher than those in the proliferative phase in myometrium. Their levels in leiomyomas were significantly lower...

objective: To detect the effects of p53 and Rb genes in uterine leiomyoma. Methods: Total RNA was extracted from samples of 14 leiomyomas and adjacent normal myometrium and 3 leiomyosarcomas. p53 and Rb mRNA levels were evaluated by Northern blot. Results: Northern blot analysis indicated that p53 and Rb mRNA levels in the secretory phase of the menstrual cycle were significantly higher than those in the proliferative phase in myometrium. Their levels in leiomyomas were significantly lower than those in the secretory phase in myometrium. The levels in leiomyosarcoma were below those in leiomyoma.Conclusion: The sex hormone may have an important effect on the regulation of p53 and Rb genes expression in human uterine myometrium. It is possible that the mitogenic effect of sex hormone on human uterine smooth muscle cells is mediated by the regulations of the tumor suppressor gene expression.

目的:探讨抑癌基因p53和Rb在子宫肌瘤发生发展中的作用。方法:用NorthernBlot方法检测14例子宫肌瘤和3例子宫平滑肌肉瘤中p53和Rb基因的mRNA表达。结果:p53和Rb基因在分泌期子宫肌肉中的表达水平明显高于增殖期,在子宫肌瘤中的表达水平明显低于分泌期子宫肌肉组织,在子宫肉瘤中的表达水平低于子宫肌瘤。结论:在子宫肌肉组织中,性激素对p53和Rb基因的表达可能有调节作用。推测性激素促使子宫平滑肌细胞增生的作用途径之一是影响p53和Rb基因的表达。

To clarify the association between Rb gene alteration and the presence of HPV E7 oncogene in the oncogenesis of cervical squmous cell carcinoma,30 primary cervical squmous cell carcinomas for the structure of Rb gene(exon 20)by PCRSSCP silver staining method were examined.The presence of HPV16E7 DNA sequences was also analyzed by dotblot hybridization using digoxigenin labelled HPV16 E7 probe.No point mutation or loss of hetrozygosity in the Rb susceptibility genes was detected in any...

To clarify the association between Rb gene alteration and the presence of HPV E7 oncogene in the oncogenesis of cervical squmous cell carcinoma,30 primary cervical squmous cell carcinomas for the structure of Rb gene(exon 20)by PCRSSCP silver staining method were examined.The presence of HPV16E7 DNA sequences was also analyzed by dotblot hybridization using digoxigenin labelled HPV16 E7 probe.No point mutation or loss of hetrozygosity in the Rb susceptibility genes was detected in any of 30 tumor specimens.HPV E7 DNA were found in 67%(20/30)of the tumors The results suggest that cervical squamous cell carcinoma is associated with HPV16 E7 oncogene.In Contrast to data derived from cultured cervical carcinoma cell lines,Rb gene alteration is infraquent in clinical samples of cervical carcinomas irrespective of the presence or absence of HPV E7 oncogene.

用多聚酶链反应—单链构象多态性分析(Single-strandconformationpolymorphismanalysisofpolymerasechainreaction,PCR-SSCP)以及地高辛标记探针斑点杂交技术对30例子宫颈鳞癌组织中Rb抑癌基因及HPV16E7癌基因进行分析。结果30例子宫颈鳞癌组织中未检出Rb基因突变或缺失;20例癌组织中检出HPV16E7DNA,阳性率为67%。提示HPV16E7癌基因与子宫颈鳞癌密切相关。子宫颈鳞癌中Rb基因结构异常并不常见,而且与HPV16E7基因的存在状况无明显相关性。

Objective To test and study the effect of inhibition on the growth of ovarian cancer cell line CAOV3 transfected by the recombinant Rb gene adenovirus vector. Methods The recombinant Rb gene and the LacZ gene in adenovirus vector were constructed and transfected into the CAOV3 cell line separately. The Rb gene expression was detected by immunohistochemical assay and agarose gel electrophoresis,etc. The inhibition on the growth of CAOV3 was tested by flow cytometry and methyl...

Objective To test and study the effect of inhibition on the growth of ovarian cancer cell line CAOV3 transfected by the recombinant Rb gene adenovirus vector. Methods The recombinant Rb gene and the LacZ gene in adenovirus vector were constructed and transfected into the CAOV3 cell line separately. The Rb gene expression was detected by immunohistochemical assay and agarose gel electrophoresis,etc. The inhibition on the growth of CAOV3 was tested by flow cytometry and methyl thiazolyl tetrazolium assay, etc. Results The constructed recombinant Rb gene adenovirus vector could infect cells with high level expression of Rb protein, and Rb cDNA could be found in the transfected cells. The proliferation of transfected CAOV3 cells was inhibited evidently. Sixty eight per cent of cells were arrested at G 0、G 1 phases of cell cycle. Conclusions The recombinant Rb gene adenovirus vector could transform CAOV3 cells efficiently and inhibit CAOV3 cell growth. It might be a new approach of gene therapy for ovarian cancer.

目的 探讨外源性Rb基因对卵巢癌细胞生长的抑制作用 ,为卵巢癌的基因治疗提供实验依据。方法 通过腺病毒介导的Rb基因 ,于体外转染卵巢癌细胞株CAOV3。应用免疫组织化学、DNA琼脂糖电泳等方法 ,检测外源性Rb基因的导入及其表达。通过四甲基偶氮唑蓝比色法及流式细胞术等 ,观察转染Rb基因的CAOV3细胞的生长情况。结果 重组腺病毒载体可有效于体外转染卵巢癌细胞株CAOV3;转染外源性Rb基因后 ,CAOV3细胞内可检测到Rb基因及其蛋白表达 ;CAOV3细胞生长受到抑制 ,约 6 8%的细胞生长停滞于G0 期及G1期。结论 外源性Rb基因可通过腺病毒载体有效转染卵巢癌细胞株CAOV3,抑制CAOV3细胞的生长。

 
<< 更多相关文摘    
图标索引 相关查询

 


 
CNKI小工具
在英文学术搜索中查有关rb gene的内容
在知识搜索中查有关rb gene的内容
在数字搜索中查有关rb gene的内容
在概念知识元中查有关rb gene的内容
在学术趋势中查有关rb gene的内容
 
 

CNKI主页设CNKI翻译助手为主页 | 收藏CNKI翻译助手 | 广告服务 | 英文学术搜索
版权图标  2008 CNKI-中国知网
京ICP证040431号 互联网出版许可证 新出网证(京)字008号
北京市公安局海淀分局 备案号:110 1081725
版权图标 2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社