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rb gene
相关语句
  rb基因
    Deletion and Rearrangement within Rb Gene in Human Gastric Cancer
    胃癌及癌旁组织中Rb基因缺失和重排的研究
短句来源
    RB Gene and Tumor Suppression .
    RB基因与肿瘤抑制
短句来源
    Study of Rb Gene Deletions in Bilateral Retinoblastomas
    双眼视网膜母细胞瘤Rb基因缺失研究
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    Loss of Rb gene protein expression and P_(53) gene mutation in human testicular seminoma
    人类睾丸精原细胞瘤组织中P_(53)基因突变和Rb基因蛋白产物表达的缺失
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    THE EXPRESSION OF Rb GENE IN RETINOBLASTOMA
    视网膜母细胞瘤Rb基因表达
短句来源
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  rb基因的
    THE DETECTION OF RB GENE IN ORAL SQUAMOUS CELL CARCINOMA
    口腔鳞状细胞癌Rb基因的检测
短句来源
    Expression and significance of p15 and Rb gene in human hepatocellular carcinoma tissue
    人肝细胞癌组织p15及Rb基因的表达意义
短句来源
    EGFr and Rb gene amplification in fetal esophageal epithelium treated by alternariol
    经交链孢酚处理胎儿食管上皮组织中EGFr、Rb基因的扩增
短句来源
    Over Expression of the Rb Gene in Human Colorectal Carcinomas and Adenomas and Its Significance in the Formation and Development of Tumor
    人类结肠癌、结肠腺瘤中Rb基因的过表达现象及其在肿瘤发生、发展中的意义
    2. The inversly correlation betweenp16 and Rb gene expression proved their negative feedback action.
    2.P16与Rb基因的蛋白表达呈显著的负相关关系,两者之间存在负反馈作用。
短句来源
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  rb表达
    Significance of p53, p16 and Rb gene expressions in tissues of human osteosarcoma and bone fibrous dysplasia
    人成骨肉瘤及骨纤维结构不良组织P53,P16及Rb表达的意义
短句来源
    THE EFFECT OF 9-cis-RA ON c-erB-2 AND Rb GENE EXPRESSION IN HUMAN LUNG CANCER CELL LINES
    9顺维甲酸对肺鳞、腺癌细胞株c-erbB-2和Rb表达的影响
短句来源
    The positivity rate of Rb expression in breast carcinomas was 36 2%(21/58) while there was a significant difference compared with that of benign breast tissues 75%(18/24) P<0 05 . The relevant analysis between the expression of cyclinD 1 gene and that of Rb gene suggested that overexpression of cyclinD 1 was positive relevant with Rb expression.
    乳腺癌中Rb蛋白表达阳性率为36.2%(21/58),显著低于良性乳腺组织的75%(18/24),P<0.05; 未见Rb失表达与临床病理参数间存在相关性,Rb表达与cyclinD1过表达呈正相关。
短句来源
    ②In A2 and A549,there was no Rb gene expression in experimence and control groups. In L78,a significant differential showed between experimental and control group.
    ②A2、A549实验组、对照组Rb未见表达 ,L78实验组Rb表达率 9 8% ,对照组Rb无表达 ,差异显著(P <0 0 1)。
短句来源
    ④The increase of Rb gene expression by 9 cis RA in L78 may have relationship with inducing apoptosis.
    ④ 9 cis RA处理后L78细胞株中Rb表达增加可能与诱导细胞凋亡有关。
短句来源
  “rb gene”译为未确定词的双语例句
    DELETION OF RB GENE IN HUMAN GASTRIC CANCER CELL LINES
    人胃癌细胞株Rb抗癌基因缺失的研究
短句来源
    Studies on the Parental Origin of the Primary Mutation of Rb Gene
    Rb基因突变的亲源研究
短句来源
    Study on Characters of Rb Gene Product
    视网膜母细胞瘤基因产物部分性质的研究
短句来源
    Study of the c-myc and Rb gene amplification in human fetal esophageal epithelium treated by altenariol
    交链孢酚(AOH)处理人胎食管上皮组织c-myc癌基因,Rb抗癌基因扩增的研究
短句来源
    The Expression of Tumor Supperssor Gene p53 and Rb Gene in Nasopharyngeal Carcinoma
    肿瘤抑制基因p53及Rb在鼻咽癌中的表达
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  rb gene
We detected allelic losses in the Rb gene and in exon 4 of the TP53 gene in a tumor region corresponding to a glioblastoma multiforme.
      
In addition, Rb gene repression is dependent on the nature of Rb-E2F interaction and the activity of the Rb-bound proteins recruited to the promoter.
      
Gossypol plasma levels were measured (n=8) and the modulation of the retinoblastoma (Rb) gene protein and Cyclin D1 was assessed by serial biopsies (n=4).
      
Those cases showing LOH in the region of the RB gene, 13q14, were excluded from the study.
      
The retinoblastoma (RB) gene is the first such gene to be identified, and was isolated based on its chromosome localization and on the recessive nature of the tumor phenotype.
      
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Southern Blott was used to detect Rb gene

利用Rb3.8Kb特异性cDNA探针,采用StuthernBlot方法,用脑外伤病人脑组织和正常胎盘组织作为对照,结果显示12例神经胶质瘤标本中均未见有Rb基因的丢失或异常。检测结果表明Rb基因在神经胶质瘤中无显著缺失,但是否存在有Rb基因的微小缺失,点突变等当需用其它方法进一步证实。

1 human primary brain gliomas and 11 humanmenigiomas were examined with RNA dot blothybridization for the expression of p53, Rband c-myc gene. It was found that the level ofp53 gene expression is lower in 48. 4% (15/31)of the tumors tested than that of normal braintissues ; the level of Rb gene expression is low-er in 21. 9% (7/32) for the tumors tested thanthat of normal tissues; and the level of c-mycgene expression is higher in 71. 9 % (23/32) forthe tumors tested than that of normal tissues.Interestingly,...

1 human primary brain gliomas and 11 humanmenigiomas were examined with RNA dot blothybridization for the expression of p53, Rband c-myc gene. It was found that the level ofp53 gene expression is lower in 48. 4% (15/31)of the tumors tested than that of normal braintissues ; the level of Rb gene expression is low-er in 21. 9% (7/32) for the tumors tested thanthat of normal tissues; and the level of c-mycgene expression is higher in 71. 9 % (23/32) forthe tumors tested than that of normal tissues.Interestingly, in 13 of the tumors tested, thelevel of p53 gene expression is lower and thelevel of c-myc gene expression is higher.These results suggested that the expressivedecrease of p53 gene and the expressive in-crease of c-myc gene are relative to the genera-tion of human primary brain tumor.

采用RNA斑点杂交分析,对21例人脑原发性胶质瘤和11例人脑膜瘤中p53,Rb和c-myc基因转录水平的表达进行研究。发现48.4%的肿瘤中p53基因表达减弱,21.9%的肿瘤中Rb基因表达减弱;71.9%的肿瘤中c-myc基因表达增强。在p53基因表达减弱的15例病例中有13例(80%)c-myc基因表达增强。结果表明,p53基因表达减弱和c-myc基因表达增强与人脑原发性肿瘤的发生有关.

he RB gene is located at chromosome 13q14which spans more than 150kb, with one interalgap. and its product is a phosphoprotein ofabout 110kD which is constantly expressed innormal retina cells. The RB Protein canspecifically bind to SV40 large T. E1A and E7antigens. The deficiency of the RB gene is thecause of retinoblastoma. Besides, RB genemutations are detected in osteosarcomas.breast carcinomas, small-cell lung cancer( SCLC ) . soft - tissue sarcomas and hematopoie-tic proliferative disorders....

he RB gene is located at chromosome 13q14which spans more than 150kb, with one interalgap. and its product is a phosphoprotein ofabout 110kD which is constantly expressed innormal retina cells. The RB Protein canspecifically bind to SV40 large T. E1A and E7antigens. The deficiency of the RB gene is thecause of retinoblastoma. Besides, RB genemutations are detected in osteosarcomas.breast carcinomas, small-cell lung cancer( SCLC ) . soft - tissue sarcomas and hematopoie-tic proliferative disorders. The tumorigenicitycan be partially or totally suppressed by intro-ducing the RB gene into the tumor cells.

RB基因位于13q14,全长150kb,编码一个由928个氨基酸组成的分子量为110000蛋白(pp110RB).它能特异性与SV40大T,E1A和E7结合.在视网膜细胞中,RB呈衡定组成性表达,其

 
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