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   rb gene 在 眼科与耳鼻咽喉科 分类中 的翻译结果: 查询用时:0.011秒
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rb gene
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  rb基因
    Initial Study in the Association between Proliferation of Rb Gene and Tumorigenesis of Retinoblastoma
    Rb基因扩增与视网膜母细胞瘤发生的关系初步探讨
短句来源
    A Study of the Rb Gene Deletions in Unilateral and Sporadic Retinoblastomas
    单眼散发性视网膜母细胞瘤Rb基因缺失的研究
短句来源
    RB Gene and Tumor Suppression .
    RB基因与肿瘤抑制
短句来源
    Study of Rb Gene Deletions in Bilateral Retinoblastomas
    双眼视网膜母细胞瘤Rb基因缺失研究
短句来源
    THE EXPRESSION OF Rb GENE IN RETINOBLASTOMA
    视网膜母细胞瘤Rb基因表达
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  rb基因的
    Conclusion The result indicated the mutation or lack of RB gene was not the only reason in the tumorigenesis of LSCC, and protein RB might cooperate with cyclin D 1, P16, CDK4 to play a role in the process of tumorigenesis.
    结论 细胞调控周期中Cyclin D1、RB、P16、CDK4等因素在喉鳞癌的发生发展中可能起着协同作用,而并非主要由于RB基因的突变和缺失造成细胞癌变。
短句来源
    [WT5”HZ]Methods [WT5”BZ]Based on establishing vitreous RB transplantation tumor in nude mouse,constructing retrovirus vector of Rb gene PBabe Rb and transfecing it into the RB transplantation model by liposome Dosper,the change of cell cycle of the RB transplantation tumor by flow cytometry(FCM)was analysed.
    方法 在建立裸鼠眼玻璃体腔 RB移植瘤模型及构建 Rb基因的逆转录病毒表达载体 PBabe- Rb的基础上 ,用脂质体 Dosper介导法将 Rb基因导入裸鼠 RB移植瘤 ,流式细胞仪检测 RB移植瘤细胞周期变化。
短句来源
    With the anti-Rb polyclonal antibody,the expression of Rb gene in 15 cases of retinoblastoma were studied by Western Bloting. Using laser densitometry technique,we made a quantitative comparison of the expression dose of Rb gene product between Rb tumor and normal retinal tissues. The relative concentrations of p105Rb in 13 RB patients were remarkably lower than those of normals.
    利用抗Rb基因蛋白产物的多克隆抗体对15例视网膜母细胞瘤Rb基因表达水平进行Western印迹分析,并采用激光密度分析仪对结果进行进一步精确的定量分析,表明15例视网膜母细胞瘤中仅有两例的Rb基因蛋白表达量与正常视网膜相似,其余13例几乎没有Rb基因的表达产物。
短句来源
    The results suggest that Rb gene activity is possibly decreased in most cases of RB.
    提示在大多数视网膜母细胞瘤中,Rb基因的蛋白质产物缺乏。
短句来源
    The results implied that the alterations of the deletion or loss of activity of Rb gene with high frequency might be associated with the carcinogenesis of NPC.
    这种高频率的异常变化,提示Rb基因的缺失或失活,与鼻咽癌的发生有密切关系。
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  “rb gene”译为未确定词的双语例句
    Studies on the Parental Origin of the Primary Mutation of Rb Gene
    Rb基因突变的亲源研究
短句来源
    Study on Characters of Rb Gene Product
    视网膜母细胞瘤基因产物部分性质的研究
短句来源
    The Expression of Tumor Supperssor Gene p53 and Rb Gene in Nasopharyngeal Carcinoma
    肿瘤抑制基因p53及Rb在鼻咽癌中的表达
短句来源
    THE CHARACTERISTICS OF Rb GENE MUTATIONS IN 108 CASES OF RETINOBLASTOMA.
    108例视网膜母细胞瘤Rb基因突变的特征
短句来源
    GENE DIAGNOSIS AND GENETIC COUNSELLING OF Rb GENE MUTATIONS IN RETINOBLASTOMA PATIENTS AND THEIR FAMILY MEMBERS
    RB患者及家庭成员Rb基因突变和患病风险的基因诊断及遗传咨询
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  rb gene
We detected allelic losses in the Rb gene and in exon 4 of the TP53 gene in a tumor region corresponding to a glioblastoma multiforme.
      
In addition, Rb gene repression is dependent on the nature of Rb-E2F interaction and the activity of the Rb-bound proteins recruited to the promoter.
      
Gossypol plasma levels were measured (n=8) and the modulation of the retinoblastoma (Rb) gene protein and Cyclin D1 was assessed by serial biopsies (n=4).
      
Those cases showing LOH in the region of the RB gene, 13q14, were excluded from the study.
      
The retinoblastoma (RB) gene is the first such gene to be identified, and was isolated based on its chromosome localization and on the recessive nature of the tumor phenotype.
      
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Retinoblastoma(Rb)is a malignant eye tumor of childhood and a desirable model for the genetic study of oncogenesis in human being. The results of genetic investigation of RB since 1982 in WCUMS were summerized in this paper. 1.Clinical genetic studies of RB The records of 327 patients with RB between 1958 and 1986 were reviewed.The clinical investiga- tion included the laterality of the involved eyes,the mean age at diagnosis,the secondary malignant neoplasm in survivors,the spontaneous...

Retinoblastoma(Rb)is a malignant eye tumor of childhood and a desirable model for the genetic study of oncogenesis in human being. The results of genetic investigation of RB since 1982 in WCUMS were summerized in this paper. 1.Clinical genetic studies of RB The records of 327 patients with RB between 1958 and 1986 were reviewed.The clinical investiga- tion included the laterality of the involved eyes,the mean age at diagnosis,the secondary malignant neoplasm in survivors,the spontaneous regression of the tumor and RB in twins. 2.Cytogenetic studies of RB (1)Among 56 patients examined for chromosome constitution,4 cases showed abnormal or variant karyotypes:46,XY/46,XY,del(13)(q14.1 q14.3).46, XY,var(15)(p13,F55)mat.46,X,del(Y)(q12)pat. 46,XY,inv(9)(P13q13). (2)Chromosome fragility study in 14 RB patients and their parents showed an increased frequency of chromosome aberration in contrast with control group.Several chromosome fragile sites in RB patients were found. (3)The results of chromosomal study of solid tumor cells from 50 samples of RB showed that in all cases there were aberration of chromosome both in number and in structure.The commonest aber- ration was an i(6p)chromosome,and double minutes (DM),homogeneously staining regions(HSR)were found. 3.The esterase D(EsD)activity and phenotype of the red blood cells in 34 patients with RB were examined,but the EsD activity showed no differ- ence between the patients and the control groups. The same examinations performed in the RB tumor cells form 11 patients revealed that either one or both EsD alleles in tumor cells were inactivated,or that the tumor cells exhibited only one of the two isozvmic types of the EsD,but the red blood cells showed heterozygous at the EsD locus.These observations indicated that in RB tumor cells there were loss,inactivation or reduction to homozygosity at RB and EsD locus on 13q,this may be important for oncogenesis. 4.With the review of literature,it was thought that the Rb gene located at 13q14 may be a pair of allelic inhibitive genes which controls some potential cancer genes(proto-oncogene).If the allelic in hibi tive genes are inactivated or lost with some reasons, the cancer genes will be freed from the inhibitive gene,and cause the induction of RB.

视网膜母细胞瘤(简称 RB)是研究肿瘤遗传学的理想的天然模式。本文总结了自1982年以来对 RB 遗传学的研究。内容包括患病年龄、患病眼别、存活者的第二恶性肿瘤、肿瘤的自发消退、双生子患者等临床遗传学问题;RB 患者外周血淋巴细胞和肿瘤细胞染色体改变、染色体脆性部位等细胞遗传学问题;以及患者红细胞和瘤细胞酯酶 D 活性和表型改变等生化遗传学问题。对 RB 的发病机理进行了初步探讨,认为癌基因和抗癌基因平衡失调是 RB 为代表的一大类恶性肿瘤发病的关键。

We found the change of proliferation with 6.2kb Hind ⅠⅡ fragment of Rb gene inretinoblastoma while the Rb gene was detected.The existence of proliferation of Rb genein retinoblastoma is first reported by us.It is contrary to the current theory that Rb geneis an antioncogene and the deletions of Rb gene is responsible for the tumorigenesis ofretinoblastoma.It is possible that the proliferation of Rb gene plays an important rolefor the tumorigenesis,so we discuss the finding preliminarily...

We found the change of proliferation with 6.2kb Hind ⅠⅡ fragment of Rb gene inretinoblastoma while the Rb gene was detected.The existence of proliferation of Rb genein retinoblastoma is first reported by us.It is contrary to the current theory that Rb geneis an antioncogene and the deletions of Rb gene is responsible for the tumorigenesis ofretinoblastoma.It is possible that the proliferation of Rb gene plays an important rolefor the tumorigenesis,so we discuss the finding preliminarily

在对视网膜母细胞瘤病人的Rb 基因存在状态进行检测时,发现一例患者体细胞Rb 基因有明显扩增改变。Rb 基因在视网膜母细胞瘤患者中的扩增改变,为首次报导,是否意味着Rb 基因扩增与肿瘤发生有着某种关联。

Using the method of Southern blot analysis, we examined twelve retinoblastomas with a complementary DNA showed to be the Rb gene as the probe. For each sample examined, the same dosage was taken and the normal fetal DNA of eyes was used as the normal control. The results showed that the Rb gene of two of 12 retinoblastomas had homozygous, internal deletions and hemizygous internal deletions in other three cases. The decreased Hind Ⅲ fragments were found in the rest of 2 cases. Comparing with the...

Using the method of Southern blot analysis, we examined twelve retinoblastomas with a complementary DNA showed to be the Rb gene as the probe. For each sample examined, the same dosage was taken and the normal fetal DNA of eyes was used as the normal control. The results showed that the Rb gene of two of 12 retinoblastomas had homozygous, internal deletions and hemizygous internal deletions in other three cases. The decreased Hind Ⅲ fragments were found in the rest of 2 cases. Comparing with the normal control, we also found a change of proliferation involved the 6.2 kb Hind Ⅲ restriction fragments for a patient in his somatic cells (periphreral lymphocyte). It is possible that the proliferation of the Rb gene plays an important role for the tumorigenesis of retinoblastomas. Our data are able to confirm that the Rb genedeletions are responsible to tumorigenesis of retinoblastoma.

对12例单眼散发性视网膜母细胞瘤患者进行了Rb基因存在状态的检测,其中3例Rb基因剂量低于正常对照、2例有异常大小DNA片段出现、2例DNA片段部分缺失,并且1例体细胞Rb基因有扩增改变,这种改变为首次报导。

 
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