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   细胞毒药物 的翻译结果: 查询用时:0.898秒
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细胞毒药物
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  cytotoxic drug
     BACKGROUND AND OBJECTIVE5-Fluorouracil (5-FU) is the most widely used and effective cytotoxic drug in the treatment of digestive tract carcinoma (esophageal, gastratic, colorectal carcinoma). Its metabolism and elimination are associated with many mechanisms.
     5-氟脲嘧啶(5-Fluorouracil,5-FU)是治疗消化道肿瘤最广泛使用和较有效的细胞毒药物,其在体内的代谢、清除与多种因素有关,药代动力学具有非线性和易饱和性的特点,毒性反应和疗效具有高度的个体内和个体间差异。
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     It is reasonable to postulate that the assay of human leukemia clonogenic cells in soft agar medium might be a practical method for identifying whether a agent was a cytotoxic drug or a cell differentiation-inducing agent and elucidating the anti-tumor mechanism of these drugs.
     本文提出人白血病克隆原细胞的检测系统可为鉴别细胞毒药物和细胞分化诱导药物以及探讨其抗癌作用机制提供一种可靠的实验方法。
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     CONCLUSION: Genistein inhibited experimental metastasis through a mechanism different from that of cyclophosphamide. The stronger life prolonging effect of co administration of genistein with cyclophosphamide suggests that it may be valuable to combine genistein with another cytotoxic drug for cancer metastasis chemotherapy.
     结论:genistein 可抑制肿瘤转移,其作用与细胞毒药物不同, 与细胞毒药物合用可提高其抗肿瘤转移的作用。
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     Objective The anti-tumor and anti-metastasis effects of TNP-470, an angiogenesis inhibitor, and Gemcitabine, a representative cytotoxic drug, were investigated using an SOI model of human pancreatic carcinoma.
     目的 探讨血管生成抑制剂 (TNP- 4 70 )和细胞毒药物 (Gemcitabine)对胰腺癌裸鼠原位移植模型 (SOI)生长、转移的抑制作用及其作用机制。
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     In the treatment of prostate cancer,monoclonal antibody could combine with target cells to kill tumor cells by antibody-dependent cell-mediated cytotoxicity,complement-dependent cell-mediated cytotoxicity and transfer cell cytotoxic drug(radioisotope and immunotoxin) or blocking tumor tissues and related growth factors essential for cell growth.
     在前列腺癌治疗中,利用抗体直接与靶细胞结合,通过抗体依赖细胞毒作用、补体依赖细胞毒作用、传递细胞毒药物(放射性同位素和免疫毒素)或封闭肿瘤组织和细胞生长所必需的相关生长因子等来实施。
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  cytotoxic drugs
     Down-regulation of extracelluar regulated protein kinases and inhibition of hepatocarcinomatous cell SMF7721 proliferation by cytotoxic drugs
     细胞毒药物下调细胞外调节蛋白激酶与抑制肝癌SMF7721细胞增殖
短句来源
     RESULTS Three kinds of cytotoxic drugs (HRT, VCR and Vp16) inhibited hepatocarcinomatous cell proliferation to some extent. The inhibition rate was (28±8)%, (25±16)% and (24±11)% respectively.
     结果 三种细胞毒药物 (三尖杉酯碱 ,长春新碱 ,足叶已甙 )均能不同程度的抑制 SMF772 1细胞增殖 ,抑制率分别为 (2 8±8) % ,(2 5± 16 ) %和 (2 4± 11) % ;
短句来源
     Induction of Cytotoxic Drugs to in situ Cell Apoptosis in Acute Leukemias
     细胞毒药物对急性白血病原位凋亡的诱导作用
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     There were remarkable effect and rapid absorption, and stronger affinity for 5-HT 3 receptor by oral administration of 5-HT 3 receptor antagonists for peripheral reflected vomiting induced by cytotoxic drugs and other vomiting-induced substances.
     口服 5 羟色胺 3(5 HT3 )受体拮抗药用于细胞毒药物和其他致吐物质引起的外周反射性呕吐有明显疗效 ,其吸收迅速 ,对 5 HT3 受体有较强亲合力。
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     ‘Atrophic telogen effluvium’from cytotoxic drugs and a randomized controlled trial to investigate the possible protective effect of pretreatment with a topical vitamin D3 analogue in humans
     局部应用维生素D3类似物预防性治疗细胞毒药物引起的人类“萎缩性休止期脱发”的可能保护性作用随机对照试验研究
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  “细胞毒药物”译为未确定词的双语例句
     Results:The range of few cytotoxic concentration of NAPP varied from 0 μg/ml to 3 125 μg/ml and at concentration from 125 μg/ml to 3 125 μg/ml could significantly decrease the level of intracellular RNA of HCV subgenetic replicon cell model(P<0.05~P<0.01).
     结果:无细胞毒药物浓度区间为(0~3 125)μg/ml,在125μg/ml~3 125μg/ml区间内对HCV复制子RNA有明显抑制作用(P<0.05~P<0.01)。
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     Method: Conditioning with ATG 7.5 mg·kg-1·d-1-1× 4d or ALG 30 mg ·kg-1· d-1× 3 d and other cytotoxicity agents for allo-SCT, investigated the therapy of ATG/ALG and their side effects.
     方法:ATG7.5mg·kg-1·d-×4d或ALG30mg·kg-1·d-1×3d联合其它细胞毒药物为造血干细胞移植预处理方案,观察ATG/ALG的临床作用和副反应。
短句来源
     The range of few cytotoxic concentration of Napp varied from 0μg/ml to 1000μg/ml and at concentration from 10μg/ml to 1000μg/ml could significantly decrease the level of intracellular RNA of HCV subgenomic replicon cell model(P<0.05~0.01).
     体外实验无细胞毒药物浓度区间为0~1000μg/ml,在10μg/ml~1000μg/ml区间内对HCV复制子RNA有明显抑制作用(P<0.05~0.01)。
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     The infection rate in combined hormone with cytotoxin drugs group was significantly higher than that in only using hormone group ( P < 0.05) .
     联合应用激素及细胞毒药物较单用激素的感染发生率高(P<0.05);
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     Conclusion Antisense oligodeoxynucleotide HA6722 and paclitaxel could inhibit the growth of breast cancer cells, which is HER2 overexpression in a synergic manner.
     结论反义寡核苷酸HA6722与细胞毒药物紫杉醇合用对HER2过表达乳腺癌细胞的体外增殖抑制具有协同作用。
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  cytotoxic drug
Short-term treatment for cytotoxic drug-induced emesis so far appears to be the only proven indication for 5-HT3 receptor antagonists.
      
In our laboratory, ferrets were evaluated on their behavioral changes, pathological changes and pharmacological responses to cytotoxic drug-induced emesis.
      
An antibody-carboxypeptidase G2 (CPG2) enzyme is delivered prior to the nontoxic prodrug, CMDA, which is converted to a cytotoxic drug by the action of the localized conjugate at the tumor site.
      
Predicting hematological toxicity (myelosuppression) of cytotoxic drug therapy from in vitro tests
      
The term multidrug resistance (MDR) describes the observation that tumour cell lines can become cross-resistant to several structurally unrelated chemotherapeutic agents after exposure to a single cytotoxic drug.
      
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  cytotoxic drugs
The response to treatment could not be assessed systematically but, in general, the patients with IgG and IgA paraproteins responded more satisfactorily (to corticosteroids, cytotoxic drugs, or plasma exchange) than did those with an IgM paraprotein.
      
Usually a combination of steroids and cytotoxic drugs is used, but there is considerable variation between centres on current therapeutic regimens.
      
Treatment intensification by simultaneous administration of cytotoxic drugs produces higher acute morbidity.
      
The aim was to ascertain whether many hundreds of clinical reports over the last decade are consistent with the prediction of a poorer outcome in cancer patients wit p53 abnormalities treated with cytotoxic drugs and radiation.
      
-Emesis caused by cytotoxic drugs is associated with an increase in the concentration of serotonin (5-hydroxytryptamine: 5-HT) in the intestine and the brainstem.
      
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The author reported the clinical analysis of 28 adult patie- nts with nephrotic syndrome on the basis of the classification defined at the Beidaiho seaside symposium,He took the immu- nological urine C_3,FDP,L_zM examinations as 3 items of sel- ective indices for the urine protein,The 28 patients were tr- eated in 2 groups,Prednisonum and cyclophosphamidum were adopted by one group (2 items with positive results),while prednisonum alone by the other group (2 items with negative results). The preliminary theraputic...

The author reported the clinical analysis of 28 adult patie- nts with nephrotic syndrome on the basis of the classification defined at the Beidaiho seaside symposium,He took the immu- nological urine C_3,FDP,L_zM examinations as 3 items of sel- ective indices for the urine protein,The 28 patients were tr- eated in 2 groups,Prednisonum and cyclophosphamidum were adopted by one group (2 items with positive results),while prednisonum alone by the other group (2 items with negative results). The preliminary theraputic observation showed that the im- munological examinations of the urine possessed apparent dif- ferences in the curative effect and they also had great signifi- cance in classification,short-term effect and prognosis.

本文按照北戴河肾炎座谈会分型及诊断标准,对28例成人原发性肾病综合征者,测其尿 C_3、FDP、L_zM 的含量作为分组治疗的指标。发现尿 C_3、FDP 二项阳性者11例有效率为45.4%,阴性者12例有效率为83.3%。提示阳性者单用激素或加用细胞毒药物疗效均较差,且复发率明显高于阴性组。在目前国内尚不能普遍开展肾活检等技术情况下,用以上指标对了解疗效,指导诊断,判断预后均有一定价值。

The cellular procoagulant activity(CPA) of the intact and lysed leukemic cells was evaluated in 34 cases of acute leukemia.The intact leukmic cells of 26 patients with acute non-lymphocytic leukmia(ANLL) without disseminated intravascular coagulation(DIC) feature showed an increase of CPA, mostly prominent in M5 subtype, while those from 8 cases of acute lymphocytic leukemia did not.The lysed leukemic cells did not show increase in CPA.Based on the results we suggest that the rapid destruction of the leukemic...

The cellular procoagulant activity(CPA) of the intact and lysed leukemic cells was evaluated in 34 cases of acute leukemia.The intact leukmic cells of 26 patients with acute non-lymphocytic leukmia(ANLL) without disseminated intravascular coagulation(DIC) feature showed an increase of CPA, mostly prominent in M5 subtype, while those from 8 cases of acute lymphocytic leukemia did not.The lysed leukemic cells did not show increase in CPA.Based on the results we suggest that the rapid destruction of the leukemic cells by cytotoxic agents still remains one of the effective approaches to prevent DIC in ANLL and to combine with heparin seems to be all the better.

本文检测34例急性白血病完整与破碎白血病细胞的促凝活性。26例急性非淋巴细胞白血病(ANLL)均无弥散性血管内凝血(DiC)依据,其完整白血病细胞的促凝活性增加,尤以M_5型为明显,而8例急性淋巴细胞白血病的完整白细胞均无促凝活性。破碎白血病细胞均无促凝活性。我们认为用细胞毒药物快速破坏白血病细胞仍是有效防止DIC的措施之一,若合用肝素可能更好。

The clinical and pathological findings from renal biopsy of 49 patients with prote-inuria were analysed. Cases of similar clinical manifestations may have different pathological findings, while patients with different clinical presentations may have the same pathological depictions. Amelioration of IgM nephropathy can be achieved by pre-dnisolone and Tripterygium wilfordii hook, when prednisolone and cytotoxic agents are used, membranous nephropathy, membrano-proliferative nephropathy or mesangial proli-ferative...

The clinical and pathological findings from renal biopsy of 49 patients with prote-inuria were analysed. Cases of similar clinical manifestations may have different pathological findings, while patients with different clinical presentations may have the same pathological depictions. Amelioration of IgM nephropathy can be achieved by pre-dnisolone and Tripterygium wilfordii hook, when prednisolone and cytotoxic agents are used, membranous nephropathy, membrano-proliferative nephropathy or mesangial proli-ferative nephropathy can be partially or completely alleviated. Renal biopsy studies in some cases are quite essential in guiding the appropriate treatment.

本文蛋白尿患者按临床表现分为肾病综合征、持续性蛋白尿及肉眼或显微镜血尿伴蛋白尿三类共49。各例经肾活组织通过光镜,电镜及免疫荧光技术进行病理诊断,所得结果分原发性及系统疾病性肾小球肾炎两大类。不同的临床表现可得相同的病理发现,相同的临床表现可得不同的病理发现。IgM肾病经强的松加雷公藤获完全缓解。一般说来,强的松无效时加用细胞毒药物可使系膜增殖性、膜增殖性肾炎及膜性肾病得到缓解。部分患者因治疗剂量不足,未获满意结果。肾活检有助诊断,用以指导治疗。

 
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