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acth
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  相似匹配句对
     The level of ACTh.
     故尚难肯定,这也说明了以A症、征的复杂性。
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     PRODUCTION OF McAb TO ACTH
     抗ACTH单克隆抗体制备及鉴定
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  acth
A comparative study of nootropic activity of semax (MEHFPGP), an analog of ACTH4-10, and some of its derivatives, in which the N-terminal methionine was modified or substituted with other amino acid residues, was performed.
      
Melanocortins, peptides of the family of adrenocorticotropic (ACTH) and melanocyte-stimulating (MSH) hormones, have a wide range of physiological activity.
      
Heptapeptide semax (MEHFPGP) is an analog of the ACTH4-10 fragment.
      
The following analogs of the N-terminal ACTH fragments were used: rMEHFPGP, where r is glucuronic acid, KEHFPGP, GEHFPGP, EHFPGP, HFPGP, and ERP.
      
Effects of Semax, a Peptide ACTH4-10Analogue, on the Respiratory Burst in Human Neutrophils
      
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It has been found, that the extracts of different tissues (liver, spleen, muscles, kidney), made according to Filatov, are capable of stimulating adrenal cortex as judged by their ability to cause a decline in adrenal ascorbic acid after intraperitoneal administration into albino rats. But this adrenocorticotropic action requires the presence of an intact pituitary gland, that is to say, all the tissue extracts examined, contain an ACTH releasing factor, which stimulates the release of ACTH from...

It has been found, that the extracts of different tissues (liver, spleen, muscles, kidney), made according to Filatov, are capable of stimulating adrenal cortex as judged by their ability to cause a decline in adrenal ascorbic acid after intraperitoneal administration into albino rats. But this adrenocorticotropic action requires the presence of an intact pituitary gland, that is to say, all the tissue extracts examined, contain an ACTH releasing factor, which stimulates the release of ACTH from anterior pituitary. It has been found, that the ACTH releasing factor is ultrafiltrable. The possible role of this factor in the regulation of anterior pituitary secretion of ACTH in stress and in clinical tissue-therapy is discussed.

以腎上腺抗壞血酸降低法證明不同的組織浸液(肝、脾、腎、肌)均具有興奮腎上腺皮質的作用,但此作用是通過腦垂體前葉ACTH的分泌而發揮的,在割出腦垂體的動物組織浸液即不再呈現作用。由於此組織浸液所含有的有效成份可以透過超瀘膜,故其可能為小分子的代謝產物。最後並將此實驗的結果聯系腦垂體前葉ACTH的分泌機制及組織療法的功效加以討論。

The adrenocortical hormone activities of △~6-6-methyl cortisone acetate (△~6), synthesized by the Institute of Organic Chemisty of the Academia Sinica, are studied and compared with those of cortisone. When adrenalectomized rats, weighing 100—200grams were injected subcutaneously with a dose of 1 mg of △~6 once daily for 4 days, the developments of granuloma on subcutaneous implantation of cotton pellets and of egg-white-induced oedema of the hind paws were inhibited markedly. Involution of the thymus of these...

The adrenocortical hormone activities of △~6-6-methyl cortisone acetate (△~6), synthesized by the Institute of Organic Chemisty of the Academia Sinica, are studied and compared with those of cortisone. When adrenalectomized rats, weighing 100—200grams were injected subcutaneously with a dose of 1 mg of △~6 once daily for 4 days, the developments of granuloma on subcutaneous implantation of cotton pellets and of egg-white-induced oedema of the hind paws were inhibited markedly. Involution of the thymus of these rats was also noted. The potency of △~6 in these respects was similar to that of cortisone. In adrenalectomized rats and mice, the liver glycogen deposition activity of △~6 was 4—5 times as potent as cortisone. When rats were pre-treated with △~6 at a dosage of 0.75 mg/rat, the emotional stress activated secretion of pituitary ACTH was markedly inhibited. With respect to water and electrolyte regulation, △~6 differs from cortisone and deoxycorticosterone in that, in stead of possessing water and sodium retaining actions, it induces diuresis in adrenalectomized rats. From these findings it would appear, therefore, that the adrenocortical hormone activities of △~6 resemble those of 6α-methyl prednisolone, triamcinolone, and dexamethasone.

△~6-6-甲基皮质酮乙酸酯为我国化学家合成的一种皮质激素同型物,我们研究了其肾上腺皮质激素样作用。结果表明,此同型物对大鼠棉球肉芽肿和后足炎性水肿及胸腺组织的抑制作用与同剂量皮质酮大致相似;其肝糖原堆积作用约为皮质酮的4—5倍,对垂体ACTH条件反射性分泌的抑制作用亦较皮质酮强;对水盐代谢的影响则与皮质酮及脱氧皮质甾酮不同,不但不引起水分和钠储留,反而有明显利尿作用。

Corydalis B has been reported to have strong analgesic and sedative actions resembling morphine and a number of tranquilizers. It is well.known that both morphine and the tranquilizers, such as reserpine and chlorpromazine, stimulate the release of ACTH, as well as depress the secretion of ACTH by the pituitary in response to a number of stressful stimuli under certain conditions. Since Corydalis B has been shown to have pharmacological properties similar to those of the aforementioned compounds,...

Corydalis B has been reported to have strong analgesic and sedative actions resembling morphine and a number of tranquilizers. It is well.known that both morphine and the tranquilizers, such as reserpine and chlorpromazine, stimulate the release of ACTH, as well as depress the secretion of ACTH by the pituitary in response to a number of stressful stimuli under certain conditions. Since Corydalis B has been shown to have pharmacological properties similar to those of the aforementioned compounds, an attempt was made to study whether corydalis B would also affect the pituitary-adrenal axis. Experiments were carried out on male rats. A fall in adrenal ascorbic acid was used as the criterion for the release of ACTH. Subcutaneous injection of Corydalis B in a dose of 50 or 70mg/kg, the effective analgesic and sedative dosage, caused marked adrenal ascorbic acid and cholesterol depletion in intact rats. However, the ascorbic acid depleting effect of the compound disappeared in hypophysectomized rats. Pretreatment of rats with pentobarbital (40 mg/kg) or prednisolone (15 mg/kg) completely prevented the adrenal ascorbic acid depletion. Repeated injections of Corydalis B for 6 days, induced the development of tolerance to the pituitary-stimulating effect of the compound. From these results, it would appear that Corydalis B has a stimulatory action on the pituitary-adrenal system.

鎮痛药嗎啡以及安定药氯丙嗪均有刺激垂体促腎上腺皮貭激素释放的作用.延胡索乙素具有类似嗎啡的鎮痛作用和类似氯丙嗪的安定作用,它是否也能引起垂体促腎上腺皮貭激素的释放是本文研究的問題. 实驗用体重80—150克的雄性大白鼠,以腎上腺維生素C含量的下降做为垂体促腎上腺皮貭激素释放的指标. 給大鼠皮下注射延胡索乙素50或70毫克/公斤(有效鎮痛和安定剂量)后,腎上腺維生素C含量明显下降,說明延胡索乙素有兴奋垂体腎上腺系統的作用。給去垂体大鼠注射延胡索乙素并不能引起腎上腺維生素C含量下降,說明延胡索乙素兴奋垂体-腎上腺系統的作用在于引起垂体促腎上腺皮貭激素的分泌,而不是直接兴奋腎上腺皮貭。給大鼠注射戊巴此妥鈉40毫克/公斤,或注射去氫皮貭醇(prednisolone)15毫克/公斤后,延胡索乙索引起垂体促腎上腺皮貭激素释放的作用消失,說明延胡索乙素这一作用的部位有可能是在下视丘.

 
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