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fluorescence cystoscopy
相关语句
  荧光膀胱镜
     Value of 5-aminolevulinic acid-induced fluorescence cystoscopy in the diagnosis and treatment of bladder cancer (report of 56 cases)
     5-氨基乙酰丙酸荧光膀胱镜在膀胱肿瘤诊治中的应用评价(附56例报告)
短句来源
  “fluorescence cystoscopy”译为未确定词的双语例句
     Biopsies were obstained from fluorescent areas of the bladder. A total of 69 biopsies was obstained. The histological results showed the sensitivity of the fluorescence cystoscopy was 100%, the specificity was 86. 7 %, the false positive was 13.3%, and no false negative.
     12例共69个活检标本,病理结果显示PDD对膀胱癌及不典型增生的诊断敏感性为100%,特异性为86.7%,假阳性率为13.3%,无假阴性。
短句来源
  相似匹配句对
     RESONANCE FLUORESCENCE
     共振荧光
短句来源
     Super fluorescence
     超荧光
短句来源
     Value of 5-aminolevulinic acid-induced fluorescence cystoscopy in the diagnosis and treatment of bladder cancer (report of 56 cases)
     5-氨基乙酰丙酸荧光膀胱镜在膀胱肿瘤诊治中的应用评价(附56例报告)
短句来源
     The Experience of Nursing Care in Cystoscopy
     膀胱镜检查的护理体会
短句来源
     Apliication of Lining Gel in Cystoscopy
     利宁凝胶在膀胱镜检查中的应用
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  fluorescence cystoscopy
False positive lesions of fluorescence cystoscopy did not differ from benign lesions detected by standard white light cystoscopy with regard to p53 and p16 immunoreactivity.
      
Of 247 biopsies, 41/49 lesions appeared suspicious on fluorescence cystoscopy, but were histopathologically benign.
      
To determine p53 and p16 status as molecular markers of bladder cancer, in histologically proven benign bladder biopsies, obtained from lesions suspect for malignancy as judged by fluorescence cystoscopy.
      
False-positive lesions detected by fluorescence cystoscopy: any association with p53 and p16 expression
      
This study in 33 patients aimed to demonstrate the role of fluorescence cystoscopy in transurethral resection of superficial bladder cancer.
      
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To study the sensitivity and specificity of detection early bladder cancer or dysplasia with fluorescence cystoscopy following intravasical instillation of 5-aminol evulinic acid (ALA ), 1.5 gram ALA hy-drochloride dissolved in 50ml 8. 4% sodium bicarbonate was instilled intravesically in 12 patients with a suspicion of primary bladder cancer. Cystoscopy under white light arc, violet light(= 375~440nm) were performed in this patients. The violet light from a xenon arclamp with a band pass filter...

To study the sensitivity and specificity of detection early bladder cancer or dysplasia with fluorescence cystoscopy following intravasical instillation of 5-aminol evulinic acid (ALA ), 1.5 gram ALA hy-drochloride dissolved in 50ml 8. 4% sodium bicarbonate was instilled intravesically in 12 patients with a suspicion of primary bladder cancer. Cystoscopy under white light arc, violet light(= 375~440nm) were performed in this patients. The violet light from a xenon arclamp with a band pass filter system, was used for intravesical induction of fluorescence. Biopsies were obstained from fluorescent areas of the bladder. A total of 69 biopsies was obstained. The histological results showed the sensitivity of the fluorescence cystoscopy was 100%, the specificity was 86. 7 %, the false positive was 13.3%, and no false negative. The fluorescence cystoscopy might help to find the tiny malignant lesions that are difficult to visualize with standard cystoscopy, and help to completly resecte the urethelial neoplasms, and decrease the recurrent rate.

为了研究以5-氨基果糖酸(ALA)作为荧光物质的光动力学诊断系统(PDD)对膀胱微小乳头状癌、上皮的不典型增生和原位癌诊断的敏感性和特异性,对12例临床诊断为膀胱癌的患者,于术前用ALA1.5克+8.4%NaHCO_3 50ml行膀胱内灌注,2~4小时后进行常规膀胱镜检和荧光膀胱镜检(光源为λ=375~440nm蓝光),然后在有荧光部位行活检送病理检查。12例共69个活检标本,病理结果显示PDD对膀胱癌及不典型增生的诊断敏感性为100%,特异性为86.7%,假阳性率为13.3%,无假阴性。荧光膀胱镜检可以发现常规膀胱镜检难以发现的微小癌灶及不典型增生,指导电切,对减少肿瘤的遗漏和降低复发率有较大的临床意义。

Objective To investigate histological distribution of PpⅨ after intravesical instillation of 5-ALA and difference of PpⅨ expression in different lesions. Methods Twenty patients with painless gross hematuria were examined by fluorescence cystoscopy. One and a half grams of 5-aminolevulinic acid were dissolved in 50ml of 1.4% sodium bicarbonate solution,then instill 5-ALA solution into bladder. After 2-3 hours, put in fluorescence cystoscope, perform fluorescence cystoscopy using photodynamic...

Objective To investigate histological distribution of PpⅨ after intravesical instillation of 5-ALA and difference of PpⅨ expression in different lesions. Methods Twenty patients with painless gross hematuria were examined by fluorescence cystoscopy. One and a half grams of 5-aminolevulinic acid were dissolved in 50ml of 1.4% sodium bicarbonate solution,then instill 5-ALA solution into bladder. After 2-3 hours, put in fluorescence cystoscope, perform fluorescence cystoscopy using photodynamic diagnosis(PDD) systems, 407nm excitated light is used to irradiate bladder wall. Perform biopsy at red fluorescence areas and non-fluorescence blue areas,respectively, make 2 freeze-sections of each biopsy specimen, one for HE staining,the other for determining fluorescence distribution and fluorescence intensity of PpⅨ in different tissues by laser confocal fluorescence microscopy after glycerine blocking. Results Pathology analysis showed, among 32 biopsy specimens, 18 were transitional cell carcinoma, 14 were benign lesions. Under laser confocal fluorescence microscopy, 5-ALA induced PpⅨ fluorescence distributed mainly in surface layer of tissues, on the contrary, fluorescence in deep layer was weak. Fluorescence analysis showed that fluorescence intensity in surface tissues was 5-10 times higher than that of deep tissues, mean fluorescence intensity of tumor tissues was higher than that of benign lesions and had statistically significance with tumor grades(G3> G 1-2). Conclusions (1) As fluorescence of PpⅨ mainly distributes in tissue surface layer, fluorescence cystoscopy could only find surface lesions, so it might have no meaning to diagnosis of lesions beneath normal mucosa, and could not guide in determining resection depth of bladder tumor during transurethral resection(TUR) under fluorescence cystoscope. (2) 5-ALA induced fluorescence cystoscopy's specificity to bladder cancer diagnosis is not enough high, but fluorescence intensity could discriminate between benign and malignant lesions.(3) Laser confocal microscopy and fluorescence image analysis are advantageous diagnostic tools for the PDD of bladder neoplasms in vivo.

目的通过膀胱灌注5-氨基酮戊酸(5-ALA)探讨其所诱导产生内源性PpⅨ在膀胱组织中分布及不同病变表达上的差异。方法20例无痛性肉眼血尿患者行荧光膀胱镜检查。以50ml5-ALA缓冲液膀胱灌注,2~3h后置入荧光膀胱镜,用光动力学诊断系统进行荧光膀胱镜检,采用407nm激发光照射膀胱壁,对产生荧光的红色区域及非荧光的蓝色区域分别进行标记活检,取活检组织做快速冰冻切片,每块组织均做2份,1份用HE染色进行组织病理学检查,另1份用甘油封闭后在激光共聚焦显微镜下荧光成像,分析各标本荧光分布并定量检测不同组织PpⅨ荧光含量。结果共取活检组织32处,病理检查结果,膀胱移行细胞癌共18处、良性病变12处、正常膀胱上皮2处。激光共聚焦显微镜下所见,5-ALA诱导PpⅨ荧光主要分布在组织表层,深部组织PpⅨ荧光很弱。荧光量化分析显示,表层组织荧光强度高出深部组织5~10倍,对比各样本表层组织荧光,其强度与肿瘤分级相关(G3>G1-2),而肿瘤组织平均荧光强度明显高于良性病变的平均荧光强度。结论(1)由于PpⅨ荧光主要分布在组织表层,荧光膀胱镜检只能发现表层的病变,因此对于位于正常膀胱黏膜下的病变进行荧光诊断可能无价值,在荧光...

目的通过膀胱灌注5-氨基酮戊酸(5-ALA)探讨其所诱导产生内源性PpⅨ在膀胱组织中分布及不同病变表达上的差异。方法20例无痛性肉眼血尿患者行荧光膀胱镜检查。以50ml5-ALA缓冲液膀胱灌注,2~3h后置入荧光膀胱镜,用光动力学诊断系统进行荧光膀胱镜检,采用407nm激发光照射膀胱壁,对产生荧光的红色区域及非荧光的蓝色区域分别进行标记活检,取活检组织做快速冰冻切片,每块组织均做2份,1份用HE染色进行组织病理学检查,另1份用甘油封闭后在激光共聚焦显微镜下荧光成像,分析各标本荧光分布并定量检测不同组织PpⅨ荧光含量。结果共取活检组织32处,病理检查结果,膀胱移行细胞癌共18处、良性病变12处、正常膀胱上皮2处。激光共聚焦显微镜下所见,5-ALA诱导PpⅨ荧光主要分布在组织表层,深部组织PpⅨ荧光很弱。荧光量化分析显示,表层组织荧光强度高出深部组织5~10倍,对比各样本表层组织荧光,其强度与肿瘤分级相关(G3>G1-2),而肿瘤组织平均荧光强度明显高于良性病变的平均荧光强度。结论(1)由于PpⅨ荧光主要分布在组织表层,荧光膀胱镜检只能发现表层的病变,因此对于位于正常膀胱黏膜下的病变进行荧光诊断可能无价值,在荧光膀胱镜指示下行经尿道切除术(TUR)时,对于切除深度无指导意义。(2)5-ALA诱导荧光膀胱镜检对膀胱癌诊断特异性尚不高,但量化荧光强度可区分良、恶性病变,从而提高荧光膀胱镜检对肿瘤诊断的特异性。(3)PpⅨ可作为肿瘤标志物来判断肿瘤生物学行为。(4)激光共聚焦显微镜及其图像分析系统对于膀胱肿瘤光动力学诊断(PDD)临床应用价值的分析是一个很有用的工具。

Objective To assess the value of 5-aminolevulinic acid-induced fluorescence endoscopy in the diagnosis and treatment of bladder cancer. Methods One half an hours prior to cystoscopy, 1.5g 5- aminolevulinic acid (5-ALA) was dissolved in 50mL 1.4% NaHCO_3 solution and instilled intravesically. For fluorescence excitation a blue light source (D-light, Karl Storz) was used. Under white and fluorescence light guidance, tumor locations were recorded, biopsies were taken and tumors were resected. Results 155 biopsies...

Objective To assess the value of 5-aminolevulinic acid-induced fluorescence endoscopy in the diagnosis and treatment of bladder cancer. Methods One half an hours prior to cystoscopy, 1.5g 5- aminolevulinic acid (5-ALA) was dissolved in 50mL 1.4% NaHCO_3 solution and instilled intravesically. For fluorescence excitation a blue light source (D-light, Karl Storz) was used. Under white and fluorescence light guidance, tumor locations were recorded, biopsies were taken and tumors were resected. Results 155 biopsies were taken from fluorescent and nonfluorescent areas (2.8 per patient) to check the effectiveness of the new method. Compared with standard cystoscopy, 5-ALA cystoscopy had a sensitivity of 98.4%(63/64 sites), specificity of 73.5%(61/83 sites). There was significant difference between operation methods (P<0.01). The 5-ALA cystoscopy helped the diagnosis of tumor in 14 sites with negative standard cystoscopic findings. Neither local nor systemic side effects were noted. Conclusion 5-Aminolevulinic acid-induced fluorescence cystoscopy has proved to be a valuable detection and treatment method with a high sensitivity for the bladder cancer, which improves the diagnostic sensitivity for carcinoma in situ and to reduce the risk of recurrence related to missed cancerous lesions or incomplete resection.

目的与普通膀胱镜相比较,评价5-氨基已酰丙酸荧光膀胱镜检查在膀胱肿瘤诊断和治疗中的价值。方法术前1.5h,1.4%的碳酸氢钠溶液50mL溶解1.5g的5-氨基乙酰丙酸(5-ALA),膀胱灌注。术中对普通光下及蓝光下的可疑部位取活检,并对活检部位电切和电灼,活检组织送病理检查。结果56例患者共取活检155处,平均2.8次/人。荧光膀胱镜的敏感性98.4%(63/64位点),特异性73.5%(61/83位点),两者有显著统计学差异(P<0.01)。蓝光下发现普通光下未发现的肿瘤位点14处。未发现5-ALA的局部和全身毒副作用。结论5-ALA荧光膀胱镜是一种高敏感的用于膀胱肿瘤诊断和治疗的有效方法,能够提高对膀胱原位癌的诊断敏感性及降低术中因未发现和切除不完全所带来的膀胱肿瘤复发危险性。

 
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