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胰腺癌细胞系     
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  pancreatic cancer cell line
     Objective:To investigate the effect of blocking signal transducer and activator of transcription 3(STAT3) signaling pathway by Janus kinase(JAK) specific inhibitor AG490 on the growth and proliferation of SW1990 human pancreatic cancer cell line harboring constitutive active STAT3 and the underlying mechanism.
     目的:探讨Janus激酶(Janus kinase,JAK)特异性抑制剂AG490阻断STAT3信号转导通路对高表达STAT3的人胰腺癌细胞系SW1990生长增殖的作用及其机制。
短句来源
     Part TwoStudy on the cytotoxicity of macrophage and PBMC to pancreatic cancer cell line PC-3transferred with GM-CSF and IL-18【Abstract】 Objectives To study the killing potential of macrophage and peripheral blood mononuclear cell (PBMC) to pancreatic cell line PC-3 transfected with IL-18 and GM-CSF.
     第二部份 IL-18和GM-CSF转染PC-3细胞后对小鼠免疫细胞的体外效应研究目的:研究巨噬细胞和外周血单个核细胞(peripheral blood mononuclear cell,PBMC)对转染 IL-18和 GM-CSF基因后的胰腺癌细胞系PC-3的杀伤作用。
短句来源
     The Effect of Bombesin on Cyclin D_1/Cyclin-dependent Kinase 4 of Human Pancreatic Cancer Cell Line CFPAC-1
     蛙皮素对人胰腺癌细胞系CFPAC-1细胞周期蛋白D_1/细胞周期蛋白依赖性激酶4的影响
短句来源
     Objective: To investigate the effect of BRAF V600E on the biological behaviors of human pancreatic cancer cell line Panc-1 by transferring BRAF V600E into Panc-1 cell, which will provide further theoretical basis for the study of pathogenesis and treatment of pancreatic cancer.
     目的通过构建BRAF V600E真核细胞表达载体并转染人胰腺癌细胞系Panc-1,探讨BRAF V600E对人胰腺癌细胞系Panc-1生物学行为的影响,为研究胰腺癌的发病机制与治疗提供理论依据。
短句来源
     Effect of sonic hedgehog signal pathway blocking on the proliferation and apoptosis of pancreatic cancer cell line SUIT-2
     特异性阻断Shh信号通路对胰腺癌细胞系SUIT-2增殖和凋亡的影响
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  pancreatic cancer cells
     Growth-inhibitory Effects of Vitamin D Analogues EB1089 in BxPC-3 Human Pancreatic Cancer Cells
     维生素D衍生物EB1089对胰腺癌细胞系生长抑制作用的实验研究
短句来源
     Objective To study the enhancement of the growth inhibition by irradiation to human pancreatic cancer cells ( PC-3 ) transfected by lipofectin-mediated insulin-like growth factor-1 receptor (IGF-1R) antisense oligonucleotides (ASON) and its tumorigenecity in nude mice.
     目的研究辐射促进脂质体(lipofectin)介导的胰岛素样生长因子-1受体(IGF-1R)反义寡核苷酸(ASON)抑制人胰腺癌细胞系PC-3的生长及接种裸鼠后的成瘤性。
短句来源
     Methods The expression of PPARγ and RXRα were examined by RT-PCR. SW1990 pancreatic cancer cells were treated with 9-cis-RA, ligand of PPARγ,15d-PGJ_2, and both.
     方法 应用逆转录 (RT) PCR检测胰腺癌细胞系SW 1990中PPARγ和维甲酸受体α(RXRα)的表达。
短句来源
     The expression of the STAT3 signaling pathway components was determined by Western blot. Results:The growth and proliferation of pancreatic cancer cells decreased significantly after AG490 treatment(P<0.05);
     结果:AG490作用于人胰腺癌细胞系SW1990后,细胞增殖水平明显下降(P<0.05);
短句来源
     Objective: To observe and investigate the effects of growth-inhibitory effect of EB1089 in BxPC-3 human pancreatic cancer cells.
     目的:观察维生素D衍生物EB1089对人胰腺癌细胞系BxPC-3的生长抑制作用及其可能机制。
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  pancreatic cell line
     Effects of Antisense EGF and Antisense EGFR Retroviral Expression Vectors on the Cell Growth of Human Pancreatic Cell Line
     人反义EGF和反义EGFR逆转录病毒表达载体对人胰腺癌细胞系细胞生长的影响
短句来源
     Part TwoStudy on the cytotoxicity of macrophage and PBMC to pancreatic cancer cell line PC-3transferred with GM-CSF and IL-18【Abstract】 Objectives To study the killing potential of macrophage and peripheral blood mononuclear cell (PBMC) to pancreatic cell line PC-3 transfected with IL-18 and GM-CSF.
     第二部份 IL-18和GM-CSF转染PC-3细胞后对小鼠免疫细胞的体外效应研究目的:研究巨噬细胞和外周血单个核细胞(peripheral blood mononuclear cell,PBMC)对转染 IL-18和 GM-CSF基因后的胰腺癌细胞系PC-3的杀伤作用。
短句来源
     A monoclonal antibody,PS-10,was generated by fusion of SP2/0 myeloma cell and spleen cell of BALB/c mouse immunized with the mucin of pancreatic cell line SW 1990. It reacted with pancreatic cancer tissue(85.3%), gastric cancer(83.3%), colorectal cancer(83.3%), and Ampulla of Vater cancer(5/5).
     以胰腺癌细胞系SW1990粘液免疫BALB/c小鼠获得稳定分泌IgG_1抗体的杂交瘤PS-10,与胰腺癌、瓦特氏腹壶癌、胃癌、大肠癌有较强反应,阳性率83.3%—100%。
短句来源
     5-FU was used to induce the chemoresistant capability of SW1990 pancreatic cell line. The XIAP expression in SW1990 was examined by RT-PCR and Western blot. The XIAP level in the cells and its chemoresistance to 5-FU were analyzed by linear regression.
     用5-氟尿嘧啶(5-FU)间歇诱导SW1990提高其对药物的耐药性,以逆转录聚合酶链反应(RT-PCR)和Western印迹检测XIAP在胰腺癌细胞系中表达的改变,探讨与细胞耐药性之间的关系。
短句来源
  pancreatic carcinoma cells
     Methods K-RAS Antisense gene was transduced into pancreatic carcinoma cells by gene gun transduction, the expression of K-RAS P21 protein on BxPC-3、AsPC-1 and MiaPaCa-2 pancreatic carcinoma cells line were examined by western blot and immunocytochemistry staining.
     方法利用基因枪技术,将反义基因转导入宿主细胞,通过免疫细胞化学和Western blot方法,观察K-RAS突变特异性反义基因转导后AsPC-1、MiaPaCa-2和BxPC-3三种人胰腺癌细胞系K-RAS P21蛋白的变化。
短句来源
     The Western blot method was used to detect the expression of ERK_1/ERK_2 proteins in the pancreatic carcinoma cells.
     Westernblot方法观察胰腺癌细胞系Panc 1及Jf 30 5中的ERK1/ERK2 蛋白表达。
短句来源
     The western blot showed that the expression of ERK_1 and ERK_2 proteins in the pancreatic carcinoma cells was also at a high level.
     胰腺癌细胞系Panc 1及Jf 30 5中均有ERK1/ERK2蛋白的高表达。
短句来源
     The expression of KAI1 in human pancreatic carcinoma cells (PANC1) was examined after Ad-KAI1 infection.
     结果构建的Ad-KAI1可以高效感染人胰腺癌细胞系PANC1,并检测到感染Ad-KAI1的PANC1细胞中KAI1的高表达;
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      pancreatic cancer cell line
    Effects of different concentrations of antisense oligodeoxynucleotides (ASODN) on human pancreatic cancer cell line PaTu8988s
          
    Objective: To study the effects of different concentrations of antisense oligodeoxynucleotides (ASODN) on human pancreatic cancer cell line PaTu8988s.
          
    Conclusions: K-ras complementary ASODN can inhibit the growth of human pancreatic cancer cell line PaTu8988s by 30.05% to 98.73%.
          
    A human pancreatic cancer cell line (JF305) was established from a pancreatic adenocarcinoma xenograft in nude mice.
          
    Objective: To construct the small interfering RNA(siRNA) expression cassettes (SECs) targeting activated K-ras gene sequence and investigate the effects of SECs on K-ras gene in human pancreatic cancer cell line MIAPaCa-2.
          
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      pancreatic cancer cells
    Inhibitive Effect of Prodigiosin on the Proliferation of Human Malignant Pancreatic Cancer Cells
          
    In this study, we find that prodigiosin could effectively inhibit the proliferation of human pancreatic cancer cells H8898 in a dose-and-time-dependent manner, with an IC50 of 75μmol according to the results of MTT and cell proliferation assays.
          
    Prodigiosin also could induce apoptosis of pancreatic cancer cells at low concentration and results in the fragmentation pattern of DNA.
          
    All these results demonstrate that prodigiosin can obviously inhibit the proliferation of pancreatic cancer cells H8898 by arresting the cell cycle and inducing apoptosis.
          
    Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer cells
          
    更多          
      pancreatic cell line
    In order to explore the expression of erythropoietin receptor (EPOR) in pancreatic cell line NIT-1 and its effect on cell apoptosis after binding with erythropoietin (EPO), NIT-1 cells were cultured and expanded.
          
    The amphicrine pancreatic cell line AR42J: a model system for combined studies on exocrine and endocrine secretion
          
    In summary, AR42J cells represent the first amphicrine pancreatic cell line with the combined expression of exocrine and neuroendocrine secretory organelles, both of which follow a regulated secretory pathway in response to various secretory stimuli.
          
    Cell cycle and gene expression in the insulin producing pancreatic cell line βTC1
          
    We sought to determine whether either CCK itself or an antogonist of CCK could modulate the sensitivity of the human pancreatic cell line MIA-PaCa2 to cisplatin (DDP).
          
    更多          
      pancreatic carcinoma cells
    Celecoxib inhibits proliferation and induces apoptosis via cyclooxygenase-2 pathway in human pancreatic carcinoma cells
          
    In order to evaluate the effects and mechanisms of celecoxib in inhibiting proliferation and inducing apoptosis on human pancreatic carcinoma cells, the anti-proliferative effect was measured by using methabenzthiazuron (MTT) assay.
          
    Cell cycle and apoptosis were analyzed by using flow cytometry (FCM), and the PGE2 levels in the supernatant of cultured pancreatic carcinoma cells were quantitated by enzyme-linked immunoabsordent assay (ELISA).
          
    It was concluded that cyclooxygenase-2 specific inhibitor celecoxib could inhibit proliferation and induced apoptosis of human pancreatic carcinoma cells via suppression of PGE2 production in vitro.
          
    Inhibition of metastatic progression of SSTR2 gene transfection mediated by adenovirus in human pancreatic carcinoma cells
          
    更多          


    A monoclonal antibody,PS-10,was generated by fusion of SP2/0 myeloma cell and spleen cell of BALB/c mouse immunized with the mucin of pancreatic cell line SW 1990. It reacted with pancreatic cancer tissue(85.3%), gastric cancer(83.3%), colorectal cancer(83.3%), and Ampulla of Vater cancer(5/5). The related antigen of PS-10 is a high molecular weight (300KD) mucin type glycoprotein and glycolipid. In order to evaluate its usefulness in clinical diagnosis, we detected the level of PS-10 related antigen in serum...

    A monoclonal antibody,PS-10,was generated by fusion of SP2/0 myeloma cell and spleen cell of BALB/c mouse immunized with the mucin of pancreatic cell line SW 1990. It reacted with pancreatic cancer tissue(85.3%), gastric cancer(83.3%), colorectal cancer(83.3%), and Ampulla of Vater cancer(5/5). The related antigen of PS-10 is a high molecular weight (300KD) mucin type glycoprotein and glycolipid. In order to evaluate its usefulness in clinical diagnosis, we detected the level of PS-10 related antigen in serum and feces by binding inhibition EL1SA. It revealed that the mean inhibition rate both in serum and in fcces are significantly higher in patients with gastrointestinal cancer than non-malignant diaease or normal individual. The positive rate in serum are: pancreatic cancer 87.5% ,gastric cancer 50% ,colorectal cancer 56.6%, and normal individual, 4%. The positive rates in feces are: -pancreatic cancer, 33.3%, gastric cancer 57.5%, colorectal cancer 62.5% and normal individual 6%. It is suggested that PS-10 may be a useful monoclonal antibody in the diagnosis of pancreatic cancer.

    胰腺癌细胞系SW1990粘液免疫BALB/c小鼠获得稳定分泌IgG_1抗体的杂交瘤PS-10,与胰腺癌、瓦特氏腹壶癌、胃癌、大肠癌有较强反应,阳性率83.3%—100%。其对应抗原属大分子糖蛋白(分子量300KD)及糖脂,并可从癌症患者血清及粪便中检出。以正常人平均抑制率加两倍标准差为阈值,则血清及粪便中相关抗原检测阳性率为:胰癌87.5%及33.3%,胃癌50%及57.5%,肠癌56.6%及62.5%;正常人4%及6%,非肿瘤疾病28%及6.3%。初步表明PS-10对胰腺癌的诊断有一定价值。

    A new human pancreatic adenocarcinoma cell line (PC- 3) was established in oar Lab. This cell line was derived from a primary tumor in the head of the pancreas of a female patient. The culture was confirmed to be a human pancreatic adenocarcinoma cell line by cytological, histological, ultrastructural and im-muocytochemical investigations. Chromosomal analysis and flow cytometrical study show that the PC-3 cells are hyperdipoid karyotypic patten.PC-3 cells are able to form colonies in soft agar and in nude mice...

    A new human pancreatic adenocarcinoma cell line (PC- 3) was established in oar Lab. This cell line was derived from a primary tumor in the head of the pancreas of a female patient. The culture was confirmed to be a human pancreatic adenocarcinoma cell line by cytological, histological, ultrastructural and im-muocytochemical investigations. Chromosomal analysis and flow cytometrical study show that the PC-3 cells are hyperdipoid karyotypic patten.PC-3 cells are able to form colonies in soft agar and in nude mice after inoculation of cultured tumor cells. Histology of xenografts in nude mice is identical to that of the original tumor. PC-3 have been widely used in molecular biology studies of the pancreatic carcinoma in several Labs. Overexpression of c-myc and c-Ki-ras oncogenes was detected by using hybridization in situ technique. PC-3 has been proved to be an useful and essential model for further studies of human pancreatic cancer.

    人胰腺癌是很难建系的癌细胞之一,特别是从原发瘤建立的细胞系。我们成功地从一个胰腺癌组织建立了一株人胰腺癌细胞系,命名为PC-3。PC-3细胞呈上皮样,贴壁生长,经过四年连续培养,细胞系稳定。通过免疫组化、电镜观察、染色体及DNA含量分析,细胞集落形成及裸鼠移植,生长因子对瘤细胞生长的影响和癌基因的表达证实PC-3细胞系为人胰腺癌细胞系。PC-3细胞系的建立进一步丰富了人胰腺癌细胞库,对深入了解人胰腺癌细胞生物学及分子生物学特性提供了有力的物质基础。

    In this study, 3 human pancreatic adenocarcinoma cell lines (PC-1, PC-2 and PC-3) and 3 other human cancer cell lines (adenocarcinoma of lung, LE-TP; gastric carcinoma, SGL7901; and breast carcinoma, BCP37) were investigated by adding EGF, anti-EGF antiserum and anti-EGFR monoclonal antibody into culture medium. EGF was found to exert a mild stimulating effect on the growth of PC-1 and LETP cells, but had no effect on the other 4 cell lines. Anti-EGF and anti-EGFR antibodies inhibited the proliferation of PC-1,...

    In this study, 3 human pancreatic adenocarcinoma cell lines (PC-1, PC-2 and PC-3) and 3 other human cancer cell lines (adenocarcinoma of lung, LE-TP; gastric carcinoma, SGL7901; and breast carcinoma, BCP37) were investigated by adding EGF, anti-EGF antiserum and anti-EGFR monoclonal antibody into culture medium. EGF was found to exert a mild stimulating effect on the growth of PC-1 and LETP cells, but had no effect on the other 4 cell lines. Anti-EGF and anti-EGFR antibodies inhibited the proliferation of PC-1, LETP and SGL7901 cells. No significant effect on the other 3 cell lines was seen.By using the Northern blot technique, expression of EGFR mRNA was identified in all 6 cell lines. There were 3 bands (10.5kb, 5.8kb and 2.8kb) of EGFR mRNA in all cell lines except for LETP, in which the 10.5kb band was absent. The results indicate that the effect of EGF on the growth of cancer cells is very complicated and may involve an unknown regulatory mechanism of cancer cell growth. EGF may exert stimulating or inhibiting effects on cancer cell proliferation, or it may have no effect at all, even though the EGFR gene was expressed in these cell lines.

    本研究观察了上皮生长因子(EGF)抗EGF抗体和抗EGF受体抗体对3个目建的人胰腺癌细胞系(PC-1,PC-2,PC-3)和3个其它人癌细胞系(肺腺癌LETP,乳腺癌BCP37和胃腺癌SGL7901)生长的影响。结果表明:EGF仅对PC-1和LETP2个细胞系有轻度刺激生长的作用,对其它4个细胞系无明显作用。在有EGF存在的条件下,抗EGF抗体和抗EGF受体抗体对PC-1,LETP和SGL7901 3个细胞系有生长抑制作用。 用Northern核酸杂交技术研究表明这6个人癌细胞系中均有EGF受体mRNA的表达。结果表明:虽然这些细胞系中均有EGF受体的基因表达,但不一定对外源性EGF处理有反应。

     
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