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metabolic cooperation
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  代谢协作
     Application of the Chinese hamster V79 cell metabolic cooperation assay for screening teratogens and its reliability
     用中国仓鼠V79细胞代谢协作试验筛选致畸物及其可靠性
短句来源
     The reliability study for predicting teratogenicity indicates that the sensitivity and specificity of the V79 cell metabolic cooperation assay for predicting teratogenicity are 0.75 and 0.62 respectively.
     维生素C则不抑制,预测可靠性初步评价表明,V79细胞代谢协作试验预测致畸性的敏感性为0.75,特异性为0.62,提示本试验有助于预测以抑制间隙接合细胞间通讯为机理的致畸物.
短句来源
     Methods By using several well-established short term,test s i.e,V79 cell cytokinesis block micronuclei test,V79 cell metabolic cooperation test and Hela cell growth ability test in soft agar,several trace elements incl u ding Zn,Se,Mn,Mo and vitamin C,E and β-carotene were used to screen the antic arcinogenic ingredients in the tea.
     方法 应用一组短期细胞学检测试验 ,即V79细胞胞质阻滞法微核试验、细胞代谢协作试验和Hela细胞软琼脂生长试验 ,筛选茶叶含有的微量元素Zn、Se、Mn、Mo和维生素E、β-胡萝卜素、维生素C的预防肿瘤作用。
短句来源
     In this paper,we report that the animal teratogens,vitamin A and cadmium sulfate,have positive results,while the animal nonteratogen vitamin C has a negative result in the Chinese hamster V79 cell metabolic cooperation assay.
     维生素A和硫酸镉可显著抑制中国仓鼠V79细胞代谢协作.
短句来源
  代谢协同
     The inhibition effect of PM 10 on GJIC was studied by two assay systems,metabolic cooperation in V79 cells and scrape loading dye transfer in human lung fibroblasts.
     采用细胞代谢协同试验和染料划痕试验观察PM1 0 对中国仓鼠肺成纤维V79细胞以及人肺成纤维细胞间隙连接通讯的影响。
短句来源
  “metabolic cooperation”译为未确定词的双语例句
     The inhibited metabolic cooperation in vitro was seen in V79 (HPRT+/HPRT-) treated with MCs. Up-regulated expressions of c-fos and c-jun as well as promoted cell proliferation were also observed in SHE cell co-incubated with MCs in vitro.
     在体外培养条件下,藻毒素能够抑制V79(HPRT+/HPRT-)细胞间代谢协同作用,并能诱导SHE细胞c-fos和c-jun表达升高,促进细胞增殖。
短句来源
     PM 10 significantly inhibited metabolic cooperation between V79 cells and the colony numbers of V79 - cells increased in a dose dependent manner in 1 0~100 mg/L.
     [结果 ]PM1 0 抑制V79细胞的代谢协同作用 ,使V79- 细胞的存活率增高 ,在 1 0~ 1 0 0mg/L剂量范围内 ,与对照组比较 ,克隆形成数明显增高 ,有剂量 反应关系 (r=0 94,P <0 0 5)。
短句来源
  相似匹配句对
     Metabolic Engineering
     代谢工程
短句来源
     the art of cooperation;
     协调的艺术 ;
短句来源
     the art of cooperation;
     求同的艺术 ;
短句来源
     Metabolic Syndrome
     代谢综合症
短句来源
     Application of the Chinese hamster V79 cell metabolic cooperation assay for screening teratogens and its reliability
     用中国仓鼠V79细胞代谢协作试验筛选致畸物及其可靠性
短句来源
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  metabolic cooperation
This suggests that in CE-A9 heterokaryons the genes required for metabolic cooperation are expressed by the previously dormant chick erythrocyte nucleus.
      
While the CE-GM29 heterokaryons participated in metabolic cooperation shortly after fusion, the CE-A9 hetero-karyons did not.
      
Genetic determinants of metabolic cooperation were studied by fusing chick erythrocytes to HGPRT- mammalian cells.
      
Restoration of metabolic cooperation in heterokaryons between HGPRT-deficient mouse A9 fibroblasts and chick embryo erythrocytes
      
Metabolic cooperation between cells does not affect recovery of either class I or class II mutants.
      
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In this paper,we report that the animal teratogens,vitamin A and cadmium sulfate,have positive results,while the animal nonteratogen vitamin C has a negative result in the Chinese hamster V79 cell metabolic cooperation assay.The reliability study for predicting teratogenicity indicates that the sensitivity and specificity of the V79 cell metabolic cooperation assay for predicting teratogenicity are 0.75 and 0.62 respectively.This assay is useful to predict theteratogens which action mechanism shows...

In this paper,we report that the animal teratogens,vitamin A and cadmium sulfate,have positive results,while the animal nonteratogen vitamin C has a negative result in the Chinese hamster V79 cell metabolic cooperation assay.The reliability study for predicting teratogenicity indicates that the sensitivity and specificity of the V79 cell metabolic cooperation assay for predicting teratogenicity are 0.75 and 0.62 respectively.This assay is useful to predict theteratogens which action mechanism shows an inhibitory effect on the gap junctional intercellular communication and can be recommended as an important supplementary test in the optimal short-term test group for predicting teratogens.

维生素A和硫酸镉可显著抑制中国仓鼠V79细胞代谢协作.维生素C则不抑制,预测可靠性初步评价表明,V79细胞代谢协作试验预测致畸性的敏感性为0.75,特异性为0.62,提示本试验有助于预测以抑制间隙接合细胞间通讯为机理的致畸物.可作为一个重要的补充试验被选入预测致畸物的最佳试验组。

The vertebrate ocular lens has been proved to a good experimental model for r studying many problems of development,such as the effects of drugs on development,formation and distribution of gap junctions,and metabolic cooperation.In this paper,we used monoclonal antibodies,termed NC6 and ND6,specific for gap junction protein,as a probe to study the time course of effect of antibodies on development in the chicken embryonic lenses.NC6 or ND6 was injected into the right eye of chicken embryo at the 20th...

The vertebrate ocular lens has been proved to a good experimental model for r studying many problems of development,such as the effects of drugs on development,formation and distribution of gap junctions,and metabolic cooperation.In this paper,we used monoclonal antibodies,termed NC6 and ND6,specific for gap junction protein,as a probe to study the time course of effect of antibodies on development in the chicken embryonic lenses.NC6 or ND6 was injected into the right eye of chicken embryo at the 20th stage.The uninjected left eye of the same embryo was used as the control.The embryonic heads were fixed 8,12,24,36,or 48hours after injection.Lenses were removed from the eyes and measured after fixation.The size difference of lenses between injected and control groups in each time group was compared statistically.A time course curve was made with the P value from each time group.The results showed;(1)In NC6 injection,a significant size difference between injected and control lenses had already appeared in the 8 hour group(P<0.05 to 0.01)and disappeared in the 48 hour group(P>0.05).The time course curve in NC6 was smooth:(2)In ND6 injection,there was a significant difference in lens size only in the 24 hour group(P<0.05 to 0.01).The time course curve in ND6 was precipitous;(3)The peak of the time course curve was at the 24 hour point in both NC 6 and ND6 injections.The change of sensitivity to antibodies in embryos at different stages was also quantitatively analyzed this study.NC6 or ND6 was injected into eyes of chicken embryos at 20th or 24th stage.After 24 hours,the size differences of lenses between injected and control groups were statistically compared.The results showed that the lenses from embryos at the 20 th stage were highly sensitive to the antibodies(P<0.01 to 0.001 for NC6;P<0.05 to 0.01 for ND6),but the sensitivity of lenses at the 24th stage was much lower(P>0.05 or P<0.0l for NC6;P>0.05 for ND6).The difference in the sensitivity to antibodies between 20th and 24th stages is considered to be related to changes in gap junction communication.These results indicate that the lens of chicken embryo at the 20th stage is a good model for investigating the effects of drugs on development,and the 24 hour period is suitable for drug treatment.

以小鼠2-细胞胚为材料,研究电融合请参数。以M2液为融合液时,除在0.31kV/cm,1280s,1次脉冲条件下获100%融合率外,其他条件均造成较多的胚胎溶解。而持续时间在10~1280s范围内,以0.3mol/L甘露醇液为融合液,电场强度为0.31~2.04kV/cm条件下;及以0.26mol/L蔗糖液为融合液,电场强度为0.31~1.41kV/cm范围内时可获较高的融合率。实验表明:在0.47kV/cm电场条件下,蔗糖液与甘露醇液的渗透压对融合率无显著的影响;电场强度为2.04kV/cm,以高渗甘露醇液(0.30mol/L)为融合液时,胚的融合率比等渗甘露醇液(0.25mol/L)和低渗甘露醇液(0.20mol/L)做融合液时的融合结果高,而胚的死亡率低。融合后的胚与对照2-细胞胚都可继续发育.48h后发生致密化,此时融合胚发育到4-细胞,对照组为8-细胞。根据0.26mol/L蔗糖液做融合液时的结果,绘制一条获高融合率时电场强度与脉冲持续时间的关系曲线。

Using short-term tes in vitro for screening anticarcinogenic compounds has been an attracting area for cancer chemoprevention, but no systematic studies have been earried out on the efficacy of those teats. In this study,V79 cells gene forward mutation test,V79 cells cytokinesis block micronuclei test,V79 cells metabolic cooperation test and Hela cells growth ability test in soft agar were selected to detect the antimutagenic and cancer cell proliferation inhibition effects of Chinese tea. The active...

Using short-term tes in vitro for screening anticarcinogenic compounds has been an attracting area for cancer chemoprevention, but no systematic studies have been earried out on the efficacy of those teats. In this study,V79 cells gene forward mutation test,V79 cells cytokinesis block micronuclei test,V79 cells metabolic cooperation test and Hela cells growth ability test in soft agar were selected to detect the antimutagenic and cancer cell proliferation inhibition effects of Chinese tea. The active components was analyzed as well. The results show that the water extract of tea(WET) and tea polyphenols(TP) are both effective in inhibiting the mutagenesis of Mitomycin C(MMC), which indicates their effects on the initiation stage. However, the four catechins(EGCG,ECG,EGC and EC) tested also showed inhibition effect on mutagenesis induceds by MMC. Among the four catechins, ECG seems to be more effective in the micronuclei test. Inthe V79 cells metabolic coopoeration test, ECG and EGCG showed strong antipromotion effects. This effects of ECG and EGCG were confirmed in the BALB/C 3T 3 cell transformation test, It is concluded that the four tests mentioned above could be used as a batch of short term tests in screening the antimutagenic and cancer inhibition compounds of Chinese tea.

选用一组体外短测指标对茶水冻干物、茶多酚及表没食子儿茶素表没食子酸酯(EGCG),表儿茶素表没食子酸酯(ECG),表没食子儿茶素(EGC)和表儿茶素(EC)四种儿茶素的防癌作用进行了检测。研究结果表明,茶木冻干物、茶多酚及四种儿茶素在代表起动阶段的基因突变及微核形成两项指标中,均表现出一定的抑制作用,并有剂量-反应关系。在四种儿茶素中,ECG对微核形成的抑制率明显高于其它三种儿茶素。在促癌阶段方面,ECG和EGCG对TPA抑制V79细胞代谢协作具有明显的阻断作用。这两种儿茶素的抗促癌作用在BALB/C3T3细胞转化试验中得到了进一步的证实。以上受试物对癌细胞的体外生长均有抑制作用,但并无特异性。本文结果表明,V79细胞基因正向突变和细胞周期阻断法微核试验作为起始阶段指标、V79细胞代谢协作试验作为促癌阶段、Hela细胞存活率及软琼脂生长能力的测定作为癌细胞增殖指标,适用于茶中防癌有效成分的筛检。

 
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