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oral route
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  经口途径
     Methods Three tests were chosen in this study,namely short-term systemic tox icity(oral route),acute systemic toxicity test(introvenous route) and haemolys is test.
     方法本研究进行三种体内外试验,即短期全身毒性试验(经口途径),静脉注射急性全身毒性试验和溶血试验。
短句来源
  “oral route”译为未确定词的双语例句
     and ED50through the oral route was 0. 554mg/kg,8. 129mg/kg,28. 895mg/kg and 0. 492mg/kg respectively.
     口服ED_(5O)分别为0.554mg/kg,8.129mg/kg,28.895mg/kg,0.492mg/kg。
短句来源
     In the mice, LD50 of F-co and F-oH by oral route were 1066±138mg/kg and 1688±276mg/kg respectively.
     小鼠口服LD_(50):F-CO为1066±138mg/kg,F-OH为1688±276mg/kg。
短句来源
     The Quercetin group received 100 mg/kg of Quercetin by oral route prior to hitting 2-3 hours.
     Quercetin组:给大鼠喂饲Quercetin(100mg/kg),2-3h后再拍打眼球。
短句来源
     Symptom were appeared at 90 h and one pig died after 9 days in oral route group(2×10~8个/mL),morbidity and mortality was 75% and 33%,respectively.
     口服攻毒组(含菌2×108个/mL)90 h后开始有发病症状,第9天有1头死亡,发病率75%,病死率33%。
短句来源
     The results showed that the LD_(50)valuewas 6937mg/kg B.W. by the oral route in mice.
     结果小鼠经口LD_(50)为6937mg/kg 体重;
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  相似匹配句对
     oral route, 49. 59%.
     口服途径平均可提高49.59%;
短句来源
     3)subacute systemic toxicity tests: oral route;
     3.溶血试验;
短句来源
     ORAL CYSTICERCOSIS
     口腔囊虫病
     Oral Cnglish
     英语口语
短句来源
     transport route;
     转运途径;
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  oral route
Parenteral, intramuscular injections of the drug are more efficient than even much higher doses of ?acid" Dipyridamole given by oral route.
      
In many instances it was shown that transmission is by an oral route.
      
Muramyl dipeptide or MDP (AcMur-L-Ala-D-iGln) is a synthetic immunoadjuvant which can also enhance non-specific resistance to bacterial infections in mice, even by the oral route.
      
Muramyl dipeptide or MDP (AcMur-L-Ala-D-iGln) is a synthetic immunoadjuvant which can also enhance non-specific resistance to bacterial infections in mice, even by the oral route.
      
The present study offers evidence that murine Peyer's patches are influenced by ofloxacin administered by the oral route for seven days (15 mg/kg).
      
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Solutions of potassium antimony tartrate and sodium antimony gluconate were given per os to infected rabbits.Although their oral dosages were,respectively,9 and 4 times as much as their intravenous ones,the therapeutic results of the oral groups were far inferior to those of intrave- nous groups,while the animal mortalities of the former decidely higher than those of the later. In similar doses,one preparation (kindly supplied to us by Hsing Hwa)of the enteric tablets of potas- sium antimony tartrate was tried...

Solutions of potassium antimony tartrate and sodium antimony gluconate were given per os to infected rabbits.Although their oral dosages were,respectively,9 and 4 times as much as their intravenous ones,the therapeutic results of the oral groups were far inferior to those of intrave- nous groups,while the animal mortalities of the former decidely higher than those of the later. In similar doses,one preparation (kindly supplied to us by Hsing Hwa)of the enteric tablets of potas- sium antimony tartrate was tried and found to be useless,in view of its great potentialities the oral route of administration for antimony com- pounds is worth further and more intensive inves- tigation.

应用酒石酸锑钾与葡萄精酸锑~(Ⅲ)钠溶液的经口给药法,试治家兎血吸虫病,确有相当疗效。口服剂量虽较注射剂量分别加至九倍与四倍,但其疗效仍远不如注射法给药各组,而动物死亡率反较高。延长治程而酌减每次口服剂量,经口给药与静脉给药适当结合,仍不能提高其安全性。所试的酒石酸锑钾肠溶片在相同剂量时完全无效。口服锑剂的进一步研究应在吸收控制与剂型改进两方面努力。

This paper reports the results of the clinical use of Corydalis B as an analgesic in 72 patients with various forms of pain. In 64 cases the drug was used in a single dose, usually of 75 mg. by oral route, while in the other 8 cases repeated doses were given orally over a period of 3 to 21 days. The pain was completely abolished or definitely improved in 50 cases (78.1%) of the former group and in all 8 cases of the latter group. The analgesic effect appeared to be most marked in medical cases with dull...

This paper reports the results of the clinical use of Corydalis B as an analgesic in 72 patients with various forms of pain. In 64 cases the drug was used in a single dose, usually of 75 mg. by oral route, while in the other 8 cases repeated doses were given orally over a period of 3 to 21 days. The pain was completely abolished or definitely improved in 50 cases (78.1%) of the former group and in all 8 cases of the latter group. The analgesic effect appeared to be most marked in medical cases with dull pain in the chest or abdomen, as in cases of peptic ulcer and lobar pneumonia. Drowsiness was found as a side-effect in 28% of the cases after a single dose of the drug and in 6 of the 8 cases treated with repeated doses. In no case was any serious toxic action noted. According to the preliminary Observations herein reported, further clinical trial with the use of Corydalis B as an analgesic agent seems warranted.

本文报告72例试用延胡索素乙硫酸盐作为鎮痛剂的临床观察,其中64例为单剂用药,主要为一次口服75毫克,另8例为长期口服。单剂用药64例中完全止痛及疼痛减轻者共50例,占78.1%,长期服药8例均有效,鎮痛作用在内科胸腹部鈍痛病例较著。用药后未見重要副作用,单剂用药者28%发生嗜睡。长期用药的8例中6例有嗜睡,血与尿常規、大便次数、血压、心率等均无明显改变。据本文病例的初步临床应用结果,延胡索素乙对钝痛有一定的镇痛效果值,得进一步试用。

The present paper reports the use of colorimetric method to determine the blood level of F-30066 in portal vein and heart in rabbits. By spectrophotometry, paper and column chromatography, the metabolites of F-30066 in the intestine and urine of the host were investigated.The therapeutic effect of the drug as shown by different routes of administration, including the oral route, was compared. Owing to the absorption of F-30066 in the gastro-intestinal tract, a certain concen- tration of the drug was found...

The present paper reports the use of colorimetric method to determine the blood level of F-30066 in portal vein and heart in rabbits. By spectrophotometry, paper and column chromatography, the metabolites of F-30066 in the intestine and urine of the host were investigated.The therapeutic effect of the drug as shown by different routes of administration, including the oral route, was compared. Owing to the absorption of F-30066 in the gastro-intestinal tract, a certain concen- tration of the drug was found in the portal blood, F-30066 could be decomposed in liver, a part of it being re-excreted into intestine after inactivation.The transformation pro- ducts did not show any effect on schistosomes in mice. After oral administration of F-30066, two metabolites were detected in urine. None of them showed any killing effect on schistosome. When the solution of F-30066 was exposed to diffused sunlight, the drug was de- composed and became inactive. When 15 mg/kg of F-30066 in suspension were given intravenously to rabbits three times daily for 14 days, no therapeutic effect was observed. When a dose of 45 mg/kg of this drug was administered intramuscularly once daily for 10 days, the result was disappointing.F-30066 was still found at the site of injec- tion four weeks later. Intraperitoneal injection of 4 mg/20 g of F-30066 to mice did produce a satisfactory response; its blood content determined 1/2, 1, and 2 hours after injection was found to be 8.2, 2.2, and 1.6 μg/ml respectively.Neither intravenous nor intramuscular injection could result in such a high level.It seemed likely that the therapeutic effect of F-30066 was closely related to the concentration in blood.

本文利用比色法测定了家兔门静脉血液及心脏血内呋喃丙胺(F30066)的含量.应用光谱分析,纸层析及柱层析法研究了宿主肠道内及尿内呋喃丙胺代谢产物.采用实验治疗血吸虫病的方法,比较胃肠道外不同给药途径的治疗效果.家兔口服呋喃丙胺经胃肠道吸收后,在门静脉血液内有一定浓度的药物.此药经过肝脏转化后部分排泄入肠道.此肠内转化物无治疗血吸虫病的效用.口服呋喃丙胺后尿内可发现二个药物的代谢产物.经体内、体外试验此二代谢产物,均无杀死血吸虫的作用.静脉、肌肉注射呋喃丙胺混悬液治疗血吸虫病家兔都无疗效.腹腔注射呋喃丙胺治疗小白鼠血吸虫病却获得良好效果.

 
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