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tissue affinity
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     Objective To compare the effect of angiotensin-converting enzyme inhibitors (ACEI) with widely differing tissue affinity (captopril) and an angiotensin receptor blockers (ARB) (irbesartan) on the production of human monocytes pro-inflammation cytokine and the activation of nuclear factor kappa B(NF-κB) induced by lipopolysaccharide.
     目的 对具有多系统保护作用的血管紧张素转化酶抑制剂 (ACEI)类药物卡托普利和血管紧张素受体阻断剂 (ARB)类药物厄贝沙坦对单核细胞炎性反应的影响进行比较。
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     Tissue Engineering
     组织工程
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     Affinity and Deviation:
     亲和与悖离——论当代女性文学中女性与城市的关系
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     the affinity of antibody.
     抗体亲和性。
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     IMMUNE TISSUE
     淋巴是一条免疫的河
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     Wheatgermagglutinin affinity glycoprotein expression profile of normal human liver tissue
     健康人肝组织麦胚凝集素亲和型糖蛋白表达谱分析
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  tissue affinity
Oxaprozin shows a different pattern of transsynovial distribution and tissue affinity as compared to other NSAIDs.
      
Furthermore, the structure-tissue affinity relationship for 3-MeSO2 metabolites was investigated, following the administration of 11 3-MeSO2-PCB congeners to rats.
      
The aim of the present study was to determine the occurrence of eye infections accompanying the infection of the central nervous system and to demonstrate the possible tissue affinity of different strains of amoebae in subsequent infections.
      
Tissue affinity for Congo red was persistent after the KMnO4 treatment.
      
Considering their general tissue affinity, however, it may be worth while f.e.
      
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Objective To compare the effect of angiotensin-converting enzyme inhibitors (ACEI) with widely differing tissue affinity (captopril) and an angiotensin receptor blockers (ARB) (irbesartan) on the production of human monocytes pro-inflammation cytokine and the activation of nuclear factor kappa B(NF-κB) induced by lipopolysaccharide. Methods Monocytes were isolated by Ficoll density gradient from blood of healthy volunteers. The amount of tumor necrosis factor-α(TNF-α) in culture medium was quantified...

Objective To compare the effect of angiotensin-converting enzyme inhibitors (ACEI) with widely differing tissue affinity (captopril) and an angiotensin receptor blockers (ARB) (irbesartan) on the production of human monocytes pro-inflammation cytokine and the activation of nuclear factor kappa B(NF-κB) induced by lipopolysaccharide. Methods Monocytes were isolated by Ficoll density gradient from blood of healthy volunteers. The amount of tumor necrosis factor-α(TNF-α) in culture medium was quantified using TNF-α ELISA systems. NF-κB translocation in monocytes was observed by immunocytochemitry. Results Captopril(40 mg/L) and irbesartan(5 mg/L) showed similar protective effects against the inflammation of monocytes(53% and 45%), but there was no significant difference between these two drugs( P>0.05). Both of them inhibited the activation of NF-κB. Conclusions Both captopril and irbesartan can be used for the secondary prevention of coronary heart diseases. Especially used for those who can not tolerant the side effects caused by other ACEI drugs.

目的 对具有多系统保护作用的血管紧张素转化酶抑制剂 (ACEI)类药物卡托普利和血管紧张素受体阻断剂 (ARB)类药物厄贝沙坦对单核细胞炎性反应的影响进行比较。 方法 密度梯度离心法分离人外周血单核细胞并进行培养 ,应用ELISA法检测培养基上清液中肿瘤坏死因子 α(TNF α)水平 ,并应用免疫细胞化学方法观察核因子 κB(NF κB)在单核细胞中的活化过程。 结果 卡托普利 (4 0mg/L)和厄贝沙坦 (5mg/L)对单核细胞TNF α的合成具有相似的抑制作用 (分别抑制 5 3%和 4 5 % ) ,卡托普利的作用略强于厄贝沙坦 ,但二者之间差异无显著性 (P >0 0 5 ) ;卡托普利和厄贝沙坦均能抑制细菌脂多糖 (LPS)诱导的单核细胞NF κB的活化 (P <0 0 5 ) ,表明这两种药物对单核细胞炎症反应的抑制可能是通过抑制NF κB的活化来实现的。 结论 ARB类药物厄贝沙坦和ACEI类药物卡托普利对单核细胞炎症反应具有相似的抑制作用 ,表明ARB类药物可以和ACEI类药物一样被应用于冠心病的二级预防中 ,特别是对于不能耐受ACEI类药物副作用的患者。

 
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