In 1990~1994, 1995~1999 and 2000~2004, the mean age of patients at the time of diagnosis was 55.77, 54.07, and 51.41 years, respectively. The ratio between carcinoma in situ and invasive carcinoma was 1∶27.7 in 1990～1994,1∶19.4 in 1995～1999 and 1∶10.8 in 2000～2004, respectively.
Methods Surface enhanced lazar desorption/ionisation-time of flight-mass spectrometry (SELDI-TOF-MS) with immobilized metal affinity capture arrays-Cu (IMAC-Cu) was used to examine the serum of 49 patients with cervical invasive cancer and 71 healthy women. The data of proteomic spectra were analysed by a Biomarker pattern software and Biomarker Wizard software to build a diagnostic model by a decision tree classification algorithm with 10-fold cross validation.
方法通过表面增强激光解吸离子化飞行时间质谱仪(sur-face enhanced lazar desorption/ionisation-time of flight-mass spectrometry,SELDI-TOF-MS),铜离子结合芯片(immobilized metal affinity capture arrays-Cu,IMAC-Cu)以及配套软件,检测49例宫颈浸润癌,71例年龄相配的健康女性血清,筛选出有分类意义的差异蛋白,寻找出合理的运算规则,构建决策树分类模型。
It was found that more enhanced expression of Ha-ras and C-myc was observed in PIN Ⅲ,CIN Ⅲ and invasive cancer than in wart of the genital organs, and the expression intensity of anti-P21 antibodies of Ha-ras showed no overlapping between PIN Ⅲ-CIN Ⅲ and the wart of the genital organs.
Between early-stage infiltration carcinoma metastatic cancer,significant difference was observed in MMP2 expression( P <0.05). The expression of TIMP2 was negatively correlated with MMP2 and bFGF( P <0.05).
[Methods] immunohistochemical SP method was used to detect the expression of HPV16-E6 and it′s positive rate in 23 cervical infiltrating carcinoma patients, 25 chronic inflammation patients and 26 normal control.
Their pathological diagnosis were 26 chronic cervicitis, 105 cervical condyloma, 57 one grade CIN, 26 two grade CIN, 20 three grade CIN,3 carcinoma in situ, one early infiltrating carcinoma and one infiltrating carcinoma.
Results The expression of HPV and FHIT protein have obvious variability in normal skin squamous epithelial tissue,atypical hyperplasia tissue,carcinoma in situ and infiltrating carcinoma tissue(P <0.05).
Results: There were 239 abnormal cases of biopsies in total of cases. Of them, there were 26 cases of chronic cervicitis, 105 cases of cervical condyloma, 57 cases of CIN I, 26 cases of CIN II, 20 cases of CIN III, 3 cases of carcinoma in situ, 1 case of early infiltrating carcinoma and 1case of infiltrating carcinoma.
Molecular studies have revealed that PanIN-2 and PanIN-3 lesions represent a distinct step toward invasive carcinoma.
PIN has a high predictive value as a marker for adenocarcinoma, and its identification warrants repeat biopsy for concurrent or subsequent invasive carcinoma.
Barrett's esophagus describes metaplastic changes from squamous mucosa to specialized columnar epithelium that can progress from low-grade dysplasia to high-grade dysplasia and even invasive carcinoma.
Although these factors may determine different treatment strategies, surgery remains the mainstay of therapy due to the favorable survival rate if the disease is diagnosed and treated prior to the development of invasive carcinoma.
Epithelial atypia was histologically classified into five groups: normal epithelium; papillary hyperplasia without atypia; atypical hyperplasia; carcinomain situ; and invasive carcinoma.
On postoperatively surgical pathology, only 10 cases were carcinoma-in-situ, while 40 cases were invasive cancer.
When a patient undergoes colonoscopic resection of a colorectal polyp found to contain invasive cancer, I carefully analyze a number of pathologic and clinical features of the case to formulate an effective management plan.
Even with the best early detection efforts, some patients will still be diagnosed with an invasive cancer.
In addition, we utilized the neoplastic progression model of colorectal cancer to evaluate HLA-G protein expression in normal colon, tubulovillous adenomas, invasive cancer, and liver metastases arising from colorectal cancer.
Many patients with invasive cancer have a compromised immune system.