At pH=9 and temperature range of 24～50 ℃,or at 24 ℃ and pH between 3.7 and 9,P(CS-g-AA/PNIPAm) can well control the delivery of coenzyme A and the release mechanism of coenzyme A was also investigated.
The development of injectable biodegradable in-situ forming gel implants based on PLA/PLGA, SAIB, organic gel or PLA/PLGA-PEG triblock copolymers as carriers, including their characteristics , drug release mechanism, preparation and application, was reviewed.
In vitro release of 5-FU from microspheres was performed by oscillating in constant temperature method. The 5-FU from microspheres in vitro could be described by double phase dynamic model and could be described by the following equation: l-Q=0.216exp(-0.084t)+0.74exp(-0.0014t), The release mechanism was erosion and diffusion.
Results The results showed that drug release rate and drug release mechanism were both related to the viscosity of sodium alginate used in matrices, pH values and ionic strength of dissolution media and rotation speeds.
Propagation of shock waves in a medium with the Rayleigh energy release mechanism
It is found that a stationary solution exists in the system of coordinates associated with the SW propagation in a medium with the Rayleigh energy release mechanism only if the boundary of the medium lies downstream from the shock layer.
In addition, the release rates of drugs from matrix tablets were evaluated and the release mechanism will be discussed.
Analysis of the release mechanism indicated that the first phase of drug release corresponded to the diffusion theory, while the second phase seemed to be due to degradation of PLGA.
It was found that the drug release mechanism is diffusion-controlled according to a non-Fickian diffusion mechanism.