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effector system
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  “effector system”译为未确定词的双语例句
     The Complement System is a very important effector system in the blood.
     补体系统是人体血液系统中的一个非常重要的效应系统。 它与纤溶系统,激肽形成系统以及凝血系统一起互相关联,构成了人体防御的一道有效的屏障。
短句来源
     However, modifications of monoclonal antibody aiming at clinical applications need more research work in the mechanisms of antibody effector system, as well as comprehensive understanding in regulation of human immune system.
     对单克隆抗体进行改造使之应用于临床治疗 ,不仅需要对抗体效应机制进行更细致深入的研究 ,同时还有赖于对人类免疫系统调控机制的全面精确认识。
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  相似匹配句对
     SYSTEM
     系统
短句来源
     system;
     油气系统是最有利的系统 ;
短句来源
     The Complement System is a very important effector system in the blood.
     补体系统是人体血液系统中的一个非常重要的效应系统。 它与纤溶系统,激肽形成系统以及凝血系统一起互相关联,构成了人体防御的一道有效的屏障。
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  effector system
The 5-HT receptor - G-protein - effector system complex in depression I.
      
So caspase 3 does not participate in downstream pathways of GM2-induced cell apoptosis, and a PCD-effector system other than the apoptosome-mediated one is involved here.
      
It is suggested that the role of the septum is to set a definite level of synchronization of brain processes at the optimal value for conduction of excitation from its afferent to its effector system.
      
To increase the likelihood of the passage of excitation from the afferent to the effector system active generation of rhythmic waves in the theta-band in both the neocortex and hippocampus is essential.
      
It is possible that a defect in the ANP-receptor-effector system in diabetes (under certain conditions such as hypertension) may be associated with abnormal Ca2+ homeostasis and the development of nephropathy.
      
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Receptors not only initiate regulation of physiological and biochemical function but also are themselves subject to many regulatory controls. There are generally two types of regulation model termed desensitization and hypersensitivity. Multiple mechanisms account for desensitization: receptor phosphorylation, receptor internalization, negative cooperativity, and variations of membrane phospholipid and signaling pathways. However, mechanisms involved in hypersensitivity are still unclear now. Many diseases arise...

Receptors not only initiate regulation of physiological and biochemical function but also are themselves subject to many regulatory controls. There are generally two types of regulation model termed desensitization and hypersensitivity. Multiple mechanisms account for desensitization: receptor phosphorylation, receptor internalization, negative cooperativity, and variations of membrane phospholipid and signaling pathways. However, mechanisms involved in hypersensitivity are still unclear now. Many diseases arise from disorders in receptors or receptor effector systems. These malfunctions may involve expression of aberrant or ectopic receptors or coupling proteins, and variations of immunity, number, affinity and specificity of receptors.

体内各组织上的受体并非不变,作为细胞的组分之一,它们在参与新陈代谢的同时,还要受到各种生理、病理及药物因素的调节而发生变化。受体调节主要有增敏和脱敏两种类型。增敏的机制尚缺乏深入的研究;而脱敏的机制则涉及受体磷酸化、受体内移、受体的负协同效应、膜磷脂代谢的变化及信号传导系统的变化等诸多方面。受体正常的调节及变化是维持内环境稳定的重要因素,而受体的异常变化则是致病的一个原因。与疾病有关的受体的异常变化主要有:异常受体及异常偶联蛋白的表达,受体免疫性、数目、亲和力及特异性的变化等

After its advent, monoclonal antibody has gone an uneven way to its present wide applications in clinical practices, during which the humanized antibody set an important milestone accompanying a series of technique renovations, such as PCR technique, phage display and transgenic animals. Humanized antibody has developed from chimeric antibody and reshaped antibody to the present fully human antibody. Humanization of murine antibodies has been the future direction of therapeutic antibodies and this can be reflected...

After its advent, monoclonal antibody has gone an uneven way to its present wide applications in clinical practices, during which the humanized antibody set an important milestone accompanying a series of technique renovations, such as PCR technique, phage display and transgenic animals. Humanized antibody has developed from chimeric antibody and reshaped antibody to the present fully human antibody. Humanization of murine antibodies has been the future direction of therapeutic antibodies and this can be reflected from the fact that humanized antibodies or even human antibodies have made up majority of the therapeutic antibodies both in clinical test and in the market. The present techniques have enabled the production of fully human antibodies and given chances to the arising of antibody derivatives. They not only overcome the deficiency in application of murine antibody with different strategies, but also provide more weapons for human therapeutics. However, modifications of monoclonal antibody aiming at clinical applications need more research work in the mechanisms of antibody effector system, as well as comprehensive understanding in regulation of human immune system.

单克隆抗体从问世到目前广泛应用于临床 ,经历了一段曲折的发展历程。其中人源化抗体是一个重要的里程碑 ,并伴随着一系列重大的技术革新 ,如PCR技术、抗体库技术、转基因动物等。人源化抗体的形式也从最初的嵌合抗体、改型抗体等逐步发展为今天的人抗体。抗体人源化已经成为治疗性抗体的发展趋势 ,同时各种抗体衍生物也不断涌现 ,它们从不同角度克服抗体本身的应用局限 ,也为治疗人类疾病提供了更多利器。对单克隆抗体进行改造使之应用于临床治疗 ,不仅需要对抗体效应机制进行更细致深入的研究 ,同时还有赖于对人类免疫系统调控机制的全面精确认识。

 
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