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mixed lymphocyte tumor cell
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  “mixed lymphocyte tumor cell”译为未确定词的双语例句
     Methods:CTL from cord blood using mixed lymphocyte tumor cell culture treat Human Ovarian cancer nude mouse models, LAK from the pheripheral blood were used as the control.
     方法采用肿瘤细胞和淋巴细胞混合培养法获得脐血来源的细胞毒性T淋巴细胞对人卵巢癌裸鼠移植瘤进行治疗并与外周血来源淋巴因子激活的杀伤细胞相对照。
短句来源
     Methods:Bone marrow or peripheral blood mononuclear cells from CML patients were stimulated with autologous CML cells by using mixed lymphocyte tumor cell coculture.
     方法:用混合淋巴瘤细胞培养技术,用自体瘤细胞和细胞因子刺激扩增CML患者骨髓和外周血单个核细胞(MNC)。
短句来源
     The proliferation index of lymphocytes was assayed by syngenic mixed lymphocyte tumor cell culturing (MTLC) and the MTT method of assay was used to determine the proliferation and tumoricidal activity of cytotoxic lymphocytes.
     用同源淋巴细胞肿瘤细胞混合培养实验 (MTLCs)测定淋巴细胞增殖指数 ,MTT法检测细胞毒淋巴细胞的增殖及其杀瘤活性。
短句来源
  相似匹配句对
     AUTOLOGOUS MIXED LYmPHOCYTE REACTION
     自身混合淋巴细胞反应
短句来源
     Lymphocyte depleted and mixed cellularity in HL;
     HL的淋巴细胞削减型和混合细胞型;
短句来源
     The mixed lymphocyte reaction (MLR) was inhibited.
     混合淋巴细胞反应 (MLR)降低 ;
短句来源
     Assisted Functional Study in Dendritic Cell in Mixed Lymphocyte Reaction
     树突状细胞在混合淋巴细胞反应中辅佐功能的研究
短句来源
     Regulating the T lymphocyte.
     调节T淋巴细胞;
短句来源
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  mixed lymphocyte tumor cell
In addition, MOPC-IL10AS were more effective as stimulator cells in mixed lymphocyte/tumor cell culture, and as target cells in a CTL assay.
      
These results imply that the short-term mixed lymphocyte/tumor cell culture with the tumor cells transduced with the gene for the B7.1 costimulatory molecule is potentially a good source of CTL for adoptive-transfer therapy of tumors.
      
To characterize the anti-melanoma reactivity of CD8+ cytotoxic T lymphocytes (CTL) from choroidal melanoma patients, CTL clones were isolated from the peripheral blood of three patients after mixed lymphocyte/tumor cell culture (MLTC).
      
Subsequently, these tumors were used to stimulate an autologous mixed lymphocyte/tumor cell culture for 5 days (MLTC) followed by further cultivation with interleukin-2 for 12 days.
      
To study antitumor immunity in patients with choroidal melanoma, T cells were generated from the peripheral blood of choroidal melanoma patients by mixed lymphocyte/tumor cell culture (MLTC).
      
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The ability to transfer anti-tumor immunity by spleen RNA of tumor bearing donors was evaluated both in in vitro and in vivo experiments in animals and human patients. In in vitro test of mixed lymphocyte-tumor cells reaction, it was found that normal lymphocytes behaved like the tumor-sensitized lymphocytes after the preincubation with spleen RNA of mice bearing Sarcoma180 in blastogenic response to these tumor cells, and thus the mediation of anti-tumor...

The ability to transfer anti-tumor immunity by spleen RNA of tumor bearing donors was evaluated both in in vitro and in vivo experiments in animals and human patients. In in vitro test of mixed lymphocyte-tumor cells reaction, it was found that normal lymphocytes behaved like the tumor-sensitized lymphocytes after the preincubation with spleen RNA of mice bearing Sarcoma180 in blastogenic response to these tumor cells, and thus the mediation of anti-tumor immunological responsiveness by spleen RNA of tumor bearing mice were confirmed. In in vivo tests, both animal experiments in mice and immunotherapeutic treatment in human cancer patients demonstrated that a tumor inhibitory effect could be induced by the administration of spleen RNA from the donors bearing the appropriate tumor, while the RNAs from the respective normal spleens were ineffective. The results presented indicated that spleen RNA from tumor bearing donors might have the same biological activity in effecting the transfer of immunoreactivity against tumor as that of immune RNA from spleen cells of immunized animals. No visible suppressive effect on the immunological responsiveness by spleen RNA from tumor bearing donors had been detected in experiments so far conducted in our laboratory.

本文对带瘤小鼠及肿瘤患者的脾RNA的传递免疫反应的能力进行了实验研究。用淋巴细胞——肿瘤细胞混合培养法对带S_(180)小鼠的脾RNA进行的体外培养实验表明,正常小鼠的淋巴细胞与带S_(180)小鼠的脾RNA温育后可以转变成为对S_(180)瘤细胞致敏的淋巴细胞。表现为在混合淋巴细胞——瘤细胞培养中的淋转率的提高。这就说明带瘤鼠的脾RNA可以有正常淋巴细胞传递抗S_(180)免疫反应的功能。在小鼠的活体抑瘤实验中,带S_(180)小鼠的脾RNA可对接种S_(180)小鼠的肿瘤生长有33.0—66.9%的抑瘤率,用正常脾RNA则没有效果;同样,用从胃癌患者切除的脾脏中提取的RNA对胃癌患者进行免疫治疗时,治疗组的四年存活率可达47.1%,对照组则为22.7%,治疗组的几项免疫指标均较治疗前有所提高。上述各项体外及活体实验的结果都说明带瘤供体的脾RNA可以传递特异的抗肿瘤免疫反应的信息,其效应和前人所报告的从免疫动物脾中提取的免疫RNA是完全一致的。

Effects of retinoic acid (RA) and N- (P-etoxycarbopgdnyl) retinamide (RI) on syngeneic cytotoxic T lymphocyte (CTL) induction and mixed lymphocyte tumor cell culture (MLTC) were investigated. After immunizing DBA/2 mice with syngeneic L5178Y lymphoma, retinoids (RA, 50μg/mouse/ d; RI, 100, 300 or 500μg/mouse/d) administered i.p. to mice for 5 days could enhance both CTL induction and MLTC in vitro. Cell reconstitution experiments showed that aside from enhancing effect of RI being mainly on responsiveness...

Effects of retinoic acid (RA) and N- (P-etoxycarbopgdnyl) retinamide (RI) on syngeneic cytotoxic T lymphocyte (CTL) induction and mixed lymphocyte tumor cell culture (MLTC) were investigated. After immunizing DBA/2 mice with syngeneic L5178Y lymphoma, retinoids (RA, 50μg/mouse/ d; RI, 100, 300 or 500μg/mouse/d) administered i.p. to mice for 5 days could enhance both CTL induction and MLTC in vitro. Cell reconstitution experiments showed that aside from enhancing effect of RI being mainly on responsiveness of T lymphocytes, it could also increase accessory funtion of spleen adherent cells.

本文报道维甲酸和维胺酯对诱导同基因小鼠杀伤性T细胞的产生和淋巴细胞增殖反应的作用。结果表明,连续5d给维甲酸和维胺酯,细胞毒T细胞的杀伤效应加强,后者的作用更为明显,亦可加强淋巴细胞的增殖反应。细胞重组试验发现,维胺酯作用于淋巴细胞和辅佐细胞,但以前者为主。

Objective:To investigate the existence of cytotoxic precursor cells in previously untreated or remissive chronic myelogenous leukemia(CML) patients,and identify their phenotypical and functional characteristics.Methods:Bone marrow or peripheral blood mononuclear cells from CML patients were stimulated with autologous CML cells by using mixed lymphocyte tumor cell coculture.Results:A kind of cytotoxic T lymphocytes could be generated from bone marrow or peripheral blood of CML patients.These T cells...

Objective:To investigate the existence of cytotoxic precursor cells in previously untreated or remissive chronic myelogenous leukemia(CML) patients,and identify their phenotypical and functional characteristics.Methods:Bone marrow or peripheral blood mononuclear cells from CML patients were stimulated with autologous CML cells by using mixed lymphocyte tumor cell coculture.Results:A kind of cytotoxic T lymphocytes could be generated from bone marrow or peripheral blood of CML patients.These T cells showed differential cytotoxicities against autologous and allogeneic CML cells and no activity to autologous and allogeneic normal bone marrow cells.They also exhibited no inhibitive effect on CFUGM yields.LAK cells had no effect on autologous CML cells,but showed intensive cytotoxic activity to allogeneic CML cells.The T lymphocytes obtained were CD3+ CD56+ nonMHC restricted or CD3+ CD56- MHC restricted.HLADR and CD25were expressed in a significantly larger proportion of T lymphocytes stimulated with autologous CML cells than those not stimulated.The T lymphocytes showed low proliferative response to autologous CML cell stimulation and no or least response to allogeneic CML cells,they showed also no response to EB virustransformed autologous B cells(obtained in remission) pulsed with peptides corresponding to the BCRABL joining region.Conclusion:There is probably a common tumor antigen among CMLs,this leukemiaspecific antigen can be recognized by T cells,and it shows no indication to be a p210 fusion sequence.

目的:验证慢性粒细胞白血病(CML)患者体内是否存在细胞毒T淋巴细胞前体细胞,并鉴定其表型和功能特征。方法:用混合淋巴瘤细胞培养技术,用自体瘤细胞和细胞因子刺激扩增CML患者骨髓和外周血单个核细胞(MNC)。结果:CML缓解期和慢性期均存在对自体和异体CML细胞杀伤活性的T淋巴细胞,这些细胞对自体和异体正常MNC没有杀伤活性,对正常CFU-GM无抑制作用。而LAK细胞对自体CML细胞无杀伤活性(<10%),只对异体CML细胞有杀伤活性。上述T细胞包括CD3+CD56+非主要组织相容性抗原(MHC)限制性T细胞,和CD3+CD6-MHC限制性T细胞。用自体CML细胞刺激可增加T细胞激活抗原CD25和HLA-DR的表达。上述T细胞对自体CML细胞呈较弱的增殖反应,对异体CML细胞几乎无增殖反应,对载有BCR-ABL肽的自体缓解期EB病毒转染B细胞也无增殖反应。结论:CML细胞可能有共同的肿瘤抗原,后者可以被T细胞识别,但尚无证据表明是p210的融合区序列。

 
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