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induced chromosome
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  诱发染色体
     The results showed that the mean spontaneous and induced chromosome aberration and expression rates of fragile sites in DAT patients were significantly higher than those in the controls. It was found that the mean spontaneous and induced chromosome aberration and expression of fragile sites were 8.3, 39.3, 4.3 and 18.2 respectively in DAT group and were 2.1, 18.3, 1.6 and 7.7 in the control group.
     实验结果表明,Alzheimer病患者的自发和诱发染色体畸变和脆性表达均高于对照组,自发畸变、诱发畸变、自发脆性表达、诱发脆性表达,实验组均值分别为8.3次、39.3次、4.3次、18.2次,对照组分别为2.1次,18.3次、1.6次、7.7次。
短句来源
     However, so far in only one report abroad, AFM was employed to analyze ionization radiation induced chromosome aberration.
     但迄今为止,利用AFM对电离辐射诱发染色体畸变进行分析的报道,国外只有一篇。
短句来源
     The relationshap between induced chromosome aberrations of human peripheral blood lymphocytes irradiated in vitro by 180 kV X-raysand the radiation dose was described in this paper.
     本文介绍用180kV X射线离体照射人体淋巴细胞诱发染色体畸变的剂量-效应关系的实验结果。
短句来源
     (2) γrays,benzene and toluene were shown all induced chromosome aberrations,SCEs and micronuclei of lymphocytes and chromosome aberrations of bone marrow cells; but CO showed no effect. (3) γrays and benzene induced chromosome aberrations and micronuclei of lymphocytes;
     (2)γ线、苯和甲苯都能单独诱发淋巴细胞染色体畸变、微核、姐妹染色单体互换(SCE)以及骨髓细胞染色体畸变,但未发现CO对诱发染色体畸变、微核和SCE有明显影响。
短句来源
     This investgation sought to address if there was any association between tumer genetic susceptibility and human chromosome fragile sites (FS). Using the method of G-banding in situ,theassociation among the spontaneous and induced chromosome breakpoints of peripheral blood lymphocytes (BP) of 21 nasopharyngeal carcinoma(NPC) patients and 30 health person by usual culture of blood and FS and oncogenes (ONC) loci.
     为了探索人类染色体脆性部位与肿瘤发生的关系.运用染色体原位G显带方法.观察和分析21例鼻咽癌患者和30例健康对照者淋巴细胞在常规培养条件下,自发和诱发染色体断裂热点与脆性部位、及其与癌基因位点的相关性。
短句来源
  “induced chromosome”译为未确定词的双语例句
     The results showed that the chromosome numbers in root tip cell of the natural chromosome doubling plant, natural chromosome-doubling F_1 and cochicines induced chromosome doubling plant of triploid hybrid F_1 are 42, which are hexaploids (2n=4x=42);
     结果显示:自然加倍植株、自然加倍植株F1代和秋水仙素诱导加倍植株的RTC染色体数目均为42条,即为六倍体(2n=6x=42);
短句来源
     The chromosome number and pairing configuration,pollen fertility,seed set of the natural chromosome doubling plant,chromosome_doubling F_1 and colchicines induced chromosome doubling plant of triploid (2n=3x=21) intergeneric hybrid F_1 between Elymus canadensis and Hordeum brevisubulatum were identified.
     对加拿大披碱草与野大麦2个四倍体亲本杂交产生的三倍体(2n=3x=21)属间杂种F1的自然加倍植株、自然加倍植株F1代及秋水仙素诱导加倍植株的染色体数目及配对构型、花粉育性、结实性进行了鉴定。
短句来源
     Conclusion As_2O_3 induced chromosome fusion and MGC803 cells apoptosis through up-regulating expressin of TRF1 and down-regulating expressin of TRF2.
     结论实验结果提示As2O3通过下调TRF2蛋白表达、上调TRF1蛋白表达及使染色体端-端融合,从而诱导MGC803细胞凋亡。
短句来源
     Autotetraploids from diploidy leaves of Paulownia elongata on the double layer MS media supplemented with 0.1 mg/L NAA and 15 mg/L BA(optimal organogenetic medium to the leaves of diploidy seedlings) with different colchicines concentrations were induced,chromosome numbering of the plant root tip cells and DNA content analysis of the leaf single cell were used to analyse the autotetra ploids.
     在含不同浓度秋水仙素的MS+0.1mg/L NAA+15mg/L BA(最适器官发生)双层培养基上进行兰考泡桐四倍体植株诱导试验,并通过变异植株根尖细胞染色体观察和叶片单细胞DNA含量测定进行倍性分析。
短句来源
     Both spontaneous and radiation\|induced chromosome aberration frequencies of A\|T cells were higher than those of GM639 control cells.
     无论是A T细胞染色体自发畸变率还是辐射诱发的染色体畸变率均明显高于正常对照的GM6 39纤维母细胞 ; A T细胞的高染色体畸变率主要是由于染色体双着丝粒体和染色体断片所至的染色体型畸变 ;
短句来源
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  相似匹配句对
     Induced into E.
     将表达载体转化E.
短句来源
     Fragment of chromosome was induced mainly by PYM.
     PYM处理则以染色体断片为主。
短句来源
     Survivin and chromosome instability induced by X-irradiation
     survivin与X射线诱导的染色体不稳定性
短句来源
     Artificial Chromosome
     人工染色体
短句来源
     Supernumerary Chromosome
     B染色体
短句来源
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  induced chromosome
Cytomegalovirus infection of mouse embryonic fibroblasts inhibited mitosis and induced chromosome aberrations.
      
Complementation of the cellular defects in FA was tested by examining sensitivity to growth inhibition by mitomycin C(MMC), spontaneous chromosome breakage, and MMC-induced chromosome breakage in the hybrid cells.
      
However, following irradiation at the G1/S border, AT cells displayed about 6-fold increased levels of UV-induced chromosome aberrations in comparison to normal human fibroblasts that were treated at this time.
      
An Improved Culture System of Mouse Peripheral Blood Lymphocytes for Analysis of Radiation-Induced Chromosome Aberrations
      
Quantitative regularities of mitomycin C-induced chromosome aberrations correspond to those of "monocentric" mutagens.
      
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The capabilities of three components of PYM, A2, A5 and A6 for inducing chromosome aberrations and SCEs were studied. The results indicated that all three components of PYM could induce aberrations. For the 1st metaphase after treatment, over 60% of the aberrated were chromosome type aberrations. The chromosome disintegration, one third of which was accompanied with double minutes, was also observed. In the concentration range of 0.2-1.0μg/ml, the aberrated cell frequencies in every treatment...

The capabilities of three components of PYM, A2, A5 and A6 for inducing chromosome aberrations and SCEs were studied. The results indicated that all three components of PYM could induce aberrations. For the 1st metaphase after treatment, over 60% of the aberrated were chromosome type aberrations. The chromosome disintegration, one third of which was accompanied with double minutes, was also observed. In the concentration range of 0.2-1.0μg/ml, the aberrated cell frequencies in every treatment increased with the increase of concentration of the three components. For the 2nd metaphase after treatment, both aberrated chromosomal frequency and SCE frequency increased with the increase of the concentration. According to their capabilities for inducing chromosomal aberrations, in particular the double minutes, and enhancing SCEs, it was believed that A2, A5 and A6 are not only mutagens but also carcinogens.

本文报道平阳霉素(Pingyangmycin,PYM)的三种成分A_2、A_5和A_6诱发CHO-K1细胞染色体畸变和姐妹染色单体交换(SCEs)。处理后第一次分裂中期染色体型畸变占优势,其中有大量的染色体碎裂(Disintegration),在含染色体碎裂的细胞中三分之一伴随出现双微体(Double minutes,DMs)。细胞畸变的频率随处理浓度升高而增加。 处理后第二次分裂中期,细胞畸变的频率仍随处理试剂浓度增加而升高,SCEs频率随处理浓度升高而递增。 上述三种成分诱发染色休畸变的类型没有质的差异。

Clastogenicity of a potential male contraceptive, gossypol, was examined in cultured Chinese hamster cells with or without presence of a metabolic activation system (rat liver S9 mix). Gossypol at concentrations of 1,5 and 10μg/ml did not induce chromosome breakage with or without presence of the Sg mix. The ability of this compound to induce chromosome breakage and polyploidy was further in human lymphocyte cultures. No increased frequency of chromosome breakage or polyploidy was found in...

Clastogenicity of a potential male contraceptive, gossypol, was examined in cultured Chinese hamster cells with or without presence of a metabolic activation system (rat liver S9 mix). Gossypol at concentrations of 1,5 and 10μg/ml did not induce chromosome breakage with or without presence of the Sg mix. The ability of this compound to induce chromosome breakage and polyploidy was further in human lymphocyte cultures. No increased frequency of chromosome breakage or polyploidy was found in lymphocyte cultures from two healthy donors. The present study indicates that gossypol does not cause genetic damage at the chrtomosomal level.Although human users reported only mild effects, our study found gossypol to be cytotoxic to cultured mammalian cells. If this compound can be further proven to be safe and approved for world-wide use as a male contraceptive, it would be for the benefit of all mankind.

棉酚在S9mix存在下,並不引起地鼠某些细胞染色体断裂也不引起多倍体增加,说明该药並不在染色体水平上引起遗传损伤,但对哺乳类培养细胞存在着毒性。如进一步证实其安全性。可作为男性避孕药推广应用。

This paper reports the changes in chromosome of bon-marrow ceils of mice at 3,4,5 and 6 months after whole body irradiationexposed to fractionated doses of ~(60)Co γ-rays(once weekly,1.7GY per fractionation and a accumulated dose of 6.8GY).It can be seen that thefrequency of cells with hypo-diploid of irradiated mice was 10.7—17.7%of the examined bone-marrow cells sampled at 3—6 months after irradiationand 4.5% in the control mice.The most frequent type of chromosomalaberration was reciprocal translocation whose...

This paper reports the changes in chromosome of bon-marrow ceils of mice at 3,4,5 and 6 months after whole body irradiationexposed to fractionated doses of ~(60)Co γ-rays(once weekly,1.7GY per fractionation and a accumulated dose of 6.8GY).It can be seen that thefrequency of cells with hypo-diploid of irradiated mice was 10.7—17.7%of the examined bone-marrow cells sampled at 3—6 months after irradiationand 4.5% in the control mice.The most frequent type of chromosomalaberration was reciprocal translocation whose frequency of for the irradiatedmice was 4.0—22.7% of the examined ceils and 0.2% for Control mice.In 6 out of 11 irradiated mice,the abnormal clones of cells with a definitechromosome change were demonstrated in bone-marrow cells by G-bandingmethod.These findings suggest that there may be a certain relationshipbetween the radiation-induced chromosome aberration and occurrence oftumour.

本文报道以~(60)Coγ射线全身分次照射小鼠,每周一次,每次照射剂量1.70Gy,共四次,累积剂量6.80Gy,于照后3、4、5、6月观察小鼠骨髓细胞染色体的变化。结果可见,在照后3—6月小鼠骨髓亚二倍体细胞的发生率为10.7—17.7%,对照组为4.5%。受照后染色体畸变发生率最高的是相互易位,为4.0—22.7%,对照组为0.2%。G 显带分析结果证明,受照的11只小鼠中有6只具有特定染色体变化的异常克隆。实验结果提示,在辐射诱发的染色体畸变与肿瘤发生之间可能存在某种关系。

 
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