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fsh receptor
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  “fsh receptor”译为未确定词的双语例句
     Five inactivating mutations of the FSH receptor (FSH-R) are known to cause ovarian failure with amenorrhea and infertility, which are Ilel61Thr (exon6 T497C), Alal89Val (exon7 T566C), Asp224Val (exon 9A 671T), Arg573Cys (exon 10A C1717T) and Leu601Val (exon 10B C1801G).
     研究人员曾在Finnish人群中发现FSH-R基因存在五种失活突变:Ile161Thr(第6外显子T497C),Ala189Val(第7外显子T566C),Asp224Val(第9外显子A671T),Arg573Cys(第10A外显子C1717T)和Leu601Val(第10B外显子C1801G)。
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     【Result】The results showed that the FSH receptor mRNA levels from the right ovary of BB(1.14±0.11)ewes were higher than those of AA(0.44±0.11)and AB(0.36±0.08)ewes(P<0.01).
     方法利用半定量PCR技术。 结果在发情期BB型右侧卵巢FSHR的mRNA水平(1.14±0.11)显著高于AA(0.44±0.11)和AB(0.36±0.08)型(P<0.01),但左侧卵巢在基因型间无显著性差异;
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     FSH receptor occupancy lesded to phosphorylation/activation of p38 MAPK in time-dependent manner.
     结果表明,FSH(50ng/m1)处理GC,可迅速激活有丝分裂原蛋白激酶(p38MAPK),FSH处理5min便可观察到磷酸化的p38MAPK;
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     Study of the Relationship between Genetic Phenotype, Serum FSH and FSH Receptor and Testicular Spermatogenesis of Idiopathic Azoospermic Patients
     特发性无精子症患者的遗传学表型、血清FSH及其受体与睾丸精子发生关系的研究
短句来源
     Methods: A biochemical method able to quickly differentiate the surface bound and internalized hormone was employed to determine the internalization of FSH receptor induced by FSH in cultured porcine granulosa cells and transfected Chinese hamster ovary (CHO) cells expressing recombinant porcine FSH receptor.
     方法 :用一种能快速区分表面螯合和内在化激素的生化方法 ,在培养的猪颗粒细胞和表达重组猪FSHR的中国仓鼠卵巢细胞确定了卵泡刺激素 (FSH)诱导受体内在化的过程。
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     FSH action is mediated by the specific receptor (FSH receptor, FSHR).
     FSH通过与其特异性的受体(FSH受体,FSHR)相结合而发挥上述生理功能。
短句来源
     FSH Induced Internalization of FSH Receptor in Transfected and Granulosa Cells
     FSH诱导转染细胞和颗粒细胞FSH受体内在化
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     Melatonin receptor
     褪黑素受体
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     neuron and receptor.
     神经元普遍存在突触前受体;
短句来源
     E 2? P? FSH?
     同时对 31例绝经后子宫内膜癌患者进行了E2 、P、FSH、LH、T的测定。
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  fsh receptor
Evidence from recent in vitro experiments also indicates that BMP-15 inhibits major FSH actions that are obligatory for follicle development and ovulation by suppressing FSH receptor expression in rats.
      
In five of the cases with proven spermatogenesis, exon 10 of the FSH receptor was sequenced to look for activating mutations.
      
FSH receptor gene polymorphisms have a role for different ovarian response to stimulation in patients entering IVF/ICSI-ET progr
      
However, the expression of the FSH receptor and androgen receptor were undetectable in both primary cultured Sertoli cells and Sertoli cell lines immortalized by SV40 large T antigen.
      
In mammals, the specificity of FSH-FSH receptor (FSHR), LH-LH receptor (LHR) and TSH-TSH receptor couples is such that no cross-activation occurs under normal physiological conditions.
      
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Mature male Wistar rats were treated with gossypol aceticacid orally at a daily dosage of 30 mg/kg for 6 or 8 weeks except on Sundays.Testosterone levels of serum, testicular interstitial and seminiferous tubular fluid were determined by radioimmunoassay. Testicular LH and FSH receptor concentrations were measured by radioligand assay. At the end of 6-week treatment there was no significant difference between the drug-treated rats and the controls in all the parameters tested. The testosterone levels of...

Mature male Wistar rats were treated with gossypol aceticacid orally at a daily dosage of 30 mg/kg for 6 or 8 weeks except on Sundays.Testosterone levels of serum, testicular interstitial and seminiferous tubular fluid were determined by radioimmunoassay. Testicular LH and FSH receptor concentrations were measured by radioligand assay. At the end of 6-week treatment there was no significant difference between the drug-treated rats and the controls in all the parameters tested. The testosterone levels of interstitial and seminiferous fluid were reducedafter 8 weeks of gossypol treatment, but there was no statistical significance as compared with the controls. It appears from the present data that gossypol may not interfere with the production of testosterone under this regimen.

给大鼠喂服醋酸棉酚每日30mg/kg,6或8wk后用放射免疫法测定血清、睾丸间质细胞液和曲精细管液中睾酮的浓度;用放射配体结合法测定睾丸中黄体生成素(LH)和卵泡刺激素(FSH)受体的含量。结果表明在上述剂量和给药时间的条件下,棉酚对垂体-睾丸轴系无影响。

In this study we examined the regulation of follitropin(FSH)receptor affi-nity and adenylate cyclase activity by guanine nucleotide binding protein(Gp) .It was shown by evidence that (1) there were two classes of guanine nucleotide binding sites on the Gp of calf testis membranes, high affinity (with low capacity) binding sites and low affinity (with high capacity) binding sites; (2) it seemed to be that the high affinity GTP binding sites which were sensitive to NEM modulated the activity of adenylate...

In this study we examined the regulation of follitropin(FSH)receptor affi-nity and adenylate cyclase activity by guanine nucleotide binding protein(Gp) .It was shown by evidence that (1) there were two classes of guanine nucleotide binding sites on the Gp of calf testis membranes, high affinity (with low capacity) binding sites and low affinity (with high capacity) binding sites; (2) it seemed to be that the high affinity GTP binding sites which were sensitive to NEM modulated the activity of adenylate cyclase; and (3) the regulation of receptor affinity for FSH by Gp mainly required the low affinity GTP binding sites to be occupied.

本文用NEM(N-ethylmaleimide)为探针研究了G蛋白(鸟嘌呤核苷酸调节蛋白,Gp)对小牛睾丸中FSH受体的亲和性及腺苷酸环化酶活性的调节作用。证据表明,①在小牛睾丸细胞膜G蛋白上存在两种类型鸟嘌呤核苷酸结合位点(下简称GTP结合位点),高亲和性低容量结合位点及低亲和性高容量结合位点;②高亲和性结合位点(对NEM敏感)调节腺苷酸环化酶活性,而对NEM相对不敏感的低亲和性位点则不直接参与该酶活性的调节;③G蛋白对受体亲和性的调节则不仅要高亲和性位点的参与,而且主要受低亲和性位点的调节。

It has been recently demonstrated that transferrin (TRF) can inhibit thefunctional differentiation of rat granulosa cells, but the mechanism remains un-known. In Present experiment, the effect of TRF on the binding of ~(125)I-rFSHto receptors and on the maintenance of FSH receptors in granulosa cells fromimmature, diethylstilbestrol treated rats were studied. The results show thatthe physiological range of TRF partially blocked the binding of ~(125)I-rFSH to gran-ulosa cells in a dose-dependent manner....

It has been recently demonstrated that transferrin (TRF) can inhibit thefunctional differentiation of rat granulosa cells, but the mechanism remains un-known. In Present experiment, the effect of TRF on the binding of ~(125)I-rFSHto receptors and on the maintenance of FSH receptors in granulosa cells fromimmature, diethylstilbestrol treated rats were studied. The results show thatthe physiological range of TRF partially blocked the binding of ~(125)I-rFSH to gran-ulosa cells in a dose-dependent manner. TRF also dosedependently inhibited themaintenanca of FSH receptors in accordance with the reduced production of pro-gesterone and estradiol. In view of the present and our previous investigation,it could be concluded that mechanisms of the inhibitory effect of TRF on thefunctional differentiation of granulosa cells mainly involve blockade of FSH bin-ding to its receptors and inhibition of FSH receptor maintenance by FSH.

转铁蛋白能抑制大鼠卵泡颗粒细胞的分化,但其机理尚不清楚。本实验用已烯雌酚处理后分离的大鼠颗粒细胞,观察了转铁蛋白对FSH结合到颗粒细胞,以及在培养过程中对颗粒细胞FSH受体量维持的影响。结果表明,生理浓度范围的转铁蛋白部分地阻断了~(125)I-rFSH结合到颗粒细胞上;将转铁蛋白与FSH一起处理细胞,发现它能剂量依赖性地抑制FSH对颗粒细胞FSH受体的维持作用,并表现为孕酮及雌二醇的分泌减少。

 
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