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oral insulin     
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  口服胰岛素
     Lytology mechanism of absorption of oral insulin liposome
     口服胰岛素脂质体吸收的细胞学机制
短句来源
     Study on the stability of oral insulin in gastrointestinal tract
     口服胰岛素的胃肠道稳定性研究
短句来源
     Conclusion IPN in soybean oil containing Tween-20 (0.5% v/v) and Vitamin E (5% v/v) could be considered as an effective and stable delivery system for oral insulin.
     结论 分散在油介质中的IPN具有较好的稳定性和相对较高的生物利用度,因此,含有 0 .5%吐温 20和 5%维生素E的豆油有望成为口服胰岛素聚氰基丙烯酸正丁酯纳米粒的有效而稳定的分散介质。
短句来源
     Preparation of oral insulin sustained-release microspheres
     口服胰岛素缓释微球的制备
短句来源
     Conclusion These results show that the oral insulin and GAD administration can prevent NOD mice from diabetes. Pancreatic and systematic expression of Th 2 type cytokine may play an important role assooiating with the preventing effect.
     结论 口服胰岛素、GAD可预防NOD小鼠发生糖尿病 ,其机制可能与诱导的Th2 型细胞因子局部和全身表达的增加有关。
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  胰岛素口服
     The application of nano in oral insulin delivery
     纳米在胰岛素口服给药中的应用
短句来源
     Results:Nanotechnology can remarkably improve the stability of insulin and the bioavailbility to effectively improve the absorb of the oral insulin.
     结果纳米技术可显著提高胰岛素在胃肠道中的稳定性及生物利用度,有效改善胰岛素口服给药的吸收。
短句来源
     STUDIES ON HYPOGLYCAEMIC EFFECT OF ORAL INSULIN PREPARATION IN NORMAL RABBITS
     胰岛素口服剂型对正常家兔降血糖作用的研究
短句来源
     Studies on the properties and application to the oral insulin delivery of a pH-sensitive hydrogel
     一种pH敏感水凝胶的性质及用于胰岛素口服给药的研究
短句来源
     Methods:Recent nano progress in the oral insulin delivery has been reviewed in this paper.
     方法叙述近年来纳米胰岛素口服给药系统方面取得的一些进展。
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  口饲胰岛素
     Effects of Oral Insulin on the Concentrations of Insulin in Plasma and the Functional Development of Glycometabolism in Newborn Piglets
     口饲胰岛素对新生仔猪血浆胰岛素水平及糖代谢的影响
短句来源
     The results show that oral insulin can stimulate the growth and development of small intestine mucosa in IUGR piglets.
     结果表明,口饲胰岛素能刺激新生IUGR仔猪小肠粘膜的生长发育及功能的成熟。
短句来源
     This study examined the effects of oral insulin on the changes of concentrations of insulin in plasma and the functional development of glycometabolism in new born normal piglets and IUGR piglets.
     分别给新生正常和子宫内发育迟缓(IUGR)仔猪口饲胰岛素,研究仔猪血浆中胰 岛素水平的变化,以及外源性胰岛素对新生仔猪体内糖代谢的影响。
短句来源
     In conclusion, great changes took place in glycometablism in the piglets during 0-3 days. Oral insulin can significantly increased the concentrations of insulin in plasma in normal piglets but show no significantly effect on the functional development of glycometabolism in piglets.
     上 述结果证明:仔猪出生0-3 d,糖代谢发生剧烈变化,口饲胰岛素使正常仔猪血浆中胰岛素水 平显著提高,但对仔猪糖代谢影响不显著。
短句来源
  “oral insulin”译为未确定词的双语例句
     Enhancing effect of Ulex europaeus agglutinin I modified liposomes on oral insulin absorption in mice
     荆豆凝集素修饰脂质体对小鼠口服吸收胰岛素的促进作用
短句来源
     EFFECTS OF ORAL INSULIN AND TRYPSINIZED FORMULA MILK ON SMALL INTESTINAL GROWTH AND DEVELOPMENT IN NEWBORN PIGS
     胰岛素和酶解配方奶粉对初生仔猪小肠生长发育的影响
短句来源
     Advanced research in oral insulin delivery
     口服型胰岛素的研究进展
短句来源
     The experimental results provide scientific data for the development of nanoparticle oral insulin agent with high bioavailability factor and for the selection of packing materials with suitable acid base endurance and reductive property.
     实验结果为研制具有高生物利用度的胰岛素纳米粒口服制剂及选择具有适当耐酸碱及还原特性的包装材料提供了科学依据。
短句来源
     Objective:This paper focus on using nanotechnology to improve the oral insulin delivery and the bioavailbility.
     目的通过纳米技术来改进胰岛素的口服给药,提高其生物利用度。
短句来源
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  oral insulin
Alginate/Chitosan Nanoparticles are Effective for Oral Insulin Delivery
      
Effect of oral insulin administration in liposomes on some indices of carbohydrate and pigment metabolism during experimental me
      
In the present study, we evaluated the protective effect of oral insulin (OI) on intestinal mucosa following lipopolysaccharide-induced intestinal damage in a rat.
      
Oral Insulin Up-regulates Toll-like Receptor 4 Expression and Enhances Intestinal Recovery Following Lipopolysaccharide-induced
      
We conclude that oral insulin supplementation exerts intestinal trophic effects, as well as systemic effects in the postweaning period in rats.
      
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A Powder consisting of Brij 58, a non-ionic surfactant stearic acid, andinsulin was administered to normal rabbits through a stomach tube, and then the changes of blood sugar concentration were followed. The preliminary experiments showed that this oral insulin preparation can reduce the blood glucose of the rabbits significantly.

由非离子型表面活性剂Brij58·硬脂酸和胰岛素制成的口服胰岛素粉剂,经管喂家兔后,追索其血糖浓度变化的初步实验表明具有显著的降血糖效应。

The insulin-loaded polyalkylcyanoacrylate nanoparticles (INSNP) were made with Dextran 70 as the stabilizer. The mean diameter of INSNP was 2524 nm with a poly dispersity of 0005. The associating ratio of insulin to the nanoparticles reached 701%±23%, while the loading capacity was 014 u·mg-1. Studies on in vitro release kinetics showed that release profiles can be well modelled using a biexponential function. The burst effect was obvious, and a faster release was observed in acidic media. After...

The insulin-loaded polyalkylcyanoacrylate nanoparticles (INSNP) were made with Dextran 70 as the stabilizer. The mean diameter of INSNP was 2524 nm with a poly dispersity of 0005. The associating ratio of insulin to the nanoparticles reached 701%±23%, while the loading capacity was 014 u·mg-1. Studies on in vitro release kinetics showed that release profiles can be well modelled using a biexponential function. The burst effect was obvious, and a faster release was observed in acidic media. After various doses of INSNP were intragastrically given to diabetic rats, significant decrease of glucose level was achieved in the 10 and 20 u·kg-1 groups, with no significant difference between these two doses. The relative bioavailability after po administration of INSNP 10 u·kg-1 over sc administration of insulin solution 1 u·kg-1 was 758% calculated by the area over the curve of glucose level (%) versus time profiles. The correlation was obvious between the % of insulin released at pH 70 and the % of glucose decresed within the first 7 hours. Hence, an oral insulin preparation with rather high bioavailability was provided in this study, and its shorter effective time will make it more convenient for the control of the glucose level in clinics. 

为研制一种生物利用度较高而降血作用时间短的口服INS制剂。制备了胰岛素聚氰基丙烯酸烷基酯毫微球(INSNP)。其平均粒径为2524nm,胰岛素的结合率为701%±23%。INSNP的体外释药符合双指数函数式,酸性介质中释放更快。Wistar大鼠po不同剂量的INSNP和胰岛素溶液(INSSOL),结果显示10u·kg-1和20u·kg-1的INSNP可显著降低血糖,但两个剂量间无显著性差异而INSSOL无降糖作用。用曲线上面积比较poINSNP和scINSSOL后的降糖作用,结果前者的相对生物利用度为758%。在血糖下降的时间范围内,体外释药的百分率与降糖速率间有一定相关性。

Objective To observe the diabetes preventing effects of oral administration of recombinant human insulin and glutamic acid decarboxylase (GAD) to female non obese diabetic (NOD) mice. The IL 4 mRNA transcription of pancreatic islet and serum IL 4 level before and after the oral antigen feeding were determined. Methods 96 female NOD mice were divided into three groups. Group 1: orally administrated PBS; Group 2: orally given insulin; Group 3: orally given GAD. The whole observation lasted one year. Serum...

Objective To observe the diabetes preventing effects of oral administration of recombinant human insulin and glutamic acid decarboxylase (GAD) to female non obese diabetic (NOD) mice. The IL 4 mRNA transcription of pancreatic islet and serum IL 4 level before and after the oral antigen feeding were determined. Methods 96 female NOD mice were divided into three groups. Group 1: orally administrated PBS; Group 2: orally given insulin; Group 3: orally given GAD. The whole observation lasted one year. Serum IL 4 was measured by ELISA and IL 4 mRNA transcription of pancreatic islet was examined by Northern blot. Results Oral administration of insulin to female NOD mice significantly suppressed incidence of diabetes. The PBS group became overt diabetes starting from 14 weeks of age while diabetes occurred in insulin and GAD groups at the age of 26 weeks. Diabetes incidences of PBS group, insulin group and GAD group were 89.4%, 66.6% and 64.7% respectively at the age of 52 weeks (P<0.01). Serum IL 4 level in NOD mice was elevated after oral administrated insulin and GAD at 12 and 16 weeks compared to control group 〔(77.94±8.12)μg/L, (83.10±9.36)μg/L vs (64.52±6.89)μg/L at 12 weeks, P all <0.01〕. IL 4 mRNA was transcripted in pancreas from insulin fed mice but not from PBS fed group. Conclusion These results show that the oral insulin and GAD administration can prevent NOD mice from diabetes. Pancreatic and systematic expression of Th 2 type cytokine may play an important role assooiating with the preventing effect.

目的 观察雌性非肥胖糖尿病 (NOD)小鼠口服胰岛素和谷氨酸脱羧酶 (GAD)对糖尿病发生的影响 ,以及对白细胞介素 4(IL 4)的血清水平和胰腺IL 4mRNA转录的影响。方法 雌性NOD小鼠分为 3组 :第一组给予PBS作为对照组 ,第二组给予胰岛素 ,第三组予以GAD。ELISA法检测血清IL 4水平 ,Northern杂交检测胰腺IL 4mRNA的表达。结果 胰岛素或GAD均能抑制NOD小鼠糖尿病的发生 ,PBS组 14周龄起病 ,胰岛素组和GAD组则 2 6周龄起病 ,5 2周龄时糖尿病的累积发病率对照组为 89.4% ,胰岛素组和GAD组分别为 6 6 .6 %和 6 4.7% (P <0 .0 1)。口服胰岛素和GAD能促进血清IL 4的水平增加 ,对照组 12周龄时血清IL 4水平 (6 4.5 2± 6 .89) μg/L ,而胰岛素组为 (77.94± 8.12 ) μg/L ,GAD组 (83.10± 9.6 3) μg/L ,胰岛素组和GAD组显著低于对照组 (P <0 .0 1)。Northern杂交检测胰腺IL 4mRNA发现胰岛素组可见IL 4mRNA的表达 ,PBS组未见表达...

目的 观察雌性非肥胖糖尿病 (NOD)小鼠口服胰岛素和谷氨酸脱羧酶 (GAD)对糖尿病发生的影响 ,以及对白细胞介素 4(IL 4)的血清水平和胰腺IL 4mRNA转录的影响。方法 雌性NOD小鼠分为 3组 :第一组给予PBS作为对照组 ,第二组给予胰岛素 ,第三组予以GAD。ELISA法检测血清IL 4水平 ,Northern杂交检测胰腺IL 4mRNA的表达。结果 胰岛素或GAD均能抑制NOD小鼠糖尿病的发生 ,PBS组 14周龄起病 ,胰岛素组和GAD组则 2 6周龄起病 ,5 2周龄时糖尿病的累积发病率对照组为 89.4% ,胰岛素组和GAD组分别为 6 6 .6 %和 6 4.7% (P <0 .0 1)。口服胰岛素和GAD能促进血清IL 4的水平增加 ,对照组 12周龄时血清IL 4水平 (6 4.5 2± 6 .89) μg/L ,而胰岛素组为 (77.94± 8.12 ) μg/L ,GAD组 (83.10± 9.6 3) μg/L ,胰岛素组和GAD组显著低于对照组 (P <0 .0 1)。Northern杂交检测胰腺IL 4mRNA发现胰岛素组可见IL 4mRNA的表达 ,PBS组未见表达。结论 口服胰岛素、GAD可预防NOD小鼠发生糖尿病 ,其机制可能与诱导的Th2 型细胞因子局部和全身表达的增加有关。

 
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