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checkpoint regulation
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  检查点调控
     Roles of p21 and Gadd45 in human cellular spindle checkpoint regulation
     p53及其效应分子p21和Gadd45在纺锤体检查点调控中的作用
短句来源
     Previous experiments have suggested that the role of web2 in S checkpoint regulation and web2 gene acts on upstream of rad53 in S checkpoint signal pathway.
     本课题组前期的实验已经证实,web2基因参与酿酒酵母S期检查点调控机制,并且在S期检查点调控通路上位于rad53基因上游。
短句来源
     Objective: To observe the roles of p21 and Gadd45 in human cellular spindle checkpoint regulation.
     目的:观察p53效应分子p21、Gadd45是否参与人源细胞纺锤体检查点调控
短句来源
     A ROLE OF WEB2 GENE IN S PHASE CHECKPOINT REGULATION OF S.CEREVISIAE
     WEB2基因参与酿酒酵母S期检查点调控
短句来源
     Roles of DNA Helicase WEB2 of Saccharomyces Cerevisiae in S Checkpoint Regulation Mechanism
     WEB2基因在酿酒酵母S期检查点调控机制中的作用
短句来源
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  关卡调控
     5. Immunocytochemistry and in situ hybridization analysis revealed that PDT resulted in an induction of G1/S checkpoint regulation factors such as Chk2 and p21WAF1/Cip1/Sdi1,and a down-regulation of cyclinD1 in a time-dependent fashion.
     5、PDT可于作用后早期(6h)诱导G1/S关卡调控因子Chk2、p21WAF1/Cip1/Sdi1蛋白表达增高,降低cyclinD1 mRNA和蛋白的表达,与G1/S期阻滞进程相一致,均呈时间依赖性变化。
短句来源
     Immunocytochemical analysis revealed that PDT resulted in an induction of G1/S checkpoint regulation factors such as Chk2 and P21WAF1/Cip1/Sdi1, and a down-regulation of CyclinD1 in a time-dependent manner. CONCLUSION: ALA-PDT causes G0-G1 phase arrest of SW480 cell cycle in post-PDT earlier period;
     光动力作用诱导SW480细胞G1/S关卡调控因子Chk2,P21wAF1/Cip1/Sdi1蛋白表达增高,降低CyclinD1 蛋白表达,与G1/S期阻滞进程相一致,均呈时间依赖性变化.
短句来源
  “checkpoint regulation”译为未确定词的双语例句
     Gl/S checkpoint regulation proteins such as p! 6 control GalT mRNA transcription and GalT surface and total activity.
     G1/S调控点调节蛋白质p16控制GalT mRNA转录、表面和总GalT活性。
短句来源
     Conclusions PC-1NTP resulted in G0/G1 phase arrest and elicited an attenuating effect on the proliferation and apoptosis of cystic-lining epithelial ceils, which may be realized through regulating the expression of G1/S checkpoint regulation factor cyclinD1/p21~(WAF1) and apoptosis regulating protein bcl-2/bax.
     结论PC-1NTP能明显抑制ADPKD囊肿衬里上皮细胞的增殖和凋亡,减慢细胞周期进程,其作用机制可能是通过调节G1/S关卡调节因子cyclinD1/p21~(WAF1)和凋亡调节蛋白bcl-2/bax的表达实现的。
短句来源
     The results indicated that c-Fos-like protein, c-Jun-like protein and Ras-like protein played important roles in checkpoint regulation in Physarum polycephalum.
     的类c-Fos、类c-Jun蛋白和类他s蛋白在细胞周期UGZ、(ZZ川
短句来源
     BRCA1 (breast cancer susceptibility gene 1) plays important roles in DNA damage repair,cell checkpoint regulation,gene transcription,chromosome stability,and apoptosis. At the C terminus of BRCA1 is the activation domain with a number of acidic amino acid residues that includes two tandem repeats of BRCT(BRCT1 and BRCT2).
     乳腺癌易感基因 (breastcancersusceptibilitygene 1,BRCA1)在DNA损伤修复、细胞周期调控、染色质的稳定、基因转录激活以及细胞凋亡等方面起着重要作用。
短句来源
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  checkpoint regulation
G1/S checkpoint regulation proteins control GalT mRNA transcription .The results indicate that FAK regulated the expression of GalT and its activity in NIH3T3 cells may contribute to the effect of FAK on the cell-cycle.
      
In this review we present DNA replication factors that are involved in different DNA transaction and checkpoint regulation pathways, with emphasis on the link between DNA replication and maintenance of genomic stability.
      
It has been shown that cell cycle checkpoint regulation pathways are associated with response to topo I poisons.
      
Checkpoint regulation of cell-cycle progression relies on the cyclin-dependent kinases.
      
All the data have shown that cell cycle checkpoint regulation pathways are associated with drug sensitivity and resistance to topo I poisons.
      


Objective: To observe the roles of p21 and Gadd45 in human cellular spindle checkpoint regulation. Methods: To establish MCF7 cell lines that constitutively express p21 and Gadd45 antisense RNA by transfecting antisense RNA expression plasmids and to observe polyploid cells after incubation in nocodazole by flow cytometry. Results: No polyploid cells were observed in MCF7 cell lines that expressed p21 and Gadd45 antisense RNA after incubation for 23 h or 60 h in medium containing nocodazole. However...

Objective: To observe the roles of p21 and Gadd45 in human cellular spindle checkpoint regulation. Methods: To establish MCF7 cell lines that constitutively express p21 and Gadd45 antisense RNA by transfecting antisense RNA expression plasmids and to observe polyploid cells after incubation in nocodazole by flow cytometry. Results: No polyploid cells were observed in MCF7 cell lines that expressed p21 and Gadd45 antisense RNA after incubation for 23 h or 60 h in medium containing nocodazole. However M phase accumulation induced by nocodazole significantly delayed in MCF7 cells transfected with p21 antisense RNA expression plasmids. Conclusion: p21 is involved in cell cycle transition from G2 to M phase, but there is a more complicated mechanism in regulation of cellular spindle checkpoint besides p53,p21 pathway in human cells than in mouse cells.

目的:观察p53效应分子p21、Gadd45是否参与人源细胞纺锤体检查点调控。方法:利用基因转染技术构建稳定表达p21、Gadd45反义RNA的MCF-7细胞系,观察纺锤体抑制剂诺考达唑(nocodazole)是否诱导多倍体细胞产生,细胞纺锤体检查点调控是否异常。结果:诺考达唑诱导23h、60h均未观察到稳定表达p21、Gadd45反义RNA的MCF-7细胞多倍体产生,但表达p21反义RNA的MCF-7细胞,诺考达唑引起的细胞M期聚集明显延迟。结论:p21参与细胞G2/M期转换的调控,但人源细胞具有除p53、p21外复杂机制调控细胞纺锤体检查点,防止多倍体产生,保持基因组的稳定。

Wortmannin(WORT)is a specific inhibitor of PI3 K kinase family. It was demonstrated that wortmannin increased the radiosensitivity of cells and inhibited the induction of p53 DNA binding activity by IR or actinomycin D and also inhibited the transcription of a p53 CAT reporter gene by actinomycin D. However, the enhancement of IR induced cytotoxicity that was obtained by WORT proved independent of these effects, since it occurred in cell lines which did not possess functional wtp53 as well as cell lines...

Wortmannin(WORT)is a specific inhibitor of PI3 K kinase family. It was demonstrated that wortmannin increased the radiosensitivity of cells and inhibited the induction of p53 DNA binding activity by IR or actinomycin D and also inhibited the transcription of a p53 CAT reporter gene by actinomycin D. However, the enhancement of IR induced cytotoxicity that was obtained by WORT proved independent of these effects, since it occurred in cell lines which did not possess functional wtp53 as well as cell lines which did. In order to elucidate the mechanism of radiosensitizing effect of WORT, the effect of WORT on tyrosine dephosphorylation delay of cdc2 in response to radiation was tested by immunoprecipitation and immunoblotting,effects of WORT on cell cycle G 2 delay and apoptosis in irradiated cells were detected by flow cytometry (FCM) and the effect of WORT on radiation damaged DNA repair in host cells was tested by reporter gene transfection. Results demonstrated that WORT could promote tyrosin dephosphorylation of cdc2 and reduce G 2 delay in irradiated cells, and that WORT inhibited repair of damaged reporter gene in host cells and enhanced apoptosis of irradiated cells. It implies that radiosensitizing effect of WORT is related to diverse pathways including disruption of cell cycle G 2/M checkpoint regulation、inhibition of DNA repair and enhancement of apoptosis.

W ortm annin( W O R T)是 P I3 K 家族激酶特异抑制剂,对 p53 野生型及突变型细胞的辐射敏感性均有提高.为了阐明 W O R T 的辐射增敏机制,通过免疫沉淀及免疫印迹法分析了 W O R T对辐射引起的细胞 G2/ M 转换中关键分子 cdc2 酪氨酸脱磷酸化延迟的影响;通过流式细胞术分析了 W O R T 对辐射引起的细胞 G2 期延迟、细胞凋亡的影响;经报告基因转染的方法分析了 W O R T对宿主细胞对辐射损伤报告基因修复的影响;发现 W O R T 可促进受照细胞 cdc2 酪氨酸脱磷酸化、减弱辐射引起的细胞 G2 期延迟、增强细胞凋亡并抑制损伤 D N A 修复.提示 W O R T 辐射增敏是通过干扰细胞 G2 期检查点调控、抑制损伤 D N A 修复和促进细胞凋亡等多种途径实现的.

WEB2 gene encodes a DNA helicase. A WEB2 mutant was treated with Hydroxyurea. Facs analysis, spindle microtubule staining by indirect immunofluorescence and % survial indicate that the mutant is defect in S phase checkpoint. We propose that WEB2 has not only helicase activity, but a role in S phase checkpoint regulation. And WEB2 gene locates in S phase checkpoint signal transduction pathway in S. cerevisiae. The study should shed light on eukaryotic cell checkpoint regulation and the origin...

WEB2 gene encodes a DNA helicase. A WEB2 mutant was treated with Hydroxyurea. Facs analysis, spindle microtubule staining by indirect immunofluorescence and % survial indicate that the mutant is defect in S phase checkpoint. We propose that WEB2 has not only helicase activity, but a role in S phase checkpoint regulation. And WEB2 gene locates in S phase checkpoint signal transduction pathway in S. cerevisiae. The study should shed light on eukaryotic cell checkpoint regulation and the origin of cancer.

WEB2基因编码产物为一种DNA解链酶。WEB2突变株经hydroxyurea阻断DNA合成后,经流式细胞仪检测DNA含量、纺锤体微管间接免疫 荧光染色及存活率测定,结果显示WEB2突变株表现S期检查点缺失。推测WEB2除了具有解链酶作用外,还参与酿酒酵母S期检查点调控机制,位于已建立的S期检查点信号传导通路模型上。本研究有助于加深对真核细胞检查点调控的了解,为研究肿瘤的发生机制提供线索。

 
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