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dna mismatch repair genes
相关语句
  dna错配修复基因
     Human MLH1 is one of the DNA mismatch repair genes and located in chromosome 3p21.3.Alterations of the MLH1 were associated with various kinds of human tumors.
     MLH1是位于3p21.3上的一个DNA错配修复基因,其异常与多种肿瘤相关。
短句来源
     The expression of DNA mismatch repair genes and detection of DNA ploidy in young patients with colorectal carcinoma
     青年人结直肠癌DNA错配修复基因表达和DNA倍性检测
短句来源
     Effects of Helicobacter pylori on expression of DNA mismatch repair genes in AGS cell line
     幽门螺杆菌对AGS细胞DNA错配修复基因表达的影响
短句来源
     Objective hMLH1 was one of DNA mismatch repair genes and located in 3p23~21.3.It was reported that allelic deletion of MLH1 gene was frequent among mismatch repair system. The study was to observe the loss of heterogeneity(LOH) of MLH1 gene in esophageal squamous cell carcinoma(ESCC).
     目的hMLH1是位于3p23-21.3上的一个DNA错配修复基因,有研究认为MLH1的缺失较为多见,本研究旨在了解食管鳞癌中MLH1基因杂合性丢失情况。
短句来源
     Frequent Ki-ras Mutation in MSI-H Colorectal Cancer Deficient in DNA Mismatch Repair Genes
     DNA错配修复基因缺陷的MSI-H大肠癌频发Ki-ras基因点突变
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  “dna mismatch repair genes”译为未确定词的双语例句
     Polymorphisms of the DNA Mismatch Repair Genes and Susceptibility to Colorectal Cancer
     DNA错配修复系统基因多态性与大肠癌易感
短句来源
     Objective To study relationship between microsatellite instability and expression of hMSH2, one of DNA mismatch repair genes in gastric cancer.
     目的探讨胃癌微卫星DNA不稳定性与错配修复基因hMSH2mRNA表达之间的关系。
短句来源
     Objective:To study the effect of X irradiation on expressions of DNA mismatch repair genes, hMSH2 and hMLH1, in nasopharyngeal carcinoma (NPC) CNE-1 cells, and explore corresponding mechanisms.
     目的研究X线照射对鼻咽癌细胞中错配修复基因hMSH2和hMLH1表达的影响,探讨放射损伤后肿瘤细胞的DNA错配修复机制。
短句来源
     Expression of DNA mismatch repair genes and microsatellite instability on the sporadic colorectal cancer
     错配修复、微卫星不稳定性与散发性结直肠癌
短句来源
     Effect of eukaryotic expression plasmid DNA methyltransferase gene on methylation status and transcription level of DNA mismatch repair genes in human colon cancer cell line
     甲基转移酶1表达质粒对结肠癌细胞错配修复基因甲基化及其表达的影响
短句来源
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  相似匹配句对
     DNA mismatch repair,MMR
     DNA错配修复
短句来源
     Polymorphisms of the DNA Mismatch Repair Genes and Susceptibility to Colorectal Cancer
     DNA错配修复系统基因多态性与大肠癌易感
短句来源
     hMSH2 is one of the genes involved in human DNA mismatch repair .
     有关hMSH2表达缺失与急性白血病发生、发展的关系目前国内少见报道。
短句来源
     Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer
     对结肠癌DNA错配修复基因突变携带者的识别及存活率的评估
短句来源
     Expression of DNA mismatch repair genes and microsatellite instability on the sporadic colorectal cancer
     错配修复、微卫星不稳定性与散发性结直肠癌
短句来源
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  dna mismatch repair genes
Most patients with HNPCC have a mutation in one of two DNA mismatch repair genes, hMSH2 or hMLH1.
      
The cellular DNA mismatch repair (MMR) pathway, involving the DNA mismatch repair genes MLH1 and MSH2, detects and repairs DNA replication errors.
      
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominantly inherited colorectal cancer syndrome attributable to mutations in one of several DNA mismatch repair genes, most commonly MLH1 and MSH2.
      
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant condition due to heterozygous germline mutations in DNA mismatch repair genes, in particular MLH1, MSH2 and MSH6.
      
Hereditary nonpolyposis colorectal cancer (HNPCC) is a multi-organ cancer syndrome associated with heritable mutations in DNA mismatch repair genes, particularly MLH1 (MutL Homologue 1) and MSH2 (MutS Homologue 2).
      
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The mutations of DNA mismatch repair genes (MMR) have been found in hereditary nonpolyposis colorectal cancer (HNPCC) and a subset of sporadic colorectal cancers (CRC) and the tumors of these patients contain alterations in microsatellite sequences (RER +, replication errors). Among them, hMSH2 seems to be the main causitive gene. 35 cases of sporadic CRC for mutations of hMSH2 and D25123 microsatellite instabilities have been analyzsed using PCR,PCRSSCP and DNA sequencing. The germline as...

The mutations of DNA mismatch repair genes (MMR) have been found in hereditary nonpolyposis colorectal cancer (HNPCC) and a subset of sporadic colorectal cancers (CRC) and the tumors of these patients contain alterations in microsatellite sequences (RER +, replication errors). Among them, hMSH2 seems to be the main causitive gene. 35 cases of sporadic CRC for mutations of hMSH2 and D25123 microsatellite instabilities have been analyzsed using PCR,PCRSSCP and DNA sequencing. The germline as well as somatic mutations were detected in 5 (exon7: 2, 8: 2, 15: 1 ) and 3 patients (exon7: 1, 8: 1 ) respectively. Two missense mutations and one samesense mutation were found in three cases sequenced. There were D2S123 alterations in 9 patients. The results suggest that the defects of MMR genes that are likely to cause transition and transversion in somatic and germline cells have been identified in sporadic CRC. Microsatellite alterations also exist in 25. 71 % of CRC.

应用PCR、SSCP和DNA序列分析等方法检测了35例散发性大肠癌患者hMSH2突变及微卫星D25123。结果在5例患者中发现生殖细胞hMSH2突变,外显子7和8各2例,外显子15有1例。2例肿瘤细胞突变中外显子7和8各1例。上述3例突变测序结果有2例为错义突变,1例为同义突变。D25123不稳定在9例患者中存在。本文结果提示,散发大肠癌患者的生殖细胞和体细胞中存在有hMSH2基因碱基置换突变。在约25.71%的大肠癌患者中有D2S123微卫星不稳定。

Objective:To study the somatic and germline mutations of a human mut S homolog (hMSH2), one of a group of DNA mismatch repair gene (MMR), and microsatellite instabilities in sporadic ovarian cancers. Methods: PCR, PCR SSCP and DNA sequencing were used to find the mutations of hMSH2 and microsatellite changes. Results: Twenty percent (3/15) patients existed D2S123 instabilities. The germline and somatic mutations were found in 3 of 15 ovarian cancers. There were same sense and nonsense...

Objective:To study the somatic and germline mutations of a human mut S homolog (hMSH2), one of a group of DNA mismatch repair gene (MMR), and microsatellite instabilities in sporadic ovarian cancers. Methods: PCR, PCR SSCP and DNA sequencing were used to find the mutations of hMSH2 and microsatellite changes. Results: Twenty percent (3/15) patients existed D2S123 instabilities. The germline and somatic mutations were found in 3 of 15 ovarian cancers. There were same sense and nonsense mutations. Conclusions: The carcinogenesis of ovarian cancers is related to the mutations of hMSH2 gene. It is postulated that the mechanism is as follows: the mutations of hMSH2 cause microsatellite instabilities and changes of a series of genes that induce cell transformation.

目的:研究卵巢癌患者DNA错配修复基因hMSH2(HumanmutShomolog)基因突变,同时检测其基因组微卫星D2S123序列变化。方法:应用PCR、PCR-SSCP和DNA序列分析方法检测了15例卵巢癌患者正常细胞和肿瘤细胞中的hMSH2基因突变。结果:3例患者存在hMSH2基因生殖细胞或体细胞突变,序列分析表明有碱基置换的同义突变,有碱基丢失产生的无义突变。有3例患者基因组表现D2S123变化,其中1例检测到hMSH2突变。结论:hMSH2基因突变和卵巢癌发生有关。机理可能为其突变引起基因组不稳定,而引起一系列基因变化,导致细胞恶性转化

Microsatellites are simply repeated nucleotide sequences scattered throughout the human genome. They are highly polymorphic among human population and inherited in a stable manner. The microsatellite instability (MI) is highly polymorphic, which is associated with the defects in DNA mismatch repair genes. MI has been widely used by scientists to study the tumorigenesis. On the basis of their findings, a “mutator that mutates the other mutator” model for tumorigenesis has been proposed. MI is also a potential...

Microsatellites are simply repeated nucleotide sequences scattered throughout the human genome. They are highly polymorphic among human population and inherited in a stable manner. The microsatellite instability (MI) is highly polymorphic, which is associated with the defects in DNA mismatch repair genes. MI has been widely used by scientists to study the tumorigenesis. On the basis of their findings, a “mutator that mutates the other mutator” model for tumorigenesis has been proposed. MI is also a potential tool for the study of genetics, aging and other life sciences.

微卫星为遍布于人类基因组中的简单重复序列。在人群中,它们呈现高度多态性,并且稳定遗传。微卫星的高度多态性是微卫星不稳定性的表现,它与错配修复基因的缺陷有关。微卫星不稳定性已广泛应用于肿瘤学的研究,并依此提出了肿瘤发生的“增变基因”途径。在遗传学、老年病学及其它一些生命科学,微卫星不稳定性同样具有广泛的应用前景。

 
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