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anti-implantation
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  抗着床
     It was found that Achyranthes bidentata saponins (ABS) showed significant anti-implantation and anti-early-pregnancy effects with dose-dependent, and ED50 were 96±27 mg/kg and 145 ± 51 mg/ kg respectively.
     给小鼠灌服怀牛藤总皂甙(ABS)75,150,300mg/kg,表明ABS具有明显的抗着床、抗早孕作用,且呈剂量依赖性关系,其ED50分别为96±27和145±51mg/kg。
短句来源
     Norethisterone-oxime-enanthat has been demonstrated in mice to be a remarkable anti-implantation agent following oral administration at the doses of 1.25~10mg/kg daily for 5days from the Ⅰst day of pregnancy on. The ED_(50) of anti-implantation for mouse was0.765±0.15 mg/kg.
     小鼠妊娠第1天起,给予庚炔诺酮肟1.25~10mg/kg 灌胃,每天1次,连续5天,有显著的抗着床作用,其ED_(50)为0.765±0.15mg/kg。
短句来源
     The experiments has also shown that as the compound was given in smalldoses(0.2mg/kg) on 3 consecutive days(day-2,-1,0),a total dosage of 0.6 mg,whichwas only 40% of the single dose,was sufficient for anti-implantation.
     此外,交配前连续3天(-2,-1,0天)投药、达100%抗着床效果的总剂量为0.6毫克/公斤,较单次剂量)1.5毫克/公斤)低2.5倍。
短句来源
     Sex hormone activities, anti-implantation action and the mechanism of action of 5α-dihydronorethisterone (5α-DNE) were studied.
     本文研究了5α-双氢炔诺酮的性激素活性、抗着床作用及其机理。
短句来源
     (3)possessed anti-implantation and early-pregnancy terminating effects in rats (P<0.01).
     ③对大白鼠有明显的抗着床、抗旱孕作用(P<0.01)。
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  抗植入
     ANTI-IMPLANTATION EFFECT OF PROPRANOLOL IN RAT
     心得安抗植入作用的实验研究
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  “anti-implantation”译为未确定词的双语例句
     The doses used were 0.125mg/kg,0.625 mg/kg. They are minimal effect doses (MED) for anti-implantation action,5 and 10 times of MED respectively. Rate and amplitude of respiration,blood pressure,and electrocadiogram were detected at 1/4,1/2,1,2,4 and 5 hours after administration.
     NETO剂量为0.125mg/kg、0.626mg/kg及1.25mg/kg,观察用药前及用药后1/4、1/2、1、2h的呼吸、血压,以及用药前、用药后1~5h的心率、心电图变化。
短句来源
     The results showed that:(1) The most of MC in the uterus was 5-hydroxytryptamine positive immunoreactive in both control group and spontaneous anti-implantation mice group,and the positive rates of(5-hydroxytryptamine) was 77.3%~93.6 %.
     结果表明:(1)绝大多数子宫MC为5-HT免疫反应阳性,阳性率在77.3%~93.6%之间;
短句来源
     d on day 1/3 of gestation resulted in 100% anti-implantation effect. However, yuehchukene at 4 mg/kg.
     金黄地鼠于妊娠1~3天,sc月橘烯碱4mg/kg·d却无此作用。
短句来源
     It was shown to be effective in anti-implantation and termination of early pregnancy in female rats, when given orally at a dose of 2.5 mg/kg/d for 4 days and 3.5 mg/kg/d for 4 days respectively. Ⅱb at a dose 10 mg/kg/d for 4 days showed only 30-40% efficacy in termination of early pregnancy.
     抗早孕最低口服有效剂量为3.5 mg/kg/4 d,Ⅱb则较弱。
短句来源
     1. Synthesis of the key precursor (57) of analogues of yuehchukene, a bis -indole alkaloid having anti -implantation activity and anti-inflammatory activity,was accomplished starting from indole and acrylic acid through Severn steps by employing the Diels -Alder cycloaddition reaction of indole diene (5) with acrylic acid and the cyclization of compound (48) in PPE as key steps.
     一、1.以吲哚和丙烯酸为基本起始原料经过七步化学反应完成了合成yuehchukene类似物的重要前体物(57)的合成。 关键步骤是吲哚双烯(5)与丙烯酸的Diels—Alder环加成反应及加成物(48)和(49)的环化反应。
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  anti-implantation
A sesquiterpene isolated from the roots ofAristolochia indica (Linn.) was found to exert 100% interceptive activity and 91.7% anti-implantation activity in mice at a single oral dose of 100mg/kg b.
      
In the pre-coital study, the treatment at 20 and 40?mg/kg body weight showed significant and dose-related anti-implantation and abortifacient properties.
      
The ethyl acetate soluble fraction of the ethanolic extract of Aristolochia bracteolata was tested for pre-coital and post-coital anti-implantation and abortifacient activities in female albino rats.
      
Pre-coital and post-coital anti-implantation and abortifacient activities of Aristolochia bracteolata Lam.
      
The biosynthesis of nucleic acids and proteins was studied in rat uterus by following the incorporation of [3H]-thymidine, [3H]-uridineand[14C]-leucinein control and pregnant rats in the presence and absence of two anti-implantation drugs.
      
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A histochemical study of placental and decidual tissue from 111 cases of early pregnancy was reported.The decidua cells were rich in glycogen,showing anegative or weakly positive of alkaline phosphatase and acid phosphatase.Slight-ly positive activities of 3β-hydroxysteroid dehydrogenase were generally seen.The endometrial glands were markedly fortuous with saw-teeth appearance orscalloped wall formed,some cells had shoe-nail configuration.The glandluminawere filled with excreted materials,which showed positive...

A histochemical study of placental and decidual tissue from 111 cases of early pregnancy was reported.The decidua cells were rich in glycogen,showing anegative or weakly positive of alkaline phosphatase and acid phosphatase.Slight-ly positive activities of 3β-hydroxysteroid dehydrogenase were generally seen.The endometrial glands were markedly fortuous with saw-teeth appearance orscalloped wall formed,some cells had shoe-nail configuration.The glandluminawere filled with excreted materials,which showed positive PAS reaction.Thisphenomenon apparently a nutritive condition supporting the early pregnancy.The placental villi in early pregnancy revealed a dual covering of syncytio-trophoblast and cytotrophoblast after day 60 of gestation,the cytotrophoblast di-sappeared gradually,the villi varied in size,many fetal blood vessels dilated andmigrated to the surface of villi,so that the feto-maternal barrier became thinningand is advantageous to the exchange of substances between fetal and maternalbodies.T histochemical observations of placental villi during early pregnancy revealed a strongly positive reaction of glycogen and alkaline phosphatase activity.It is an index of active metabolism of syncytiotrophoblast and cytotrophoblastof the villi.The acid phosphatase activity of cytotrophoblast increasing graduallyday 60 to 9o of gestation may be related to the involution of the trophoblast cellsin this stage.The 3β-HSD plays an important role in the steroid biosynthesis,and thetrophoblast of placental villi revealed a postive 3β-HSD reaction.It seemsreasonable to conclude,that the trophoblasts possess a biosynthetic ability forsteroids.The placental villi and decidua are tissues contributing to the contact andconnection between fetal and maternal bodies during implantation and earlypregnancy.From the point of view of family planning,as well as of developingnew drugs for anti-implantation and early abortifacients,the research of morpho-logy and function of placental villi and decidua should be emphasized.

111例正常早孕人工流产的胎盘组织作绒毛蜕膜组织化学观察。蜕膜细胞,富于糖元,碱性磷酸酶多呈阳性或弱阳性,酸性磷酸酶多数阴性或弱阳性,少数阳性。3β-HSD弱阳性,蜕膜腺体弯曲呈锯齿状,腺体壁呈扇形,有时细胞向内突出如鞋钉状,腔内充满分泌物,糖元强阳性,对维持早期妊娠是一个重要营养条件。早期妊娠绒毛具有完整两层滋养层,即合体滋养层及细胞滋养层,60天后则细胞滋养层逐步消失,绒毛大小不等,胎儿血管扩大并移向绒毛表面,从而使胎儿-母体胎盘屏障变薄,有利于胎儿-母体的物质交换,是适应胚胎发育的一个重要条件。早孕期绒毛组织化学检查显示绒毛两层细胞糖元和碱性磷酸酶活性都很强,反映代谢机能活跃,细胞滋养层胞浆酸性磷酸酶活性60—90天逐渐加强,这应与此时期细胞滋养层退化有关。3β-HSD 在甾体生物合成过程中起重要作用,绒毛滋养层细胞3β-HSD皆为阳性,表明具有甾体生物合成机能。着床、早孕过程中,绒毛、蜕膜是母体-胚胎直接接触和相互联系的两种组织,从计划生育角度,在发展抗着床、抗早孕药物研究工作中,对于蜕膜、绒毛形态和机能的研究应当受到重视。

A remarkable anti-implantation effect of Norethisterone-oxime-acetate was observedin experimental animals.In mice,rats and rabbits implantation was totally inhibitedwhen the drug was orally administered from day 2 of pregnancy at a daily dose of 0.51,and 2 mg/kg respectively for 3 days.The same effect could also be demonstrated in rats receiving a single dose of 5 or 10mg/kg of the drug on day 2 or 3 of pregnancy.4 healthy rabbits used for testing the toxicity received the drug orally at a dose of 10mg/kg/day(about...

A remarkable anti-implantation effect of Norethisterone-oxime-acetate was observedin experimental animals.In mice,rats and rabbits implantation was totally inhibitedwhen the drug was orally administered from day 2 of pregnancy at a daily dose of 0.51,and 2 mg/kg respectively for 3 days.The same effect could also be demonstrated in rats receiving a single dose of 5 or 10mg/kg of the drug on day 2 or 3 of pregnancy.4 healthy rabbits used for testing the toxicity received the drug orally at a dose of 10mg/kg/day(about 500 times as much as the clinical dose)for 3 weeks,and all were nor-mal in blood routine and renal function tests but a raised change was shown in their liverfunction(completely restored 2 weeks after cessation of the drug).3 dogs were given the drug at the dose of 1-2 mg/kg/day(about 50-100 times as muchas the clinical dose )for 14 months,no obvious toxic effect being observed.

醋炔诺酮肟对实验动物有明显的抗着床作用。小鼠、大鼠和家兔在妊娠第2天起,分别给予醋炔诺酮肟0.5、1和2毫克/公斤,每天一次,连续3天,均有显著的抗着床作用。大鼠在妊娠第2或3天一次给醋炔诺肟酮5或10毫克/公斤,亦有明显的抗着床作用。家兔4只,每日灌服醋炔诺酮肟10毫克/公斤(约为临床剂量500倍),连续3周,给药后肝功能升高,停药2周后恢复正常,血象和肾功能均无明显变化。犬3只,每日灌服醋炔诺酮肟1~2毫克/公斤(约为临床剂量50~100倍),连服14个月,无明显毒性。

7α-methyl-17β-hydroxy-estr-5-en-3-one (2b) was synthesized through 1,6-conjugated addition of organocopper reagent to 17β-hydroxy-Δ~(4,6)-estra-dien-3-one (4) obtained from Δ~4-estren-3,17-dione (5) in good yield. Biological Study of (2b) revealed that it has significant anti-implantation and termination of early pregnancy activities in animals[3b].

以△~4-雌甾烯-3,17-二酮(5)为原料,经四步得到17β-羟基-△~(4,6)-雌甾二烯-3-酮(4),(4)与二甲基铜锂试剂经1,6共轭加成合成了目的物7α-甲基-17β-羟基-雌甾-5-烯-3-酮(2b)。经药理试验表明2b具有明显的抗着床及抗早孕活性。

 
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